Assessment of subjective and objective cognitive function in bipolar disorder: Correlations, predictors and the relation to psychosocial function
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Assessment of subjective and objective cognitive function in bipolar disorder : Correlations, predictors and the relation to psychosocial function. / Demant, Kirsa M; Vinberg, Maj; Kessing, Lars V; Miskowiak, Kamilla W.
In: Psychiatry Research, Vol. 229, No. 1-2, 30.09.2015, p. 565-71.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Assessment of subjective and objective cognitive function in bipolar disorder
T2 - Correlations, predictors and the relation to psychosocial function
AU - Demant, Kirsa M
AU - Vinberg, Maj
AU - Kessing, Lars V
AU - Miskowiak, Kamilla W
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/9/30
Y1 - 2015/9/30
N2 - Cognitive dysfunction is prevalent in bipolar disorder (BD). However, the evidence regarding the association between subjective cognitive complaints, objective cognitive performance and psychosocial function is sparse and inconsistent. Seventy seven patients with bipolar disorder who presented cognitive complaints underwent assessment of objective and subjective cognitive function and psychosocial functioning as part of their participation in two clinical trials. We investigated the association between global and domain-specific objective and subjective cognitive function and between global cognitive function and psychosocial function. We also identified clinical variables that predicted objective and subjective cognitive function and psychosocial functioning. There was a correlation between global subjective and objective measures of cognitive dysfunction but not within the individual cognitive domains. However, the correlation was weak, suggesting that cognitive complaints are not an assay of cognition per se. Self-rated psychosocial difficulties were associated with subjective (but not objective) cognitive impairment and both subjective cognitive and psychosocial difficulties were predicted by depressive symptoms. Our findings indicate that adequate assessment of cognition in the clinical treatment of BD and in drug trials targeting cognition requires implementation of not only subjective measures but also of objective neuropsychological tests.
AB - Cognitive dysfunction is prevalent in bipolar disorder (BD). However, the evidence regarding the association between subjective cognitive complaints, objective cognitive performance and psychosocial function is sparse and inconsistent. Seventy seven patients with bipolar disorder who presented cognitive complaints underwent assessment of objective and subjective cognitive function and psychosocial functioning as part of their participation in two clinical trials. We investigated the association between global and domain-specific objective and subjective cognitive function and between global cognitive function and psychosocial function. We also identified clinical variables that predicted objective and subjective cognitive function and psychosocial functioning. There was a correlation between global subjective and objective measures of cognitive dysfunction but not within the individual cognitive domains. However, the correlation was weak, suggesting that cognitive complaints are not an assay of cognition per se. Self-rated psychosocial difficulties were associated with subjective (but not objective) cognitive impairment and both subjective cognitive and psychosocial difficulties were predicted by depressive symptoms. Our findings indicate that adequate assessment of cognition in the clinical treatment of BD and in drug trials targeting cognition requires implementation of not only subjective measures but also of objective neuropsychological tests.
KW - Adult
KW - Bipolar Disorder
KW - Cognition
KW - Cognition Disorders
KW - Cohort Studies
KW - Depression
KW - Executive Function
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neuropsychological Tests
KW - Predictive Value of Tests
KW - Psychology
U2 - 10.1016/j.psychres.2015.05.022
DO - 10.1016/j.psychres.2015.05.022
M3 - Journal article
C2 - 26073281
VL - 229
SP - 565
EP - 571
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1-2
ER -
ID: 162339709