Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. / Thomsen, L L; Iversen, Helle Klingenberg; Brinck, T A; Olesen, J.

In: Cephalalgia : an international journal of headache, Vol. 13, No. 6, 12.1993, p. 395-9; discussion 376.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thomsen, LL, Iversen, HK, Brinck, TA & Olesen, J 1993, 'Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers', Cephalalgia : an international journal of headache, vol. 13, no. 6, pp. 395-9; discussion 376.

APA

Thomsen, L. L., Iversen, H. K., Brinck, T. A., & Olesen, J. (1993). Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia : an international journal of headache, 13(6), 395-9; discussion 376.

Vancouver

Thomsen LL, Iversen HK, Brinck TA, Olesen J. Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia : an international journal of headache. 1993 Dec;13(6):395-9; discussion 376.

Author

Thomsen, L L ; Iversen, Helle Klingenberg ; Brinck, T A ; Olesen, J. / Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. In: Cephalalgia : an international journal of headache. 1993 ; Vol. 13, No. 6. pp. 395-9; discussion 376.

Bibtex

@article{597576c787d94f9bb098e1d8f38ca545,
title = "Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers",
abstract = "The sensitivity to nitroglycerin-induced dilatation of large intracranial arteries was studied in 17 patients with migraine without aura, 17 age and sex-matched healthy subjects and 9 patients with episodic tension-type headache. Nitroglycerin in the doses of 0.015, 0.03, 0.25 microgram/kg/min was successively infused for 15 min per dose. Blood velocity (Vmean) in the middle cerebral artery (MCA) was recorded with transcranial Doppler before and at the end of every infusion period, and 30 and 60 min after end of the last infusion. In all three groups Vmean decreased with increasing doses (p < 0.001). The response was more pronounced in migraine patients at the two higher doses (p < 0.05). Since nitroglycerin acts as an exogenous source of nitric oxide (NO), these data support that NO supersensitivity may be an important molecular mechanism of migraine pain.",
keywords = "Adult, Analysis of Variance, Cerebral Arteries, Female, Humans, Male, Middle Aged, Migraine Disorders, Nitric Oxide, Nitroglycerin, Ultrasonography, Doppler, Transcranial, Vasodilation",
author = "Thomsen, {L L} and Iversen, {Helle Klingenberg} and Brinck, {T A} and J Olesen",
year = "1993",
month = dec,
language = "English",
volume = "13",
pages = "395--9; discussion 376",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers

AU - Thomsen, L L

AU - Iversen, Helle Klingenberg

AU - Brinck, T A

AU - Olesen, J

PY - 1993/12

Y1 - 1993/12

N2 - The sensitivity to nitroglycerin-induced dilatation of large intracranial arteries was studied in 17 patients with migraine without aura, 17 age and sex-matched healthy subjects and 9 patients with episodic tension-type headache. Nitroglycerin in the doses of 0.015, 0.03, 0.25 microgram/kg/min was successively infused for 15 min per dose. Blood velocity (Vmean) in the middle cerebral artery (MCA) was recorded with transcranial Doppler before and at the end of every infusion period, and 30 and 60 min after end of the last infusion. In all three groups Vmean decreased with increasing doses (p < 0.001). The response was more pronounced in migraine patients at the two higher doses (p < 0.05). Since nitroglycerin acts as an exogenous source of nitric oxide (NO), these data support that NO supersensitivity may be an important molecular mechanism of migraine pain.

AB - The sensitivity to nitroglycerin-induced dilatation of large intracranial arteries was studied in 17 patients with migraine without aura, 17 age and sex-matched healthy subjects and 9 patients with episodic tension-type headache. Nitroglycerin in the doses of 0.015, 0.03, 0.25 microgram/kg/min was successively infused for 15 min per dose. Blood velocity (Vmean) in the middle cerebral artery (MCA) was recorded with transcranial Doppler before and at the end of every infusion period, and 30 and 60 min after end of the last infusion. In all three groups Vmean decreased with increasing doses (p < 0.001). The response was more pronounced in migraine patients at the two higher doses (p < 0.05). Since nitroglycerin acts as an exogenous source of nitric oxide (NO), these data support that NO supersensitivity may be an important molecular mechanism of migraine pain.

KW - Adult

KW - Analysis of Variance

KW - Cerebral Arteries

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Migraine Disorders

KW - Nitric Oxide

KW - Nitroglycerin

KW - Ultrasonography, Doppler, Transcranial

KW - Vasodilation

M3 - Journal article

C2 - 7906202

VL - 13

SP - 395-9; discussion 376

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 6

ER -

ID: 128984494