Applying insights from biofilm biology to drug development - can a new approach be developed?
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Applying insights from biofilm biology to drug development - can a new approach be developed? / Bjarnsholt, Thomas; Ciofu, Oana; Molin, Søren; Givskov, Michael; Høiby, Niels.
In: Nature Reviews. Drug Discovery, Vol. 12, No. 10, 01.10.2013, p. 791-808.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Applying insights from biofilm biology to drug development - can a new approach be developed?
AU - Bjarnsholt, Thomas
AU - Ciofu, Oana
AU - Molin, Søren
AU - Givskov, Michael
AU - Høiby, Niels
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Most of the research on bacterial pathogenesis has focused on acute infections, but much less is known about the pathogenesis of infections caused by bacteria that grow as aggregates in biofilms. These infections tend to be chronic as they resist innate and adaptive immune defence mechanisms as well as antibiotics, and the treatment of biofilm infections presents a considerable unmet clinical need. To date, there are no drugs that specifically target bacteria in biofilms; however, several approaches are in early-stage development. Here, we review current insights into biofilm physiology and pathology, and discuss how a deep insight into the physical and biological characteristics of biofilms can inform therapeutic strategies and molecular targets for the development of anti-biofilm drugs.
AB - Most of the research on bacterial pathogenesis has focused on acute infections, but much less is known about the pathogenesis of infections caused by bacteria that grow as aggregates in biofilms. These infections tend to be chronic as they resist innate and adaptive immune defence mechanisms as well as antibiotics, and the treatment of biofilm infections presents a considerable unmet clinical need. To date, there are no drugs that specifically target bacteria in biofilms; however, several approaches are in early-stage development. Here, we review current insights into biofilm physiology and pathology, and discuss how a deep insight into the physical and biological characteristics of biofilms can inform therapeutic strategies and molecular targets for the development of anti-biofilm drugs.
U2 - 10.1038/nrd4000
DO - 10.1038/nrd4000
M3 - Journal article
C2 - 24080700
VL - 12
SP - 791
EP - 808
JO - Nature Reviews. Drug Discovery
JF - Nature Reviews. Drug Discovery
SN - 1474-1776
IS - 10
ER -
ID: 62354566