Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?

Research output: Contribution to journal › Journal article › Research › peer-review

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Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker? / Loft, Steffen; Møller, Peter; Cooke, Marcus S; Rozalski, Rafal; Olinski, Ryszard.

In: European Journal of Nutrition, Vol. 47 Suppl 2, 2008, p. 19-28.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Loft, S, Møller, P, Cooke, MS, Rozalski, R & Olinski, R 2008, 'Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?', European Journal of Nutrition, vol. 47 Suppl 2, pp. 19-28. https://doi.org/10.1007/s00394-008-2004-0

APA

Loft, S., Møller, P., Cooke, M. S., Rozalski, R., & Olinski, R. (2008). Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker? European Journal of Nutrition, 47 Suppl 2, 19-28. https://doi.org/10.1007/s00394-008-2004-0

Vancouver

Loft S, Møller P, Cooke MS, Rozalski R, Olinski R. Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker? European Journal of Nutrition. 2008;47 Suppl 2:19-28. https://doi.org/10.1007/s00394-008-2004-0

Author

Loft, Steffen ; Møller, Peter ; Cooke, Marcus S ; Rozalski, Rafal ; Olinski, Ryszard. / Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?. In: European Journal of Nutrition. 2008 ; Vol. 47 Suppl 2. pp. 19-28.

Bibtex

@article{6a395920443d11ddb7b4000ea68e967b,
title = "Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?",
abstract = "Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.",
author = "Steffen Loft and Peter M{\o}ller and Cooke, {Marcus S} and Rafal Rozalski and Ryszard Olinski",
year = "2008",
doi = "10.1007/s00394-008-2004-0",
language = "English",
volume = "47 Suppl 2",
pages = "19--28",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Medizin",

}

RIS

TY - JOUR

T1 - Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?

AU - Loft, Steffen

AU - Møller, Peter

AU - Cooke, Marcus S

AU - Rozalski, Rafal

AU - Olinski, Ryszard

PY - 2008

Y1 - 2008

N2 - Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.

AB - Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-dihydroguanine (8-oxodG) are increasingly being regarded as reliable biomarkers of oxidative stress and they may have a predictive value of cancer risk, although this needs to be established independently in several cohort studies. A survey of intervention studies of the ingestion of antioxidant-containing foods or tablets of antioxidants indicate that about one-third of the studies reported a protective effect in terms of lower levels of oxidative damage to DNA in white blood cells or decreased urinary excretion of 8-oxodG. Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer.

U2 - 10.1007/s00394-008-2004-0

DO - 10.1007/s00394-008-2004-0

M3 - Journal article

C2 - 18458832

VL - 47 Suppl 2

SP - 19

EP - 28

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -

ID: 4786256