An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms

Research output: Contribution to journalJournal articlepeer-review

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An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. / Wildisen, Lea; Del Giovane, Cinzia; Moutzouri, Elisavet; Beglinger, Shanthi; Syrogiannouli, Lamprini; Collet, Tinh-Hai; Cappola, Anne R.; Asvold, Bjørn O.; Bakker, Stephan J. L.; Yeap, Bu B.; Almeida, Osvaldo P.; Ceresini, Graziano; Dullaart, Robin P. F.; Ferrucci, Luigi; Grabe, Hans; Jukema, J. Wouter; Nauck, Matthias; Trompet, Stella; Voelzke, Henry; Westendorp, Rudi; Gussekloo, Jacobijn; Kloppel, Stefan; Aujesky, Drahomir; Bauer, Douglas; Peeters, Robin; Feller, Martin; Rodondi, Nicolas.

In: Scientific Reports, Vol. 10, No. 1, 19111, 2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Wildisen, L, Del Giovane, C, Moutzouri, E, Beglinger, S, Syrogiannouli, L, Collet, T-H, Cappola, AR, Asvold, BO, Bakker, SJL, Yeap, BB, Almeida, OP, Ceresini, G, Dullaart, RPF, Ferrucci, L, Grabe, H, Jukema, JW, Nauck, M, Trompet, S, Voelzke, H, Westendorp, R, Gussekloo, J, Kloppel, S, Aujesky, D, Bauer, D, Peeters, R, Feller, M & Rodondi, N 2020, 'An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms', Scientific Reports, vol. 10, no. 1, 19111. https://doi.org/10.1038/s41598-020-75776-1

APA

Wildisen, L., Del Giovane, C., Moutzouri, E., Beglinger, S., Syrogiannouli, L., Collet, T-H., Cappola, A. R., Asvold, B. O., Bakker, S. J. L., Yeap, B. B., Almeida, O. P., Ceresini, G., Dullaart, R. P. F., Ferrucci, L., Grabe, H., Jukema, J. W., Nauck, M., Trompet, S., Voelzke, H., ... Rodondi, N. (2020). An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Scientific Reports, 10(1), [19111]. https://doi.org/10.1038/s41598-020-75776-1

Vancouver

Wildisen L, Del Giovane C, Moutzouri E, Beglinger S, Syrogiannouli L, Collet T-H et al. An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Scientific Reports. 2020;10(1). 19111. https://doi.org/10.1038/s41598-020-75776-1

Author

Wildisen, Lea ; Del Giovane, Cinzia ; Moutzouri, Elisavet ; Beglinger, Shanthi ; Syrogiannouli, Lamprini ; Collet, Tinh-Hai ; Cappola, Anne R. ; Asvold, Bjørn O. ; Bakker, Stephan J. L. ; Yeap, Bu B. ; Almeida, Osvaldo P. ; Ceresini, Graziano ; Dullaart, Robin P. F. ; Ferrucci, Luigi ; Grabe, Hans ; Jukema, J. Wouter ; Nauck, Matthias ; Trompet, Stella ; Voelzke, Henry ; Westendorp, Rudi ; Gussekloo, Jacobijn ; Kloppel, Stefan ; Aujesky, Drahomir ; Bauer, Douglas ; Peeters, Robin ; Feller, Martin ; Rodondi, Nicolas. / An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex

@article{24785b8242a94e60b46931e668bfd061,
title = "An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms",
abstract = "In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library from inception to 10th May 2019. We included prospective cohorts with data on thyroid status at baseline and depressive symptoms during follow-up. The primary outcome was depressive symptoms measured at first available follow-up, expressed on the Beck's Depression Inventory (BDI) scale (range 0-63, higher values indicate more depressive symptoms, minimal clinically important difference: 5 points). We performed a two-stage individual participant data (IPD) analysis comparing participants with subclinical hypo- or hyperthyroidism versus euthyroidism, adjusting for depressive symptoms at baseline, age, sex, education, and income (PROSPERO CRD42018091627). Six cohorts met the inclusion criteria, with IPD on 23,038 participants. Their mean age was 60 years, 65% were female, 21,025 were euthyroid, 1342 had subclinical hypothyroidism and 671 subclinical hyperthyroidism. At first available follow-up [mean 8.2 (+/- 4.3) years], BDI scores did not differ between participants with subclinical hypothyroidism (mean difference = 0.29, 95% confidence interval = - 0.17 to 0.76, I-2 = 15.6) or subclinical hyperthyroidism (- 0.10, 95% confidence interval = - 0.67 to 0.48, I-2 = 3.2) compared to euthyroidism. This systematic review and IPD analysis of six prospective cohort studies found no clinically relevant association between subclinical thyroid dysfunction at baseline and depressive symptoms during follow-up. The results were robust in all sensitivity and subgroup analyses. Our results are in contrast with the traditional notion that subclinical thyroid dysfunction, and subclinical hypothyroidism in particular, is associated with depressive symptoms. Consequently, our results do not support the practice of prescribing levothyroxine in patients with subclinical hypothyroidism to reduce the risk of developing depressive symptoms.",
keywords = "BASE-LINE CHARACTERISTICS, OSTEOPOROTIC FRACTURES, RISK-FACTORS, HYPOTHYROIDISM, METAANALYSIS, HEALTH, MEN, DISEASE, DESIGN, STAGE",
author = "Lea Wildisen and {Del Giovane}, Cinzia and Elisavet Moutzouri and Shanthi Beglinger and Lamprini Syrogiannouli and Tinh-Hai Collet and Cappola, {Anne R.} and Asvold, {Bj{\o}rn O.} and Bakker, {Stephan J. L.} and Yeap, {Bu B.} and Almeida, {Osvaldo P.} and Graziano Ceresini and Dullaart, {Robin P. F.} and Luigi Ferrucci and Hans Grabe and Jukema, {J. Wouter} and Matthias Nauck and Stella Trompet and Henry Voelzke and Rudi Westendorp and Jacobijn Gussekloo and Stefan Kloppel and Drahomir Aujesky and Douglas Bauer and Robin Peeters and Martin Feller and Nicolas Rodondi",
year = "2020",
doi = "10.1038/s41598-020-75776-1",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms

AU - Wildisen, Lea

AU - Del Giovane, Cinzia

AU - Moutzouri, Elisavet

AU - Beglinger, Shanthi

AU - Syrogiannouli, Lamprini

AU - Collet, Tinh-Hai

AU - Cappola, Anne R.

AU - Asvold, Bjørn O.

AU - Bakker, Stephan J. L.

AU - Yeap, Bu B.

AU - Almeida, Osvaldo P.

AU - Ceresini, Graziano

AU - Dullaart, Robin P. F.

AU - Ferrucci, Luigi

AU - Grabe, Hans

AU - Jukema, J. Wouter

AU - Nauck, Matthias

AU - Trompet, Stella

AU - Voelzke, Henry

AU - Westendorp, Rudi

AU - Gussekloo, Jacobijn

AU - Kloppel, Stefan

AU - Aujesky, Drahomir

AU - Bauer, Douglas

AU - Peeters, Robin

AU - Feller, Martin

AU - Rodondi, Nicolas

PY - 2020

Y1 - 2020

N2 - In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library from inception to 10th May 2019. We included prospective cohorts with data on thyroid status at baseline and depressive symptoms during follow-up. The primary outcome was depressive symptoms measured at first available follow-up, expressed on the Beck's Depression Inventory (BDI) scale (range 0-63, higher values indicate more depressive symptoms, minimal clinically important difference: 5 points). We performed a two-stage individual participant data (IPD) analysis comparing participants with subclinical hypo- or hyperthyroidism versus euthyroidism, adjusting for depressive symptoms at baseline, age, sex, education, and income (PROSPERO CRD42018091627). Six cohorts met the inclusion criteria, with IPD on 23,038 participants. Their mean age was 60 years, 65% were female, 21,025 were euthyroid, 1342 had subclinical hypothyroidism and 671 subclinical hyperthyroidism. At first available follow-up [mean 8.2 (+/- 4.3) years], BDI scores did not differ between participants with subclinical hypothyroidism (mean difference = 0.29, 95% confidence interval = - 0.17 to 0.76, I-2 = 15.6) or subclinical hyperthyroidism (- 0.10, 95% confidence interval = - 0.67 to 0.48, I-2 = 3.2) compared to euthyroidism. This systematic review and IPD analysis of six prospective cohort studies found no clinically relevant association between subclinical thyroid dysfunction at baseline and depressive symptoms during follow-up. The results were robust in all sensitivity and subgroup analyses. Our results are in contrast with the traditional notion that subclinical thyroid dysfunction, and subclinical hypothyroidism in particular, is associated with depressive symptoms. Consequently, our results do not support the practice of prescribing levothyroxine in patients with subclinical hypothyroidism to reduce the risk of developing depressive symptoms.

AB - In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library from inception to 10th May 2019. We included prospective cohorts with data on thyroid status at baseline and depressive symptoms during follow-up. The primary outcome was depressive symptoms measured at first available follow-up, expressed on the Beck's Depression Inventory (BDI) scale (range 0-63, higher values indicate more depressive symptoms, minimal clinically important difference: 5 points). We performed a two-stage individual participant data (IPD) analysis comparing participants with subclinical hypo- or hyperthyroidism versus euthyroidism, adjusting for depressive symptoms at baseline, age, sex, education, and income (PROSPERO CRD42018091627). Six cohorts met the inclusion criteria, with IPD on 23,038 participants. Their mean age was 60 years, 65% were female, 21,025 were euthyroid, 1342 had subclinical hypothyroidism and 671 subclinical hyperthyroidism. At first available follow-up [mean 8.2 (+/- 4.3) years], BDI scores did not differ between participants with subclinical hypothyroidism (mean difference = 0.29, 95% confidence interval = - 0.17 to 0.76, I-2 = 15.6) or subclinical hyperthyroidism (- 0.10, 95% confidence interval = - 0.67 to 0.48, I-2 = 3.2) compared to euthyroidism. This systematic review and IPD analysis of six prospective cohort studies found no clinically relevant association between subclinical thyroid dysfunction at baseline and depressive symptoms during follow-up. The results were robust in all sensitivity and subgroup analyses. Our results are in contrast with the traditional notion that subclinical thyroid dysfunction, and subclinical hypothyroidism in particular, is associated with depressive symptoms. Consequently, our results do not support the practice of prescribing levothyroxine in patients with subclinical hypothyroidism to reduce the risk of developing depressive symptoms.

KW - BASE-LINE CHARACTERISTICS

KW - OSTEOPOROTIC FRACTURES

KW - RISK-FACTORS

KW - HYPOTHYROIDISM

KW - METAANALYSIS

KW - HEALTH

KW - MEN

KW - DISEASE

KW - DESIGN

KW - STAGE

U2 - 10.1038/s41598-020-75776-1

DO - 10.1038/s41598-020-75776-1

M3 - Journal article

C2 - 33154486

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 19111

ER -

ID: 252036835