An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. / Pedersen, Mikael Egebjerg; Snieckute, Goda; Kagias, Konstantinos; Nehammer, Camilla; Multhaupt, Hinke A B; Couchman, John R; Pocock, Roger.

In: Science, Vol. 341, No. 6152, 20.09.2013, p. 1404-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, ME, Snieckute, G, Kagias, K, Nehammer, C, Multhaupt, HAB, Couchman, JR & Pocock, R 2013, 'An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state', Science, vol. 341, no. 6152, pp. 1404-8. https://doi.org/10.1126/science.1242528

APA

Pedersen, M. E., Snieckute, G., Kagias, K., Nehammer, C., Multhaupt, H. A. B., Couchman, J. R., & Pocock, R. (2013). An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Science, 341(6152), 1404-8. https://doi.org/10.1126/science.1242528

Vancouver

Pedersen ME, Snieckute G, Kagias K, Nehammer C, Multhaupt HAB, Couchman JR et al. An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Science. 2013 Sep 20;341(6152):1404-8. https://doi.org/10.1126/science.1242528

Author

Pedersen, Mikael Egebjerg ; Snieckute, Goda ; Kagias, Konstantinos ; Nehammer, Camilla ; Multhaupt, Hinke A B ; Couchman, John R ; Pocock, Roger. / An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. In: Science. 2013 ; Vol. 341, No. 6152. pp. 1404-8.

Bibtex

@article{0ed2a65ca7fe40d5897cd7795a7efd29,
title = "An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state",
abstract = "An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.",
author = "Pedersen, {Mikael Egebjerg} and Goda Snieckute and Konstantinos Kagias and Camilla Nehammer and Multhaupt, {Hinke A B} and Couchman, {John R} and Roger Pocock",
year = "2013",
month = sep,
day = "20",
doi = "10.1126/science.1242528",
language = "English",
volume = "341",
pages = "1404--8",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6152",

}

RIS

TY - JOUR

T1 - An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state

AU - Pedersen, Mikael Egebjerg

AU - Snieckute, Goda

AU - Kagias, Konstantinos

AU - Nehammer, Camilla

AU - Multhaupt, Hinke A B

AU - Couchman, John R

AU - Pocock, Roger

PY - 2013/9/20

Y1 - 2013/9/20

N2 - An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.

AB - An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.

U2 - 10.1126/science.1242528

DO - 10.1126/science.1242528

M3 - Journal article

C2 - 24052309

VL - 341

SP - 1404

EP - 1408

JO - Science

JF - Science

SN - 0036-8075

IS - 6152

ER -

ID: 50947454