Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. / Boesgaard, S; Iversen, Helle Klingenberg; Wroblewski, H; Poulsen, H E; Frandsen, H; Kastrup, J; Aldershvile, J.

In: American College of Cardiology. Symposia, Vol. 23, No. 1, 01.1994, p. 163-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boesgaard, S, Iversen, HK, Wroblewski, H, Poulsen, HE, Frandsen, H, Kastrup, J & Aldershvile, J 1994, 'Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine', American College of Cardiology. Symposia, vol. 23, no. 1, pp. 163-9.

APA

Boesgaard, S., Iversen, H. K., Wroblewski, H., Poulsen, H. E., Frandsen, H., Kastrup, J., & Aldershvile, J. (1994). Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. American College of Cardiology. Symposia, 23(1), 163-9.

Vancouver

Boesgaard S, Iversen HK, Wroblewski H, Poulsen HE, Frandsen H, Kastrup J et al. Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. American College of Cardiology. Symposia. 1994 Jan;23(1):163-9.

Author

Boesgaard, S ; Iversen, Helle Klingenberg ; Wroblewski, H ; Poulsen, H E ; Frandsen, H ; Kastrup, J ; Aldershvile, J. / Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. In: American College of Cardiology. Symposia. 1994 ; Vol. 23, No. 1. pp. 163-9.

Bibtex

@article{a861105209ca481bab98406edc9c8afb,
title = "Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine",
abstract = "OBJECTIVES: The aim of this study was to compare the short- and long-term effects of intravenous nitroglycerin plus placebo and nitroglycerin plus N-acetylcysteine on peripheral arteries, veins and microcirculation in humans.BACKGROUND: The thiol donor N-acetylcysteine may potentiate the hemodynamic response to nitrates in nitrate-tolerant and nontolerant patients. The vascular changes responsible for this effect are not clear.METHODS: Eight male volunteers were treated with nitroglycerin (0.1 microgram/kg per min) combined with N-acetylcysteine (2 g intravenously, followed by 5 mg/kg per h) or placebo for 23 h in a double-blind, randomized, crossover study. Venous volume, the diameter of the radial and temporal arteries, calf blood flow and subcutaneous blood flow were measured at baseline and repeated after 1 and 23 h of infusion.RESULTS: Prolonged coadministration of N-acetylcysteine and nitroglycerin potentiated the acute venodilator effect of nitroglycerin as estimated by changes in venous volume (nitroglycerin plus N-acetylcysteine, 4.45 +/- 0.36 ml/100 g; nitroglycerin plus placebo, 3.65 +/- 0.46 ml/100 g, mean +/- SEM, p < 0.05) and prevented development of tolerance as seen after 23 h of treatment with nitroglycerin plus placebo (4.35 +/- 0.25 vs. 3.47 +/- 0.41 ml/100 g, p < 0.05). N-acetylcysteine had no effect on nitroglycerin-induced changes in arterial diameters (p > 0.05) but significantly increased microcirculatory subcutaneous blood flow after 1 h (nitroglycerin plus N-acetylcysteine: 6.3 +/- 1.3 ml/100 g per min vs. nitroglycerin plus placebo: 3.5 +/- 0.3 ml/100 g per min, p < 0.05) and after 23 h (4.4 +/- 0.6 vs. 3.1 +/- 0.5 ml/100 g per min, p < 0.05).CONCLUSIONS: The results suggest that coadministration of nitroglycerin and N-acetylcysteine in humans 1) potentiates and preserves nitroglycerin-induced venodilation and 2) augments the effect of nitroglycerin on small resistance vessels (regulating subcutaneous blood flow) without affecting the response to nitroglycerin in middle-sized arteries. Both the development of nitrate tolerance and the administration of N-acetylcysteine significantly change the normal vasodilator profile of nitroglycerin in humans.",
keywords = "Acetylcysteine, Adult, Arteries, Blood Vessels, Double-Blind Method, Drug Synergism, Hemodynamics, Humans, Infusions, Intravenous, Male, Microcirculation, Nitroglycerin, Vasodilation, Veins",
author = "S Boesgaard and Iversen, {Helle Klingenberg} and H Wroblewski and Poulsen, {H E} and H Frandsen and J Kastrup and J Aldershvile",
year = "1994",
month = jan,
language = "English",
volume = "23",
pages = "163--9",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine

AU - Boesgaard, S

AU - Iversen, Helle Klingenberg

AU - Wroblewski, H

AU - Poulsen, H E

AU - Frandsen, H

AU - Kastrup, J

AU - Aldershvile, J

PY - 1994/1

Y1 - 1994/1

N2 - OBJECTIVES: The aim of this study was to compare the short- and long-term effects of intravenous nitroglycerin plus placebo and nitroglycerin plus N-acetylcysteine on peripheral arteries, veins and microcirculation in humans.BACKGROUND: The thiol donor N-acetylcysteine may potentiate the hemodynamic response to nitrates in nitrate-tolerant and nontolerant patients. The vascular changes responsible for this effect are not clear.METHODS: Eight male volunteers were treated with nitroglycerin (0.1 microgram/kg per min) combined with N-acetylcysteine (2 g intravenously, followed by 5 mg/kg per h) or placebo for 23 h in a double-blind, randomized, crossover study. Venous volume, the diameter of the radial and temporal arteries, calf blood flow and subcutaneous blood flow were measured at baseline and repeated after 1 and 23 h of infusion.RESULTS: Prolonged coadministration of N-acetylcysteine and nitroglycerin potentiated the acute venodilator effect of nitroglycerin as estimated by changes in venous volume (nitroglycerin plus N-acetylcysteine, 4.45 +/- 0.36 ml/100 g; nitroglycerin plus placebo, 3.65 +/- 0.46 ml/100 g, mean +/- SEM, p < 0.05) and prevented development of tolerance as seen after 23 h of treatment with nitroglycerin plus placebo (4.35 +/- 0.25 vs. 3.47 +/- 0.41 ml/100 g, p < 0.05). N-acetylcysteine had no effect on nitroglycerin-induced changes in arterial diameters (p > 0.05) but significantly increased microcirculatory subcutaneous blood flow after 1 h (nitroglycerin plus N-acetylcysteine: 6.3 +/- 1.3 ml/100 g per min vs. nitroglycerin plus placebo: 3.5 +/- 0.3 ml/100 g per min, p < 0.05) and after 23 h (4.4 +/- 0.6 vs. 3.1 +/- 0.5 ml/100 g per min, p < 0.05).CONCLUSIONS: The results suggest that coadministration of nitroglycerin and N-acetylcysteine in humans 1) potentiates and preserves nitroglycerin-induced venodilation and 2) augments the effect of nitroglycerin on small resistance vessels (regulating subcutaneous blood flow) without affecting the response to nitroglycerin in middle-sized arteries. Both the development of nitrate tolerance and the administration of N-acetylcysteine significantly change the normal vasodilator profile of nitroglycerin in humans.

AB - OBJECTIVES: The aim of this study was to compare the short- and long-term effects of intravenous nitroglycerin plus placebo and nitroglycerin plus N-acetylcysteine on peripheral arteries, veins and microcirculation in humans.BACKGROUND: The thiol donor N-acetylcysteine may potentiate the hemodynamic response to nitrates in nitrate-tolerant and nontolerant patients. The vascular changes responsible for this effect are not clear.METHODS: Eight male volunteers were treated with nitroglycerin (0.1 microgram/kg per min) combined with N-acetylcysteine (2 g intravenously, followed by 5 mg/kg per h) or placebo for 23 h in a double-blind, randomized, crossover study. Venous volume, the diameter of the radial and temporal arteries, calf blood flow and subcutaneous blood flow were measured at baseline and repeated after 1 and 23 h of infusion.RESULTS: Prolonged coadministration of N-acetylcysteine and nitroglycerin potentiated the acute venodilator effect of nitroglycerin as estimated by changes in venous volume (nitroglycerin plus N-acetylcysteine, 4.45 +/- 0.36 ml/100 g; nitroglycerin plus placebo, 3.65 +/- 0.46 ml/100 g, mean +/- SEM, p < 0.05) and prevented development of tolerance as seen after 23 h of treatment with nitroglycerin plus placebo (4.35 +/- 0.25 vs. 3.47 +/- 0.41 ml/100 g, p < 0.05). N-acetylcysteine had no effect on nitroglycerin-induced changes in arterial diameters (p > 0.05) but significantly increased microcirculatory subcutaneous blood flow after 1 h (nitroglycerin plus N-acetylcysteine: 6.3 +/- 1.3 ml/100 g per min vs. nitroglycerin plus placebo: 3.5 +/- 0.3 ml/100 g per min, p < 0.05) and after 23 h (4.4 +/- 0.6 vs. 3.1 +/- 0.5 ml/100 g per min, p < 0.05).CONCLUSIONS: The results suggest that coadministration of nitroglycerin and N-acetylcysteine in humans 1) potentiates and preserves nitroglycerin-induced venodilation and 2) augments the effect of nitroglycerin on small resistance vessels (regulating subcutaneous blood flow) without affecting the response to nitroglycerin in middle-sized arteries. Both the development of nitrate tolerance and the administration of N-acetylcysteine significantly change the normal vasodilator profile of nitroglycerin in humans.

KW - Acetylcysteine

KW - Adult

KW - Arteries

KW - Blood Vessels

KW - Double-Blind Method

KW - Drug Synergism

KW - Hemodynamics

KW - Humans

KW - Infusions, Intravenous

KW - Male

KW - Microcirculation

KW - Nitroglycerin

KW - Vasodilation

KW - Veins

M3 - Journal article

C2 - 8277075

VL - 23

SP - 163

EP - 169

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 1

ER -

ID: 128984439