Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana

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Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana. / Prince, David C.; Rallapalli, Ghanasyam ; Xu, Deyang; Schoonbeek, Henk-Jan ; Cevik, Volkan; Asai, Shuta ; Kemen, Eric; Cruz-Mireles, Neftaly ; Kemen, Ariane ; Belhaj, Khaoula ; Schornack, Sebastian; Kamoun, Sophien; B Holub, Eric ; Halkier, Barbara Ann; Jones, Jonathan D G.

In: B M C Biology, Vol. 15, 20, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Prince, DC, Rallapalli, G, Xu, D, Schoonbeek, H-J, Cevik, V, Asai, S, Kemen, E, Cruz-Mireles, N, Kemen, A, Belhaj, K, Schornack, S, Kamoun, S, B Holub, E, Halkier, BA & Jones, JDG 2017, 'Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana', B M C Biology, vol. 15, 20. https://doi.org/10.1186/s12915-017-0360-z

APA

Prince, D. C., Rallapalli, G., Xu, D., Schoonbeek, H-J., Cevik, V., Asai, S., ... Jones, J. D. G. (2017). Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana. B M C Biology, 15, [20]. https://doi.org/10.1186/s12915-017-0360-z

Vancouver

Prince DC, Rallapalli G, Xu D, Schoonbeek H-J, Cevik V, Asai S et al. Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana. B M C Biology. 2017;15. 20. https://doi.org/10.1186/s12915-017-0360-z

Author

Prince, David C. ; Rallapalli, Ghanasyam ; Xu, Deyang ; Schoonbeek, Henk-Jan ; Cevik, Volkan ; Asai, Shuta ; Kemen, Eric ; Cruz-Mireles, Neftaly ; Kemen, Ariane ; Belhaj, Khaoula ; Schornack, Sebastian ; Kamoun, Sophien ; B Holub, Eric ; Halkier, Barbara Ann ; Jones, Jonathan D G. / Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana. In: B M C Biology. 2017 ; Vol. 15.

Bibtex

@article{42df8e762885449fa9847d65733646a1,
title = "Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana",
abstract = "BACKGROUND: Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex plant-microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by Albugo infection.RESULTS: Gene expression profiling revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis. Albugo laibachii-infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these Albugo-imposed phenotypes to suppression of non-host resistance to P. infestans. Absence of tryptophan-derived antimicrobial compounds enables P. infestans colonization of Arabidopsis, although to a lesser extent than Albugo-infected tissue. A. laibachii also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to P. infestans.CONCLUSIONS: Albugo sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis. Albugo sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to P. infestans. Understanding the basis of non-host resistance to pathogens such as P. infestans could assist in development of strategies to elevate food security.",
keywords = "Journal Article",
author = "Prince, {David C.} and Ghanasyam Rallapalli and Deyang Xu and Henk-Jan Schoonbeek and Volkan Cevik and Shuta Asai and Eric Kemen and Neftaly Cruz-Mireles and Ariane Kemen and Khaoula Belhaj and Sebastian Schornack and Sophien Kamoun and {B Holub}, Eric and Halkier, {Barbara Ann} and Jones, {Jonathan D G}",
year = "2017",
doi = "10.1186/s12915-017-0360-z",
language = "English",
volume = "15",
journal = "B M C Biology",
issn = "1741-7007",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana

AU - Prince, David C.

AU - Rallapalli, Ghanasyam

AU - Xu, Deyang

AU - Schoonbeek, Henk-Jan

AU - Cevik, Volkan

AU - Asai, Shuta

AU - Kemen, Eric

AU - Cruz-Mireles, Neftaly

AU - Kemen, Ariane

AU - Belhaj, Khaoula

AU - Schornack, Sebastian

AU - Kamoun, Sophien

AU - B Holub, Eric

AU - Halkier, Barbara Ann

AU - Jones, Jonathan D G

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex plant-microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by Albugo infection.RESULTS: Gene expression profiling revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis. Albugo laibachii-infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these Albugo-imposed phenotypes to suppression of non-host resistance to P. infestans. Absence of tryptophan-derived antimicrobial compounds enables P. infestans colonization of Arabidopsis, although to a lesser extent than Albugo-infected tissue. A. laibachii also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to P. infestans.CONCLUSIONS: Albugo sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis. Albugo sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to P. infestans. Understanding the basis of non-host resistance to pathogens such as P. infestans could assist in development of strategies to elevate food security.

AB - BACKGROUND: Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex plant-microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by Albugo infection.RESULTS: Gene expression profiling revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis. Albugo laibachii-infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these Albugo-imposed phenotypes to suppression of non-host resistance to P. infestans. Absence of tryptophan-derived antimicrobial compounds enables P. infestans colonization of Arabidopsis, although to a lesser extent than Albugo-infected tissue. A. laibachii also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to P. infestans.CONCLUSIONS: Albugo sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis. Albugo sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to P. infestans. Understanding the basis of non-host resistance to pathogens such as P. infestans could assist in development of strategies to elevate food security.

KW - Journal Article

U2 - 10.1186/s12915-017-0360-z

DO - 10.1186/s12915-017-0360-z

M3 - Journal article

C2 - 28320402

VL - 15

JO - B M C Biology

JF - B M C Biology

SN - 1741-7007

M1 - 20

ER -

ID: 179925237