Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination. / Kongsgaard, Michael; Bassi, Maria R; Rasmussen, Michael; Skjødt, Karsten; Thybo, Søren; Gabriel, Mette; Hansen, Morten Bagge; Christensen, Jan Pravsgaard; Thomsen, Allan Randrup; Buus, Soren; Buus, Anette Stryhn.

In: Scientific Reports, Vol. 7, No. 1, 662, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kongsgaard, M, Bassi, MR, Rasmussen, M, Skjødt, K, Thybo, S, Gabriel, M, Hansen, MB, Christensen, JP, Thomsen, AR, Buus, S & Buus, AS 2017, 'Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination', Scientific Reports, vol. 7, no. 1, 662. https://doi.org/10.1038/s41598-017-00798-1

APA

Kongsgaard, M., Bassi, M. R., Rasmussen, M., Skjødt, K., Thybo, S., Gabriel, M., ... Buus, A. S. (2017). Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination. Scientific Reports, 7(1), [662]. https://doi.org/10.1038/s41598-017-00798-1

Vancouver

Kongsgaard M, Bassi MR, Rasmussen M, Skjødt K, Thybo S, Gabriel M et al. Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination. Scientific Reports. 2017;7(1). 662. https://doi.org/10.1038/s41598-017-00798-1

Author

Kongsgaard, Michael ; Bassi, Maria R ; Rasmussen, Michael ; Skjødt, Karsten ; Thybo, Søren ; Gabriel, Mette ; Hansen, Morten Bagge ; Christensen, Jan Pravsgaard ; Thomsen, Allan Randrup ; Buus, Soren ; Buus, Anette Stryhn. / Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination. In: Scientific Reports. 2017 ; Vol. 7, No. 1.

Bibtex

@article{39b81feb4bb34eada17e08fcb5aad11f,
title = "Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination",
abstract = "Outbreaks of Yellow Fever occur regularly in endemic areas of Africa and South America frequently leading to mass vaccination campaigns straining the availability of the attenuated Yellow Fever vaccine, YF-17D. The WHO has recently decided to discontinue regular booster-vaccinations since a single vaccination is deemed to confer life-long immune protection. Here, we have examined humoral (neutralizing antibody) and cellular (CD8 and CD4 T cell) immune responses in primary and booster vaccinees (the latter spanning 8 to 36 years after primary vaccination). After primary vaccination, we observed strong cellular immune responses with T cell activation peaking ≈2 weeks and subsiding to background levels ≈ 4 weeks post-vaccination. The number of antigen-specific CD8+ T cells declined over the following years. In >90{\%} of vaccinees, in vitro expandable T cells could still be detected >10 years post-vaccination. Although most vaccinees responded to a booster vaccination, both the humoral and cellular immune responses observed following booster vaccination were strikingly reduced compared to primary responses. This suggests that pre-existing immunity efficiently controls booster inoculums of YF-17D. In a situation with epidemic outbreaks, one could argue that a more efficient use of a limited supply of the vaccine would be to focus on primary vaccinations.",
author = "Michael Kongsgaard and Bassi, {Maria R} and Michael Rasmussen and Karsten Skj{\o}dt and S{\o}ren Thybo and Mette Gabriel and Hansen, {Morten Bagge} and Christensen, {Jan Pravsgaard} and Thomsen, {Allan Randrup} and Soren Buus and Buus, {Anette Stryhn}",
year = "2017",
doi = "10.1038/s41598-017-00798-1",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination

AU - Kongsgaard, Michael

AU - Bassi, Maria R

AU - Rasmussen, Michael

AU - Skjødt, Karsten

AU - Thybo, Søren

AU - Gabriel, Mette

AU - Hansen, Morten Bagge

AU - Christensen, Jan Pravsgaard

AU - Thomsen, Allan Randrup

AU - Buus, Soren

AU - Buus, Anette Stryhn

PY - 2017

Y1 - 2017

N2 - Outbreaks of Yellow Fever occur regularly in endemic areas of Africa and South America frequently leading to mass vaccination campaigns straining the availability of the attenuated Yellow Fever vaccine, YF-17D. The WHO has recently decided to discontinue regular booster-vaccinations since a single vaccination is deemed to confer life-long immune protection. Here, we have examined humoral (neutralizing antibody) and cellular (CD8 and CD4 T cell) immune responses in primary and booster vaccinees (the latter spanning 8 to 36 years after primary vaccination). After primary vaccination, we observed strong cellular immune responses with T cell activation peaking ≈2 weeks and subsiding to background levels ≈ 4 weeks post-vaccination. The number of antigen-specific CD8+ T cells declined over the following years. In >90% of vaccinees, in vitro expandable T cells could still be detected >10 years post-vaccination. Although most vaccinees responded to a booster vaccination, both the humoral and cellular immune responses observed following booster vaccination were strikingly reduced compared to primary responses. This suggests that pre-existing immunity efficiently controls booster inoculums of YF-17D. In a situation with epidemic outbreaks, one could argue that a more efficient use of a limited supply of the vaccine would be to focus on primary vaccinations.

AB - Outbreaks of Yellow Fever occur regularly in endemic areas of Africa and South America frequently leading to mass vaccination campaigns straining the availability of the attenuated Yellow Fever vaccine, YF-17D. The WHO has recently decided to discontinue regular booster-vaccinations since a single vaccination is deemed to confer life-long immune protection. Here, we have examined humoral (neutralizing antibody) and cellular (CD8 and CD4 T cell) immune responses in primary and booster vaccinees (the latter spanning 8 to 36 years after primary vaccination). After primary vaccination, we observed strong cellular immune responses with T cell activation peaking ≈2 weeks and subsiding to background levels ≈ 4 weeks post-vaccination. The number of antigen-specific CD8+ T cells declined over the following years. In >90% of vaccinees, in vitro expandable T cells could still be detected >10 years post-vaccination. Although most vaccinees responded to a booster vaccination, both the humoral and cellular immune responses observed following booster vaccination were strikingly reduced compared to primary responses. This suggests that pre-existing immunity efficiently controls booster inoculums of YF-17D. In a situation with epidemic outbreaks, one could argue that a more efficient use of a limited supply of the vaccine would be to focus on primary vaccinations.

U2 - 10.1038/s41598-017-00798-1

DO - 10.1038/s41598-017-00798-1

M3 - Journal article

C2 - 28386132

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 662

ER -

ID: 176957594