Acute effects of the Glucagon-Like Peptide 2 analogue, teduglutide, on intestinal adaptation in newborn pigs with short bowel syndrome
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Acute effects of the Glucagon-Like Peptide 2 analogue, teduglutide, on intestinal adaptation in newborn pigs with short bowel syndrome. / Thymann, Thomas; Stoll, Barbara; Mecklenburg, Lars; Burrin, Douglas G; Vegge, Andreas; Qvist, Niels; Eriksen, Thomas; Jeppesen, Palle Bekker; Sangild, Per Torp.
In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 58, No. 6, 2014, p. 694-702.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acute effects of the Glucagon-Like Peptide 2 analogue, teduglutide, on intestinal adaptation in newborn pigs with short bowel syndrome
AU - Thymann, Thomas
AU - Stoll, Barbara
AU - Mecklenburg, Lars
AU - Burrin, Douglas G
AU - Vegge, Andreas
AU - Qvist, Niels
AU - Eriksen, Thomas
AU - Jeppesen, Palle Bekker
AU - Sangild, Per Torp
N1 - CURIS 2014 NEXS 063
PY - 2014
Y1 - 2014
N2 - Neonatal short bowel syndrome following massive gut resection associates with malabsorption of nutrients. The intestinotrophic factor glucagon-like peptide 2 (GLP-2) improves gut function in adult short bowel patients, but its effect in pediatric patients remains unknown. Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600, Nycomed GmbH) in a neonatal piglet jejunostomy model. Two-day old pigs were subjected to resection of 50% of the small intestine and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy. All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6); 0.02 (n = 6); 0.1 (n = 5) or 0.2 mg/kg/day (n = 6) and compared with placebo (n = 9). Body weight increment was similar for all four teduglutide groups but higher than placebo (P
AB - Neonatal short bowel syndrome following massive gut resection associates with malabsorption of nutrients. The intestinotrophic factor glucagon-like peptide 2 (GLP-2) improves gut function in adult short bowel patients, but its effect in pediatric patients remains unknown. Our objective was to test the efficacy of the long-acting synthetic human GLP-2 analogue, teduglutide (ALX-0600, Nycomed GmbH) in a neonatal piglet jejunostomy model. Two-day old pigs were subjected to resection of 50% of the small intestine and the remnant intestine was exteriorized on the abdominal wall as a jejunostomy. All pigs were given total parenteral nutrition for 7 days and a single daily injection of the following doses of teduglutide: 0.01 (n = 6); 0.02 (n = 6); 0.1 (n = 5) or 0.2 mg/kg/day (n = 6) and compared with placebo (n = 9). Body weight increment was similar for all four teduglutide groups but higher than placebo (P
U2 - 10.1097/MPG.0000000000000295
DO - 10.1097/MPG.0000000000000295
M3 - Journal article
C2 - 24399211
VL - 58
SP - 694
EP - 702
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 6
ER -
ID: 102225278