Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Acute and preventive pharmacological treatment of post-traumatic headache
Final published version, 1.3 MB, PDF document
Background: Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH treatment. Thus, we found it timely to provide a systematic review of the current literature on acute and preventive pharmacological treatment of PTH using PubMed and Embase databases. Findings: Included studies involved acute and preventive pharmacological treatment of headache attributed to traumatic injury to the head in adherence to the International Classification of Headache Disorders (ICHD) criteria. Of 1424 potentially relevant articles identified, 63 were retrieved for detailed evaluation and seven studies (one prospective and six retrospective) met the inclusion criteria. None of the seven included studies were randomized clinical trials (RCTs) or used a placebo-controlled study design. Conclusion: We found that there is a lack of high-quality evidence-based studies on the pharmacological treatment of PTH. Future studies are highly needed and must emphasize open-label studies with rigorous methodology or RCTs with a placebo-controlled design.
Original language | English |
---|---|
Article number | 98 |
Journal | Journal of Headache and Pain |
Volume | 20 |
Number of pages | 9 |
ISSN | 1129-2369 |
DOIs | |
Publication status | Published - Oct 2019 |
- Concussion, Head injury, Post-traumatic headache, Systematic review, Traumatic brain injury, Treatment
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 241205119