A single-cell atlas of human and mouse white adipose tissue

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A single-cell atlas of human and mouse white adipose tissue. / Emont, Margo P.; Jacobs, Christopher; Essene, Adam L.; Pant, Deepti; Tenen, Danielle; Colleluori, Georgia; Di Vincenzo, Angelica; Jørgensen, Anja M.; Dashti, Hesam; Stefek, Adam; McGonagle, Elizabeth; Strobel, Sophie; Laber, Samantha; Agrawal, Saaket; Westcott, Gregory P.; Kar, Amrita; Veregge, Molly L.; Gulko, Anton; Srinivasan, Harini; Kramer, Zachary; De Filippis, Eleanna; Merkel, Erin; Ducie, Jennifer; Boyd, Christopher G.; Gourash, William; Courcoulas, Anita; Lin, Samuel J.; Lee, Bernard T.; Morris, Donald; Tobias, Adam; Khera, Amit V.; Claussnitzer, Melina; Pers, Tune H.; Giordano, Antonio; Ashenberg, Orr; Regev, Aviv; Tsai, Linus T.; Rosen, Evan D.

In: Nature, Vol. 603, 2022, p. 926-933.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Emont, MP, Jacobs, C, Essene, AL, Pant, D, Tenen, D, Colleluori, G, Di Vincenzo, A, Jørgensen, AM, Dashti, H, Stefek, A, McGonagle, E, Strobel, S, Laber, S, Agrawal, S, Westcott, GP, Kar, A, Veregge, ML, Gulko, A, Srinivasan, H, Kramer, Z, De Filippis, E, Merkel, E, Ducie, J, Boyd, CG, Gourash, W, Courcoulas, A, Lin, SJ, Lee, BT, Morris, D, Tobias, A, Khera, AV, Claussnitzer, M, Pers, TH, Giordano, A, Ashenberg, O, Regev, A, Tsai, LT & Rosen, ED 2022, 'A single-cell atlas of human and mouse white adipose tissue', Nature, vol. 603, pp. 926-933. https://doi.org/10.1038/s41586-022-04518-2

APA

Emont, M. P., Jacobs, C., Essene, A. L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jørgensen, A. M., Dashti, H., Stefek, A., McGonagle, E., Strobel, S., Laber, S., Agrawal, S., Westcott, G. P., Kar, A., Veregge, M. L., Gulko, A., Srinivasan, H., ... Rosen, E. D. (2022). A single-cell atlas of human and mouse white adipose tissue. Nature, 603, 926-933. https://doi.org/10.1038/s41586-022-04518-2

Vancouver

Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G et al. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022;603:926-933. https://doi.org/10.1038/s41586-022-04518-2

Author

Emont, Margo P. ; Jacobs, Christopher ; Essene, Adam L. ; Pant, Deepti ; Tenen, Danielle ; Colleluori, Georgia ; Di Vincenzo, Angelica ; Jørgensen, Anja M. ; Dashti, Hesam ; Stefek, Adam ; McGonagle, Elizabeth ; Strobel, Sophie ; Laber, Samantha ; Agrawal, Saaket ; Westcott, Gregory P. ; Kar, Amrita ; Veregge, Molly L. ; Gulko, Anton ; Srinivasan, Harini ; Kramer, Zachary ; De Filippis, Eleanna ; Merkel, Erin ; Ducie, Jennifer ; Boyd, Christopher G. ; Gourash, William ; Courcoulas, Anita ; Lin, Samuel J. ; Lee, Bernard T. ; Morris, Donald ; Tobias, Adam ; Khera, Amit V. ; Claussnitzer, Melina ; Pers, Tune H. ; Giordano, Antonio ; Ashenberg, Orr ; Regev, Aviv ; Tsai, Linus T. ; Rosen, Evan D. / A single-cell atlas of human and mouse white adipose tissue. In: Nature. 2022 ; Vol. 603. pp. 926-933.

Bibtex

@article{d0fb60a77bb346f68f1fcaab676a7e81,

title = "A single-cell atlas of human and mouse white adipose tissue",

abstract = "White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.",

author = "Emont, {Margo P.} and Christopher Jacobs and Essene, {Adam L.} and Deepti Pant and Danielle Tenen and Georgia Colleluori and {Di Vincenzo}, Angelica and J{\o}rgensen, {Anja M.} and Hesam Dashti and Adam Stefek and Elizabeth McGonagle and Sophie Strobel and Samantha Laber and Saaket Agrawal and Westcott, {Gregory P.} and Amrita Kar and Veregge, {Molly L.} and Anton Gulko and Harini Srinivasan and Zachary Kramer and {De Filippis}, Eleanna and Erin Merkel and Jennifer Ducie and Boyd, {Christopher G.} and William Gourash and Anita Courcoulas and Lin, {Samuel J.} and Lee, {Bernard T.} and Donald Morris and Adam Tobias and Khera, {Amit V.} and Melina Claussnitzer and Pers, {Tune H.} and Antonio Giordano and Orr Ashenberg and Aviv Regev and Tsai, {Linus T.} and Rosen, {Evan D.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2022",

doi = "10.1038/s41586-022-04518-2",

language = "English",

volume = "603",

pages = "926--933",

journal = "Nature",

issn = "0028-0836",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A single-cell atlas of human and mouse white adipose tissue

AU - Emont, Margo P.

AU - Jacobs, Christopher

AU - Essene, Adam L.

AU - Pant, Deepti

AU - Tenen, Danielle

AU - Colleluori, Georgia

AU - Di Vincenzo, Angelica

AU - Jørgensen, Anja M.

AU - Dashti, Hesam

AU - Stefek, Adam

AU - McGonagle, Elizabeth

AU - Strobel, Sophie

AU - Laber, Samantha

AU - Agrawal, Saaket

AU - Westcott, Gregory P.

AU - Kar, Amrita

AU - Veregge, Molly L.

AU - Gulko, Anton

AU - Srinivasan, Harini

AU - Kramer, Zachary

AU - De Filippis, Eleanna

AU - Merkel, Erin

AU - Ducie, Jennifer

AU - Boyd, Christopher G.

AU - Gourash, William

AU - Courcoulas, Anita

AU - Lin, Samuel J.

AU - Lee, Bernard T.

AU - Morris, Donald

AU - Tobias, Adam

AU - Khera, Amit V.

AU - Claussnitzer, Melina

AU - Pers, Tune H.

AU - Giordano, Antonio

AU - Ashenberg, Orr

AU - Regev, Aviv

AU - Tsai, Linus T.

AU - Rosen, Evan D.

PY - 2022

Y1 - 2022

N2 - White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

AB - White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

U2 - 10.1038/s41586-022-04518-2

DO - 10.1038/s41586-022-04518-2

M3 - Journal article

C2 - 35296864

AN - SCOPUS:85126384772

VL - 603

SP - 926

EP - 933

JO - Nature

JF - Nature

SN - 0028-0836

ER -

ID: 300907929