A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial

Research output: Contribution to journalJournal articlepeer-review

Standard

A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial. / Magkos, Faidon; Hjorth, Mads Fiil; Asping, Sarah; Rosenkrans, Maria I; Rasmussen, Sidse Ingemann; Ritz, Christian; Sjödin, Anders; Geiker, Nina Rica Wium.

In: Clinical Nutrition, Vol. 40, No. 12, 2021, p. 5726-5733.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Magkos, F, Hjorth, MF, Asping, S, Rosenkrans, MI, Rasmussen, SI, Ritz, C, Sjödin, A & Geiker, NRW 2021, 'A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial', Clinical Nutrition, vol. 40, no. 12, pp. 5726-5733. https://doi.org/10.1016/j.clnu.2021.10.006

APA

Magkos, F., Hjorth, M. F., Asping, S., Rosenkrans, M. I., Rasmussen, S. I., Ritz, C., Sjödin, A., & Geiker, N. R. W. (2021). A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial. Clinical Nutrition, 40(12), 5726-5733. https://doi.org/10.1016/j.clnu.2021.10.006

Vancouver

Magkos F, Hjorth MF, Asping S, Rosenkrans MI, Rasmussen SI, Ritz C et al. A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial. Clinical Nutrition. 2021;40(12):5726-5733. https://doi.org/10.1016/j.clnu.2021.10.006

Author

Magkos, Faidon ; Hjorth, Mads Fiil ; Asping, Sarah ; Rosenkrans, Maria I ; Rasmussen, Sidse Ingemann ; Ritz, Christian ; Sjödin, Anders ; Geiker, Nina Rica Wium. / A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial. In: Clinical Nutrition. 2021 ; Vol. 40, No. 12. pp. 5726-5733.

Bibtex

@article{4f5c2795c7a74d6a8d013280adc08a04,
title = "A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial",
abstract = "Background & aims: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement.Methods: We randomized 108 adults with overweight or obesity (body mass index 28-40 kg/m2) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry.Results: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973).Conclusions: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months.Clinical trial registry: ClinicalTrials.gov # NCT04156165.",
keywords = "Faculty of Science, Weight loss, Protein, Fat-free mass, Low-calorie diet, Resting energy expenditure",
author = "Faidon Magkos and Hjorth, {Mads Fiil} and Sarah Asping and Rosenkrans, {Maria I} and Rasmussen, {Sidse Ingemann} and Christian Ritz and Anders Sj{\"o}din and Geiker, {Nina Rica Wium}",
note = "Copyright {\textcopyright} 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
doi = "10.1016/j.clnu.2021.10.006",
language = "English",
volume = "40",
pages = "5726--5733",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial

AU - Magkos, Faidon

AU - Hjorth, Mads Fiil

AU - Asping, Sarah

AU - Rosenkrans, Maria I

AU - Rasmussen, Sidse Ingemann

AU - Ritz, Christian

AU - Sjödin, Anders

AU - Geiker, Nina Rica Wium

N1 - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Background & aims: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement.Methods: We randomized 108 adults with overweight or obesity (body mass index 28-40 kg/m2) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry.Results: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973).Conclusions: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months.Clinical trial registry: ClinicalTrials.gov # NCT04156165.

AB - Background & aims: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement.Methods: We randomized 108 adults with overweight or obesity (body mass index 28-40 kg/m2) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry.Results: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973).Conclusions: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months.Clinical trial registry: ClinicalTrials.gov # NCT04156165.

KW - Faculty of Science

KW - Weight loss

KW - Protein

KW - Fat-free mass

KW - Low-calorie diet

KW - Resting energy expenditure

U2 - 10.1016/j.clnu.2021.10.006

DO - 10.1016/j.clnu.2021.10.006

M3 - Journal article

C2 - 34749132

VL - 40

SP - 5726

EP - 5733

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 12

ER -

ID: 284397700