A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

Research output: Contribution to journalJournal articleResearchpeer-review

  • Jonas Møller Kristensen
  • Vibe Skov
  • Stine Juhl Petersson
  • Niels Ørtenblad
  • Wojtaszewski, Jørgen
  • Henning Beck-Nielsen
  • Kurt Højlund
Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling.
Original languageEnglish
JournalDiabetologia
Volume57
Issue number5
Pages (from-to)1006-1015
Number of pages10
ISSN0012-186X
DOIs
Publication statusPublished - 2014

ID: 99123126