A novel multiplex analysis of filaggrin polymorphisms: A universally applicable method for genotyping

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The filaggrin protein is expressed as profilaggrin mainly in stratum granulosum cells of the epidermis. The profilaggrin gene codes for 10-12 filaggrin repeats. The filaggrin protein is important for skin barrier function. Filaggrin deficiency due to functional null-polymorphisms affects 8-10% of the people in Northern Europe and is a strong risk factor for several diseases. Here, we describe a novel method for efficient, multiplexed genotyping of variations in the profilaggrin gene.
Original languageEnglish
JournalClinica Chimica Acta
Issue number19-20
Pages (from-to)1488-92
Number of pages5
Publication statusPublished - 2012

ID: 40165585