A novel endoscopic ultrasound-guided through-the-needle microbiopsy procedure improves diagnosis of pancreatic cystic lesions
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A novel endoscopic ultrasound-guided through-the-needle microbiopsy procedure improves diagnosis of pancreatic cystic lesions. / Kovacevic, Bojan; Klausen, Pia; Hasselby, Jane Preuss; Karstensen, John Gásdal; Rift, Charlotte Vestrup; Kalaitzakis, Evangelos; Toxværd, Anders; Hansen, Carsten Palnæs; Storkholm, Jan; Hassan, Hazem; Vilmann, Peter.
In: Endoscopy, Vol. 50, No. 11, 2018, p. 1105-1111.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A novel endoscopic ultrasound-guided through-the-needle microbiopsy procedure improves diagnosis of pancreatic cystic lesions
AU - Kovacevic, Bojan
AU - Klausen, Pia
AU - Hasselby, Jane Preuss
AU - Karstensen, John Gásdal
AU - Rift, Charlotte Vestrup
AU - Kalaitzakis, Evangelos
AU - Toxværd, Anders
AU - Hansen, Carsten Palnæs
AU - Storkholm, Jan
AU - Hassan, Hazem
AU - Vilmann, Peter
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Pancreatic cystic lesions represent a diagnostic dilemma as some may harbor malignancy or have potential for malignant transformation. The aim of this study was to present our experience with a novel endoscopic ultrasound (EUS)-guided microbiopsy procedure enabling procurement of tissue from the wall of the cystic lesion.METHODS: We collected data from 31 consecutive patients with pancreatic cystic lesions who underwent an EUS-guided microbiopsy procedure at our institution. Records were retrospectively reviewed from a prospectively maintained database.RESULTS: The technical success was 87.1 %. Diagnostic yield of microbiopsies was 71.0 %. Microbiopsies offered sufficient tissue for morphological and immunohistochemical characterization of the lesions, as well as determination of grade of dysplasia. Furthermore, evaluation of microbiopsies changed the clinical management in six patients (19.4 %). Three nonsevere adverse events were observed (9.7 %): two cases of mild infection and one case of mild pancreatitis. All three patients recovered completely.CONCLUSIONS: EUS-guided microbiopsy procedure was technically feasible, with a high diagnostic yield. Further prospective studies are needed to confirm these promising results.
AB - BACKGROUND: Pancreatic cystic lesions represent a diagnostic dilemma as some may harbor malignancy or have potential for malignant transformation. The aim of this study was to present our experience with a novel endoscopic ultrasound (EUS)-guided microbiopsy procedure enabling procurement of tissue from the wall of the cystic lesion.METHODS: We collected data from 31 consecutive patients with pancreatic cystic lesions who underwent an EUS-guided microbiopsy procedure at our institution. Records were retrospectively reviewed from a prospectively maintained database.RESULTS: The technical success was 87.1 %. Diagnostic yield of microbiopsies was 71.0 %. Microbiopsies offered sufficient tissue for morphological and immunohistochemical characterization of the lesions, as well as determination of grade of dysplasia. Furthermore, evaluation of microbiopsies changed the clinical management in six patients (19.4 %). Three nonsevere adverse events were observed (9.7 %): two cases of mild infection and one case of mild pancreatitis. All three patients recovered completely.CONCLUSIONS: EUS-guided microbiopsy procedure was technically feasible, with a high diagnostic yield. Further prospective studies are needed to confirm these promising results.
U2 - 10.1055/a-0625-6440
DO - 10.1055/a-0625-6440
M3 - Journal article
C2 - 29980151
VL - 50
SP - 1105
EP - 1111
JO - Endoscopy
JF - Endoscopy
SN - 0013-726X
IS - 11
ER -
ID: 217658781