A new look at lipid-membrane structure in relation to drug research

Research output: Contribution to journal › Review › Research › peer-review

Standard

A new look at lipid-membrane structure in relation to drug research. / Mouritsen, Ole G.; Jørgensen, Kent.

In: Pharmaceutical Research, Vol. 15, No. 10, 21.10.1998, p. 1507-1519.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mouritsen, OG & Jørgensen, K 1998, 'A new look at lipid-membrane structure in relation to drug research', Pharmaceutical Research, vol. 15, no. 10, pp. 1507-1519. https://doi.org/10.1023/A:1011986613392

APA

Mouritsen, O. G., & Jørgensen, K. (1998). A new look at lipid-membrane structure in relation to drug research. Pharmaceutical Research, 15(10), 1507-1519. https://doi.org/10.1023/A:1011986613392

Vancouver

Mouritsen OG, Jørgensen K. A new look at lipid-membrane structure in relation to drug research. Pharmaceutical Research. 1998 Oct 21;15(10):1507-1519. https://doi.org/10.1023/A:1011986613392

Author

Mouritsen, Ole G. ; Jørgensen, Kent. / A new look at lipid-membrane structure in relation to drug research. In: Pharmaceutical Research. 1998 ; Vol. 15, No. 10. pp. 1507-1519.

Bibtex

@article{12ae2d1417694e9ea32826ccce1f9ceb,
title = "A new look at lipid-membrane structure in relation to drug research",
abstract = "Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requires insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality.",
keywords = "Lipid bilayer, Lipid-protein interaction, Molecular organization, Permeability, Phase transitions",
author = "Mouritsen, {Ole G.} and Kent J{\o}rgensen",
year = "1998",
month = oct,
day = "21",
doi = "10.1023/A:1011986613392",
language = "English",
volume = "15",
pages = "1507--1519",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - A new look at lipid-membrane structure in relation to drug research

AU - Mouritsen, Ole G.

AU - Jørgensen, Kent

PY - 1998/10/21

Y1 - 1998/10/21

N2 - Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requires insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality.

AB - Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requires insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality.

KW - Lipid bilayer

KW - Lipid-protein interaction

KW - Molecular organization

KW - Permeability

KW - Phase transitions

UR - http://www.scopus.com/inward/record.url?scp=0031695897&partnerID=8YFLogxK

U2 - 10.1023/A:1011986613392

DO - 10.1023/A:1011986613392

M3 - Review

C2 - 9794491

AN - SCOPUS:0031695897

VL - 15

SP - 1507

EP - 1519

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 10

ER -

ID: 236886687