Standard
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. / Escala-Garcia, Maria; Abraham, Jean; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Ashworth, Alan; Auer, Paul L; Auvinen, Päivi; Beckmann, Matthias W; Beesley, Jonathan; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y; Burwinkel, Barbara; Caldas, Carlos; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Dennis, Joe; Devilee, Peter; Dunn, Janet A; Dunning, Alison M; Dwek, Miriam; Earl, Helena M; Eccles, Diana M; Eliassen, A Heather; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Closas, Montserrat; García-Sáenz, José A; Gaudet, Mia M; George, Angela; Giles, Graham G; Goldgar, David E; González-Neira, Anna; Grip, Mervi; Guénel, Pascal; Guo, Qi; Haiman, Christopher A; Håkansson, Niclas; Hamann, Ute; Harrington, Patricia A; Hiller, Louise; Hooning, Maartje J; Hopper, John L; Howell, Anthony; Huang, Chiun-Sheng; Huang, Guanmengqian; Hunter, David J; Jakubowska, Anna; John, Esther M; Kaaks, Rudolf; Kapoor, Pooja Middha; Keeman, Renske; Kitahara, Cari M; Koppert, Linetta B; Kraft, Peter; Kristensen, Vessela N; Lambrechts, Diether; Le Marchand, Loic; Lejbkowicz, Flavio; Lindblom, Annika; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Maria Elena; Maurer, Tabea; Mavroudis, Dimitrios; Meindl, Alfons; Milne, Roger L; Mulligan, Anna Marie; Neuhausen, Susan L; Nevanlinna, Heli; Newman, William G; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orr, Nick; Peterlongo, Paolo; Petridis, Christos; Prentice, Ross L; Presneau, Nadege; Punie, Kevin; Ramachandran, Dhanya; Rennert, Gad; Romero, Atocha; Sachchithananthan, Mythily; Saloustros, Emmanouil; Sawyer, Elinor J; Schmutzler, Rita K; Schwentner, Lukas; Scott, Christopher; Simard, Jacques; Sohn, Christof; Southey, Melissa C; Swerdlow, Anthony J; Tamimi, Rulla M; Tapper, William J; Teixeira, Manuel R; Terry, Mary Beth; Thorne, Heather; Tollenaar, Rob A E M; Tomlinson, Ian; Troester, Melissa A; Truong, Thérèse; Turnbull, Clare; Vachon, Celine M; van der Kolk, Lizet E; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R; Ziogas, Argyrios; Pharoah, Paul D P; Hall, Per; Wessels, Lodewyk F A; Chenevix-Trench, Georgia; Bader, Gary D; Dörk, Thilo; Easton, Douglas F; Canisius, Sander; Schmidt, Marjanka K.
In:
Nature Communications, Vol. 11, No. 1, 312, 16.01.2020.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Escala-Garcia, M, Abraham, J, Andrulis, IL, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, PL, Auvinen, P, Beckmann, MW, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, NV
, Bojesen, SE, Bolla, MK, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, SY, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, SJ, Chin, S-F, Clarke, CL, Couch, FJ, Cox, A, Cross, SS, Czene, K, Daly, MB, Dennis, J, Devilee, P, Dunn, JA, Dunning, AM, Dwek, M, Earl, HM, Eccles, DM, Eliassen, AH, Ellberg, C, Evans, DG, Fasching, PA, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, SM, García-Closas, M, García-Sáenz, JA, Gaudet, MM, George, A, Giles, GG, Goldgar, DE, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, CA, Håkansson, N, Hamann, U, Harrington, PA, Hiller, L, Hooning, MJ, Hopper, JL, Howell, A, Huang, C-S, Huang, G, Hunter, DJ, Jakubowska, A, John, EM, Kaaks, R, Kapoor, PM, Keeman, R, Kitahara, CM, Koppert, LB, Kraft, P, Kristensen, VN, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, ME, Maurer, T, Mavroudis, D, Meindl, A, Milne, RL, Mulligan, AM, Neuhausen, SL, Nevanlinna, H, Newman, WG, Olshan, AF, Olson, JE, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, RL, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, EJ, Schmutzler, RK, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, MC, Swerdlow, AJ, Tamimi, RM, Tapper, WJ, Teixeira, MR, Terry, MB, Thorne, H, Tollenaar, RAEM, Tomlinson, I, Troester, MA, Truong, T, Turnbull, C, Vachon, CM, van der Kolk, LE, Winqvist, R, Wolk, A, Yang, XR, Ziogas, A, Pharoah, PDP, Hall, P, Wessels, LFA, Chenevix-Trench, G, Bader, GD, Dörk, T, Easton, DF, Canisius, S & Schmidt, MK 2020, '
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis',
Nature Communications, vol. 11, no. 1, 312.
https://doi.org/10.1038/s41467-019-14100-6APA
Escala-Garcia, M., Abraham, J., Andrulis, I. L., Anton-Culver, H., Arndt, V., Ashworth, A., Auer, P. L., Auvinen, P., Beckmann, M. W., Beesley, J., Behrens, S., Benitez, J., Bermisheva, M., Blomqvist, C., Blot, W., Bogdanova, N. V.
, Bojesen, S. E., Bolla, M. K., Børresen-Dale, A-L., ... Schmidt, M. K. (2020).
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Nature Communications,
11(1), [312].
https://doi.org/10.1038/s41467-019-14100-6Vancouver
Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A et al.
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Nature Communications. 2020 Jan 16;11(1). 312.
https://doi.org/10.1038/s41467-019-14100-6Author
Escala-Garcia, Maria ; Abraham, Jean ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Ashworth, Alan ; Auer, Paul L ; Auvinen, Päivi ; Beckmann, Matthias W ; Beesley, Jonathan ; Behrens, Sabine ; Benitez, Javier ; Bermisheva, Marina ; Blomqvist, Carl ; Blot, William ; Bogdanova, Natalia V ; Bojesen, Stig E ; Bolla, Manjeet K ; Børresen-Dale, Anne-Lise ; Brauch, Hiltrud ; Brenner, Hermann ; Brucker, Sara Y ; Burwinkel, Barbara ; Caldas, Carlos ; Canzian, Federico ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chin, Suet-Feung ; Clarke, Christine L ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Daly, Mary B ; Dennis, Joe ; Devilee, Peter ; Dunn, Janet A ; Dunning, Alison M ; Dwek, Miriam ; Earl, Helena M ; Eccles, Diana M ; Eliassen, A Heather ; Ellberg, Carolina ; Evans, D Gareth ; Fasching, Peter A ; Figueroa, Jonine ; Flyger, Henrik ; Gago-Dominguez, Manuela ; Gapstur, Susan M ; García-Closas, Montserrat ; García-Sáenz, José A ; Gaudet, Mia M ; George, Angela ; Giles, Graham G ; Goldgar, David E ; González-Neira, Anna ; Grip, Mervi ; Guénel, Pascal ; Guo, Qi ; Haiman, Christopher A ; Håkansson, Niclas ; Hamann, Ute ; Harrington, Patricia A ; Hiller, Louise ; Hooning, Maartje J ; Hopper, John L ; Howell, Anthony ; Huang, Chiun-Sheng ; Huang, Guanmengqian ; Hunter, David J ; Jakubowska, Anna ; John, Esther M ; Kaaks, Rudolf ; Kapoor, Pooja Middha ; Keeman, Renske ; Kitahara, Cari M ; Koppert, Linetta B ; Kraft, Peter ; Kristensen, Vessela N ; Lambrechts, Diether ; Le Marchand, Loic ; Lejbkowicz, Flavio ; Lindblom, Annika ; Lubiński, Jan ; Mannermaa, Arto ; Manoochehri, Mehdi ; Manoukian, Siranoush ; Margolin, Sara ; Martinez, Maria Elena ; Maurer, Tabea ; Mavroudis, Dimitrios ; Meindl, Alfons ; Milne, Roger L ; Mulligan, Anna Marie ; Neuhausen, Susan L ; Nevanlinna, Heli ; Newman, William G ; Olshan, Andrew F ; Olson, Janet E ; Olsson, Håkan ; Orr, Nick ; Peterlongo, Paolo ; Petridis, Christos ; Prentice, Ross L ; Presneau, Nadege ; Punie, Kevin ; Ramachandran, Dhanya ; Rennert, Gad ; Romero, Atocha ; Sachchithananthan, Mythily ; Saloustros, Emmanouil ; Sawyer, Elinor J ; Schmutzler, Rita K ; Schwentner, Lukas ; Scott, Christopher ; Simard, Jacques ; Sohn, Christof ; Southey, Melissa C ; Swerdlow, Anthony J ; Tamimi, Rulla M ; Tapper, William J ; Teixeira, Manuel R ; Terry, Mary Beth ; Thorne, Heather ; Tollenaar, Rob A E M ; Tomlinson, Ian ; Troester, Melissa A ; Truong, Thérèse ; Turnbull, Clare ; Vachon, Celine M ; van der Kolk, Lizet E ; Winqvist, Robert ; Wolk, Alicja ; Yang, Xiaohong R ; Ziogas, Argyrios ; Pharoah, Paul D P ; Hall, Per ; Wessels, Lodewyk F A ; Chenevix-Trench, Georgia ; Bader, Gary D ; Dörk, Thilo ; Easton, Douglas F ; Canisius, Sander ; Schmidt, Marjanka K. / A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. In: Nature Communications. 2020 ; Vol. 11, No. 1.
Bibtex
@article{15fde694b0904d249b5b7ff344fbec66,
title = "A network analysis to identify mediators of germline-driven differences in breast cancer prognosis",
abstract = "Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.",
keywords = "Apoptosis, Breast Neoplasms/genetics, Circadian Clocks, Computational Biology, Female, GTP-Binding Protein alpha Subunits/genetics, GTP-Binding Protein alpha Subunits, Gq-G11/genetics, Gene Regulatory Networks, Genetic Variation, Genome-Wide Association Study, Genotype, Germ Cells, Humans, Prognosis, Receptors, Estrogen/genetics, Signal Transduction",
author = "Maria Escala-Garcia and Jean Abraham and Andrulis, {Irene L} and Hoda Anton-Culver and Volker Arndt and Alan Ashworth and Auer, {Paul L} and P{\"a}ivi Auvinen and Beckmann, {Matthias W} and Jonathan Beesley and Sabine Behrens and Javier Benitez and Marina Bermisheva and Carl Blomqvist and William Blot and Bogdanova, {Natalia V} and Bojesen, {Stig E} and Bolla, {Manjeet K} and Anne-Lise B{\o}rresen-Dale and Hiltrud Brauch and Hermann Brenner and Brucker, {Sara Y} and Barbara Burwinkel and Carlos Caldas and Federico Canzian and Jenny Chang-Claude and Chanock, {Stephen J} and Suet-Feung Chin and Clarke, {Christine L} and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Daly, {Mary B} and Joe Dennis and Peter Devilee and Dunn, {Janet A} and Dunning, {Alison M} and Miriam Dwek and Earl, {Helena M} and Eccles, {Diana M} and Eliassen, {A Heather} and Carolina Ellberg and Evans, {D Gareth} and Fasching, {Peter A} and Jonine Figueroa and Henrik Flyger and Manuela Gago-Dominguez and Gapstur, {Susan M} and Montserrat Garc{\'i}a-Closas and Garc{\'i}a-S{\'a}enz, {Jos{\'e} A} and Gaudet, {Mia M} and Angela George and Giles, {Graham G} and Goldgar, {David E} and Anna Gonz{\'a}lez-Neira and Mervi Grip and Pascal Gu{\'e}nel and Qi Guo and Haiman, {Christopher A} and Niclas H{\aa}kansson and Ute Hamann and Harrington, {Patricia A} and Louise Hiller and Hooning, {Maartje J} and Hopper, {John L} and Anthony Howell and Chiun-Sheng Huang and Guanmengqian Huang and Hunter, {David J} and Anna Jakubowska and John, {Esther M} and Rudolf Kaaks and Kapoor, {Pooja Middha} and Renske Keeman and Kitahara, {Cari M} and Koppert, {Linetta B} and Peter Kraft and Kristensen, {Vessela N} and Diether Lambrechts and {Le Marchand}, Loic and Flavio Lejbkowicz and Annika Lindblom and Jan Lubi{\'n}ski and Arto Mannermaa and Mehdi Manoochehri and Siranoush Manoukian and Sara Margolin and Martinez, {Maria Elena} and Tabea Maurer and Dimitrios Mavroudis and Alfons Meindl and Milne, {Roger L} and Mulligan, {Anna Marie} and Neuhausen, {Susan L} and Heli Nevanlinna and Newman, {William G} and Olshan, {Andrew F} and Olson, {Janet E} and H{\aa}kan Olsson and Nick Orr and Paolo Peterlongo and Christos Petridis and Prentice, {Ross L} and Nadege Presneau and Kevin Punie and Dhanya Ramachandran and Gad Rennert and Atocha Romero and Mythily Sachchithananthan and Emmanouil Saloustros and Sawyer, {Elinor J} and Schmutzler, {Rita K} and Lukas Schwentner and Christopher Scott and Jacques Simard and Christof Sohn and Southey, {Melissa C} and Swerdlow, {Anthony J} and Tamimi, {Rulla M} and Tapper, {William J} and Teixeira, {Manuel R} and Terry, {Mary Beth} and Heather Thorne and Tollenaar, {Rob A E M} and Ian Tomlinson and Troester, {Melissa A} and Th{\'e}r{\`e}se Truong and Clare Turnbull and Vachon, {Celine M} and {van der Kolk}, {Lizet E} and Robert Winqvist and Alicja Wolk and Yang, {Xiaohong R} and Argyrios Ziogas and Pharoah, {Paul D P} and Per Hall and Wessels, {Lodewyk F A} and Georgia Chenevix-Trench and Bader, {Gary D} and Thilo D{\"o}rk and Easton, {Douglas F} and Sander Canisius and Schmidt, {Marjanka K}",
year = "2020",
month = jan,
day = "16",
doi = "10.1038/s41467-019-14100-6",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
AU - Escala-Garcia, Maria
AU - Abraham, Jean
AU - Andrulis, Irene L
AU - Anton-Culver, Hoda
AU - Arndt, Volker
AU - Ashworth, Alan
AU - Auer, Paul L
AU - Auvinen, Päivi
AU - Beckmann, Matthias W
AU - Beesley, Jonathan
AU - Behrens, Sabine
AU - Benitez, Javier
AU - Bermisheva, Marina
AU - Blomqvist, Carl
AU - Blot, William
AU - Bogdanova, Natalia V
AU - Bojesen, Stig E
AU - Bolla, Manjeet K
AU - Børresen-Dale, Anne-Lise
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Brucker, Sara Y
AU - Burwinkel, Barbara
AU - Caldas, Carlos
AU - Canzian, Federico
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J
AU - Chin, Suet-Feung
AU - Clarke, Christine L
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cross, Simon S
AU - Czene, Kamila
AU - Daly, Mary B
AU - Dennis, Joe
AU - Devilee, Peter
AU - Dunn, Janet A
AU - Dunning, Alison M
AU - Dwek, Miriam
AU - Earl, Helena M
AU - Eccles, Diana M
AU - Eliassen, A Heather
AU - Ellberg, Carolina
AU - Evans, D Gareth
AU - Fasching, Peter A
AU - Figueroa, Jonine
AU - Flyger, Henrik
AU - Gago-Dominguez, Manuela
AU - Gapstur, Susan M
AU - García-Closas, Montserrat
AU - García-Sáenz, José A
AU - Gaudet, Mia M
AU - George, Angela
AU - Giles, Graham G
AU - Goldgar, David E
AU - González-Neira, Anna
AU - Grip, Mervi
AU - Guénel, Pascal
AU - Guo, Qi
AU - Haiman, Christopher A
AU - Håkansson, Niclas
AU - Hamann, Ute
AU - Harrington, Patricia A
AU - Hiller, Louise
AU - Hooning, Maartje J
AU - Hopper, John L
AU - Howell, Anthony
AU - Huang, Chiun-Sheng
AU - Huang, Guanmengqian
AU - Hunter, David J
AU - Jakubowska, Anna
AU - John, Esther M
AU - Kaaks, Rudolf
AU - Kapoor, Pooja Middha
AU - Keeman, Renske
AU - Kitahara, Cari M
AU - Koppert, Linetta B
AU - Kraft, Peter
AU - Kristensen, Vessela N
AU - Lambrechts, Diether
AU - Le Marchand, Loic
AU - Lejbkowicz, Flavio
AU - Lindblom, Annika
AU - Lubiński, Jan
AU - Mannermaa, Arto
AU - Manoochehri, Mehdi
AU - Manoukian, Siranoush
AU - Margolin, Sara
AU - Martinez, Maria Elena
AU - Maurer, Tabea
AU - Mavroudis, Dimitrios
AU - Meindl, Alfons
AU - Milne, Roger L
AU - Mulligan, Anna Marie
AU - Neuhausen, Susan L
AU - Nevanlinna, Heli
AU - Newman, William G
AU - Olshan, Andrew F
AU - Olson, Janet E
AU - Olsson, Håkan
AU - Orr, Nick
AU - Peterlongo, Paolo
AU - Petridis, Christos
AU - Prentice, Ross L
AU - Presneau, Nadege
AU - Punie, Kevin
AU - Ramachandran, Dhanya
AU - Rennert, Gad
AU - Romero, Atocha
AU - Sachchithananthan, Mythily
AU - Saloustros, Emmanouil
AU - Sawyer, Elinor J
AU - Schmutzler, Rita K
AU - Schwentner, Lukas
AU - Scott, Christopher
AU - Simard, Jacques
AU - Sohn, Christof
AU - Southey, Melissa C
AU - Swerdlow, Anthony J
AU - Tamimi, Rulla M
AU - Tapper, William J
AU - Teixeira, Manuel R
AU - Terry, Mary Beth
AU - Thorne, Heather
AU - Tollenaar, Rob A E M
AU - Tomlinson, Ian
AU - Troester, Melissa A
AU - Truong, Thérèse
AU - Turnbull, Clare
AU - Vachon, Celine M
AU - van der Kolk, Lizet E
AU - Winqvist, Robert
AU - Wolk, Alicja
AU - Yang, Xiaohong R
AU - Ziogas, Argyrios
AU - Pharoah, Paul D P
AU - Hall, Per
AU - Wessels, Lodewyk F A
AU - Chenevix-Trench, Georgia
AU - Bader, Gary D
AU - Dörk, Thilo
AU - Easton, Douglas F
AU - Canisius, Sander
AU - Schmidt, Marjanka K
PY - 2020/1/16
Y1 - 2020/1/16
N2 - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
AB - Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
KW - Apoptosis
KW - Breast Neoplasms/genetics
KW - Circadian Clocks
KW - Computational Biology
KW - Female
KW - GTP-Binding Protein alpha Subunits/genetics
KW - GTP-Binding Protein alpha Subunits, Gq-G11/genetics
KW - Gene Regulatory Networks
KW - Genetic Variation
KW - Genome-Wide Association Study
KW - Genotype
KW - Germ Cells
KW - Humans
KW - Prognosis
KW - Receptors, Estrogen/genetics
KW - Signal Transduction
U2 - 10.1038/s41467-019-14100-6
DO - 10.1038/s41467-019-14100-6
M3 - Journal article
C2 - 31949161
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 312
ER -
