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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. / Amin Al Olama, Ali; Kote-Jarai, Zsofia; Schumacher, Fredrick R; Wiklund, Fredrik; Berndt, Sonja I; Benlloch, Sara; Giles, Graham G; Severi, Gianluca; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Hunter, David J; Henderson, Brian E; Thun, Michael J; Gaziano, Michael; Giovannucci, Edward L; Siddiq, Afshan; Travis, Ruth C; Cox, David G; Canzian, Federico; Riboli, Elio; Key, Timothy J; Andriole, Gerald; Albanes, Demetrius; Hayes, Richard B; Schleutker, Johanna; Auvinen, Anssi; Tammela, Teuvo L J; Weischer, Maren; Stanford, Janet L; Ostrander, Elaine A; Cybulski, Cezary; Lubinski, Jan; Thibodeau, Stephen N; Schaid, Daniel J; Sorensen, Karina D; Batra, Jyotsna; Clements, Judith A; Chambers, Suzanne; Aitken, Joanne; Gardiner, Robert A; Maier, Christiane; Vogel, Walther; Dörk, Thilo; Brenner, Hermann; Klarskov, Peter; Nordestgaard, Børge G; Røder, Martin Andreas; Frikke-Schmidt, Ruth; Bojesen, Stig Egil; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology.
In:
Human Molecular Genetics, Vol. 22, No. 2, 2013, p. 408-415.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Amin Al Olama, A, Kote-Jarai, Z, Schumacher, FR, Wiklund, F, Berndt, SI, Benlloch, S, Giles, GG, Severi, G, Neal, DE, Hamdy, FC, Donovan, JL, Hunter, DJ, Henderson, BE, Thun, MJ, Gaziano, M, Giovannucci, EL, Siddiq, A, Travis, RC, Cox, DG, Canzian, F, Riboli, E, Key, TJ, Andriole, G, Albanes, D, Hayes, RB, Schleutker, J, Auvinen, A, Tammela, TLJ, Weischer, M, Stanford, JL, Ostrander, EA, Cybulski, C, Lubinski, J, Thibodeau, SN, Schaid, DJ, Sorensen, KD, Batra, J, Clements, JA, Chambers, S, Aitken, J, Gardiner, RA, Maier, C, Vogel, W, Dörk, T, Brenner, H, Klarskov, P
, Nordestgaard, BG, Røder, MA, Frikke-Schmidt, R, Bojesen, SE & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2013, '
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease',
Human Molecular Genetics, vol. 22, no. 2, pp. 408-415.
https://doi.org/10.1093/hmg/dds425APA
Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Hunter, D. J., Henderson, B. E., Thun, M. J., Gaziano, M., Giovannucci, E. L., Siddiq, A., Travis, R. C., Cox, D. G., ... The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2013).
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Human Molecular Genetics,
22(2), 408-415.
https://doi.org/10.1093/hmg/dds425Vancouver
Amin Al Olama A, Kote-Jarai Z, Schumacher FR, Wiklund F, Berndt SI, Benlloch S et al.
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Human Molecular Genetics. 2013;22(2):408-415.
https://doi.org/10.1093/hmg/dds425Author
Amin Al Olama, Ali ; Kote-Jarai, Zsofia ; Schumacher, Fredrick R ; Wiklund, Fredrik ; Berndt, Sonja I ; Benlloch, Sara ; Giles, Graham G ; Severi, Gianluca ; Neal, David E ; Hamdy, Freddie C ; Donovan, Jenny L ; Hunter, David J ; Henderson, Brian E ; Thun, Michael J ; Gaziano, Michael ; Giovannucci, Edward L ; Siddiq, Afshan ; Travis, Ruth C ; Cox, David G ; Canzian, Federico ; Riboli, Elio ; Key, Timothy J ; Andriole, Gerald ; Albanes, Demetrius ; Hayes, Richard B ; Schleutker, Johanna ; Auvinen, Anssi ; Tammela, Teuvo L J ; Weischer, Maren ; Stanford, Janet L ; Ostrander, Elaine A ; Cybulski, Cezary ; Lubinski, Jan ; Thibodeau, Stephen N ; Schaid, Daniel J ; Sorensen, Karina D ; Batra, Jyotsna ; Clements, Judith A ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, Robert A ; Maier, Christiane ; Vogel, Walther ; Dörk, Thilo ; Brenner, Hermann ; Klarskov, Peter ; Nordestgaard, Børge G ; Røder, Martin Andreas ; Frikke-Schmidt, Ruth ; Bojesen, Stig Egil ; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology. / A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. In: Human Molecular Genetics. 2013 ; Vol. 22, No. 2. pp. 408-415.
Bibtex
@article{ee46d8a3cf7e4d4dbd2d3623384ae7be,
title = "A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease",
abstract = "Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.",
author = "{Amin Al Olama}, Ali and Zsofia Kote-Jarai and Schumacher, {Fredrick R} and Fredrik Wiklund and Berndt, {Sonja I} and Sara Benlloch and Giles, {Graham G} and Gianluca Severi and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Hunter, {David J} and Henderson, {Brian E} and Thun, {Michael J} and Michael Gaziano and Giovannucci, {Edward L} and Afshan Siddiq and Travis, {Ruth C} and Cox, {David G} and Federico Canzian and Elio Riboli and Key, {Timothy J} and Gerald Andriole and Demetrius Albanes and Hayes, {Richard B} and Johanna Schleutker and Anssi Auvinen and Tammela, {Teuvo L J} and Maren Weischer and Stanford, {Janet L} and Ostrander, {Elaine A} and Cezary Cybulski and Jan Lubinski and Thibodeau, {Stephen N} and Schaid, {Daniel J} and Sorensen, {Karina D} and Jyotsna Batra and Clements, {Judith A} and Suzanne Chambers and Joanne Aitken and Gardiner, {Robert A} and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Hermann Brenner and Peter Klarskov and Nordestgaard, {B{\o}rge G} and R{\o}der, {Martin Andreas} and Ruth Frikke-Schmidt and Bojesen, {Stig Egil} and B{\o}rge Nordestgaard",
year = "2013",
doi = "10.1093/hmg/dds425",
language = "English",
volume = "22",
pages = "408--415",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "2",
}
RIS
TY - JOUR
T1 - A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
AU - Amin Al Olama, Ali
AU - Kote-Jarai, Zsofia
AU - Schumacher, Fredrick R
AU - Wiklund, Fredrik
AU - Berndt, Sonja I
AU - Benlloch, Sara
AU - Giles, Graham G
AU - Severi, Gianluca
AU - Neal, David E
AU - Hamdy, Freddie C
AU - Donovan, Jenny L
AU - Hunter, David J
AU - Henderson, Brian E
AU - Thun, Michael J
AU - Gaziano, Michael
AU - Giovannucci, Edward L
AU - Siddiq, Afshan
AU - Travis, Ruth C
AU - Cox, David G
AU - Canzian, Federico
AU - Riboli, Elio
AU - Key, Timothy J
AU - Andriole, Gerald
AU - Albanes, Demetrius
AU - Hayes, Richard B
AU - Schleutker, Johanna
AU - Auvinen, Anssi
AU - Tammela, Teuvo L J
AU - Weischer, Maren
AU - Stanford, Janet L
AU - Ostrander, Elaine A
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Thibodeau, Stephen N
AU - Schaid, Daniel J
AU - Sorensen, Karina D
AU - Batra, Jyotsna
AU - Clements, Judith A
AU - Chambers, Suzanne
AU - Aitken, Joanne
AU - Gardiner, Robert A
AU - Maier, Christiane
AU - Vogel, Walther
AU - Dörk, Thilo
AU - Brenner, Hermann
AU - Klarskov, Peter
AU - Nordestgaard, Børge G
AU - Røder, Martin Andreas
AU - Frikke-Schmidt, Ruth
AU - Bojesen, Stig Egil
AU - The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology
PY - 2013
Y1 - 2013
N2 - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
AB - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
U2 - 10.1093/hmg/dds425
DO - 10.1093/hmg/dds425
M3 - Journal article
C2 - 23065704
VL - 22
SP - 408
EP - 415
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 2
ER -
