A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis

Research output: Contribution to journalJournal articleResearchpeer-review

  • María Brion
  • Berit M Dupuy
  • Marielle Heinrich
  • Carsten Hohoff
  • Bernardette Hoste
  • Bertrand Ludes
  • Bente Mevag
  • Morling, Niels
  • Harald Niederstätter
  • Walther Parson
  • Juan Jose Sanchez Sanchez
  • Klaus Bender
  • Nathalie Siebert
  • Catherine Thacker
  • Conceiçao Vide
  • Angel Carracedo
A collaborative study was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the performance of Y-chromosome binary polymorphism analysis in different European laboratories. Four blood samples were sent to the laboratories, to be analysed for 11 Y-chromosome single nucleotide polymorphisms (SNPs): SRY-1532, M40, M35, M213, M9, 92R7, M17, P25, M18, M153 and M167. All the labs were also asked to submit a population study including these markers. All participating laboratories reported the same results, indicating the reproducibility and robustness of Y-chromosome SNP typing. A total of 535 samples from six different European populations were also analysed. In Galicia (NW Spain) and Belgium, the most frequent haplogroup was R1b*(xR1b1,R1b3df). Haplogroup F*(xK) is one of the most frequent in Austria and Denmark, while the lowest frequency appear in Belgium. Haplogroup frequencies found in this collaborative study were compared with previously published European Y-chromosome haplogroup data.
Original languageEnglish
JournalForensic Science International
Issue number2-3
Pages (from-to)103-8
Number of pages5
Publication statusPublished - 2005

Bibliographical note

Keywords: Chromosomes, Human, Y; DNA Fingerprinting; Europe; Genetic Markers; Genetics, Population; Haplotypes; Humans; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Reproducibility of Results

ID: 14145136