Yen-Hsi Chen

Yen-Hsi Chen

Guest Researcher


Publication year:
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1 - 16 out of 16Page size: 500
  1. 2023
  2. Published

    A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

    Chen, Yen-Hsi, Tian, W., Yasuda, M., Ye, Z., Song, Ming, Mandel, Ulla, Kristensen, C., Povolo, Lorenzo, Marques, A. R. A., Čaval, T., Heck, A. J. R., Sampaio, J. L., Johannes, L., Tsukimura, T., Desnick, R., Vakhrushev, Sergey, Yang, Zhang & Clausen, Henrik, 2023, In: Frontiers in Bioengineering and Biotechnology. 11, 1128371.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

    Bagdonaite, Ieva , Marinova, I. N., Levann, Asha Maria Rudjord, Pallesen, E. M. H., King-Smith, S. L., Karlsson, R., Rømer, T. B., Chen, Yen-Hsi, Miller, Rebecca Louise, Olofsson, S., Nordén, R., Bergström, T., Dabelsteen, Sally & Wandall, Hans H., 2023, In: Nature Communications. 14, 19 p., 7000.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2022
  5. Published

    Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction

    Guimond, S. E., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., Humbert, M. V., Buttigieg, K. R., Coombes, N., Elmore, M. J., Wand, M., Nyström, K., Said, J., Setoh, Y. X., Amarilla, A. A., Modhiran, N., Sng, J. D. J., Chhabra, M., Young, P. R., Rawle, D. J. & 22 others, Lima, M. A., Yates, E. A., Karlsson, R., Miller, Rebecca Louise, Chen, Yen-Hsi, Bagdonaite, Ieva , Yang, Zhang, Stewart, J., Nguyen, D., Laidlaw, S., Hammond, E., Dredge, K., Wilkinson, T. M. A., Watterson, D., Khromykh, A. A., Suhrbier, A., Carroll, M. W., Trybala, E., Bergström, T., Ferro, V., Skidmore, M. A. & Turnbull, Jeremy Ewan, 2022, In: ACS Central Science. 8, 5, p. 527-545 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

    Karlsson, R., Chopra, P., Joshi, A., Yang, Zhang, Vakhrushev, Sergey, Clausen, Thomas Mandel, Painter, C. D., Szekeres, G. P., Chen, Yen-Hsi, Sandoval, D. R., Hansen, Lars, Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, Jeremy Ewan, Clausen, Henrik, Boons, G. J. & Miller, Rebecca Louise, 2021, In: Science Advances. 7, 52, eabl6026.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

    Schuurs, Z. P., Hammond, E., Elli, S., Rudd, T. R., Mycroft-West, C. J., Lima, M. A., Skidmore, M. A., Karlsson, R., Chen, Yen-Hsi, Bagdonaite, Ieva , Yang, Zhang, Ahmed, Y. A., Richard, D. J., Turnbull, Jeremy Ewan, Ferro, V., Coombe, D. R. & Gandhi, N. S., 2021, In: Computational and Structural Biotechnology Journal. 19, p. 2806-2818 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Genetic glycoengineering in mammalian cells

    Narimatsu, Yoshiki, Büll, Christian, Chen, Yen-Hsi, Wandall, Hans H., Yang, Zhang & Clausen, Henrik, 2021, In: Journal of Biological Chemistry. 296, 25 p., 100448.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

    Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

    Davies, S. P., Mycroft-West, C. J., Pagani, I., Hill, H. J., Chen, Yen-Hsi, Karlsson, R., Bagdonaite, Ieva , Guimond, S. E., Stamataki, Z., De Lima, M. A., Turnbull, Jeremy Ewan, Yang, Zhang, Vicenzi, E., Skidmore, M. A., Khanim, F. L. & Richardson, A., 2021, In: Frontiers in Pharmacology. 12, 660490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations

    Tree, J. A., Turnbull, Jeremy Ewan, Buttigieg, K. R., Elmore, M. J., Coombes, N., Hogwood, J., Mycroft-West, C. J., Lima, M. A., Skidmore, M. A., Karlsson, R., Chen, Yen-Hsi, Yang, Zhang, Spalluto, C. M., Staples, K. J., Yates, E. A., Gray, E., Singh, D., Wilkinson, T., Page, C. P. & Carroll, M. W., 2021, In: British Journal of Pharmacology. 178, 3, p. 626-635 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2019
  14. Published

    An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

    Narimatsu, Y., Joshi, H. J., Nason, R., Van Coillie, J., Karlsson, R., Sun, L., Ye, Z., Chen, Y-H., Schjoldager, K. T., Steentoft, C., Furukawa, S., Bensing, B. A., Sullam, P. M., Thompson, A. J., Paulson, J. C., Büll, C., Adema, G. J., Mandel, U., Hansen, L., Bennett, E. P. & 4 others, Varki, A., Vakhrushev, Sergey, Yang, Zhang & Clausen, Henrik, 2019, In: Molecular Cell. 75, 2, p. 394-407, e1-e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

    Tian, W., Ye, Z., Wang, S., Schulz, M. A., Van Coillie, Julie, Sun, L., Chen, Yen-Hsi, Narimatsu, Yoshiki, Hansen, Lars, Kristensen, C., Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, S., Schiffmann, R., Shen, J., Vakhrushev, Sergey, Clausen, Henrik & Yang, Zhang, 2019, In: Nature Communications. 10, 13 p., 1785.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2018
  17. Published

    Turning Glycosaminoglycans into Lego-toying

    Chen, Yen-Hsi, 20 Apr 2018, Københavns Universitet.

    Research output: Book/Report › Ph.D. thesis › Research

  18. Published

    A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome

    Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Zhang, Y., Gomes, C., Chen, Yen-Hsi, Lorenzetti, F., Furukawa, S., Schjoldager, Katrine Ter-Borch Gram, Hansen, Lars, Clausen, Henrik, Bennett, Eric Paul & Wandall, Hans H., 2018, In: Glycobiology. 28, 5, p. 295–305

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Glycoengineering design options for IgG1 in CHO cells using precise gene editing

    Schulz, M. A., Tian, W., Mao, Y., Van Coillie, Julie, Sun, L., Larsen, J. S., Chen, Yen-Hsi, Kristensen, C., Vakhrushev, Sergey, Clausen, Henrik & Yang, Zhang, 2018, In: Glycobiology. 28, 7, p. 542–549

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The GAGOme: a cell-based library of displayed glycosaminoglycans

    Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas Mandel, Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, Tobias, Salanti, Ali, Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, Eric Paul, Mao, Y., Clausen, Henrik & Yang, Zhang, 2018, In: Nature Methods. 15, 11, p. 881-888

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2015
  22. Published

    A novel chemosensitivity profiling platform for small acute lymphoblastic leukemia cell populations

    Groth-Pedersen, L., Chen, Yen-Hsi, Faber, M., Valentin, R., Albertsen, B. K., Wehner, P. S., Rosthøj, S., Frandsen, T. L., Marquart, H. V. & Schmiegelow, Kjeld, 2015, In: Leukemia and Lymphoma. 56, 7, p. 2208-11 4 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

ID: 126195133