Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In : Scientific Reports. 7, 46208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    The role of DNA base excision repair in brain homeostasis and disease

    Akbari, Mansour, Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In : DNA Repair. 32, p. 172-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

    de Souza-Pinto, N. C., Maynard, S., Hashiguchi, K., Hu, J., Muftuoglu, M. & Bohr, Vilhelm, Aug 2009, In : Molecular and Cellular Biology. 29, 16, p. 4441-54 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair

    Canugovi, C., Maynard, S., Bayne, A. V., Sykora, P., Tian, J., de Souza-Pinto, N. C., Croteau, D. L. & Bohr, Vilhelm, 5 Oct 2010, In : DNA Repair. 9, 10, p. 1080-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The involvement of human RECQL4 in DNA double-strand break repair

    Singh, D. K., Karmakar, P., Aamann, M. D., Schurman, S. H., May, A., Croteau, D. L., Burks, L., Plon, S. E. & Bohr, Vilhelm, 1 Jun 2010, In : Aging Cell. 9, 3, p. 358-71 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Telomerer--begyndelsen og enden

    Bohr, Vilhelm, 4 Oct 2010, In : Ugeskrift for Laeger. 172, 40, p. 2744

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases

    Popuri, V., Croteau, D. L. & Bohr, Vilhelm, 4 Jun 2010, In : DNA Repair. 9, 6, p. 636-42 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, Mansour, Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In : Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Sarcopenia, Aging and Prospective Interventional Strategies

    Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In : Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

    McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., Bohr, Vilhelm & Chua, K. F., 1 Jan 2009, In : Aging. 1, 1, p. 109-21 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Roles of Werner syndrome protein in protection of genome integrity

    Rossi, M. L., Ghosh, A. K. & Bohr, Vilhelm, 2 Mar 2010, In : DNA Repair. 9, 3, p. 331-44 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

    Soerensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T. V., Bohr, Vilhelm & Christiansen, L., 1 Dec 2010, In : Aging Cell. 9, 6, p. 1010-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, Guido, Gram, M., Madsen, Claus Desler, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In : Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

    Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J., Sykora, P., Ramamoorthy, M., Wang, Z. M., Singh, D. K., Akbari, Mansour, Kasiviswanathan, R., Copeland, W. C. & Bohr, Vilhelm, 2012, In : Aging Cell. 11, 3, p. 456-66 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, Guido, Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Carcinogenesis. 35, 11, p. 2415-2424 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples

    Lachapelle, S., Gagné, J., Garand, C., Desbiens, M., Coulombe, Y., Bohr, Vilhelm, Hendzel, M. J., Masson, J., Poirier, G. G. & Lebel, M., 4 Mar 2011, In : Journal of Proteome Research. 10, 3, p. 1216-27 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Protecting the mitochondrial powerhouse

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, Vilhelm, 1 Mar 2015, In : Trends in Cell Biology. 25, 3, p. 158-170 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, Mansour, Keijzers, Guido, Maynard, S., Scheibye-Knudsen, M., Madsen, Claus Desler, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In : DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Nutrition and aging

    Cheng, W., Bohr, Vilhelm & de Cabo, R., 1 Apr 2010, In : Mechanisms of Ageing and Development. 131, 4, p. 223-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Nuclear DNA damage signalling to mitochondria in ageing

    Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In : Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells

    Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J. R., Cooper, D. N., Bohr, Vilhelm & Vasquez, K. M., 25 Mar 2011, In : The Journal of Biological Chemistry. 286, 12, p. 10017-26 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1

    Yang, J., Tadokoro, T., Keijzers, Guido, Mattson, M. P. & Bohr, Vilhelm, 2010, In : Journal of Biological Chemistry. 285, 36, p. 28191-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

    Bernier, M., Paul, R. K., Martin-Montalvo, A., Scheibye-Knudsen, M., Song, S., He, H., Armour, S. M., Hubbard, B. P., Bohr, Vilhelm, Wang, L., Zong, Y., Sinclair, D. A. & de Cabo, R., 3 Jun 2011, In : The Journal of Biological Chemistry. 286, 22, p. 19270-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

    Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In : Free Radical Biology and Medicine. 141, p. 47-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In : Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H., Kato, H., Kassahun, H., Lee, J., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L., Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In : Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, Morten, Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In : Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Modulation of DNA base excision repair during neuronal differentiation

    Sykora, P., Yang, J., Ferrarelli, L. K., Tian, J., Tadokoro, T., Kulkarni, A., Weissman, L., Keijzers, Guido, Wilson, D. M., Mattson, M. P. & Bohr, Vilhelm, Jul 2013, In : Neurobiology of Aging. 34, 7, p. 1717-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, Mansour, Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In : Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Mitophagy in neurodegeneration and aging

    Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In : Neurochemistry International. 109, p. 202-209

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In : Trends in Neurosciences. 40, 3, p. 151-166 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Mitochondrial helicases and mitochondrial genome maintenance

    de Souza-Pinto, N. C., Aamann, M. D., Kulikowicz, T., Stevnsner, T. V. & Bohr, Vilhelm, 2010, In : Mechanisms of Ageing and Development. 131, 7-8, p. 503-10 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease

    Diaz, R. G., Weissman, L., Yang, J., Bohr, Vilhelm & Stevnsner, T. V., 12 Aug 2010, In : Neurobiology of Aging.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Mitochondrial base excision repair assays

    Maynard, S., de Souza-Pinto, N. C., Scheibye-Knudsen, M. & Bohr, Vilhelm, 1 Aug 2010, In : Methods. 51, 4, p. 416-25 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Mitochondrial DNA repair and association with aging--an update

    Diaz, R. G., Bohr, Vilhelm & Stevnsner, T. V., 1 Aug 2010, In : Experimental Gerontology. 45, 7-8, p. 478-88 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, Mansour, Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In : Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Mitochondria and aging

    Prolla, T. A., Bohr, Vilhelm & de Souza-Pinto, N. C., Jul 2010, In : Mechanisms of Ageing and Development. 131, 7-8, p. 449-50 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Metabolism, genomics, and DNA repair in the mouse aging liver

    Lebel, M., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2011, In : Current Gerontology and Geriatrics Research. 2011, p. 859415

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Loss of NEIL1 causes defects in olfactory function in mice

    Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In : Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, Guido, Akbari, Mansour, Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In : Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Madsen, Claus Desler, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, Guido, Fagerlund, B., Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In : Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Impact papers on aging in 2009

    Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, Vilhelm, Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. & Vijg, J., 1 Mar 2010, In : Aging. 2, 3, p. 111-21 11 p.

    Research output: Contribution to journalReviewResearch

  49. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, Guido, Bohr, Vilhelm & Rasmussen, Lene Juel, 25 Apr 2015, In : Bioscience Reports. 35, 3, 23 p., e00206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

    Maynard, S., Swistowska, A. M., Lee, J. W., Liu, Y., Liu, S., Da Cruz, A. B., Rao, M., de Souza-Pinto, N. C., Zeng, X. & Bohr, Vilhelm, 1 Sep 2008, In : Stem Cells. 26, 9, p. 2266-74 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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