Vilhelm Bohr
Affiliate professor, Affiliate Professor
Molecular Aging Program
Panum Instituttet, Blegdamsvej 3, 2200 København N, 07 Bygning 7, Building: 07-3-13
Member of:
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14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In: Journal of Visualized Experiments. 129, e56301.Research output: Contribution to journal › Journal article › Research › peer-review
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Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside
Anugula, Sharath, Li, Zhiquan, Li, Yuan, Hendriksen, A., Christensen, P. B., Wang, L., Monk, J. M., de Wind, N., Bohr, Vilhelm, Desler, Claus, Naviaux, R. K. & Rasmussen, Lene Juel, 2023, In: Heliyon. 9, 6, e17392.Research output: Contribution to journal › Journal article › Research › peer-review
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A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In: Chemistry & Biology. 20, 1, p. 55-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome
Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, L. H., Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L. & 2 others, , 4 Nov 2014, In: Cell Metabolism. 20, 5, p. 840-855 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, L. H., Dec 2016, In: Neurobiology of Aging. 48, p. 34-47Research output: Contribution to journal › Journal article › Research › peer-review
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A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function
Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
A research agenda for aging in China in the 21st century
Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In: Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Acetylation regulates WRN catalytic activities and affects base excision DNA repair
Muftuoglu, M., Kusumoto, R., Speina, E., Beck, G., Cheng, W. & Bohr, Vilhelm, Jan 2008, In: P L o S One. 3, 4, p. e1918Research output: Contribution to journal › Journal article › Research › peer-review
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Acquired Localized Cutis Laxa due to Increased Elastin Turnover
Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.Research output: Contribution to journal › Review › Research › peer-review
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Aging, longevity and health
Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy
Palikaras, K., Achanta, K., Choi, S., Akbari, M. & Bohr, Vilhelm, 2021, In: Aging. 13, 21, p. 23876-23894 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Aprataxin localizes to mitochondria and preserves mitochondrial function
Sykora, P., Croteau, D. L., Bohr, Vilhelm & Wilson, D. M., 3 May 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 18, p. 7437-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance
Maynard, S., Keijzers, G., Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In: Acta Physiologica (Print). 213, 1, p. 156-170 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Base excision repair activities differ in human lung cancer cells and corresponding normal controls
Karahalil, B., Bohr, Vilhelm & De Souza-Pinto, N. C., 1 Dec 2010, In: Anticancer Research. 30, 12, p. 4963-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
SenGupta, T., Palikaras, K., Esbensen, Y. Q., Konstantinidis, G., Galindo, F. J. N., Achanta, K., Kassahun, H., Stavgiannoudaki, I., Bohr, Vilhelm, Akbari, M., Gaare, J., Tzoulis, C., Tavernarakis, N. & Nilsen, H., 2021, In: Cell Reports. 36, 10, 109668.Research output: Contribution to journal › Journal article › Research › peer-review
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Base excision repair of oxidative DNA damage and association with cancer and aging
Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2009, In: Carcinogenesis. 30, 1, p. 2-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, G., Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In: DNA Repair. 10, 1, p. 73-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bohr på ny
Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, Finn, Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.Research output: Book/Report › Book › Communication
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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double-strand break repair pathway choice
Lee, J. H., Shamanna, R. A., Kulikowicz, T., Fakouri, N. B., Kim, E. W., Christiansen, L. S., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 11, 14 p., e13484.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, G., Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In: Mechanisms of Ageing and Development. 135, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome: Clinical features, model systems and pathways
Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, 2017, In: Ageing Research Reviews. 33, p. 3-17Research output: Contribution to journal › Review › Research › peer-review
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Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J. & 2 others, , 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation
Okur, M. N., Lee, J., Osmani, W., Kimura, R., Demarest, T. G., Croteau, D. L. & Bohr, Vilhelm, 18 Mar 2020, In: Nucleic Acids Research. 48, 5, p. 2473-2485 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging
Lee, J., Demarest, T. G., Babbar, M., Kim, E. W., Okur, M. N., De, S., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 16, p. 8548-8562Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy
Scheibye-Knudsen, M., Ramamoorthy, M., Sykora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M., Spencer, R., de Cabo, R., Croteau, D. L. & Bohr, Vilhelm, Apr 2012, In: The Journal of Experimental Medicine. 209, 4, p. 855-69 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane
Aamann, M. D., Sorensen, M. M., Hvitby, C. P., Berquist, B. R., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson, D. M., Stevnsner, T. V. & Bohr, Vilhelm, 1 Jul 2010, In: The FASEB Journal. 24, 7, p. 2334-46 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase
Muftuoglu, M., de Souza-Pinto, N. C., Dogan, A., Aamann, M., Stevnsner, T., Rybanska, I., Kirkali, G., Dizdaroglu, M. & Bohr, Vilhelm, Apr 2009, In: Journal of Biological Chemistry. 284, 14, p. 9270-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling
Okur, M. N., Fang, E. F., Fivenson, E. M., Tiwari, V., Croteau, D. L. & Bohr, Vilhelm, Dec 2020, In: Aging Cell. 19, 12, p. e13268Research output: Contribution to journal › Journal article › Research › peer-review
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Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding
Rossi, M. L., Ghosh, A. K., Kulikowicz, T., Croteau, D. L. & Bohr, Vilhelm, 1 Jul 2010, In: DNA Repair. 9, 7, p. 796-804 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders
Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L. & Bohr, Vilhelm, 2014, In: Autophagy. 10, 8, p. 1468-1469 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
Kusumoto-Matsuo, R., Opresko, P. L., Ramsden, D., Tahara, H. & Bohr, Vilhelm, 1 May 2010, In: Aging. 2, 5, p. 274-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytosolic self-DNA—A potential source of chronic inflammation in aging
Akbari, M., Shanley, D. P., Bohr, Vilhelm & Rasmussen, Lene Juel, 2021, In: Cells. 10, 12, 3544.Research output: Contribution to journal › Review › Research › peer-review
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DNA Damage, DNA Repair, Aging, and Neurodegeneration
Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Repair and the Accumulation of Oxidatively Damaged DNA Are Affected by Fruit Intake in Mice
Croteau, D. L., de Souza-Pinto, N. C., Harboe, C., Keijzers, G., Zhang, Y., Becker, K., Sheng, S. & Bohr, Vilhelm, Dec 2010, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65, 12, p. 1300-1311 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage invokes mitophagy through a pathway involving Spata18
Dan, X., Babbar, M., Moore, A., Wechter, N., Tian, J., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6611-6623 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population
Rasmussen, Lene Juel, Shiloh, Y., Bergersen, L. H., Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In: Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA polymerase beta participates in mitochondrial DNA repair
Sykora, P., Kanno, S., Akbari, M., Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In: Molecular and Cellular Biology. 37, 16, e00237-17.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA repair deficiency in neurodegeneration
Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In: Progress in Neurobiology. 94, 2, p. 166-200 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In: Cell. 157, 4, p. 882-96 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms
Massip, L., Garand, C., Labbé, A., Perreault, E., Turaga, R. V. N., Bohr, Vilhelm & Lebel, M., 11 Mar 2010, In: Oncogene. 29, 10, p. 1486-97 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis
Li, X., Fang, E. F., Scheibye-Knudsen, Morten, Cui, H., Qiu, L., Li, J., He, Y., Huang, J., Bohr, Vilhelm, Ng, T. B. & Guo, H., 2014, In: Scientific Reports. 4, 6434.Research output: Contribution to journal › Journal article › Research › peer-review
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Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells
Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2019, In: Nucleic Acids Research. 47, 8, p. 4086–4110Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516Research output: Contribution to journal › Journal article › Research › peer-review
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Earl R. Stadtman
Levine, R. L. & Bohr, Vilhelm, 1 Jan 2010, In: Mechanisms of Ageing and Development. 131, 1, p. 1Research output: Contribution to journal › Journal article › Research › peer-review
Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)
Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In: Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions
Liu, D., Croteau, D. L., Souza-Pinto, N., Pitta, M., Tian, J., Wu, C., Jiang, H., Mustafa, K., Keijzers, G., Bohr, Vilhelm & Mattson, M. P., Feb 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 680-692 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
Rhee, D. B., Ghosh, A., Lu, J., Bohr, Vilhelm & Liu, Y., 2 Jan 2011, In: DNA Repair. 10, 1, p. 34-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4975983
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Mitochondria in the signaling pathways that control longevity and health span
Research output: Contribution to journal › Review › Research › peer-review
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281
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
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Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Research output: Contribution to journal › Journal article › Research › peer-review
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