Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


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  1. Published

    Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

    Aamann, M. D., Sorensen, M. M., Hvitby, C. P., Berquist, B. R., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson, D. M., Stevnsner, T. V. & Bohr, Vilhelm, 1 Jul 2010, In : The FASEB Journal. 24, 7, p. 2334-46 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

    Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, G., Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In : Mechanisms of Ageing and Development. 135, p. 1-14 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, Mansour, Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In : Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, Mansour, Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Madsen, Claus Desler, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In : DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, Mansour, Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In : Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    The role of DNA base excision repair in brain homeostasis and disease

    Akbari, Mansour, Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In : DNA Repair. 32, p. 172-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells

    Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J. R., Cooper, D. N., Bohr, Vilhelm & Vasquez, K. M., 25 Mar 2011, In : The Journal of Biological Chemistry. 286, 12, p. 10017-26 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

    Bernier, M., Paul, R. K., Martin-Montalvo, A., Scheibye-Knudsen, M., Song, S., He, H., Armour, S. M., Hubbard, B. P., Bohr, Vilhelm, Wang, L., Zong, Y., Sinclair, D. A. & de Cabo, R., 3 Jun 2011, In : The Journal of Biological Chemistry. 286, 22, p. 19270-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

    Berquist, B. R., Singh, D. K., Fan, J., Kim, D., Gillenwater, E., Kulkarni, A., Bohr, Vilhelm, Ackerman, E. J., Tomkinson, A. E. & Wilson, D. M., 1 Aug 2010, In : Nucleic Acids Symposium Series. 38, 15, p. 5023-35 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Impact papers on aging in 2009

    Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, Vilhelm, Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. & Vijg, J., 1 Mar 2010, In : Aging. 2, 3, p. 111-21 11 p.

    Research output: Contribution to journal › Review › Research

  14. Published

    Bohr på ny

    Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, F., Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.

    Research output: Book/Report › Book

  15. Published

    Telomerer--begyndelsen og enden

    Bohr, Vilhelm, 4 Oct 2010, In : Ugeskrift for Laeger. 172, 40, p. 2744

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair

    Canugovi, C., Maynard, S., Bayne, A. V., Sykora, P., Tian, J., de Souza-Pinto, N. C., Croteau, D. L. & Bohr, Vilhelm, 5 Oct 2010, In : DNA Repair. 9, 10, p. 1080-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Loss of NEIL1 causes defects in olfactory function in mice

    Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In : Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Nutrition and aging

    Cheng, W., Bohr, Vilhelm & de Cabo, R., 1 Apr 2010, In : Mechanisms of Ageing and Development. 131, 4, p. 223-4 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

    Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J., Sykora, P., Ramamoorthy, M., Wang, Z. M., Singh, D. K., Akbari, Mansour, Kasiviswanathan, R., Copeland, W. C. & Bohr, Vilhelm, 2012, In : Aging Cell. 11, 3, p. 456-66 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    DNA Repair and the Accumulation of Oxidatively Damaged DNA Are Affected by Fruit Intake in Mice

    Croteau, D. L., de Souza-Pinto, N. C., Harboe, C., Keijzers, G., Zhang, Y., Becker, K., Sheng, S. & Bohr, Vilhelm, Dec 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65, 12, p. 1300-1311 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Mitochondrial DNA repair and association with aging--an update

    Diaz, R. G., Bohr, Vilhelm & Stevnsner, T. V., 1 Aug 2010, In : Experimental Gerontology. 45, 7-8, p. 478-88 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease

    Diaz, R. G., Weissman, L., Yang, J., Bohr, Vilhelm & Stevnsner, T. V., 12 Aug 2010, In : Neurobiology of Aging.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In : Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Toward understanding genomic instability, mitochondrial dysfunction and aging

    Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, Louise Slot, Okur, M. N., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2019, In : F E B S Journal. 286, 6, p. 1058-1073 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H., Kato, H., Kassahun, H., Lee, J., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L., Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In : Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, Mansour, Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In : Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In : Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

    Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In : Journal of Visualized Experiments. 129, e56301.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

    Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In : Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Nuclear DNA damage signalling to mitochondria in ageing

    Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In : Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In : Scientific Reports. 7, 46208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. A research agenda for aging in China in the 21st century

    Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In : Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

    Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In : Cell. 157, 4, p. 882-96 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, Morten, Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In : Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Mitophagy in neurodegeneration and aging

    Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In : Neurochemistry International. 109, p. 202-209

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

    Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In : The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Genome instability in Alzheimer disease

    Hou, Y., Song, H., Croteau, D. L., Akbari, Mansour & Bohr, Vilhelm, Jan 2017, In : Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Ageing as a risk factor for neurodegenerative disease

    Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    DNA repair deficiency in neurodegeneration

    Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In : Progress in Neurobiology. 94, 2, p. 166-200 35 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Base excision repair activities differ in human lung cancer cells and corresponding normal controls

    Karahalil, B., Bohr, Vilhelm & De Souza-Pinto, N. C., 1 Dec 2010, In : Anticancer Research. 30, 12, p. 4963-71 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Cockayne syndrome: Clinical features, model systems and pathways

    Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, 2017, In : Ageing Research Reviews. 33, p. 3-17

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  46. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In : Bioscience Reports. 35, 3, 13 p., e00206.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In : Trends in Neurosciences. 40, 3, p. 151-166 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

    Kusumoto-Matsuo, R., Opresko, P. L., Ramsden, D., Tahara, H. & Bohr, Vilhelm, 1 May 2010, In : Aging. 2, 5, p. 274-84 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples

    Lachapelle, S., Gagné, J., Garand, C., Desbiens, M., Coulombe, Y., Bohr, Vilhelm, Hendzel, M. J., Masson, J., Poirier, G. G. & Lebel, M., 4 Mar 2011, In : Journal of Proteome Research. 10, 3, p. 1216-27 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

    Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, Linda Hildegard, Dec 2016, In : Neurobiology of Aging. 48, p. 34-47

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 4975983