Vilhelm Bohr
Affiliate professor
Molecular Aging Program
Mærsk Tårnet, Building: 7.3.40
2200 København N
Member of:
Web: Center for Healthy Aging
Web Track 3: Individualized health
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Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane
Aamann, M. D., Sorensen, M. M., Hvitby, C. P., Berquist, B. R., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson, D. M., Stevnsner, T. V. & Bohr, Vilhelm, 1 Jul 2010, In : The FASEB Journal. 24, 7, p. 2334-46 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, G., Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In : Mechanisms of Ageing and Development. 135, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells
Akbari, Mansour, Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In : Scientific Reports. 5, 8 p., 12876 .Research output: Contribution to journal › Journal article › Research › peer-review
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Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair
Akbari, Mansour, Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Madsen, Claus Desler, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In : DNA Repair. 16, p. 44-53 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondria in the signaling pathways that control longevity and health span
Akbari, Mansour, Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In : Ageing Research Reviews. 54, 100940.Research output: Contribution to journal › Review › Research › peer-review
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The role of DNA base excision repair in brain homeostasis and disease
Akbari, Mansour, Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In : DNA Repair. 32, p. 172-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.Research output: Contribution to journal › Journal article › Research › peer-review
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14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells
Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J. R., Cooper, D. N., Bohr, Vilhelm & Vasquez, K. M., 25 Mar 2011, In : The Journal of Biological Chemistry. 286, 12, p. 10017-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516Research output: Contribution to journal › Journal article › Research › peer-review
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Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
Bernier, M., Paul, R. K., Martin-Montalvo, A., Scheibye-Knudsen, M., Song, S., He, H., Armour, S. M., Hubbard, B. P., Bohr, Vilhelm, Wang, L., Zong, Y., Sinclair, D. A. & de Cabo, R., 3 Jun 2011, In : The Journal of Biological Chemistry. 286, 22, p. 19270-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population
Berquist, B. R., Singh, D. K., Fan, J., Kim, D., Gillenwater, E., Kulkarni, A., Bohr, Vilhelm, Ackerman, E. J., Tomkinson, A. E. & Wilson, D. M., 1 Aug 2010, In : Nucleic Acids Symposium Series. 38, 15, p. 5023-35 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact papers on aging in 2009
Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, Vilhelm, Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. & Vijg, J., 1 Mar 2010, In : Aging. 2, 3, p. 111-21 11 p.Research output: Contribution to journal › Review › Research
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Bohr på ny
Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, F., Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.Research output: Book/Report › Book
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Telomerer--begyndelsen og enden
Bohr, Vilhelm, 4 Oct 2010, In : Ugeskrift for Laeger. 172, 40, p. 2744Research output: Contribution to journal › Journal article › Research › peer-review
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The mitochondrial transcription factor A functions in mitochondrial base excision repair
Canugovi, C., Maynard, S., Bayne, A. V., Sykora, P., Tian, J., de Souza-Pinto, N. C., Croteau, D. L. & Bohr, Vilhelm, 5 Oct 2010, In : DNA Repair. 9, 10, p. 1080-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Loss of NEIL1 causes defects in olfactory function in mice
Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In : Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nutrition and aging
Cheng, W., Bohr, Vilhelm & de Cabo, R., 1 Apr 2010, In : Mechanisms of Ageing and Development. 131, 4, p. 223-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity
Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J., Sykora, P., Ramamoorthy, M., Wang, Z. M., Singh, D. K., Akbari, Mansour, Kasiviswanathan, R., Copeland, W. C. & Bohr, Vilhelm, 2012, In : Aging Cell. 11, 3, p. 456-66 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Repair and the Accumulation of Oxidatively Damaged DNA Are Affected by Fruit Intake in Mice
Croteau, D. L., de Souza-Pinto, N. C., Harboe, C., Keijzers, G., Zhang, Y., Becker, K., Sheng, S. & Bohr, Vilhelm, Dec 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65, 12, p. 1300-1311 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial DNA repair and association with aging--an update
Diaz, R. G., Bohr, Vilhelm & Stevnsner, T. V., 1 Aug 2010, In : Experimental Gerontology. 45, 7-8, p. 478-88 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
Diaz, R. G., Weissman, L., Yang, J., Bohr, Vilhelm & Stevnsner, T. V., 12 Aug 2010, In : Neurobiology of Aging.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In : Nucleic Acids Research. 48, 12, p. 6530–6546Research output: Contribution to journal › Journal article › Research › peer-review
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, Louise Slot, Okur, M. N., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2019, In : F E B S Journal. 286, 6, p. 1058-1073 16 p.Research output: Contribution to journal › Review › Research › peer-review
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Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H., Kato, H., Kassahun, H., Lee, J., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L., Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In : Nature Communications. 10, 1, 18 p., 5284.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, Mansour, Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In : Nature Neuroscience. 22, p. 401-412Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ in Aging: Molecular Mechanisms and Translational Implications
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In : Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.Research output: Contribution to journal › Review › Research › peer-review
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In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In : Journal of Visualized Experiments. 129, e56301.Research output: Contribution to journal › Journal article › Research › peer-review
Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)
Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In : Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nuclear DNA damage signalling to mitochondria in ageing
Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In : Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In : Scientific Reports. 7, 46208.Research output: Contribution to journal › Journal article › Research › peer-review
A research agenda for aging in China in the 21st century
Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In : Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In : Cell. 157, 4, p. 882-96 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, Morten, Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In : Cell Metabolism. 24, 4, p. 566-581 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy in neurodegeneration and aging
Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In : Neurochemistry International. 109, p. 202-209Research output: Contribution to journal › Review › Research › peer-review
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A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function
Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In : The Journal of Physiology. 593, 17, p. 3991-4010 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome instability in Alzheimer disease
Hou, Y., Song, H., Croteau, D. L., Akbari, Mansour & Bohr, Vilhelm, Jan 2017, In : Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.Research output: Contribution to journal › Review › Research › peer-review
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NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885Research output: Contribution to journal › Journal article › Research › peer-review
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The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA repair deficiency in neurodegeneration
Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In : Progress in Neurobiology. 94, 2, p. 166-200 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Base excision repair activities differ in human lung cancer cells and corresponding normal controls
Karahalil, B., Bohr, Vilhelm & De Souza-Pinto, N. C., 1 Dec 2010, In : Anticancer Research. 30, 12, p. 4963-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome: Clinical features, model systems and pathways
Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, 2017, In : Ageing Research Reviews. 33, p. 3-17Research output: Contribution to journal › Review › Research › peer-review
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The role of RecQ helicases in non-homologous end-joining
Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures
Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In : Bioscience Reports. 35, 3, 13 p., e00206.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In : Trends in Neurosciences. 40, 3, p. 151-166 16 p.Research output: Contribution to journal › Review › Research › peer-review
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Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
Kusumoto-Matsuo, R., Opresko, P. L., Ramsden, D., Tahara, H. & Bohr, Vilhelm, 1 May 2010, In : Aging. 2, 5, p. 274-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples
Lachapelle, S., Gagné, J., Garand, C., Desbiens, M., Coulombe, Y., Bohr, Vilhelm, Hendzel, M. J., Masson, J., Poirier, G. G. & Lebel, M., 4 Mar 2011, In : Journal of Proteome Research. 10, 3, p. 1216-27 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, Linda Hildegard, Dec 2016, In : Neurobiology of Aging. 48, p. 34-47Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4975983
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501
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RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
171
downloads
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
164
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Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Research output: Contribution to journal › Journal article › Research › peer-review
Published