Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. 2020
  2. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 20 May 2020, In : Nucleic Acids Research. 45, 12, p. 6530–6546

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

    Zheng, Jin, Akbari, Mansour, Schirmer, C., Reynaert, M. L., Loyens, A., Lefebvre, B., Buée, L., Croteau, D. L., Galas, M. C. & Bohr, Vilhelm, 2020, In : Acta Neuropathologica Communications. 8, 1, 23 p., 25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2019
  6. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, Mansour, Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In : Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, Mansour, Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In : Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H., Kato, H., Kassahun, H., Lee, J., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L., Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In : Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

    Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In : Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ageing as a risk factor for neurodegenerative disease

    Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

    Lee, J., Demarest, T. G., Babbar, M., Kim, E. W., Okur, M. N., De, S., Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nucleic Acids Research. 47, 16, p. 8548-8562

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, Guido, Akbari, Mansour, Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In : Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

    Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In : Free Radical Biology and Medicine. 141, p. 47-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

    Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, Mansour, 2019, In : Nucleic Acids Research. 47, 8, p. 4086–4110

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2018
  16. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Sarcopenia, Aging and Prospective Interventional Strategies

    Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In : Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. 2017
  19. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

    Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In : Journal of Visualized Experiments. 129, e56301.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In : Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In : Scientific Reports. 7, 46208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Mitophagy in neurodegeneration and aging

    Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In : Neurochemistry International. 109, p. 202-209

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Genome instability in Alzheimer disease

    Hou, Y., Song, H., Croteau, D. L., Akbari, Mansour & Bohr, Vilhelm, Jan 2017, In : Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Cockayne syndrome: Clinical features, model systems and pathways

    Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, Jan 2017, In : Ageing Research Reviews. 33, p. 3-17

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In : Trends in Neurosciences. 40, 3, p. 151-166 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    DNA polymerase beta participates in mitochondrial DNA repair

    Sykora, P., Kanno, S., Akbari, Mansour, Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In : Molecular and Cellular Biology. 37, 16, e00237-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2016
  29. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, Morten, Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In : Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Nuclear DNA damage signalling to mitochondria in ageing

    Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In : Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

    Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, Linda Hildegard, Dec 2016, In : Neurobiology of Aging. 48, p. 34-47

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, Michael, 14 Jun 2016, In : Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

    Scheibye-Knudsen, Morten, Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. ,. I., Brosh, R. M. ,. J., Gorospe, M. & Bohr, Vilhelm, 1 Nov 2016, In : National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2015
  36. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, Mansour, Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In : Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The role of DNA base excision repair in brain homeostasis and disease

    Akbari, Mansour, Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In : DNA Repair. 32, p. 172-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Loss of NEIL1 causes defects in olfactory function in mice

    Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In : Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. A research agenda for aging in China in the 21st century

    Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In : Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

    Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In : The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, Guido, Bohr, Vilhelm & Rasmussen, Lene Juel, 25 Apr 2015, In : Bioscience Reports. 35, 3, 23 p., e00206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Madsen, Claus Desler, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, Guido, Fagerlund, B., Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In : Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

    Maynard, S., Keijzers, Guido, Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In : Acta Physiologica (Print). 213, 1, p. 156-170 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration

    Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In : Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, Guido, Hansen, Åse Marie, Madsen, Claus Desler, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In : Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Protecting the mitochondrial powerhouse

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, Vilhelm, 1 Mar 2015, In : Trends in Cell Biology. 25, 3, p. 158-170 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. 2014
  48. Published

    Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

    Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, Guido, Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In : Mechanisms of Ageing and Development. 135, p. 1-14 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, Mansour, Keijzers, Guido, Maynard, S., Scheibye-Knudsen, M., Madsen, Claus Desler, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In : DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

    Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In : Cell. 157, 4, p. 882-96 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis

    Li, X., Fang, E. F., Scheibye-Knudsen, Morten, Cui, H., Qiu, L., Li, J., He, Y., Huang, Jing, Bohr, Vilhelm, Ng, T. B. & Guo, H., 2014, In : Scientific Reports. 4, 6434.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome

    Scheibye-Knudsen, Morten, Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, Linda Hildegard, Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L., De Cabo, R. & Bohr, Vilhelm, 4 Nov 2014, In : Cell Metabolism. 20, 5, p. 840-855 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L. & Bohr, Vilhelm, 2014, In : Autophagy. 10, 8, p. 1468-1469 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, Guido, Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Carcinogenesis. 35, 11, p. 2415-2424 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2013
  58. Published

    Bohr på ny

    Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, F., Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.

    Research output: Book/ReportBookCommunication

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