Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. 2020
  2. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In : Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

    Zheng, Jin, Akbari, Mansour, Schirmer, C., Reynaert, M. L., Loyens, A., Lefebvre, B., Buée, L., Croteau, D. L., Galas, M. C. & Bohr, Vilhelm, 2020, In : Acta Neuropathologica Communications. 8, 1, 23 p., 25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2019
  6. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, Mansour, Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In : Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, Mansour, Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In : Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H., Kato, H., Kassahun, H., Lee, J., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L., Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In : Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

    Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In : Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ageing as a risk factor for neurodegenerative disease

    Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

    Lee, J., Demarest, T. G., Babbar, M., Kim, E. W., Okur, M. N., De, S., Croteau, D. L. & Bohr, Vilhelm, 2019, In : Nucleic Acids Research. 47, 16, p. 8548-8562

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, Guido, Akbari, Mansour, Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In : Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

    Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In : Free Radical Biology and Medicine. 141, p. 47-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

    Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, Mansour, 2019, In : Nucleic Acids Research. 47, 8, p. 4086–4110

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2018
  16. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Sarcopenia, Aging and Prospective Interventional Strategies

    Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In : Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. 2017
  19. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

    Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In : Journal of Visualized Experiments. 129, e56301.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In : Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In : Scientific Reports. 7, 46208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Mitophagy in neurodegeneration and aging

    Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In : Neurochemistry International. 109, p. 202-209

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Genome instability in Alzheimer disease

    Hou, Y., Song, H., Croteau, D. L., Akbari, Mansour & Bohr, Vilhelm, Jan 2017, In : Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Cockayne syndrome: Clinical features, model systems and pathways

    Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, Jan 2017, In : Ageing Research Reviews. 33, p. 3-17

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In : Trends in Neurosciences. 40, 3, p. 151-166 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    DNA polymerase beta participates in mitochondrial DNA repair

    Sykora, P., Kanno, S., Akbari, Mansour, Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In : Molecular and Cellular Biology. 37, 16, e00237-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2016
  29. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, Morten, Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P., Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In : Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Nuclear DNA damage signalling to mitochondria in ageing

    Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In : Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

    Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, Linda Hildegard, Dec 2016, In : Neurobiology of Aging. 48, p. 34-47

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In : Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

    Scheibye-Knudsen, Morten, Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. ,. I., Brosh, R. M. ,. J., Gorospe, M. & Bohr, Vilhelm, 1 Nov 2016, In : National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2015
  36. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, Mansour, Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In : Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The role of DNA base excision repair in brain homeostasis and disease

    Akbari, Mansour, Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In : DNA Repair. 32, p. 172-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Loss of NEIL1 causes defects in olfactory function in mice

    Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In : Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. A research agenda for aging in China in the 21st century

    Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In : Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

    Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In : The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, Guido, Bohr, Vilhelm & Rasmussen, Lene Juel, 25 Apr 2015, In : Bioscience Reports. 35, 3, 23 p., e00206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Madsen, Claus Desler, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, Guido, Fagerlund, B., Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In : Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

    Maynard, S., Keijzers, Guido, Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In : Acta Physiologica (Print). 213, 1, p. 156-170 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration

    Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In : Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, Guido, Hansen, Åse Marie, Madsen, Claus Desler, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In : Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Protecting the mitochondrial powerhouse

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, Vilhelm, 1 Mar 2015, In : Trends in Cell Biology. 25, 3, p. 158-170 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. 2014
  48. Published

    Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

    Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, Guido, Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In : Mechanisms of Ageing and Development. 135, p. 1-14 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, Mansour, Keijzers, Guido, Maynard, S., Scheibye-Knudsen, M., Madsen, Claus Desler, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In : DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

    Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In : Cell. 157, 4, p. 882-96 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis

    Li, X., Fang, E. F., Scheibye-Knudsen, Morten, Cui, H., Qiu, L., Li, J., He, Y., Huang, Jing, Bohr, Vilhelm, Ng, T. B. & Guo, H., 2014, In : Scientific Reports. 4, 6434.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome

    Scheibye-Knudsen, Morten, Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, Linda Hildegard, Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L., De Cabo, R. & Bohr, Vilhelm, 4 Nov 2014, In : Cell Metabolism. 20, 5, p. 840-855 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L. & Bohr, Vilhelm, 2014, In : Autophagy. 10, 8, p. 1468-1469 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, Guido, Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Carcinogenesis. 35, 11, p. 2415-2424 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2013
  58. Published

    Bohr på ny

    Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, F., Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.

    Research output: Book/ReportBookCommunication

  59. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, Guido, Gram, M., Madsen, Claus Desler, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In : Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

    Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In : Chemistry & Biology. 20, 1, p. 55-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

    Rasmussen, Lene Juel, Shiloh, Y., Bergersen, Linda Hildegard, Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Modulation of DNA base excision repair during neuronal differentiation

    Sykora, P., Yang, J., Ferrarelli, L. K., Tian, J., Tadokoro, T., Kulkarni, A., Weissman, L., Keijzers, Guido, Wilson, D. M., Mattson, M. P. & Bohr, Vilhelm, Jul 2013, In : Neurobiology of Aging. 34, 7, p. 1717-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. 2012
  64. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

    Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J., Sykora, P., Ramamoorthy, M., Wang, Z. M., Singh, D. K., Akbari, Mansour, Kasiviswanathan, R., Copeland, W. C. & Bohr, Vilhelm, 2012, In : Aging Cell. 11, 3, p. 456-66 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

    Scheibye-Knudsen, M., Ramamoorthy, M., Sykora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M., Spencer, R., de Cabo, R., Croteau, D. L. & Bohr, Vilhelm, Apr 2012, In : The Journal of Experimental Medicine. 209, 4, p. 855-69 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. 2011
  69. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells

    Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J. R., Cooper, D. N., Bohr, Vilhelm & Vasquez, K. M., 25 Mar 2011, In : The Journal of Biological Chemistry. 286, 12, p. 10017-26 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

    Bernier, M., Paul, R. K., Martin-Montalvo, A., Scheibye-Knudsen, M., Song, S., He, H., Armour, S. M., Hubbard, B. P., Bohr, Vilhelm, Wang, L., Zong, Y., Sinclair, D. A. & de Cabo, R., 3 Jun 2011, In : The Journal of Biological Chemistry. 286, 22, p. 19270-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    DNA repair deficiency in neurodegeneration

    Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In : Progress in Neurobiology. 94, 2, p. 166-200 35 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples

    Lachapelle, S., Gagné, J., Garand, C., Desbiens, M., Coulombe, Y., Bohr, Vilhelm, Hendzel, M. J., Masson, J., Poirier, G. G. & Lebel, M., 4 Mar 2011, In : Journal of Proteome Research. 10, 3, p. 1216-27 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Metabolism, genomics, and DNA repair in the mouse aging liver

    Lebel, M., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2011, In : Current Gerontology and Geriatrics Research. 2011, p. 859415

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, Guido, Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In : DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions

    Liu, D., Croteau, D. L., Souza-Pinto, N., Pitta, M., Tian, J., Wu, C., Jiang, H., Mustafa, K., Keijzers, Guido, Bohr, Vilhelm & Mattson, M. P., Feb 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 680-692 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In : Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1

    Rhee, D. B., Ghosh, A., Lu, J., Bohr, Vilhelm & Liu, Y., 2 Jan 2011, In : DNA Repair. 10, 1, p. 34-44 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Aprataxin localizes to mitochondria and preserves mitochondrial function

    Sykora, P., Croteau, D. L., Bohr, Vilhelm & Wilson, D. M., 3 May 2011, In : Proceedings of the National Academy of Sciences USA (PNAS). 108, 18, p. 7437-42 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. 2010
  80. Published

    Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

    Aamann, M. D., Sorensen, M. M., Hvitby, C. P., Berquist, B. R., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson, D. M., Stevnsner, T. V. & Bohr, Vilhelm, 1 Jul 2010, In : The FASEB Journal. 24, 7, p. 2334-46 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

    Berquist, B. R., Singh, D. K., Fan, J., Kim, D., Gillenwater, E., Kulkarni, A., Bohr, Vilhelm, Ackerman, E. J., Tomkinson, A. E. & Wilson, D. M., 1 Aug 2010, In : Nucleic Acids Symposium Series. 38, 15, p. 5023-35 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Impact papers on aging in 2009

    Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, Vilhelm, Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. & Vijg, J., 1 Mar 2010, In : Aging. 2, 3, p. 111-21 11 p.

    Research output: Contribution to journalReviewResearch

  83. Published

    Telomerer--begyndelsen og enden

    Bohr, Vilhelm, 4 Oct 2010, In : Ugeskrift for Laeger. 172, 40, p. 2744

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair

    Canugovi, C., Maynard, S., Bayne, A. V., Sykora, P., Tian, J., de Souza-Pinto, N. C., Croteau, D. L. & Bohr, Vilhelm, 5 Oct 2010, In : DNA Repair. 9, 10, p. 1080-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Nutrition and aging

    Cheng, W., Bohr, Vilhelm & de Cabo, R., 1 Apr 2010, In : Mechanisms of Ageing and Development. 131, 4, p. 223-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    DNA Repair and the Accumulation of Oxidatively Damaged DNA Are Affected by Fruit Intake in Mice

    Croteau, D. L., de Souza-Pinto, N. C., Harboe, C., Keijzers, Guido, Zhang, Y., Becker, K., Sheng, S. & Bohr, Vilhelm, Dec 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65, 12, p. 1300-1311 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Mitochondrial DNA repair and association with aging--an update

    Diaz, R. G., Bohr, Vilhelm & Stevnsner, T. V., 1 Aug 2010, In : Experimental Gerontology. 45, 7-8, p. 478-88 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  88. Published

    Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease

    Diaz, R. G., Weissman, L., Yang, J., Bohr, Vilhelm & Stevnsner, T. V., 12 Aug 2010, In : Neurobiology of Aging.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Base excision repair activities differ in human lung cancer cells and corresponding normal controls

    Karahalil, B., Bohr, Vilhelm & De Souza-Pinto, N. C., 1 Dec 2010, In : Anticancer Research. 30, 12, p. 4963-71 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

    Kusumoto-Matsuo, R., Opresko, P. L., Ramsden, D., Tahara, H. & Bohr, Vilhelm, 1 May 2010, In : Aging. 2, 5, p. 274-84 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Earl R. Stadtman

    Levine, R. L. & Bohr, Vilhelm, 1 Jan 2010, In : Mechanisms of Ageing and Development. 131, 1, p. 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms

    Massip, L., Garand, C., Labbé, A., Perreault, E., Turaga, R. V. N., Bohr, Vilhelm & Lebel, M., 11 Mar 2010, In : Oncogene. 29, 10, p. 1486-97 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Mitochondrial base excision repair assays

    Maynard, S., de Souza-Pinto, N. C., Scheibye-Knudsen, M. & Bohr, Vilhelm, 1 Aug 2010, In : Methods. 51, 4, p. 416-25 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  94. Published

    Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases

    Popuri, V., Croteau, D. L. & Bohr, Vilhelm, 4 Jun 2010, In : DNA Repair. 9, 6, p. 636-42 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Mitochondria and aging

    Prolla, T. A., Bohr, Vilhelm & de Souza-Pinto, N. C., Jul 2010, In : Mechanisms of Ageing and Development. 131, 7-8, p. 449-50 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding

    Rossi, M. L., Ghosh, A. K., Kulikowicz, T., Croteau, D. L. & Bohr, Vilhelm, 1 Jul 2010, In : DNA Repair. 9, 7, p. 796-804 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Roles of Werner syndrome protein in protection of genome integrity

    Rossi, M. L., Ghosh, A. K. & Bohr, Vilhelm, 2 Mar 2010, In : DNA Repair. 9, 3, p. 331-44 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    The involvement of human RECQL4 in DNA double-strand break repair

    Singh, D. K., Karmakar, P., Aamann, M. D., Schurman, S. H., May, A., Croteau, D. L., Burks, L., Plon, S. E. & Bohr, Vilhelm, 1 Jun 2010, In : Aging Cell. 9, 3, p. 358-71 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

    Soerensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T. V., Bohr, Vilhelm & Christiansen, L., 1 Dec 2010, In : Aging Cell. 9, 6, p. 1010-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Human RECQL5beta stimulates flap endonuclease 1

    Speina, E., Dawut, L., Hedayati, M., Wang, Z., May, A., Schwendener, S., Janscak, P., Croteau, D. L. & Bohr, Vilhelm, 1 May 2010, In : Nucleic Acids Symposium Series. 38, 9, p. 2904-16 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Human RecQL4 helicase plays critical roles in prostate carcinogenesis

    Su, Y., Meador, J. A., Calaf, G. M., Proietti De-Santis, L., Zhao, Y., Bohr, Vilhelm & Balajee, A. S., 15 Nov 2010, In : Cancer Research. 70, 22, p. 9207-17 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1

    Yang, J., Tadokoro, T., Keijzers, Guido, Mattson, M. P. & Bohr, Vilhelm, 2010, In : Journal of Biological Chemistry. 285, 36, p. 28191-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. Published

    Mitochondrial helicases and mitochondrial genome maintenance

    de Souza-Pinto, N. C., Aamann, M. D., Kulikowicz, T., Stevnsner, T. V. & Bohr, Vilhelm, 2010, In : Mechanisms of Ageing and Development. 131, 7-8, p. 503-10 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. 2009
  105. Published

    Base excision repair of oxidative DNA damage and association with cancer and aging

    Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2009, In : Carcinogenesis. 30, 1, p. 2-10 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

    McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., Bohr, Vilhelm & Chua, K. F., 1 Jan 2009, In : Aging. 1, 1, p. 109-21 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase

    Muftuoglu, M., de Souza-Pinto, N. C., Dogan, A., Aamann, M., Stevnsner, T., Rybanska, I., Kirkali, G., Dizdaroglu, M. & Bohr, Vilhelm, Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9270-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. Published

    The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

    de Souza-Pinto, N. C., Maynard, S., Hashiguchi, K., Hu, J., Muftuoglu, M. & Bohr, Vilhelm, Aug 2009, In : Molecular and Cellular Biology. 29, 16, p. 4441-54 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. 2008
  110. Published

    Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

    Maynard, S., Swistowska, A. M., Lee, J. W., Liu, Y., Liu, S., Da Cruz, A. B., Rao, M., de Souza-Pinto, N. C., Zeng, X. & Bohr, Vilhelm, 1 Sep 2008, In : Stem Cells. 26, 9, p. 2266-74 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  111. Published

    Acetylation regulates WRN catalytic activities and affects base excision DNA repair

    Muftuoglu, M., Kusumoto, R., Speina, E., Beck, G., Cheng, W. & Bohr, Vilhelm, Jan 2008, In : P L o S One. 3, 4, p. e1918

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4975983