Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
- 2006
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A. & Gether, Ulrik, 2006, In: Neuron. 51, 4, p. 417-429 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Martinat, C., Bacci, J., Leete, T., Kim, J., Vanti, W. B., Newman, A. H., Cha, J. H., Gether, Ulrik, Wang, H. & Abeliovich, A., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 8, p. 2874-2879 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (vol 279, pg 3228, 2004)
Loland, C. J., Granas, C., Javitch, J. A. & Gether, Ulrik, 2006, In: Journal of Biological Chemistry. 281, 35, p. 25867-25867Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanisms of GPCR activation
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, A., 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-383 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization
Jayanthi, L. D., Annamalai, B., Samuvel, D. J., Gether, Ulrik & Ramamoorthy, S., 2006, In: Journal of Biological Chemistry. 281, 33, p. 23326-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn2+ modulation of neurotransmitter transporters
Nørgaard-Nielsen, K. & Gether, Ulrik, 2006, In: Handbook of Experimental Pharmacology. 175, p. 1-22 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
Henriksen, U. B., Fog, J. U., Litman, Thomas & Gether, Ulrik, 4 Nov 2005, In: Journal of Biological Chemistry. 280, 44, p. 36926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2
Henriksen, U. B., Gether, Ulrik & Litman, Thomas, 1 Apr 2005, In: Journal of Cell Science. 118, Pt 7, p. 1417-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and fluorescent labeling of the human serotonin transporter
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specifity of the PDZ domain in PICK1
Madsen, K. L., Beuming, T., Niv, M. Y., Chang, C. W., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. Vol. 280, no. 21, p. 20539-48Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters
Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding
Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions
Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions
Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter
Meinild, A., Sitte, H. H. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. 279, 48, p. 49671-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy
Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing dopamine transporter structure and function y Zn2+ site engineering
Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97Research output: Contribution to journal › Review › Research › peer-review
- Published
Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.
MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering at the oligomeric interface of the dopamine transporter
Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A. & Gether, Ulrik, 31 Jul 2002, In: FEBS Letters. 524, 1-3, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zinc ions in reverse transport mediated by monoamine transporters
Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In: Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 2002, In: Journal of Physiology. 544, 2, p. 447-458Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zine ions in reverse transport mediated by monoamine transporters
Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In: Journal of Biological Chemistry. 277, p. 21505-21513Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding G-protein coupled receptors and their role in the CNS
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor
Kobilka, B. K. & Gether, Ulrik, 2002, In: Methods in Enzymology. 343, 343, p. 170-182 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering oat the oligomeric interface of the dopamine transporter
Nørgaard-Nielsen, K., Norregaard, L., Hastrup-Nielsen, H., Javitch, J. A. & Gether, Ulrik, 2002, In: FEBS Letters. vol. 524(1-3), p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter
Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites
Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents
MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations
Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In: Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In: Journal of Physiology. 530 (Pt 3), p. 367-378Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
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