Ulrik Gether

Ulrik Gether

Head of Department, Professor


  1. 1990
  2. Published

    Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase

    Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & tml152, tml152, 1990, In : F E B S Letters. 260, 1, p. 73-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist

    Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., tml152, tml152 & Schwartz, Thue W., 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 1998
  5. Published

    Delineation of an endogenous zinc-binding site in the human dopamine transporter.

    Norregaard, L., Frederiksen, D., Nielsen, E. Ø. & Gether, Ulrik, 1998, In : EMBO Journal. 17, p. 4266-4273

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 1999
  7. Published

    Assessing adrenergic receptor using chemically reactive fluorescent probes

    Dam Jensen, A. & Gether, Ulrik, 1999, In Adrenergic Receptor Protocols, in the Methods for Molecular Biology. Humana Press, p. 345-361

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  8. Published

    Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor

    Kobilka, B. K., Gether, Ulrik, Seifert, R., Lin, S. & Ghanouni, P., 1999, In : Journal of Receptors and Signal Transduction. 19, p. 293-300

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

    Loland, Claus Juul, Norregaard, L. & Gether, Ulrik, 1999, In : Journal of Biological Chemistry. 274, 52, p. 36928-34 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Direct assessment of conformational changes in G protein coupled receptors using fluorescence spectroscopy

    Gether, Ulrik & Kobilka, B. K., 1999, In Signal Transduction - A practical Approach, in The practical Approach series, 2nd edition. Oxford: Oxford University Press, p. 01-17

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  11. Published

    Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

    Seifert, R., Gether, Ulrik, Wenzel-Seifert, K. & Kobilka, B. K., 1999, In : Molecular Pharmacology. 56, p. 348-358

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-Gsalpha fusion protein

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik, Lam, V. T. & Kobilka, B. K., 1999, In : European Journal of Biochemistry. 260, p. 661-666

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Fluorescence spectrosocpy analysis of conformational changes in the Β2 adrenergic receptor

    Gether, Ulrik, 1999, In Structure/Function of G-protein coupled receptors, in the Receptor Biochemistry and Methodology. New York: Wiley, p. 315-334

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  14. Published

    Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI

    Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In : Molecular Pharmacology. 56, p. 175-184

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2000
  16. Published

    Assessing adrenergic receptor conformation using chemically reactive fluorescent probes

    Jensen Dam, A. & Gether, Ulrik, 2000, Methods in Molecular Biology, vol.126: Adrenergic Receptors Protocols. Totowa, NJ: Humana Press, p. 345-359

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  17. Published

    The effect of pH on ß2 adrenoceptor function

    Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In : Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Uncovering molecular mechanism involved in activation of G protein-coupled receptors

    Gether, Ulrik, 2000, In : Endocrine Reviews. 21(1), p. 90-113

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In : Biochemistry. 39, 51, p. 15836-15846 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2001
  21. Published

    Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6

    Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In : Journal of Biological Chemistry. 276 (31), p. 29171-29177

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling

    Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In : Journal of Biological Chemistry. 276 (12), p. 9279-9290

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter

    Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In : Journal of Biological Chemistry. 276 (7), p. 4717-4723

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

    Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In : Life Sciences. 68 (19-20), p. 2187-2198

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

    MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, T., Kanner, B. I. & Gether, Ulrik, 2001, In : Journal of Biological Chemistry. 276, p. 40476-40485

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In : Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In : Biochemistry. 39 (51), p. 15836-15846

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes

    MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In : Journal of Physiology. 530 (Pt 3), p. 367-378

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2002
  30. Published

    Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1

    MacAulay, Nanna, Zeuthen, T. & Gether, Ulrik, 2002, In : Journal of Physiology. 544, 2, p. 447-458

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In : Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes

    MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, T., 2002, In : Journal of Physiology. 542, 3, p. 817-828 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Structural basis for activation of G-protein-coupled receptors.

    Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In : Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The role of zine ions in reverse transport mediated by monoamine transporters

    Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In : Journal of Biological Chemistry. 277, p. 21505-21513

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Understanding G-protein coupled receptors and their role in the CNS

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  36. Published

    Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor

    Kobilka, B. K. & Gether, Ulrik, 2002, In : Methods in Enzymology. 343, 343, p. 170-182 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Zn(2+) site engineering oat the oligomeric interface of the dopamine transporter

    Nørgaard-Nielsen, K., Norregaard, L., Hastrup-Nielsen, H., Javitch, J. A. & Gether, Ulrik, 2002, In : FEBS Letters. vol. 524(1-3), p. 87-91

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The role of zinc ions in reverse transport mediated by monoamine transporters

    Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In : Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Zn(2+) site engineering at the oligomeric interface of the dopamine transporter

    Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A. & Gether, Ulrik, 31 Jul 2002, In : FEBS letters. 524, 1-3, p. 87-91 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1

    MacAulay, Nanna, Zeuthen, T. & Gether, Ulrik, 15 Oct 2002, In : Journal of Physiology. 544, Pt 2, p. 447-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2003
  43. Published

    Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In : Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In : Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Probing dopamine transporter structure and function y Zn2+ site engineering

    Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In : European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97

    Research output: Contribution to journalReviewResearchpeer-review

  46. Published

    Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

    MacAulay, Nanna, Meinild, A., Zeuthen, T. & Gether, Ulrik, 2003, In : Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In : The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In : The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Probing dopamine transporter structure and function by Zn2+-site engineering

    Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In : European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy

    Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In : European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2004
  52. Published

    Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters

    Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  53. Published

    Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding

    Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In : Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions

    Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In : Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions

    Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In : Journal of Neuroscience. 24, 31, p. 7024-36 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter

    Meinild, A., Sitte, H. H. & Gether, Ulrik, 2004, In : Journal of Biological Chemistry. 279, 48, p. 49671-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding

    Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In : The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2005
  59. Published

    Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

    Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In : Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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