Ulrik Gether

Ulrik Gether

Head of Department, Professor


  1. Published

    Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase

    Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & tml152, tml152, 1990, In : F E B S Letters. 260, 1, p. 73-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching

    Adkins, E. M., Samuvel, D. J., Fog, J. U., Eriksen, J., Jayanthi, L. D., Vaegter, C. B., Ramamoorthy, S. & Gether, Ulrik, 2007, In : Biochemistry. 46, 37, p. 10484-97 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding

    Ammendrup-Johnsen, I., Thorsen, Thor Seneca, Gether, Ulrik & Madsen, Kenneth Lindegaard, 17 Jan 2012, In : Biochemistry. 51, 2, p. 586-96 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

    Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In : Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

    Bach, Anders, Stuhr-Hansen, N., Thorsen, Thor Seneca, Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In : Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6

    Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In : Journal of Biological Chemistry. 276 (31), p. 29171-29177

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Glycine transporter dimers - Evidence for occurrence in the plasma membrane

    Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In : Journal of Biological Chemistry. 283, 16, p. 10978-10991 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glycine transporter dimers: evidence for occurrence in the plasma membrane

    Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In : Journal of Biological Chemistry. 283, 16, p. 10978-91 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1

    Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In : European Journal of Neuroscience. 27, 1, p. 66-82 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The binding sites for cocaine and dopamine in the dopamine transporter overlap.

    Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In : Nature Neuroscience. 11, 7, p. 780-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Amphipathic motifs in BAR domains are essential for membrane curvature sensing

    Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In : EMBO Journal. 28, 21, p. 3303-3314 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

    Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, Kamil, Mortensen, J. S., Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In : Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

    Billesbølle, C. B., Mortensen, J. S., Sohail, A., Schmidt, Solveig Gaarde, Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In : Nature Communications. 7, 12 p., 12755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux

    Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, Ulrik, Javitch, J. A., Erreger, K. & Galli, A., 2008, In : Molecular Pharmacology. 74, 4, p. 1101-1108 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions

    Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In : Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions

    Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In : Journal of Neuroscience. 24, 31, p. 7024-36 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Are life events prior to first episode of major depression a predictor of medical treatment outcome?

    Bock, C., Bukh, J. D., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In : European Psychiatry. 23, Suppl. 2, p. S200-S200

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Validity of the diagnosis of a single depressive episode in a case register

    Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In : Clinical Practice and Epidemiology in Mental Health. 5, p. 4

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Do stressful life events predict medical treatment outcome in first episode of depression?

    Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In : Social Psychiatry and Psychiatric Epidemiology. 44, 9, p. 752-60 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression

    Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. O. D., Vinberg, Maj, Kessing, Lars Vedel & Gether, U., 1 Jan 2010, In : Psychopathology. 43, 3, p. 197-204 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Do stressful life events predict medical treatment outcome in first episode of depression?

    Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, Sep 2009, In : Social Psychiatry and Psychiatric Epidemiology. 44, 9, p. 752-60 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The second sodium site in the dopamine transporter controls cation permeability and is regulated by chloride

    Borre, L., Andreassen, T. F., Shi, L., Weinstein, H. & Gether, Ulrik, 25 Jul 2014, In : The Journal of Biological Chemistry. 289, p. 25764-25773 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. E-pub ahead of print

    G protein-coupled receptor pharmacology-The next generation

    Bräuner-Osborne, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In : Basic & Clinical Pharmacology & Toxicology.

    Research output: Contribution to journalEditorialResearchpeer-review

  24. Published

    The solute carrier 6 family of transporters

    Bröer, S. & Gether, Ulrik, 22 Aug 2012, In : British Journal of Pharmacology. 167, 2, p. 256-78 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Obituary

    Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In : Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.

    Research output: Contribution to journalComment/debateCommunication

  26. Published

    Genetic Polymorphisms and the outcome of antidepressant Treatment

    Bukh, J. D., Bock, C., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In : European Psychiatry. 23, p. S200-S200

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Gender Differences among Patients with a Single Depressive Episode

    Bukh, J. D., Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. O. D., Bock, C., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2010, In : Psychopathology. 43, 3, p. 159-169 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression

    Bukh, J. D., Bock, C., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 1 Dec 2010, In : Journal of Affective Disorders. 127, 1-3, p. 199-202 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

    Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In : European Neuropsychopharmacology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Interaction between genetic polymorphisms and stressful life events in first episode depression

    Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In : Journal of Affective Disorders. 119, 1-3, p. 107-15 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Structural biology: Antidepressants at work

    Caron, M. G. & Gether, Ulrik, 21 Apr 2016, In : Nature. 532, p. 320-321 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  32. Published

    Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

    Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, Ulrik, Veenstra-Vanderweele, J., Sutcliffe, J. S., Ulery-Reynolds, P. G., Erreger, K., Matthies, H. J. G. & Galli, A., Feb 2015, In : EBioMedicine. 2, 2, p. 135-146 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

    Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In : Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Novel Tripod Amphiphiles for Membrane Protein Analysis

    Chae, P. S., Kruse, A. C., Gotfryd, Kamil, Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In : Chemistry: A European Journal. 19, 46

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Correction to "tandem facial amphiphiles for membrane protein stabilization"

    Chae, P. S., Gotfryd, Kamil, Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 28 Aug 2013, In : Journal of the American Chemical Society. 135, 34, p. 12922 1 p.

    Research output: Contribution to journalJournal articleResearch

  36. Published

    Tandem Facial Amphiphiles for Membrane Protein Stabilization

    Chae, P. S., Gotfryd, Kamil, Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In : Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

    Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, Kamil, Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In : Nature Methods. 7, p. 1003-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

    Chae, P. S., Rana, R. R., Gotfryd, Kamil, Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In : Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

    Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, Kamil, Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S., Gether, Ulrik, Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Gellman, S. H., 27 Jul 2012, In : Chemistry: A European Journal. 18, 31, p. 9485-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Accepted/In press

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, Nikolaj Riis, De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, Gith, Jensen, Kathrine Louise, Rathje, Mette, Jensen, Dennis Bo, Erlendsson, Simon, Bartling, Christian Reinhard Otto, Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, Kaare, Arleth, Lise, Sørensen, Andreas Toft, Bach, Anders, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 30 Apr 2020, (Accepted/In press) In : EMBO Molecular Medicine. e11248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

    Apuschkin, Mia, Stilling, S., Rahbek-Clemmensen, T., Sørensen, G., Fortin, G., Herborg, Freja, Eriksen, J., Trudeau, L., Egerod, Kristoffer Lihme, Gether, Ulrik & Rickhag, Karl Mattias, 2015, In : European Journal of Neuroscience. 42, 7, p. 2438-2454 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Assessing adrenergic receptor using chemically reactive fluorescent probes

    Dam Jensen, A. & Gether, Ulrik, 1999, In Adrenergic Receptor Protocols, in the Methods for Molecular Biology. Humana Press, p. 345-361

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  43. Published

    Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

    DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, Freja, Rickhag, M., Chen, H., Gether, Ulrik, Wallace, M. T. & Galli, A., 2019, In : Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Differences between early and late onset adult depression

    Drachmann Bukh, J., Bock, C., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2011, In : Clinical Practice and Epidemiology in Mental Health. 7, p. 140-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges

    Eriksen, J., Jørgensen, T. N. & Gether, Ulrik, 2010, In : Journal of Neurochemistry. 113, 1, p. 27-41 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons

    Eriksen, J., Bjørn-Yoshimoto, Walden, Jørgensen, T. N., Newman, A. H. & Gether, Ulrik, 2010, In : Journal of Biological Chemistry. 285, 35, p. 27289-301 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs

    Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In : Journal of Neuroscience. 29, 21, p. 6794-808 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    Erlendsson, Simon, Gotfryd, Kamil, Larsen, F. H., Mortensen, J. S., Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In : eLife. 6, 9 p., e19314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

    Erlendsson, Simon, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In : Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Erlendsson, Simon, Thorsen, Thor Seneca, Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In : eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journalJournal articleResearchpeer-review

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