Ulrik Gether

Ulrik Gether

Head of Department, Professor


  1. 2020
  2. Published

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, Gith, Jensen, Kathrine Louise, Rathje, Mette, Jensen, Dennis Bo, Erlendsson, Simon, Bartling, Christian Reinhard Otto, Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, Kaare, Arleth, Lise, Sørensen, Andreas Toft, Bach, Anders, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In : EMBO Molecular Medicine. 12, 6, 25 p., e11248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    G protein-coupled receptor pharmacology-The next generation

    Bräuner-Osborne, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In : Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  4. Published

    Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

    Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In : Neurochemistry International. 138, 9 p., 104772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, P., Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In : Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

    Gotfryd, Kamil, Boesen, T., Mortensen, J. S., Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In : Nature Communications. 11, 1, 14 p., 1005.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2019
  8. Published

    Conformational dynamics of the human serotonin transporter during substrate and drug binding

    Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In : Nature Communications. 10, 1, 1687.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

    DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, Freja, Rickhag, M., Chen, H., Gether, Ulrik, Wallace, M. T. & Galli, A., 2019, In : Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

    Kønig, A. B., Ciriachi, C., Gether, Ulrik & Rickhag, Karl Mattias, 2019, In : Neuroscience. 401, p. 106-116

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

    Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, Amaia, Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In : Neuropharmacology. 161, 107663.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

    Giguère, N., Delignat-Lavaud, B., Herborg, Freja, Voisin, A., Li, Yuan, Jacquemet, V., Anand-Srivastava, M., Gether, Ulrik, Giros, B. & Trudeau, L., 2019, In : PLOS Genetics. 15, 8, 26 p., e1008352.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

    Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In : European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Erlendsson, Simon, Thorsen, Thor Seneca, Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In : eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

    Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In : Pharmacological Reviews. 71, 2, p. 123-156 34 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. 2018
  18. Published

    An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

    Herlo, R., Lund, Viktor Karlovich, Lycas, Matthew Domenic, Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., Erlendsson, Simon, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In : Cell Reports. 23, 7, p. 2056-2069 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    An unsuspected role for organic cation transporter 3 in the actions of amphetamine

    Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, Mia, Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H., Gether, Ulrik, Koek, W., Daws, L. C. & Sitte, H. H., 2018, In : Neuropsychopharmacology. 43, p. 2408-2417 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published
  21. Published

    Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

    Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In : The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Obituary

    Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In : Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.

    Research output: Contribution to journalComment/debateCommunication

  23. Published

    PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

    Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In : eNeuro. 5, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. 2017
  26. Published

    Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research

    Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In : Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

    Jensen, Kathrine Louise, Runegaard, A. H., Weikop, P., Gether, Ulrik & Rickhag, Karl Mattias, Sep 2017, In : Journal of Visualized Experiments. 127, 10 p., e56093.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

    Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, P., Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In : European Journal of Neuroscience. 45, 1, p. 121-128

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    Erlendsson, Simon, Gotfryd, Kamil, Larsen, F. H., Mortensen, J. S., Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In : eLife. 6, 9 p., e19314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

    Jacobsen, S. E., Gether, Ulrik & Bräuner-Osborne, Hans, 2017, In : Scientific Reports. 7, 14 p., 46355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Neurotransmitter Transporters: Structure, Function, and Drug Binding

    Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  32. Published

    Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

    Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In : Journal of Neuroscience Methods. 289, p. 85-92 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

    Rahbek-Clemmensen, T., Lycas, Matthew Domenic, Erlendsson, Simon, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In : Nature Communications. 8, 14 p., 740.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway

    Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner-Osborne, Hans, 2017, In : The Journal of Biological Chemistry. 292, 17, p. 6910-6926

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

    Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, Ulrik, Habekost, Thomas, Bundesen, Claus, Vangkilde, Signe, Woldbye, David Paul Drucker, Andreasen T., Jesper & Petersen, Anders, 2017, In : Psychopharmacology. 234, 5, p. 845-855

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2016
  37. Published

    The Environment Shapes the Inner Vestibule of LeuT

    Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, Kamil, Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In : PLoS Computational Biology. 12, 11, 24 p., e1005197.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

    Billesbølle, C. B., Mortensen, J. S., Sohail, A., Schmidt, Solveig Gaarde, Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In : Nature Communications. 7, 12 p., 12755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)

    Khelashvili, G., Schmidt, Solveig Gaarde, Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In : Journal of Biological Chemistry. 291, 38, p. 19786-19799

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function

    Vuorenpää, A. E., Ammendrup-Johnsen, I., Jorgensen, T. N. & Gether, Ulrik, Sep 2016, In : Neurochemistry International. 98, p. 103-114

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Structural biology: Antidepressants at work

    Caron, M. G. & Gether, Ulrik, 21 Apr 2016, In : Nature. 532, p. 320-321 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  42. Published

    No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

    Knorr, Ulla Benedichte Søsted, Koefoed, P., Soendergaard, M. H. G., Vinberg, Maj, Gether, Ulrik, Gluud, C., Wetterslev, J., Winkel, P. & Kessing, Lars Vedel, Apr 2016, In : Acta Neuropsychiatrica. 28, 2, p. 101-109 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini

    Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

    Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In : British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial

    Knorr, Ulla Benedichte Søsted, Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, Ulrik, Vinberg, Maj & Kessing, Lars Vedel, 11 Jan 2016, In : Nordic Journal of Psychiatry. 70, 4, p. 297-302 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2015
  47. Published

    Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

    Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, Kamil, Mortensen, J. S., Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In : Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

    Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In : Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Functional regulation of amphetamine-induced efflux by CaMKII

    Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Pollak, D. D., Aug 2015, In : Amino Acids. 47, 8, p. 1659-1659 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  50. Published

    Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering

    Karlsen, M. L., Thorsen, Thor Seneca, Johner, N., Ammendrup-Johnsen, I., Erlendsson, Simon, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In : Structure. 23, 7, p. 1258-1270 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation

    Rajamanickam, J., Annamalai, B., Rahbek-Clemmensen, T., Sundaramurthy, S., Gether, Ulrik, Jayanthi, L. D. & Ramamoorthy, S., 15 May 2015, In : Biochemical Journal. 468, 1, p. 177-190 14 p., BJ20140826.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

    Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, Ulrik, Veenstra-Vanderweele, J., Sutcliffe, J. S., Ulery-Reynolds, P. G., Erreger, K., Matthies, H. J. G. & Galli, A., Feb 2015, In : EBioMedicine. 2, 2, p. 135-146 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

    Apuschkin, Mia, Stilling, S., Rahbek-Clemmensen, T., Sørensen, G., Fortin, G., Herborg, Freja, Eriksen, J., Trudeau, L., Egerod, Kristoffer Lihme, Gether, Ulrik & Rickhag, Karl Mattias, 2015, In : European Journal of Neuroscience. 42, 7, p. 2438-2454 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII

    Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Rickhag, Karl Mattias, Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Sitte, H. H., 2015, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 21, p. 8258-8271 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

    Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, Kamil, Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In : The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. 2014
  57. Published

    In vivo amphetamine action is contingent on αCaMKII

    Steinkellner, T., Mus, L., Eisenrauch, B., Constantinescu, A., Leo, D., Konrad, L., Rickhag, Karl Mattias, Sørensen, G., Efimova, E. V., Kong, E., Willeit, M., Sotnikova, T. D., Kudlacek, O., Gether, Ulrik, Freissmuth, M., Pollak, D. D., Gainetdinov, R. R. & Sitte, H. H., Oct 2014, In : Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39, 11, p. 2681-93 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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