Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
- 2004
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specifity of the PDZ domain in PICK1
Madsen, K. L., Beuming, T., Niv, M. Y., Chang, C. W., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. Vol. 280, no. 21, p. 20539-48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and fluorescent labeling of the human serotonin transporter
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2
Henriksen, U. B., Gether, Ulrik & Litman, Thomas, 1 Apr 2005, In: Journal of Cell Science. 118, Pt 7, p. 1417-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
Henriksen, U. B., Fog, J. U., Litman, Thomas & Gether, Ulrik, 4 Nov 2005, In: Journal of Biological Chemistry. 280, 44, p. 36926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A. & Gether, Ulrik, 2006, In: Neuron. 51, 4, p. 417-429 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Martinat, C., Bacci, J., Leete, T., Kim, J., Vanti, W. B., Newman, A. H., Cha, J. H., Gether, Ulrik, Wang, H. & Abeliovich, A., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 8, p. 2874-2879 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (vol 279, pg 3228, 2004)
Loland, C. J., Granas, C., Javitch, J. A. & Gether, Ulrik, 2006, In: Journal of Biological Chemistry. 281, 35, p. 25867-25867Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanisms of GPCR activation
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, A., 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-383 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization
Jayanthi, L. D., Annamalai, B., Samuvel, D. J., Gether, Ulrik & Ramamoorthy, S., 2006, In: Journal of Biological Chemistry. 281, 33, p. 23326-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn2+ modulation of neurotransmitter transporters
Nørgaard-Nielsen, K. & Gether, Ulrik, 2006, In: Handbook of Experimental Pharmacology. 175, p. 1-22 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching
Adkins, E. M., Samuvel, D. J., Fog, J. U., Eriksen, J., Jayanthi, L. D., Vaegter, C. B., Ramamoorthy, S. & Gether, Ulrik, 2007, In: Biochemistry. 46, 37, p. 10484-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.
Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
An intracellular interaction network regulates conformational transitions in the dopamine transporter.
Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Are life events prior to first episode of major depression a predictor of medical treatment outcome?
Bock, C., Bukh, J. D., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, Suppl. 2, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between genetic and geographic structure in Europe
Lao, O., Lu, T. T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U. & 13 others, , 2008, In: Current Biology. 18, 16, p. 1241-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Polymorphisms and the outcome of antidepressant Treatment
Bukh, J. D., Bock, C., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers - Evidence for occurrence in the plasma membrane
Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-10991 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers: evidence for occurrence in the plasma membrane
Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-91 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In: European Journal of Neuroscience. 27, 1, p. 66-82 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane localization is critical for activation of the PICK1 BAR domain
Madsen, Kenneth Lindegaard, Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., Ammendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-43 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane localization is critical for activation of the PICK1BAR domain
Madsen, K. L., Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., mmendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-1343 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling
Klewe, I. V., Nielsen, S. M., Tarpø, L., Urizar, E., Dipace, C., Javitch, J. A., Gether, Ulrik, Egebjerg, J. & Christensen, K. V., 2008, In: Neuropharmacology. 54, 8, p. 1215-1222 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reliability of clinical ICD-10 diagnoses among electroconvulsive therapy patients with chronic affective disorders
Jakobsen, K. D., Hansen, T. F., Dam, H., Larsen, E. B., Gether, Ulrik & Werge, Thomas, 2008, In: European Journal of Psychiatry. 22, 3, p. 161-172 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, Ulrik, Javitch, J. A., Erreger, K. & Galli, A., 2008, In: Molecular Pharmacology. 74, 4, p. 1101-1108 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation
Rasmussen, T. N., Plenge, P., Bay, T., Egebjerg, J. & Gether, Ulrik, 2009, In: Neuropharmacology. 57, 3, p. 287-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amphipathic motifs in BAR domains are essential for membrane curvature sensing
Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In: EMBO Journal. 28, 21, p. 3303-3314 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population
Lu, T. T., Lao, O., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Nielsen, F., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A. & 14 others, , 2009, In: European Journal of Human Genetics. 17, 7, p. 967-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do stressful life events predict medical treatment outcome in first episode of depression?
Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Social Psychiatry and Psychiatric Epidemiology. 44, p. 752-760Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does bereavement-related first episode depression differ from other kinds of first depressions?
Kessing, Lars Vedel, Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj & Gether, U., 2009, In: Social Psychiatry and Psychiatric Epidemiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1
Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How curved membranes recruit amphipathic helices and protein anchoring motifs
Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between genetic polymorphisms and stressful life events in first episode depression
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: Journal of Affective Disorders. 119, 1-3, p. 107-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Introducing tetraCys motifs at two different sites results in a functional dopamine transporter
Orun, O., Rasmussen, S. & Gether, Ulrik, 2009, In: Acta Biologica Hungarica. 60, 1, p. 15-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: structure and function
Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: European Neuropsychopharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system
Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Gade, A., Haastrup, E., Paulson, Olaf B., Wetterslev, J., Gluud, C., Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Trials. 10, p. 66Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Validity of the diagnosis of a single depressive episode in a case register
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In: Clinical Practice and Epidemiology in Mental Health. 5, p. 4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature
Madsen, Kenneth Lindegaard, Bhatia, V. K., Gether, Ulrik & Stamou, Dimitrios, 2010, In: FEBS Letters. 584, 9, p. 1848-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
David versus Goliath
Mollenhauer, J., Stamou, Dimitrios, Flyvbjerg, A., Wengel, J., Gether, Ulrik, Kjems, J., Bjørnholm, T. & Besenbacher, F., 2010, In: Nanomedicine: Nanotechnology, Biology and Medicine. 6, 4, p. 504-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
Research output: Contribution to journal › Journal article › Research › peer-review
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