Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
- 1987
- Published
High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.
O'Hare, M., Tortora, O., Gether, Ulrik, Nielsen, Henrik & Schwartz, Thue W., Mar 1987, In: Journal of Chromatography.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
- Published
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Molecular mechanism of action of non-peptide ligands for peptide receptors
Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Delineation of an endogenous zinc-binding site in the human dopamine transporter.
Norregaard, L., Frederiksen, D., Nielsen, E. Ø. & Gether, Ulrik, 1998, In: EMBO Journal. 17, p. 4266-4273Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Assessing adrenergic receptor using chemically reactive fluorescent probes
Dam Jensen, A. & Gether, Ulrik, 1999, In Adrenergic Receptor Protocols, in the Methods for Molecular Biology. Humana Press, p. 345-361Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor
Kobilka, B. K., Gether, Ulrik, Seifert, R., Lin, S. & Ghanouni, P., 1999, In: Journal of Receptors and Signal Transduction. 19, p. 293-300Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.
Loland, Claus Juul, Norregaard, L. & Gether, Ulrik, 1999, In: Journal of Biological Chemistry. 274, 52, p. 36928-34 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct assessment of conformational changes in G protein coupled receptors using fluorescence spectroscopy
Gether, Ulrik & Kobilka, B. K., 1999, In Signal Transduction - A practical Approach, in The practical Approach series, 2nd edition. Oxford: Oxford University Press, p. 01-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations
Seifert, R., Gether, Ulrik, Wenzel-Seifert, K. & Kobilka, B. K., 1999, In: Molecular Pharmacology. 56, p. 348-358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-Gsalpha fusion protein
Seifert, R., Wenzel-Seifert, K., Gether, Ulrik, Lam, V. T. & Kobilka, B. K., 1999, In: European Journal of Biochemistry. 260, p. 661-666Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescence spectrosocpy analysis of conformational changes in the Β2 adrenergic receptor
Gether, Ulrik, 1999, In Structure/Function of G-protein coupled receptors, in the Receptor Biochemistry and Methodology. New York: Wiley, p. 315-334Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI
Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Assessing adrenergic receptor conformation using chemically reactive fluorescent probes
Jensen Dam, A. & Gether, Ulrik, 2000, Methods in Molecular Biology, vol.126: Adrenergic Receptors Protocols. Totowa, NJ: Humana Press, p. 345-359Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
The effect of pH on ß2 adrenoceptor function
Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncovering molecular mechanism involved in activation of G protein-coupled receptors
Gether, Ulrik, 2000, In: Endocrine Reviews. 21(1), p. 90-113Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter
Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites
Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents
MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations
Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In: Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In: Journal of Physiology. 530 (Pt 3), p. 367-378Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 2002, In: Journal of Physiology. 544, 2, p. 447-458Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zine ions in reverse transport mediated by monoamine transporters
Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In: Journal of Biological Chemistry. 277, p. 21505-21513Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding G-protein coupled receptors and their role in the CNS
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor
Kobilka, B. K. & Gether, Ulrik, 2002, In: Methods in Enzymology. 343, 343, p. 170-182 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering oat the oligomeric interface of the dopamine transporter
Nørgaard-Nielsen, K., Norregaard, L., Hastrup-Nielsen, H., Javitch, J. A. & Gether, Ulrik, 2002, In: FEBS Letters. vol. 524(1-3), p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zinc ions in reverse transport mediated by monoamine transporters
Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In: Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering at the oligomeric interface of the dopamine transporter
Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A. & Gether, Ulrik, 31 Jul 2002, In: FEBS Letters. 524, 1-3, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing dopamine transporter structure and function y Zn2+ site engineering
Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97Research output: Contribution to journal › Review › Research › peer-review
- Published
Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.
MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy
Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters
Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding
Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions
Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions
Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter
Meinild, A., Sitte, H. H. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. 279, 48, p. 49671-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specifity of the PDZ domain in PICK1
Madsen, K. L., Beuming, T., Niv, M. Y., Chang, C. W., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. Vol. 280, no. 21, p. 20539-48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and fluorescent labeling of the human serotonin transporter
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2
Henriksen, U. B., Gether, Ulrik & Litman, Thomas, 1 Apr 2005, In: Journal of Cell Science. 118, Pt 7, p. 1417-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
Henriksen, U. B., Fog, J. U., Litman, Thomas & Gether, Ulrik, 4 Nov 2005, In: Journal of Biological Chemistry. 280, 44, p. 36926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A. & Gether, Ulrik, 2006, In: Neuron. 51, 4, p. 417-429 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Martinat, C., Bacci, J., Leete, T., Kim, J., Vanti, W. B., Newman, A. H., Cha, J. H., Gether, Ulrik, Wang, H. & Abeliovich, A., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 8, p. 2874-2879 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (vol 279, pg 3228, 2004)
Loland, C. J., Granas, C., Javitch, J. A. & Gether, Ulrik, 2006, In: Journal of Biological Chemistry. 281, 35, p. 25867-25867Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanisms of GPCR activation
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, A., 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-383 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization
Jayanthi, L. D., Annamalai, B., Samuvel, D. J., Gether, Ulrik & Ramamoorthy, S., 2006, In: Journal of Biological Chemistry. 281, 33, p. 23326-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn2+ modulation of neurotransmitter transporters
Nørgaard-Nielsen, K. & Gether, Ulrik, 2006, In: Handbook of Experimental Pharmacology. 175, p. 1-22 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching
Adkins, E. M., Samuvel, D. J., Fog, J. U., Eriksen, J., Jayanthi, L. D., Vaegter, C. B., Ramamoorthy, S. & Gether, Ulrik, 2007, In: Biochemistry. 46, 37, p. 10484-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.
Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
An intracellular interaction network regulates conformational transitions in the dopamine transporter.
Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Are life events prior to first episode of major depression a predictor of medical treatment outcome?
Bock, C., Bukh, J. D., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, Suppl. 2, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between genetic and geographic structure in Europe
Lao, O., Lu, T. T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U. & 13 others, , 2008, In: Current Biology. 18, 16, p. 1241-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Polymorphisms and the outcome of antidepressant Treatment
Bukh, J. D., Bock, C., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers - Evidence for occurrence in the plasma membrane
Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-10991 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers: evidence for occurrence in the plasma membrane
Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-91 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In: European Journal of Neuroscience. 27, 1, p. 66-82 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane localization is critical for activation of the PICK1 BAR domain
Madsen, Kenneth Lindegaard, Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., Ammendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-43 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane localization is critical for activation of the PICK1BAR domain
Madsen, K. L., Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., mmendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-1343 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling
Klewe, I. V., Nielsen, S. M., Tarpø, L., Urizar, E., Dipace, C., Javitch, J. A., Gether, Ulrik, Egebjerg, J. & Christensen, K. V., 2008, In: Neuropharmacology. 54, 8, p. 1215-1222 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reliability of clinical ICD-10 diagnoses among electroconvulsive therapy patients with chronic affective disorders
Jakobsen, K. D., Hansen, T. F., Dam, H., Larsen, E. B., Gether, Ulrik & Werge, Thomas, 2008, In: European Journal of Psychiatry. 22, 3, p. 161-172 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, Ulrik, Javitch, J. A., Erreger, K. & Galli, A., 2008, In: Molecular Pharmacology. 74, 4, p. 1101-1108 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation
Rasmussen, T. N., Plenge, P., Bay, T., Egebjerg, J. & Gether, Ulrik, 2009, In: Neuropharmacology. 57, 3, p. 287-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amphipathic motifs in BAR domains are essential for membrane curvature sensing
Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In: EMBO Journal. 28, 21, p. 3303-3314 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population
Lu, T. T., Lao, O., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Nielsen, F., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A. & 14 others, , 2009, In: European Journal of Human Genetics. 17, 7, p. 967-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do stressful life events predict medical treatment outcome in first episode of depression?
Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Social Psychiatry and Psychiatric Epidemiology. 44, p. 752-760Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does bereavement-related first episode depression differ from other kinds of first depressions?
Kessing, Lars Vedel, Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj & Gether, U., 2009, In: Social Psychiatry and Psychiatric Epidemiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1
Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How curved membranes recruit amphipathic helices and protein anchoring motifs
Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between genetic polymorphisms and stressful life events in first episode depression
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: Journal of Affective Disorders. 119, 1-3, p. 107-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Introducing tetraCys motifs at two different sites results in a functional dopamine transporter
Orun, O., Rasmussen, S. & Gether, Ulrik, 2009, In: Acta Biologica Hungarica. 60, 1, p. 15-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: structure and function
Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: European Neuropsychopharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system
Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Gade, A., Haastrup, E., Paulson, Olaf B., Wetterslev, J., Gluud, C., Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Trials. 10, p. 66Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Validity of the diagnosis of a single depressive episode in a case register
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In: Clinical Practice and Epidemiology in Mental Health. 5, p. 4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature
Madsen, Kenneth Lindegaard, Bhatia, V. K., Gether, Ulrik & Stamou, Dimitrios, 2010, In: FEBS Letters. 584, 9, p. 1848-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
David versus Goliath
Mollenhauer, J., Stamou, Dimitrios, Flyvbjerg, A., Wengel, J., Gether, Ulrik, Kjems, J., Bjørnholm, T. & Besenbacher, F., 2010, In: Nanomedicine: Nanotechnology, Biology and Medicine. 6, 4, p. 504-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
Research output: Contribution to journal › Journal article › Research › peer-review
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