Ulla M. Wewer

Ulla M. Wewer

Professor

  • BRIC Administration

    Ole Maaløes Vej 5

    2200 København N.

    Phone: +4535327051Mobile: +4528757051

  1. 2018
  2. Published

    Personlig medicin vil involvere alle specialer, og det handler om andet end genomet

    Ullum, H., Hersom, C., Wewer, Ulla M., Skøtt, O., Nielsen, L. B. & Rasmussen, L. H., 2018, In: Ugeskrift for Laeger. 180, 6, p. 501 1 p.

    Research output: Contribution to journalEditorialResearch

  3. 2017
  4. Published

    Corporate culture: research can benefit

    Westendorp, Rudi GJ & Wewer, Ulla M., 2017, In: Nature. 542, 7641, 1 p., 295.

    Research output: Contribution to journalJournal articleCommunication

  5. 2016
  6. Published

    The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour

    Høye, A. M., Couchman, John Robert, Wewer, Ulla M. & Yoneda, A., 2016, In: Scientific Reports. 6, 14 p., 28529.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2013
  8. Published

    ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth

    Albrechtsen, Reidar, Kveiborg, Marie, Hansen, D. S., Vikeså, J., Noer, Julie Boertmann, Kotzsh, A., Nielsen, Finn Cilius, Wewer, Ulla M. & Frohlich, C., 15 Oct 2013, In: Journal of Cell Science. 126, 20, p. 4707-20 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    ADAM12

    Kveiborg, Marie, Fröhlich, C., Albrechtsen, Reidar & Wewer, Ulla M., 29 Aug 2013, Handbook of Proteolytic Enzymes. Elsevier, Vol. 1. p. 1114-1122 9 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. Published

    ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins

    Frohlich, C., Klitgaard, M., Noer, J. B., Kotzsch, A., Nehammer, C., Kronqvist, P., Berthelsen, J., Blobel, C., Kveiborg, Marie, Albrechtsen, Reidar & Wewer, Ulla M., 15 May 2013, In: Biochemical Journal. 452, 1, p. 97-109 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Regulation of ROCK Activity in Cancer

    Morgan-Fisher, M., Wewer, Ulla M. & Yoneda, A., 29 Jan 2013, In: Journal of Histochemistry and Cytochemistry. 61, 3, p. 185-198

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2012
  13. Published

    The newcomer in the integrin family: Integrin α9 in biology and cancer.

    Høye, A. M., Couchman, John Robert, Wewer, Ulla M., Yoneda, A. & Fukami, K., May 2012, In: Advances in Biological Regulation. 52, 2, p. 326-339

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II

    Yoneda, A., Morgan-Fisher, M., Wait, R., Couchman, John Robert & Wewer, Ulla M., 2012, In: Molecular and Cellular Biology. 32, 10, p. 1788-804 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism

    Hansen, D. S., Leyme, A., Grandal, M. V., Albrechtsen, Reidar, van Deurs, B., Wewer, Ulla M. & Kveiborg, Marie, 2012, In: Traffic - International Journal of Intracellular Transport. 13, 11, p. 1532-46 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Functional Analysis of a Breast Cancer-Associated Mutation in the Intracellular Domain of the Metalloprotease ADAM12

    Stautz, D., Wewer, Ulla M. & Kveiborg, Marie, 2012, In: P L o S One. 7, 5, p. e37628

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2011
  18. Published

    ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression

    Frohlich, C., Nehammer, C., Albrechtsen, Reidar, Kronqvist, P., Kveiborg, Marie, Sehara-Fujisawa, A., Mercurio, A. M. & Wewer, Ulla M., 29 Aug 2011, In: Molecular Cancer Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    KU bestemmer selv over sin forskning

    Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

  21. Published

    Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity

    Albrechtsen, Reidar, Hansen, D. S., Sanjay, A., Kveiborg, Marie & Wewer, Ulla M., 15 Jan 2011, In: Experimental Cell Research. 317, 2, p. 195-209 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2010
  23. Published

    ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity

    Stautz, D., Sanjay, A., Hansen, M. T., Albrechtsen, Reidar, Wewer, Ulla M. & Kveiborg, Marie, 2010, In: Experimental Cell Research. 316, 1, p. 55-67

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

    Kveiborg, Marie, Jacobsen, J., Lee, M., Nagase, H., Wewer, Ulla M. & Murphy, G., 2010, In: Biochemical Journal. 430, 1, p. 79-86 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2009
  26. Published

    Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage

    Lydolph, M. C., Morgan-Fisher, M., Høye, A. M., Couchman, John Robert, Wewer, Ulla M. & Yoneda, A., 2009, In: Experimental Cell Research. 315, 19, p. 3312-24 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Impaired cutaneous wound healing in mice lacking tetranectin

    Iba, K., Hatakeyama, N., Kojima, T., Murata, M., Matsumura, T., Wewer, Ulla M., Wada, T., Sawada, N. & Yamashita, T., 2009, In: Wound Repair and Regeneration. 17, 1, p. 108-12 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Targeting ADAM12 in human disease: head, body or tail?

    Jacobsen, J. & Wewer, Ulla M., 2009, In: Current Pharmaceutical Design. 15, 20, p. 2300-10 10 p.

    Research output: Contribution to journalReviewResearch

  29. 2008
  30. Published

    ADAM12: a potential target for the treatment of chronic wounds

    Harsha, A., Stojadinovic, O., Brem, H., Sehara-Fujisawa, A., Wewer, Ulla M., Loomis, C. A., Blobel, C. P. & Tomic-Canic, M., 1 Aug 2008, In: Journal of Molecular Medicine. 86, 8, p. 961-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Urinary metalloproteinases: noninvasive biomarkers for breast cancer risk assessment

    Pories, S. E., Zurakowski, D., Roy, R., Lamb, C. C., Raza, S., Exarhopoulos, A., Scheib, R. G., Schumer, S., Lenahan, C., Borges, V., Louis, G. W., Anand, A., Isakovich, N., Hirshfield-Bartek, J., Wewer, Ulla M., Lotz, M. M. & Moses, M. A., 1 May 2008, In: Cancer Epidemiology, Biomarkers & Prevention. 17, 5, p. 1034-42 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Aging-From molecules to populations.

    Sander, M., Avlund, K., Lauritzen, Martin, Gottlieb, T., Stevnsner, T., Wewer, Ulla M. & Bohr, V. A., 2008, In: Mechanisms of Ageing and Development. 129, p. 614-623

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Catalytic properties of ADAM12 and its domain deletion mutants.

    Jacobsen, J., Visse, R., Sørensen, H. P., Enghild, J. J., Brew, K., Wewer, Ulla M. & Nagase, H., 2008, In: Biochemistry. 47, 2, p. 537-547 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Cellular roles of ADAM12 in health and disease.

    Kveiborg, Marie, Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2008, In: International Journal of Biochemistry & Cell Biology. 40, 9, p. 1685-702 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Expression, purification and insights into structure and folding of the ADAM22 pro domain.

    Sørensen, H. P., Jacobsen, J., Nielbo, S., Poulsen, F. M. & Wewer, Ulla M., 2008, In: Protein Expression and Purification. 61, 2, p. 175-83 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Heparan sulfate regulates ADAM12 through a molecular switch mechanism.

    Sørensen, H. P., Vives, R. R., Manetopoulos, C., Albrechtsen, Reidar, Lydolph, M. C., Jacobsen, J., Couchman, John Robert & Wewer, Ulla M., 2008, In: Journal of Biological Chemistry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2007
  38. Published

    Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice

    Jørgensen, L. H., Jensen, C. H., Wewer, Ulla M. & Schrøder, H. D., 1 Nov 2007, In: American Journal of Pathology. 171, 5, p. 1599-607 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome

    Christiansen, M., Spencer, K., Laigaard, J., Cowans, N. J., Larsen, S. O. & Wewer, Ulla M., 2007, In: Prenatal Diagnosis. 27, 7, p. 611-615 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Forsknings- og ytringsfriheden på universiteterne: forskningspolitisk årsmøde 2007

    Kærgård, Niels, Bache, C., Flensted-Jensen, M., Harder, Peter, Olesen, Søren-Peter & Wewer, Ulla M., 2007, København: Det Kongelige Danske Videnskabernes Selskab.

    Research output: Book/ReportBookCommunication

  41. Published

    The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor

    Atfi, A., Dumont, E., Colland, F., Bonnier, D., L'helgoualc'h, A., Prunier, C., Ferrand, N., Clément, B., Wewer, Ulla M. & Théret, N., 2007, In: Journal of Cell Biology. 178, 2, p. 201-208 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2006
  43. Published

    ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome

    Laigaard, J., Spencer, K., Christiansen, M., Cowans, N. J., Larsen, S. O., Pedersen, B. N. & Wewer, Ulla M., 2006, In: Prenatal Diagnosis. 26, 10, p. 973-979 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.

    Wewer, Ulla M., Mörgelin, M., Holck, P., Jacobsen, J., Lydolph, M. C., Johnsen, A. H., Kveiborg, Marie & Albrechtsen, Reidar, 2006, In: Journal of Biological Chemistry. 281, 14, p. 9418-22 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.

    Kveiborg, Marie, Albrechtsen, Reidar, Rudkjaer, L., Wen, G., Damgaard-Pedersen, K. & Wewer, Ulla M., 2006, In: Journal of Bone and Mineral Research. 21, 8, p. 1288-96 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9-12 weeks' gestation

    Laigaard, J., Cuckle, H., Wewer, Ulla M. & Christiansen, M., 2006, In: Prenatal Diagnosis. 26, 8, p. 689-691 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Molecular profiling of ADAM12 in human bladder cancer.

    Albrechtsen, Reidar, Dyrskjøt, L., Rudkjaer, L., Ørntoft, T. F., Frohlich, C. & Wewer, Ulla M., 2006, In: Clinical Cancer Research. 12, 24, p. 7359-68 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    RNA-binding IMPs promote cell adhesion and invadopodia formation.

    Vikesaa, J., Hansen, T. V. O., Jønson, L., Borup, R., Wewer, Ulla M., Christiansen, Jan & Nielsen, Finn Cilius, 2006, In: EMBO Journal. 25, 7, p. 1456-68 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2005
  50. Published

    Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells

    Le Pabic, H., L'Helgoualc'h, A., Coutant, A., Wewer, Ulla M., Baffet, G., Clément, B. & Théret, N., 1 Dec 2005, In: Journal of Hepatology. 43, 6, p. 1038-44 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Sub-cellular localisation of fukutin related protein in different cell lines and in the muscle of patients with MDC1C and LGMD2I

    Torelli, S., Brown, S. C., Brockington, M., Dolatshad, N. F., Jimenez, C., Skordis, L., Feng, L. H., Merlini, L., Jones, D. H., Romero, N., Wewer, Ulla M., Voit, T., Sewry, C. A., Noguchi, S., Nishino, I. & Muntoni, F., 1 Dec 2005, In: Neuromuscular Disorders. 15, 12, p. 836-43 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

    Guo, L. T., Shelton, G. D., Wewer, Ulla M. & Engvall, E., 1 Nov 2005, In: Neuromuscular Disorders. 15, 11, p. 786-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

    Li, S., Bordoy, R., Stanchi, F., Moser, M., Braun, A., Kudlacek, O., Wewer, Ulla M., Yurchenco, P. D. & Fässler, R., 1 Jul 2005, In: Journal of Cell Science. 118, Pt 13, p. 2913-21 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation

    Lafuste, P., Sonnet, C., Chazaud, B., Dreyfus, P. A., Gherardi, R. K., Wewer, Ulla M. & Authier, F., 1 Feb 2005, In: Molecular Biology of the Cell. 16, 2, p. 861-70 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    A role for ADAM12 in breast tumor progression and stromal cell apoptosis.

    Kveiborg, Marie, Frohlich, C., Albrechtsen, Reidar, Tischler, V., Dietrich, N., Holck, P., Kronqvist, P., Rank, F., Mercurio, A. M. & Wewer, Ulla M., 2005, In: Cancer Research. 65, 11, p. 4754-61 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.

    Thodeti, C. K., Frohlich, C., Nielsen, C. K., Takada, Y., Fässler, R., Albrechtsen, Reidar & Wewer, Ulla M., 2005, In: FEBS Letters. 579, 25, p. 5589-95 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer

    Hammer, N. A., Hansen, Thomas van Overeem, Byskov, A. G., Rajpert-De Meyts, E., Grøndahl, M. L., Bredkjaer, H. E., Wewer, Ulla M., Christiansen, Jan & Nielsen, Finn Cilius, 2005, In: Reproduction. 130, 2, p. 203-12 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Hierarchy of ADAM12 binding to integrins in tumor cells.

    Thodeti, C. K., Fröhlich, C., Nielsen, C. K., Holck, P., Sundberg, C., Kveiborg, Marie, Mahalingam, Y., Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2005, In: Experimental Cell Research. 309, 2, p. 438-50 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.

    Laigaard, J., Sørensen, T., Placing, S., Holck, P., Frohlich, C., Wøjdemann, K. R., Sundberg, K., Shalmi, A., Tabor, A., Nørgaard-Pedersen, B., Ottesen, B., Christiansen, M. & Wewer, Ulla M., 2005, In: Obstetrics and Gynecology. 106, 1, p. 144-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.

    Laigaard, J., Christiansen, M., Frohlich, C., Pedersen, B. N., Ottesen, B. & Wewer, Ulla M., 2005, In: Prenatal Diagnosis. 25, 1, p. 45-6 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 2004
  62. Published

    ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage

    Roy, R., Wewer, Ulla M., Zurakowski, D., Pories, S. E. & Moses, M. A., 3 Dec 2004, In: Journal of Biological Chemistry. 279, 49, p. 51323-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

    Hansen, Thomas van Overeem, Hammer, N. A., Nielsen, J., Madsen, Mette, Dalbaeck, C., Wewer, Ulla M., Christiansen, Jan & Nielsen, Finn Cilius, 2004, In: Molecular and Cellular Biology. 24, 10, p. 4448-64 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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