Tuomas Oskari Kilpeläinen

Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

Carrasquilla, Germán D., Ängquist, Lars, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Loos, Ruth, 2024, In: Diabetologia. 67, p. 864–873 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Estimating causality between smoking and abdominal obesity by Mendelian randomization

Carrasquilla, Germán D., García Ureña, Mario, Romero Lado, María José & Kilpeläinen, Tuomas O., 2024, (E-pub ahead of print) In: Addiction.

Research output: Contribution to journal › Journal article › Research › peer-review

Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment

Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Apuschkin, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, Madsen, Kenneth Lindegaard & Clemmensen, Christoffer, 2024, In: Science Advances. 10, 9, 20 p., eadg2636.

Research output: Contribution to journal › Journal article › Research › peer-review

Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

Christiansen, Malene Revsbech, Kilpeläinen, Tuomas O. & McCaffery, J. M., 2023, In: Diabetes. 72, 10, p. 1424-1432 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I. & 178 others, Lim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L. P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, Tuomas O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2023, In: Frontiers in Genetics. 14, 16 p., 1235337.

Research output: Contribution to journal › Journal article › Research › peer-review

Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, C. S., Flethøj, M., Lyhne, Mille Kronborg, Møller, J. E., Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier & Kilpeläinen, Tuomas O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.

Research output: Contribution to journal › Journal article › Research › peer-review

Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis

Skaaby, T., Kilpeläinen, Tuomas O., Mahendran, Y., Huang, L. O., Sallis, H., Thuesen, B. H., Kårhus, L. L., Leth-Møller, K. B., Grarup, Niels, Hansen, Torben, Pedersen, Oluf Borbye, Burgess, S., Munafò, M. R. & Linneberg, Allan René, 2022, In: European Journal of Epidemiology. 37, p. 713-722

Research output: Contribution to journal › Journal article › Research › peer-review

Causality between physical activity, sedentary behavior and obesity: A Mendelian randomization study

Carrasquilla, Germán D., García Ureña, Mario, Fall, T., Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 536-536 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy

Viitasalo, A., Pahkala, K., Lehtimäki, T., Viikari, J. S. A., Tammelin, T. H., Raitakari, O. & Kilpeläinen, Tuomas O., 2022, In: Frontiers in Endocrinology. 13, 7 p., 923327.

Research output: Contribution to journal › Journal article › Research › peer-review

Do gene-environment interactions have implications for the precision prevention of type 2 diabetes?

Sørensen, Thorkild I.A., Metz, Sophia & Kilpeläinen, Tuomas O., 2022, In: Diabetologia. 65, p. 1804–1813 10 p.

Research output: Contribution to journal › Review › Research › peer-review

Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

McCaffery, J. M., Jablonski, K. A., Pan, Q., Astrup, A., Christiansen, Malene Revsbech, Corella, D., Corso, L. M. L., Florez, J. C., Franks, P. W., Gardner, C., Hansen, Torben, Kilpeläinen, Tuomas O., Knowler, W. C., Lindström, J., Saris, W. H. M., Sørensen, Thorkild I.A., Tuomilehto, J., Uusitupa, M., Wing, R. R. & Agurs-Collins, T., 2022, In: Diabetes. 71, 4, p. 669-676 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic studies indicate that fetal - and not maternal - insulin resistance is associated with birth weight

Jakupovic, Hermina, García Ureña, Mario, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 592-593 2 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jorgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Pacolet, A., Zhao, J., Balslev-Harder, M. N., Grarup, Niels, Linneberg, Allan René, Hansen, Torben, Melbye, M., Pedersen, Oluf Borbye, Pers, Tune H, Sørensen, Thorkild I.A., Zierath, Juleen R, Kilpeläinen, Tuomas O., Loos, Ruth & LifeLines Cohort Study, L. C. S., 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

Leppanen, M. H., Haapala, E. A., Vaisto, J., Ekelund, U., Brage, S., Kilpeläinen, Tuomas O. & Lakka, T. A., 2022, In: Scandinavian Journal of Medicine & Science in Sports. 32, 1, p. 255-266

Research output: Contribution to journal › Journal article › Research › peer-review

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

Carrasquilla, Germán D., García Ureña, Mario, Fall, T., Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2022, In: eLife. 11, 25 p., e70386.

Research output: Contribution to journal › Journal article › Research › peer-review

Mendelian randomization suggests a causal effect of abdominal obesity on postprandial lipemia

Christiansen, Malene Revsbech, Hansen, Torben, Sørensen, Thorkild I.A., Grarup, Niels, García Ureña, Mario, Borisevich, D., Oppert, J., Martinez Hernandez, J. A., Blaak, E. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 184 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

Metz, Sophia, Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, Christina, Neville, M. J., Christiansen, Malene Revsbech, Jonsson, Anna Elisabet, Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, Niklas Rye, Karpe, F., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.

Research output: Contribution to journal › Journal article › Research › peer-review

With obesity becoming the new normal, what should we do? Volume II

Tziomalos, K., Kilpeläinen, Tuomas O. & Samaras, K., 2022, In: Frontiers in Endocrinology. 13, 3 p., 1119910.

Research output: Contribution to journal › Editorial › Research

Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia

Christiansen, Malene Revsbech, García Ureña, Mario, Borisevich, D., Grarup, Niels, Martínez, J. A., Oppert, J., Sørensen, Thorkild I.A., Hansen, Torben, Blaak, E. E. & Kilpeläinen, Tuomas O., 2021, In: American Journal of Clinical Nutrition. 114, 4, p. 1467–1475 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Cell-free DNA and RNA - measurement and applications in clinical diagnostics with focus on metabolic disorders

Drag, Markus Hodal & Kilpeläinen, Tuomas O., 2021, In: Physiological Genomics. 53, 1, p. 33-46

Research output: Contribution to journal › Journal article › Research › peer-review

Changes in intake of dairy product subgroups and risk of type 2 diabetes: modelling specified food substitutions in the Danish Diet, Cancer and Health cohort

Ibsen, D. B., Overvad, K., Laursen, A. S. D., Halkjær, J., Tjønneland, Anne, Kilpeläinen, Tuomas O., Parner, E. T. & Jakobsen, M. U., 2021, In: European Journal of Nutrition. 60, p. 3449–3459 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

Sulc, J., Sonrel, A., Mounier, N., Auwerx, C., Marouli, E., Darrous, L., Draganski, B., Kilpeläinen, Tuomas O., Joshi, P., Loos, R. J. F. & Kutalik, Z., 2021, In: Communications Biology . 4, 13 p., 1064.

Research output: Contribution to journal › Journal article › Research › peer-review

Do genetic risk scores for childhood adiposity operate independent of BMI of their mothers?

Huang, L. O., Morgen, C. S., Ängquist, Lars, Nohr, E. A., Kilpeläinen, Tuomas O., Hansen, Torben, Sørensen, Thorkild I.A. & Schnurr, T. M., 2021, In: International Journal of Obesity. 45, 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health

Williams, K., Carrasquilla, Germán D., Ingerslev, L. R., Hochreuter, Mette Yde, Hansson, Svenja, Pillon, N. J., Donkin, I., Versteyhe, S., Zierath, Juleen R, Kilpeläinen, Tuomas O. & Barrès, Romain, 2021, In: Molecular Metabolism. 53, 13 p., 101290.

Research output: Contribution to journal › Journal article › Research › peer-review

Evidence for shared genetics between physical activity, sedentary behaviour and adiposity-related traits

Schnurr, T. M., Stallknecht, Bente Merete, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Hansen, Torben, 2021, In: Obesity Reviews. 22, 4, 12 p., e13182.

Research output: Contribution to journal › Journal article › Research › peer-review

FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer

Thibord, F., Song, C., Pattee, J., Rodriguez, B. A. T., Chen, M-H., O'Donnell, C. J., Kleber, M. E., Delgado, G. E., Guo, X., Yao, J., Taylor, K. D., Ozel, A. B., Brody, J. A., McKnight, B., Gyorgy, B., Simonsick, E., Leonard, H. L., Carrasquilla, G. D., Guindo-Martinez, M., Silveira, A. & 30 others, Temprano-Sagrera, G., Yanek, L. R., Becker, D. M., Mathias, R. A., Becker, L. C., Raffield, L. M., Kilpeläinen, Tuomas O., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Hamsten, A., Watkins, H., Sabater-Lleal, M., Nalls, M. A., Trégouët, D., Morange, P., Psaty, B. M., Tracy, R. P., Smith, N. L., Desch, K. C., Cushman, M., Rotter, J. I., de Vries, P. S., Pankratz, N. D., Folsom, A. R., Morrison, A. C., März, W., Tang, W. & Johnson, A. D., 2021, In: Journal of Thrombosis and Haemostasis. 19, 8, p. 2019-2028

Research output: Contribution to journal › Journal article › Research › peer-review

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

de Las Fuentes, L., Sung, Y. J., Noordam, R., Winkler, T., Feitosa, M. F., Schwander, K., Bentley, A. R., Brown, M. R., Guo, X., Manning, A., Chasman, D. I., Aschard, H., Bartz, T. M., Bielak, L. F., Campbell, A., Cheng, C-Y., Dorajoo, R., Hartwig, F. P., Horimoto, A. R. V. R., Li, C. & 31 others, Li-Gao, R., Liu, Y., Marten, J., Musani, S. K., Ntalla, I., Rankinen, T., Richard, M., Sim, X., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Vojinovic, D., Warren, H. R., Xuan, D., Alver, M., Boissel, M., Chai, J., Chen, X., Christensen, K., Divers, J., Evangelou, E., Gao, C., Girotto, G., Harris, S. E., He, M., Hsu, F., Kühnel, B., Laguzzi, F., Li, X., Kilpeläinen, Tuomas O. & LifeLines Cohort Study, L. C. S., 2021, In: Molecular Psychiatry. 26, p. 2111-2125

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

Huang, L. O., Rauch, A., Mazzaferro, E., Preuss, M., Carobbio, S., Bayrak, C. S., Chami, N., Wang, Z., Schick, U. M., Yang, N., Itan, Y., Vidal-Puig, A., den Hoed, M., Mandrup, S., Kilpeläinen, Tuomas O. & Loos, R. J. F., 2021, In: Nature Metabolism. 3, 2, p. 228-243 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

LifeLines Cohort Study, L. C. S., 2021, In: Human Genetics and Genomics Advances. 2, 1, 12 p., 100013.

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y. & 105 others, Chitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L., O'Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S. & van Heemst, D., 2021, In: Molecular Psychiatry. 26, p. 6293-6304

Research output: Contribution to journal › Journal article › Research › peer-review

Replacing Red Meat with Other Nonmeat Food Sources of Protein is Associated with a Reduced Risk of Type 2 Diabetes in a Danish Cohort of Middle-Aged Adults

Ibsen, D. B., Jakobsen, M. U., Halkjær, J., Tjønneland, Anne, Kilpeläinen, Tuomas O., Parner, E. T. & Overvad, K., 2021, In: The Journal of Nutrition. 151, 5, p. 1241-1248 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Genetic Basis of Hypertriglyceridemia

Carrasquilla, Germán D., Christiansen, Malene Revsbech & Kilpeläinen, Tuomas O., 2021, In: Current Atherosclerosis Reports. 23, 10 p., 39.

Research output: Contribution to journal › Journal article › Research › peer-review

The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study

Eloranta, A-M., Sallinen, T., Viitasalo, A., Lintu, N., Väistö, J., Jalkanen, H., Tompuri, T. T., Soininen, S., Haapala, E. A., Kiiskinen, S., Schnurr, T. M., Kilpeläinen, T. O., Mikkonen, S., Savonen, K., Atalay, M., Brage, S., Laaksonen, D. E., Lindi, V., Ågren, J., Schwab, U. & 2 others, Jääskeläinen, J. & Lakka, T. A., 2021, In: European Journal of Nutrition. 60, p. 425-434

Research output: Contribution to journal › Journal article › Research › peer-review

A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study

Lakka, T. A., Lintu, N., Väistö, J., Viitasalo, A., Sallinen, T., Haapala, E. A., Tompuri, T. T., Soininen, S., Karjalainen, P., Schnurr, T. M., Mikkonen, S., Atalay, M., Kilpeläinen, T. O., Laitinen, T., Laaksonen, D. E., Savonen, K., Brage, S., Schwab, U., Jääskeläinen, J., Lindi, V. & 1 others, Eloranta, A., 2020, In: Diabetologia. 63, p. 2270-2281

Research output: Contribution to journal › Journal article › Research › peer-review

From man to mouse: The discovery and validation of CYR61 as a regulator of body composition

Metz, Sophia, Grevengoed, Trisha Jean, Kilpeläinen, Tuomas O. & Gillum, M. P., 2020, In: European Journal of Human Genetics. 28, SUPPL 1, p. 741-742 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Yaghootkar, H., Zhang, Y., Spracklen, C. N., Karaderi, T., Huang, L. O., Bradfield, J., Schurmann, C., Fine, R. S., Preuss, M. H., Kutalik, Z., Wittemans, L. B., Lu, Y., Metz, S., Willems, S. M., Li-Gao, R., Grarup, N., Wang, S., Molnos, S., Sandoval-Zárate, A. A., Nalls, M. A. & 32 others, Lange, L. A., Haesser, J., Guo, X., Lyytikäinen, L., Feitosa, M. F., Sitlani, C. M., Venturini, C., Mahajan, A., Kacprowski, T., Wang, C. A., Chasman, D. I., Amin, N., Broer, L., Robertson, N., Young, K. L., Allison, M., Auer, P. L., Blüher, M., Borja, J. B., Bork-Jensen, J., Carrasquilla, Germán D., Christofidou, P., Demirkan, A., Doege, C. A., Jakupovic, Hermina, Li, J., Lind, L., Kovacs, P., Hansen, Torben, Loos, R. J., Kilpeläinen, Tuomas O. & Leptin Exomechip Collaboration, L. E. C., 2020, In: Diabetes. 69, 11, 93 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic variation, adipokines, and cardiometabolic disease

Metz, Sophia, Huang, L. O. & Kilpeläinen, Tuomas O., 2020, In: Current Opinion in Pharmacology. 52, p. 33-39 7 p.

Research output: Contribution to journal › Review › Research › peer-review

Impact of abdominal obesity on postprandial lipid concentrations

Christiansen, Malene Revsbech, Sørensen, Thorkild I.A., Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 279-280 2 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults

Viitasalo, A., Pitkänen, N., Pahkala, K., Lehtimäki, T., Viikari, J. S. A., Raitakari, O. & Kilpeläinen, Tuomas O., 2020, In: International Journal of Obesity. 44, p. 848-851

Research output: Contribution to journal › Journal article › Research › peer-review

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Zheng, Y., Huang, T., Wang, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J-F., Sim, X., van Dam, R. M., Tai, E-S., Koh, W-P., Dorajoo, R., Saw, S-M., Sabanayagam, C., Wong, T. Y., Gupta, P., Rossing, P., Ahluwalia, T. S., Vinding, R. K. & 98 others, Bisgaard, H., Bønnelykke, Klaus, Wang, Y., Graff, M., Voortman, T., van Rooij, F. J. A., Hofman, A., van Heemst, D., Noordam, R., Estampador, A. C., V Varga, Tibor, Enzenbach, C., Scholz, M., Thiery, J., Burkhardt, R., Orho-Melander, M., Schulz, C., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpeläinen, Tuomas O., Hansen, Torben, Kleber, M. E., Delgado, G., McCarthy, M., Lemaitre, R. N., Felix, J. F., Jaddoe, V. W. V., Wu, Y., Mohlke, K. L., Lehtimäki, T., Wang, C. A., Pennell, C. E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L. A., Lai, C., Pitkänen, N., Boreham, C. A., Ridker, P. M., Rosendaal, F. R., de Mutsert, R., Power, C., Paternoster, L., Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Djousse, L., Rivadeneira, F., Lee, N. R., Raitakari, O. T., Kähönen, M., Viikari, J., Langhendries, J., Escribano, J., Verduci, E., Dedoussis, G., König, I., Balkau, B., Coltell, O., Dallongeville, J., Meirhaeghe, A., Amouyel, P., Gottrand, F., Pahkala, K., Niinikoski, H., Hyppönen, E., März, W., Mackey, D. A., Gruszfeld, D., Tucker, K. L., Fumeron, F., Estruch, R., Ordovas, J. M., Arnett, D. K., Mook-Kanamori, D. O., Mozaffarian, D., Psaty, B. M., North, K. E., Chasman, D. I. & Qi, L., 2020, In: European Journal of Epidemiology. 35, p. 685–697 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

Schnurr, T. M., Jakupovic, Hermina, Carrasquilla, Germán D., Ängquist, Lars, Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: Diabetologia. 63, 7, p. 1324-1332 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Editorial: Novel biomarkers for type 2 diabetes

Ahluwalia, T. S., Kilpeläinen, Tuomas O., Singh, S. & Rossing, Peter, 1 Sep 2019, In: Frontiers in Endocrinology. 10, p. 1-3 3 p., 649.

Research output: Contribution to journal › Editorial › Research › peer-review

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J. & 263 others, Musani, S. K., Kilpelainen, T. O., Richard, M. A., Aslibekyan, S., Bartz, T. M., Dorajoo, R., Li, C., Liu, Y., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F., Jackson, A. U., Kammerer, C. M., Kasturiratne, A., Komulainen, P., Kuehnel, B., Leander, K., Lee, W., Lin, K., Luan, J., Lyytikainen, L., McKenzie, C. A., Nelson, C. P., Noordam, R., Scott, R. A., Sheu, W. H. H., Stancakova, A., Takeuchi, F., van Der Most, P. J., V Varga, Tibor, Waken, R. J., Wang, H., Wang, Y., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Alfred, T., Amin, N., Arking, D. E., Aung, T., Barr, R. G., Bielak, L. F., Boerwinkle, E., Bottinger, E. P., Braund, P. S., Brody, J. A., Broeckel, U., Cade, B., Campbell, A., Canouil, M., Chakravarti, A., Cocca, M., Collins, F. S., Connell, J. M., de Mutsert, R., de Silva, H. J., Doerr, M., Duan, Q., Eaton, C. B., Ehret, G., Evangelou, E., Faul, J. D., Forouhi, N. G., Franco, O. H., Friedlander, Y., Gao, H., Gigante, B., Gu, C. C., Gupta, P., Hagenaars, S. P., Harris, T. B., He, J., Heikkinen, S., Heng, C., Hofman, A., Howard, B. V., Hunt, S. C., Irvin, M. R., Jia, Y., Katsuya, T., Kaufman, J., Kerrison, N. D., Khor, C. C., Koh, W., Koistinen, H. A., Kooperberg, C. B., Krieger, J. E., Kubo, M., Kutalik, Z., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. H., Lehne, B., Levy, D., Lewis, C. E., Li, Y., Lim, S. H., Liu, C., Liu, J., Liu, J., Liu, Y., Loh, M., Lohman, K. K., Louie, T., Magi, R., Matsuda, K., Meitinger, T., Metspalu, A., Milani, L., Momozawa, Y., Mosley, T. H. ,. J., Nalls, M. A., Nasri, U., O'Connell, J. R., Ogunniyi, A., Palmas, W. R., Palmer, N. D., Pankow, J. S., Pedersen, N. L., Peters, A., Peyser, P. A., Polasek, O., Porteous, D., Raitakari, O. T., Renstrom, F., Rice, T. K., Ridker, P. M., Robino, A., Robinson, J. G., Rose, L. M., Rudan, I., Sabanayagam, C., Salako, B. L., Sandow, K., Schmidt, C. O., Schreiner, P. J., Scott, W. R., Sever, P., Sims, M., Sitlani, C. M., Smith, B. H., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Uitterlinden, A. G., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Wilson, G., Wojczynski, M. K., Xiang, Y., Yao, J., Yu, C., Yuan, J., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Chen, Y. I., Weir, D. R., de Faire, U., Deary, I. J., Esko, T., Farrall, M., Forrester, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Horta, B. L., Hung, Y., Jonas, J. B., Kato, N., Kooner, J. S., Laakso, M., Lehtimaki, T., Liang, K., Magnusson, P. K. E., Oldehinkel, A. J., Pereira, A. C., Perls, T., Rauramaa, R., Redline, S., Rettig, R., Samani, N. J., Scott, J., Shu, X., van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Wickremasinghe, A. R., Wu, T., Kamatani, Y., Laurie, C. C., Bouchard, C., Cooper, R. S., Evans, M. K., Gudnason, V., Hixson, J., Kardia, S. L. R., Kritchevsky, S. B., Psaty, B. M., van Dam, R. M., Arnett, D. K., Mook-Kanamori, D. O., Fornage, M., Fox, E. R., Hayward, C., van Duijn, C. M., Tai, E. S., Wong, T. Y., Loos, Ruth, Reiner, A. P., Rotimi, C. N., Bierut, L. J., Zhu, X., Cupples, L. A., Province, M. A., Rotter, J. I., Franks, P. W., Rice, K., Elliott, P., Caulfield, M. J., Gauderman, W. J., Munroe, P. B., Rao, D. C., Morrison, A. C. & Kilpeläinen, Tuomas O., 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2615-2633

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F. & 32 others, Richard, M. A., Noordam, R., Baker, J., Chen, G., Aschard, H., Bartz, T. M., Ding, J., Dorajoo, R., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Zhao, W., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., Zhao, J. H., Christensen, K., Kilpeläinen, Tuomas O., Wang, J., Loos, Ruth, COGENT-Kidney Consortium, C. C. & V Varga, Tibor, Apr 2019, In: Nature Genetics. 51, 4, p. 636-648 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

Blond, Martin Bæk, Schnurr, T. M., Rasenkilde, M., Quist, Jonas Salling, Gram, A. S., Reichkendler, M. H., Auerbach, P. L., Nordby, P., Skovgaard, Lene Theil, Ribel-Madsen, R., Justesen, Johanne Marie, Kilpeläinen, Tuomas O., Ploug, Thorkil, Stallknecht, Bente Merete & Hansen, Torben, 2019, In: Physiological Genomics. 51, 6, p. 254-260

Research output: Contribution to journal › Journal article › Research › peer-review

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 others, Pedersen, Oluf Borbye, Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, Peter, Kilpeläinen, Tuomas O. & Hansen, Torben, 2019, In: Diabetologia. 62, 2, p. 292-305

Research output: Contribution to journal › Journal article › Research › peer-review

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis

Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J-C., Lehtimäki, T. & 3 others, Raitakari, O., Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: American Journal of Clinical Nutrition. 110, 5, p. 1079-1087 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Huang, T., Wang, T., Zheng, Y., Ellervik, C., Li, X., Gao, M., Fang, Z., Chai, J-F., Ahluwalia, T. V. S., Wang, Y., Voortman, T., Noordam, R., Frazier-Wood, A., Scholz, M., Sonestedt, E., Akiyama, M., Dorajoo, R., Zhou, A., Kilpeläinen, T. O., Kleber, M. E. & 31 others, Crozier, S. R., Godfrey, K. M., Lemaitre, R., Felix, J. F., Shi, Y., Gupta, P., Khor, C., Lehtimäki, T., Wang, C. A., Tiesler, C. M. T., Thiering, E., Standl, M., Rzehak, P., Marouli, E., He, M., Lecoeur, C., Corella, D., Lai, C., Moreno, L. A., Pitkänen, N., Boreham, C. A., Zhang, T., Hansen, Torben, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Bisgaard, H., Pedersen, Oluf Borbye, Bønnelykke, Klaus, Rossing, Peter & BIRTH-GENE (BIG) Study Working Group, B. (. S. W. G., 2019, In: JAMA Network Open. 2, 9, 18 p., e1910915.

Research output: Contribution to journal › Journal article › Research › peer-review

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., Leth-Møller, K. B. & 27 others, Shabanzadeh, D. M., Gonzalez-Quintela, A., Power, C., Hyppönen, E., Kuh, D., Hardy, R., Meitinger, T., Jukema, J. W., Völker, U., Nauck, M., Völzke, H., Friedrich, N., Bonten, T. N., Noordam, R., Mook-Kanamori, D. O., Tolstrup, J. S., Taube, C., Peters, A., Grallert, H., Strauch, K., Schulz, H., Grarup, Niels, Hansen, Torben, Pedersen, Oluf Borbye, Burgess, S., Munafò, M. R. & Linneberg, Allan René, 2019, In: Addiction. 114, 2, p. 216-225 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, Anna Elisabet, Justice, A. E., Kernson, N. D., Larson, N. B., Lin, K., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., drb459, drb459, Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, Oluf Borbye, Nohr, E. A., Newman, A. B., Linneberg, Allan René, Langenberg, C., Kilpeläinen, Tuomas O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, Thorkild I.A., Homuth, G., Hansen, Torben, Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. I., Chakravarti, A., Brandslund, I., Bønnelykke, Klaus, Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, Niels, Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, Ruth, Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies

Huang, T., Sun, D., Heianza, Y., Bergholdt, H. K. M., Gao, M., Fang, Z., Ding, M., Frazier-Wood, A. C., North, K. E., Marouli, E., Graff, M., Smith, C. E., Varbo, A., Lemaitre, R. N., Corella, D., Wang, C. A., Tjønneland, A., Overvad, K., Sørensen, T. I. A., Feitosa, M. F. & 36 others, Wojczynski, M. K., Kahonen, M., Mikkila, V., Bartz, T. M., Psaty, B. M., Siscovick, D. S., Danning, R. D., Dedoussis, G., Pedersen, Oluf Borbye, Hansen, Torben, Havulinna, A. S., Mannisto, S., Rotter, J. I., Sares-Jaske, L., Allison, M. A., Rich, S. S., Sorli, J. V., Coltell, O., Pennell, C. E., Eastwood, P., Ridker, P. M., Viikari, J., Raitakari, O., Lehtimaki, T., Helminen, M., Wang, Y., Deloukas, P., Knekt, P., Kanerva, N., Kilpeläinen, Tuomas O., Province, M. A., Mozaffarian, D., Chasman, D. I., Nordestgaard, B. G., Ellervik, Christina & Qi, L., 2019, In: Clinical Chemistry. 65, 6, p. 751-760 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dietary Fat and the Genetic Risk of Type 2 Diabetes

Carrasquilla, Germán D., Jakupovic, Hermina & Kilpeläinen, Tuomas O., 2019, In: Current Diabetes Reports. 19, 6 p., 109.

Research output: Contribution to journal › Review › Research › peer-review

Disentangling the genetics of lean mass

Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, Cho, N. H., Choi, H. J., Chou, W. C., Cummings, S. R., de Groot, L. C. P. G. M., De Jager, P. L., Demuth, I., Diatchenko, L., Econs, M. J., Eiriksdottir, G., Enneman, A. W., Eriksson, J., Eriksson, J. G., Estrada, K., Evans, D. S., Feitosa, M. F., Fu, M., Gieger, C., Grallert, H., Gudnason, V., Lenore, L. J., Hayward, C., Hofman, A., Homuth, G., Huffman, K. M., Husted, L. B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J. O., Johnson, T., Biffar, R., Jordan, J. M., Jula, A., Karlsson, M., Khaw, K. T., Kilpeläinen, Tuomas O., Klopp, N., Kloth, J. S. L., Koller, D. L., Kooner, J. S., Kraus, W. E., Kritchevsky, S., Kutalik, Z., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B. L., Lerch, M. M., Lewis, J. R., Lill, C., Lind, L., Lindgren, C., Liu, Y., Livshits, G., Ljunggren, Ö., Loos, Ruth, Lorentzon, M., Luan, J., Luben, R. N., Malkin, I., McGuigan, F. E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellström, D., Michaëlsson, K., Mitchell, B. D., Morris, A. P., Mosekilde, L., Nethander, M., Newman, A. B., O'Connell, J. R., Oostra, B. A., Orwoll, E. S., Palotie, A., Peacock, M., Perola, M., Peters, A., Prince, R. L., Psaty, B. M., Räikkönen, K., Ralston, S. H., Ripatti, S., Rivadeneira, F., Robbins, J. A., Rotter, J. I., Rudan, I., Salomaa, V., Satterfield, S., Schipf, S., Shin, C. S., Smith, A. V., Smith, S. B., Soranzo, N., Spector, T. D., Stancáková, A., Stefansson, K., Steinhagen-Thiessen, E., Stolk, L., Streeten, E. A., Styrkarsdottir, U., Swart, K. M. A., Thompson, P., Thomson, C. A., Thorleifsson, G., Thorsteinsdottir, U., Tikkanen, E., Tranah, G. J., Uitterlinden, A. G., van Duijn, C. M., van Schoor, N. M., Vandenput, L., Vollenweider, P., Völzke, H., Wactawski-Wende, J., Walker, M., J Wareham, N., Waterworth, D., Weedon, M. N., Wichmann, H. E., Widen, E., Williams, F. M. K., Wilson, J. F., Wright, N. C., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Zhou, Y., Nielson, C. M., Harris, T. B., Demissie, S., Kiel, D. P. & Ohlsson, C., 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287

Research output: Contribution to journal › Journal article › Research › peer-review

Does genetic predisposition to higher fat expandability attenuate the impact of weight gain on cardiometabolic risk?

Carrasquilla, Germán D., Linneberg, Allan René, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Sørensen, Thorkild I.A. & Kilpeläinen, Tuomas O., 2019, In: European Journal of Human Genetics. 27, Suppl. 2, p. 1764 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]

Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., Chasman, D. I. & 31 others, Chen, Y. D. I., Chirstofidou, P., Demirkan, A., van Duijn, C. M., Feitosa, M. F., Garcia, M. E., Graff, M., Grallert, H., Grarup, Niels, Guo, X., Haesser, J., Hansen, Torben, Harris, T. B., Highland, H. M., Hong, J., Ikram, M. A., Ingelsson, E., Jackson, R., Jousilahti, P., Kähönen, M., Kizer, J. R., Kovacs, P., Kriebel, J., Laakso, M., Lange, L. A., Lehtimäki, T., Li, J., Lind, L., Kilpeläinen, Tuomas O., Loos, R. J. F. & Mohlke, K. L., 2019, In: American Journal of Human Genetics. 105, 1, p. 15-28 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Lintu, N., Lind, M. V., Atalay, M., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Larnkjær, A., Pedersen, O. B., Holm, J-C., Michaelsen, K. F., Lakka, T. A., Lehtimäki, T., Raitakari, O. & 2 others, Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: International Journal of Obesity. 43, p. 2007-2016 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children

Väistö, J., Haapala, E. A., Viitasalo, A., Schnurr, T. M., Kilpeläinen, Tuomas O., Karjalainen, P., Westgate, K., Lakka, H., Laaksonen, D. E., Ekelund, U., Brage, S. & Lakka, T. A., 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, 1, p. 113-123

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry Genome-wide Meta-analysis Accounting for Gene-education Interactions in Up to 227,850 Individuals Identifies Several Novel Lipid Loci

Sung, Y. J., Schwander, K. L., Bentley, A. R., de Vries, P. S., Kilpeläinen, Tuomas O., Noordam, R., Musani, S. K., Aschard, H., de las Fuentes, L. & CHARGE Gene-Lifestyle Interactions, C. G. I., 2019, In: Genetic Epidemiology. 43, 7, p. 912-912 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Noordam, R., Bos, M. M., Wang, H., Winkler, T. W., Bentley, A. R., Kilpeläinen, T. O., de Vries, P. S., Sung, Y. J., Schwander, K., Cade, B. E., Manning, A., Aschard, H., Brown, M. R., Chen, H., Franceschini, N., Musani, S. K., Richard, M., Vojinovic, D., Aslibekyan, S., Bartz, T. M. & 128 others, de Las Fuentes, L., Feitosa, M., Horimoto, A. R., Ilkov, M., Kho, M., Kraja, A., Li, C., Lim, E., Liu, Y., Mook-Kanamori, D. O., Rankinen, T., Tajuddin, S. M., van der Spek, A., Wang, Z., Marten, J., Laville, V., Alver, M., Evangelou, E., Graff, M. E., He, M., Kühnel, B., Lyytikäinen, L., Marques-Vidal, P., Nolte, I. M., Palmer, N. D., Rauramaa, R., Shu, X., Snieder, H., Weiss, S., Wen, W., Yanek, L. R., Adolfo, C., Ballantyne, C., Bielak, L., Biermasz, N. R., Boerwinkle, E., Dimou, N., Eiriksdottir, G., Gao, C., Gharib, S. A., Gottlieb, D. J., Haba-Rubio, J., Harris, T. B., Heikkinen, S., Heinzer, R., Hixson, J. E., Homuth, G., Ikram, M. A., Komulainen, P., Krieger, J. E., Lee, J., Liu, J., Lohman, K. K., Luik, A. I., Mägi, R., Martin, L. W., Meitinger, T., Metspalu, A., Milaneschi, Y., Nalls, M. A., O'Connell, J., Peters, A., Peyser, P., Raitakari, O. T., Reiner, A. P., Rensen, P. C. N., Rice, T. K., Rich, S. S., Roenneberg, T., Rotter, J. I., Schreiner, P. J., Shikany, J., Sidney, S. S., Sims, M., Sitlani, C. M., Sofer, T., Strauch, K., Swertz, M. A., Taylor, K. D., Uitterlinden, A. G., van Duijn, C. M., Völzke, H., Waldenberger, M., Wallance, R. B., van Dijk, K. W., Yu, C., Zonderman, A. B., Becker, D. M., Elliott, P., Esko, T., Gieger, C., Grabe, H. J., Lakka, T. A., Lehtimäki, T., North, K. E., Penninx, B. W. J. H., Vollenweider, P., Wagenknecht, L. E., Wu, T., Xiang, Y., Zheng, W., Arnett, D. K., Bouchard, C., Evans, M. K., Gudnason, V., Kardia, S., Kelly, T. N., Kritchevsky, S. B., Loos, R. J. F., Pereira, A. C., Province, M., Psaty, B. M., Rotimi, C., Zhu, X., Amin, N., Cupples, L. A., Fornage, M., Fox, E. F., Guo, X., Gauderman, W. J., Rice, K., Kooperberg, C., Munroe, P. B., Liu, C., Morrison, A. C., Rao, D. C., van Heemst, D. & Redline, S., 2019, In: Nature Communications. 10, 1, 13 p., 5121.

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. & 32 others, Richard, M., Wang, H., Wang, Z., Bartz, T. M., Bielak, L. F., Campbell, A., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Li, C., Lohman, K. K., Marten, J., Sim, X., Smith, A. V., Tajuddin, S. M., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Graff, M., Harris, S. E., He, M., Hsu, F. C., Zhao, J. H., Loos, Ruth, LifeLines Cohort Study, L. C. S. & V Varga, Tibor, 2019, In: Nature Communications. 10, 11 p., 376.

Research output: Contribution to journal › Journal article › Research › peer-review

Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

de Vries, P. S., Brown, M. R., Bentley, A. R., Sung, Y. J., Winkler, T. W., Ntalla, I., Schwander, K., Kraja, A. T., Guo, X., Franceschini, N., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F., Richard, M. A., Noordam, R., Aschard, H. & 32 others, Bartz, T. M., Bielak, L. F., Deng, X., Dorajoo, R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Evangelou, E., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F., Jackson, A. U., Kasturiratne, A., Komulainen, P., Zhao, J. H., Kilpeläinen, Tuomas O., InterAct Consortium, I. C. & V Varga, Tibor, 2019, In: American Journal of Epidemiology. 188, 6, p. 1033-1054

Research output: Contribution to journal › Journal article › Research › peer-review

Obesity and unfavourable lifestyle increase type 2 diabetes-risk independent of genetic predisposition

Jakupovic, Hermina, Schnurr, T. M., Carrasquilla, Germán D., Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: Diabetologia. 62, Suppl. 1, p. S188 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis

Merino, J., Guasch-Ferré, M., Ellervik, C., Dashti, H. S., Sharp, S. J., Wu, P., Overvad, K., Sarnowski, C., Kuokkanen, M., Lemaitre, R. N., Justice, A. E., Ericson, U., Braun, K. V. E., Mahendran, Y., Frazier-Wood, A. C., Sun, D., Chu, A. Y., Tanaka, T., Luan, J., Hong, J. & 48 others, Tjønneland, Anne, Ding, M., Lundqvist, A., Mukamal, K., Rohde, R., Schulz, C., Franco, O. H., Grarup, Niels, Chen, Y. I., Bazzano, L., Franks, P. W., Buring, J. E., Langenberg, C., Liu, C., Hansen, Torben, Jensen, Majken Karoline, Sääksjärvi, K., Psaty, B. M., Young, K. L., Hindy, G., Sandholt, C. H., Ridker, P. M., Ordovas, J. M., Meigs, J. B., Pedersen, Oluf Borbye, Kraft, P., Perola, M., North, K. E., Orho-Melander, M., Voortman, T., Toft, Ulla Marie Nørgaard, Rotter, J. I., Qi, L., Forouhi, N. G., Mozaffarian, D., Sørensen, Thorkild I.A., Stampfer, M. J., Männistö, S., Selvin, E., Imamura, F., Salomaa, V., Hu, F. B., Wareham, N. J., Dupuis, J., Smith, C. E., Kilpeläinen, Tuomas O., Chasman, D. I. & Florez, J. C., 2019, In: BMJ (Clinical research ed.). 366, p. l4292

Research output: Contribution to journal › Journal article › Research › peer-review

The Promise of Selecting Individuals from the Extremes of Exposure in the Analysis of Gene-Physical Activity Interactions

Osazuwa-Peters, O. L., Schwander, K., Waken, R. J., de Las Fuentes, L., Kilpeläinen, Tuomas O., Loos, R. J. F., Racette, S. B., Sung, Y. J. & Rao, D. C., 2019, In: Human Heredity. 83, 6, p. 315-332

Research output: Contribution to journal › Journal article › Research › peer-review

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Sung, Y. J., Winkler, T. W., de Las Fuentes, L., Bentley, A. R., Brown, M. R., Kraja, A. T., Schwander, K., Ntalla, I., Guo, X., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Feitosa, M. F., Kilpeläinen, T. O., Richard, M. A. & 30 others, Noordam, R., Aslibekyan, S., Aschard, H., Bartz, T. M., Dorajoo, R., Liu, Y., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Warren, H. R., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., Christensen, K. & Loos, Ruth, 2018, In: American Journal of Human Genetics. 102, 3, p. 375-400 26 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight

Huang, L. O., Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Physiological Genomics. 50, 3, p. 169-178 10 p.

Research output: Contribution to journal › Review › Research › peer-review

Genes that make you fat, but keep you healthy

Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Journal of Internal Medicine. 284, 5, p. 450-463 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

Schnurr, T. M., Viitasalo, A., Eloranta, A., Damsgaard, Camilla Trab, Mahendran, Y., Have, C. T., Väistö, J., Hjorth, Mads Fiil, Christensen, L. B., Brage, S., Atalay, M., Lyytikäinen, L., Lindi, V., Lakka, T., Michaelsen, Kim F., Kilpeläinen, Tuomas O. & Hansen, Torben, 2018, In: International Journal of Obesity. 42, 1, p. 111-114 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Smith, C. E., Follis, J. L., Dashti, H. S., Tanaka, T., Graff, M., Fretts, A. M., Kilpeläinen, T. O., Wojczynski, M. K., Richardson, K., Nalls, M. A., Schulz, C-A., Liu, Y., Frazier-Wood, A. C., van Eekelen, E., Wang, C., de Vries, P. S., Mikkilä, V., Rohde, R., Psaty, B. M., Hansen, T. & 43 others, Feitosa, M. F., Lai, C., Houston, D. K., Ferruci, L., Ericson, U., Wang, Z., de Mutsert, R., Oddy, W. H., de Jonge, E. A. L., Seppälä, I., Justice, A. E., Lemaitre, R. N., Sørensen, Thorkild I.A., Province, M. A., Parnell, L. D., Garcia, M. E., Bandinelli, S., Orho-Melander, M., Rich, S. S., Rosendaal, F. R., Pennell, C. E., Kiefte-de Jong, J. C., Kähönen, M., Young, K. L., Pedersen, Oluf Borbye, Aslibekyan, S., Rotter, J. I., Mook-Kanamori, D. O., Zillikens, M. C., Raitakari, O. T., North, K. E., Overvad, K., Arnett, D. K., Hofman, A., Lehtimäki, T., Tjønneland, A., Uitterlinden, A. G., Rivadeneira, F., Franco, O. H., German, J. B., Siscovick, D. S., Cupples, L. A. & Ordovás, J. M., 2018, In: Molecular Nutrition & Food Research. 62, 3, p. 1-12 12 p., 1700347.

Research output: Contribution to journal › Journal article › Research › peer-review

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Feitosa, M. F., Kraja, A. T., Chasman, D. I., Sung, Y. J., Winkler, T. W., Ntalla, I., Guo, X., Franceschini, N., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Bentley, A. R., Brown, M. R., Schwander, K., Richard, M. A., Noordam, R., Aschard, H. & 31 others, Bartz, T. M., Bielak, L. F., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Wojczynski, M. K., Alver, M., Boissel, M., Cai, Q., Campbell, A., Chai, J. F., Chen, X., Divers, J., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., He, M., Hsu, F., Jackson, A. U., Kähönen, M., Zhao, J. H., Kilpeläinen, Tuomas O., Christensen, K. & V Varga, Tibor, 2018, In: PLoS ONE. 13, 6, p. 1-36 e0198166.

Research output: Contribution to journal › Journal article › Research › peer-review

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens, M. C., Demissie, S., Hsu, Y-H., Yerges-Armstrong, L. M., Chou, W-C., Stolk, L., Livshits, G., Broer, L., Johnson, T., Koller, D. L., Kutalik, Z., Luan, J., Malkin, I., Ried, J. S., Smith, A. V., Thorleifsson, G., Vandenput, L., Hua Zhao, J., Zhang, W., Aghdassi, A. & 173 others, Åkesson, K., Amin, N., Baier, L. J., Barroso, I., Bennett, D. A., Bertram, L., Biffar, R., Bochud, M., Boehnke, M., Borecki, I. B., Buchman, A. S., Byberg, L., Campbell, H., Campos Obanda, N., Cauley, J. A., Cawthon, P. M., Cederberg, H., Chen, Z., Cho, N. H., Jin Choi, H., Claussnitzer, M., Collins, F., Cummings, S. R., De Jager, P. L., Demuth, I., Dhonukshe-Rutten, R. A. M., Diatchenko, L., Eiriksdottir, G., Enneman, A. W., Erdos, M., Eriksson, J. G., Eriksson, J., Estrada, K., Evans, D. S., Feitosa, M. F., Fu, M., Garcia, M., Gieger, C., Girke, T., Glazer, N. L., Grallert, H., Grewal, J., Han, B., Hanson, R. L., Hayward, C., Hofman, A., Hoffman, E. P., Homuth, G., Hsueh, W., Hubal, M. J., Hubbard, A., Huffman, K. M., Husted, L. B., Illig, T., Ingelsson, E., Ittermann, T., Jansson, J., Jordan, J. M., Jula, A., Karlsson, M., Khaw, K., Kilpeläinen, Tuomas O., Klopp, N., Kloth, J. S. L., Koistinen, H. A., Kraus, W. E., Kritchevsky, S., Kuulasmaa, T., Kuusisto, J., Laakso, M., Lahti, J., Lang, T., Langdahl, B. L., Launer, L. J., Lee, J., Lerch, M. M., Lewis, J. R., Lind, L., Lindgren, C., Liu, Y., Liu, T., Liu, Y., Ljunggren, Ö., Lorentzon, M., Luben, R. N., Maixner, W., McGuigan, F. E., Medina-Gomez, C., Meitinger, T., Melhus, H., Mellström, D., Melov, S., Michaëlsson, K., Mitchell, B. D., Morris, A. P., Mosekilde, L., Newman, A., Nielson, C. M., O'Connell, J. R., Oostra, B. A., Orwoll, E. S., Palotie, A., Parker, S., Peacock, M., Perola, M., Peters, A., Polasek, O., Prince, R. L., Räikkönen, K., Ralston, S. H., Ripatti, S., Robbins, J. A., Rotter, J. I., Rudan, I., Salomaa, V., Satterfield, S., Schadt, E. E., Schipf, S., Scott, L., Sehmi, J., Shen, J., Soo Shin, C., Sigurdsson, G., Smith, S., Soranzo, N., Stančáková, A., Steinhagen-Thiessen, E., Streeten, E. A., Styrkarsdottir, U., Swart, K. M. A., Tan, S., Tarnopolsky, M. A., Thompson, P., Thomson, C. A., Thorsteinsdottir, U., Tikkanen, E., Tranah, G. J., Tuomilehto, J., van Schoor, N. M., Verma, A., Vollenweider, P., Völzke, H., Wactawski-Wende, J., Walker, M., Weedon, M. N., Welch, R., Wichmann, H., Widen, E., Williams, F. M. K., Wilson, J. F., Wright, N. C., Xie, W., Yu, L., Zhou, Y., Chambers, J. C., Döring, A., van Duijn, C. M., Econs, M. J., Gudnason, V., Kooner, J. S., Psaty, B. M., Spector, T. D., Stefansson, K., Rivadeneira, F., Uitterlinden, A. G., Wareham, N. J., Ossowski, V., Waterworth, D., Loos, R. J. F., Karasik, D., Harris, T. B., Ohlsson, C. & Kiel, D. P., 19 Jul 2017, In: Nature Communications. 8, 13 p., 80.

Research output: Contribution to journal › Journal article › Research › peer-review

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Shungin, D., Deng, W. Q., Varga, T. V., Luan, J., Mihailov, E., Metspalu, A., Morris, A. P., Forouhi, N. G., Lindgren, C., Magnusson, P. K. E., Pedersen, N. L., Hallmans, G., Chu, A. Y., Justice, A. E., Graff, M., Winkler, T. W., Rose, L. M., Langenberg, C., Cupples, L. A., Ridker, P. M. & 11 others, Wareham, N. J., Ong, K. K., Loos, R. J. F., Chasman, D. I., Ingelsson, E., Kilpeläinen, Tuomas O., Scott, R. A., Mägi, R., Paré, G., Franks, P. W. & GIANT Consortium, G. C., Jun 2017, In: P L o S Genetics. 13, 6, 15 p., e1006812.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K. L., Barata, L., Deng, X., Czajkowski, J., Hadley, D., Ngwa, J. S., Ahluwalia, T. S., Chu, A. Y., Heard-Costa, N. L., Lim, E., Perez, J., Eicher, J. D., Kutalik, Z., Xue, L., Mahajan, A. & 297 others, Renström, F., Wu, J. C., Qi, Q., Ahmad, S., Alfred, T., Amin, N., Bielak, L. F., Bonnefond, A., Bragg-Gresham, J. L., Cadby, G., Chittani, M., Coggeshall, S., Corre, T., Direk, N., Eriksson, J., Fischer, K., Gorski, M., Neergaard Harder, M., Horikoshi, M., Huang, T., Huffman, J. E., Jackson, A. U., Justesen, Johanne Marie, Kanoni, S., Kinnunen, L., Kleber, M. E., Komulainen, P., Kumari, M., Lim, U., Luan, J., Lyytikäinen, L., Mangino, M., Manichaikul, A., Marten, J., Middelberg, R. P. S., Müller-Nurasyid, M., Navarro, P., Pérusse, L., Pervjakova, N., Sarti, C., Smith, A. V., Smith, J. A., Stančáková, A., Strawbridge, R. J., Stringham, H. M., Sung, Y. J., Tanaka, T., Teumer, A., Trompet, S., van der Laan, S. W., van der Most, P. J., van Vliet-Ostaptchouk, J. V., Vedantam, S. L., Verweij, N., Vink, J. M., Vitart, V., Wu, Y., Yengo, L., Zhang, W., Hua Zhao, J., Zimmermann, M. E., Zubair, N., Abecasis, G. R., Adair, L. S., Afaq, S., Afzal, U., Bakker, S. J. L., Bartz, T. M., Beilby, J., Bergman, R. N., Bergmann, S., Biffar, R., Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E. P., Braga, D., Buckley, B. M., Buyske, S., Campbell, H., Chambers, J. C., Collins, F. S., Curran, J. E., de Borst, G. J., De Craen, A. J. M., de Geus, E. J. C., Dedoussis, G., Delgado, G. E., den Ruijter, H. M., Eiriksdottir, G., Eriksson, A. L., Esko, T., Faul, J. D., Ford, I., Forrester, T., Gertow, K., Gigante, B., Glorioso, N., Gong, J., Grallert, H., Grammer, T. B., Grarup, Niels, Haitjema, S., Hallmans, G., Hamsten, A., Hansen, Torben, Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N. D., Heath, A. C., Hernandez, D., Hindorff, L. A., Hocking, L. J., Hollensted, M., Holmen, O. L., Homuth, G., Jan Hottenga, J., Huang, J., Hung, J., Hutri-Kähönen, N., Ingelsson, E., James, A. L., Jansson, J., Jarvelin, M. R., Jhun, M. A., Jørgensen, M. E., Juonala, M., Kähönen, M., Karlsson, M., Koistinen, H. A., Kolcic, I., Kolovou, G., Kooperberg, C., Krämer, B. K., Kuusisto, J., Kvaløy, K., Lakka, T. A., Langenberg, C., Launer, L. J., Leander, K., Lee, N. R., Lind, L., Lindgren, C. M., Linneberg, Allan René, Lobbens, S., Loh, M., Lorentzon, M., Luben, R., Lubke, G., Ludolph-Donislawski, A., Lupoli, S., Madden, P. A. F., Männikkö, R., Marques-Vidal, P., Martin, N. G., Mckenzie, C. A., McKnight, B., Mellström, D., Menni, C., Montgomery, G. W., Musk, A. B., Narisu, N., Nauck, M., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Peyser, P. A., Pisinger, C., Porteous, D. J., Raitakari, O. T., Rankinen, T., Rao, D. C., Rasmussen-Torvik, L. J., Rawal, R., Rice, T. K., Ridker, P. M., Rose, L. M., Bien, S. A., Rudan, I., Sanna, S., Sarzynski, M. A., Sattar, N., Savonen, K., Schlessinger, D., Scholtens, S., Schurmann, C., Scott, R. A., Sennblad, B., Siemelink, M. A., Silbernagel, G., Slagboom, P. E., Snieder, H., Staessen, J. A., Stott, D. J., Swertz, M. A., Swift, A. J., Taylor, K. D., Tayo, B. O., Thorand, B., Thuillier, D., Tuomilehto, J., Uitterlinden, A. G., Vandenput, L., Vohl, M., Völzke, H., Vonk, J. M., Waeber, G., Waldenberger, M., Westendorp, R. G. J., Wild, S., Willemsen, G., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zhao, W., Zillikens, M. C., Baldassarre, D., Balkau, B., Bandinelli, S., Böger, C. A., Boomsma, D. I., Bouchard, C., Bruinenberg, M., Chasman, D. I., Chen, Y., Chines, P. S., Cooper, R. S., Cucca, F., Cusi, D., Faire, U. D., Ferrucci, L., Franks, P. W., Froguel, P., Gordon-Larsen, P., Grabe, H. J., Gudnason, V., Haiman, C. A., Hayward, C., Hveem, K., Johnson, A. D., Wouter Jukema, J., Kardia, S. L. R., Kivimaki, M., Kooner, J. S., Kuh, D., Laakso, M., Lehtimäki, T., Marchand, L. L., März, W., McCarthy, M. I., Metspalu, A., Morris, A. P., Ohlsson, C., Palmer, L. J., Pasterkamp, G., Pedersen, Oluf Borbye, Peters, A., Peters, U., Polasek, O., Psaty, B. M., Qi, L., Rauramaa, R., Smith, B. H., Sørensen, Thorkild I.A., Strauch, K., Tiemeier, H., Tremoli, E., van der Harst, P., drb459, drb459, Vollenweider, P., Wareham, N. J., Weir, D. R., Whitfield, J. B., Wilson, J. F., Tyrrell, J., Frayling, T. M., Barroso, I., Boehnke, M., Deloukas, P., Fox, C. S., Hirschhorn, J. N., Hunter, D. J., Spector, T. D., Strachan, D. P., van Duijn, C. M., Heid, I. M., Mohlke, K. L., Marchini, J. L., Loos, R. J. F., Kilpeläinen, Tuomas O., Liu, C., Borecki, I. B., North, K. E. & Cupples, L. A., 26 Apr 2017, In: Nature Communications. 8, 19 p., 14977.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 34 others, Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, Johanne Marie, Kleber, M. E., Hollensted, M., Aadahl, Mette, Færch, K., Grarup, Niels, drb459, drb459, Sørensen, Thorkild I.A., Linneberg, Allan René, Hansen, Torben, Pedersen, Oluf Borbye, Loos, Ruth, Kilpeläinen, Tuomas O., CHARGE Consortium, C. C., EPIC-InterAct Consortium, E. C. & PAGE Consortium, P. C., 1 Apr 2017, In: PLOS Genetics. 13, 4, e1006528.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels

Mahendran, Y., Jonsson, Anna Elisabet, Have, C. T., Allin, K. H., Witte, D. R., Jørgensen, M. E., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 10 Feb 2017, In: Diabetologia. 60, 5, p. 873-878 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study

Ding, M., Huang, T., Bergholdt, H. K. M., Sørensen, Thorkild I.A., Linneberg, Allan René, Sandholt, C. H., Pedersen, Oluf Borbye, Hansen, Torben, Kilpeläinen, Tuomas O., CHARGE Consortium, C. C., Nordestgaard, Børge, Ellervik, Christina, Qi, L. & Mendelian Randomization of Dairy Consumption Working Group, M. R. O. D. C. W. G., 2017, In: The BMJ. 356, 10 p., j1000.

Research output: Contribution to journal › Journal article › Research › peer-review

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L-P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 31 others, Chasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, Tuomas O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Bork-Jensen, J., Glümer, C., Grarup, Niels, Husemoen, L. L. N., Jørgensen, T., Linneberg, Allan René, Pedersen, Oluf Borbye & CHARGE Glycemic-T2D Working Group, C. G. W. G., 2017, In: Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology

Schnurr, T. M., Gjesing, A. M. P., Sandholt, C. H., Jonsson, Anna Elisabet, Mahendran, Y., Have, C. T., Ekstrøm, Claus Thorn, Bjerregaard, A., Brage, S., Witte, D., Jørgensen, M. E., Aadahl, Mette, Thuesen, B. H., Linneberg, Allan René, Eiberg, Hans Rudolf Lytchoff, Pedersen, Oluf Borbye, Grarup, Niels, Kilpeläinen, Tuomas O. & Hansen, Torben, 15 Nov 2016, In: P L o S One. 11, 11, 14 p., e0166738.

Research output: Contribution to journal › Journal article › Research › peer-review

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M-H., Chen, T. C., Chen, Y-D. I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N. & 31 others, Gnewuch, C., Goodarzi, M. O., Grarup, Niels, Guo, T., Hammer, E., Hayes, R. B., Hicks, A. A., Hofman, A., Houwing-Duistermaat, J. J., Hu, F., Hunter, D. J., Husemoen, L. L., Isaacs, A., Jacobs, K. B., Janssen, J. A. M. J. L., Jansson, J., Jehmlich, N., Johnson, S., Juul, Anders, Karlsson, M., Kilpeläinen, Tuomas O., Kovacs, P., Kraft, P., Li, C., Linneberg, Allan René, Liu, Y., Loos, Ruth, Lorentzon, M., Lu, Y., Maggio, M. & CHARGE Longevity Working Group, C. L. W. G., 29 Jun 2016, In: Aging Cell. 15, 5, p. 811-824 14 p., e1006166.

Research output: Contribution to journal › Journal article › Research › peer-review