Thomas Svava Nielsen

Thomas Svava Nielsen

Research consultant

ORCID: 0000-0002-9457-8000

Publication year:
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1 - 39 out of 39Page size: 500
  1. 2023
  2. Published

    NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner

    Basse, A. L., Nielsen, K. N., Karavaeva, Iuliia, Ingerslev, L. R., Ma, Tao, Havelund, J. F., Nielsen, Thomas Svava, Frost, M., Peics, J., Kellezi, Emilie Dalbram, Dall, M., Zierath, Juleen R, Barrès, Romain, Færgeman, N. J., Treebak, Jonas Thue & Gerhart-Hines, Zach, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2220102120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

    Peluso, A. A., Lundgaard, A. T., Babaei, P., Mousovich-Neto, F., Rocha, A. L., Damgaard, M. V., Bak, E. G., Gnanasekaran, T., Dollerup, O. L., Trammell, S. A. J., Nielsen, T. S., Kern, T., Abild, C. B., Sulek, K., Ma, T., Gerhart-Hines, Z., Gillum, M. P., Arumugam, M., Ørskov, C., McCloskey, D. & 4 others, Jessen, N., Herrgård, M. J., Mori, M. A. S. & Treebak, Jonas Thue, 2023, In: npj Aging. 9, 21 p., 7.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2022
  5. Published

    Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

    Tozzi, M., Brown, E. L., Petersen, P. S., Lundh, M., Isidor, Marie Sophie, Plucinska, Kaja, Nielsen, Thomas Svava, Agueda Oyarzabal, Marina, Small, Lewin Barkla, Treebak, Jonas Thue & Emanuelli, Brice, 2022, In: The Journal of Physiology. 600, 4, p. 885-902

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    From trainee to trainer: lessons Learned through implementation of a dual-catheter model in mice

    Nielsen, Thomas Svava & Treebak, Jonas Thue, 2022, In: Laboratory Animals. 56, S1, p. 105 1 p., S5C1.2.

    Research output: Contribution to journal › Conference abstract in journal › Research

  7. Published

    Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

    Damgaard, Mads Vargas, Nielsen, Thomas Svava, Basse, A. L., Chubanava, Sabina, Trost, K., Moritz, Thomas, Dellinger, R. W., Larsen, Steen & Treebak, Jonas Thue, 2022, In: iScience. 25, 2, 21 p., 103863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Laboratory animal surgery, can we do better?

    Gantenbein, F., Nielsen, Thomas Svava, Hankenson, F. C., Cesarovic, N., Bollen, Peter & Bouard, D., 2022, In: Laboratory Animals. 56, Suppl. 1, p. 104-105 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  9. 2021
  10. Published

    Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

    Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    An abundant biliary fatty acid metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides

    Grevengoed, Trisha Jean, Trammell, Sam, Svenningsen, J. S., Makarov, M., Nielsen, Thomas Svava, Jacobsen, Jens Christian Brings, Calder, P. C., Migaud, M. E., Cravatt, B. & Gillum, M. P., 2021, In: Journal of Clinical Investigation. 131, 6, 12 p., e143861.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Discovery of thymosin β4 as a human exerkine and growth factor

    Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Borg, M. L., Kuefner, M., Kellezi, Emilie Dalbram, Nielsen, Thomas Svava, Agrawal, A., Pankratova, Stanislava, Chibalin, A. V., Karlsson, H. K. R., Gheibi, S., Björnholm, M., Jørgensen, Niklas Rye, Clemmensen, Christoffer, Treebak, Jonas Thue, Hostrup, Morten, Krook, A., Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: American Journal of Physiology: Cell Physiology. 321, 5, p. C770-C778 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

    Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2020
  16. Published

    Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

    Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, Kornfeld, J., Kahn, C. R., Vienberg, S. G., Zierath, Juleen R, Treebak, Jonas Thue & Mori, M. A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2019
  18. Published

    Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle

    de Guia, R. M., Agerholm, M., Nielsen, Thomas Svava, Consitt, L. A., Sogaard, D., Helge, Jørn Wulff, Larsen, Steen, Brandauer, J., Houmard, J. A. & Treebak, Jonas Thue, 2019, In: Physiological Reports. 7, 12, 15 p., e14139.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS

    Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, Thomas Svava, Sundekilde, U. K., Treebak, Jonas Thue, Jessen, N. & Stødkilde-Jørgensen, H., 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans

    Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, Thomas Svava, Frystyk, J. & Møller, N., 2019, In: Metabolism: Clinical and Experimental. 99, p. 1-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

    Park, S., Turner, K. D., Zheng, D., Brault, J. J., Zou, K., Chaves, A. B., Nielsen, Thomas Svava, Tanner, C. J., Treebak, Jonas Thue & Houmard, J. A., 2019, In: The Journal of Physiology. 597, 2, p. 449-466

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

    Sharma, V. M., Vestergaard, E. T., Jessen, N., Kolind-Thomsen, P., Nellemann, B., Nielsen, Thomas Svava, Vendelbo, M. H., Møller, N., Sharma, R., Lee, K. Y., Kopchick, J. J., Jørgensen, J. O. L. & Puri, V., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 1, p. E34-E42

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis

    Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, Thomas Svava, Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., 2019, In: Diabetologia. 62, 3, p. 494-503

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2018
  25. Published

    Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo

    Høyer, K. F., Nielsen, Thomas Svava, Risis, S., Treebak, Jonas Thue & Jessen, N., 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 6, p. 732-738

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

    Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., Fisher, T., Andersen, M. M., Shen, Z., Hansen, U. K., England, E. M., Cheng, Z., Højlund, K., Wojtaszewski, J., Yang, X., Hulver, M. W. & 3 others, Helm, R. F., Treebak, Jonas Thue & Gerrard, D. E., 2018, In: Molecular Metabolism. 11, p. 160-177 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2017
  28. Published

    Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study

    Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, Thomas Svava, Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., Jan 2017, In: Diabetologia. 60, 1, p. 143-52 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2016
  30. Published

    Stress hormone release is a key component of the metabolic response to lipopolysaccharide (LPS): studies in hypopituitary and healthy subjects

    Bach, E., Møller, A. B., Jorgensen, J. O. L., Vendelbo, M. H., Jessen, N., Pedersen, S. B., Nielsen, Thomas Svava & Møller, N., 25 Aug 2016, In: European Journal of Endocrinology. 175, 5, p. 455-465 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

    Bak, A. M., Møller, A. B., Vendelbo, M. H., Nielsen, Thomas Svava, Viggers, R., Rungby, Jørgen, Pedersen, S. B., Jørgensen, J. O. L., Jessen, N. & Møller, N., 1 Jul 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 1, p. E224-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Combined insulin deficiency and endotoxin exposure stimulate lipid mobilization and alter adipose tissue signaling in an experimental model of ketoacidosis in subjects with type 1 diabetes: A randomized, controlled, cross over trial

    Svart, M., Kampmann, U., Voss, T., Pedersen, S. B., Johannsen, M., Rittig, N., Poulsen, P. L., Nielsen, Thomas Svava, Jessen, N. & Møller, N., May 2016, In: Diabetes. 65, 5, p. 1380-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Pronounced expression of the lipolytic inhibitor G0/G1 Switch Gene 2 (G0S2) in adipose tissue from brown bears (Ursus arctos) prior to hibernation

    Jessen, N., Nielsen, Thomas Svava, Vendelbo, M. H., Viggers, R., Støen, O., Evans, A. & Frøbert, O., Apr 2016, In: Physiological Reports. 4, 8, p. 1-7 7 p., e12781.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

    Jensen, Benjamin Anderschou Holbech, Nielsen, Thomas Svava, Fritzen, Andreas Mæchel, Holm, J. B., Fjære, E., Serup, A. K. L., Borkowski, K., Risis, S., Pærregaard, S. I., Søgaard, I., Poupeau, A. A. G., Poulsen, M., Ma, Tao, Sina, C., Kiens, Bente, Madsen, L., Kristiansen, Karsten & Treebak, Jonas Thue, 2016, In: Metabolism. 65, 12, p. 1706-1719 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial

    Rittig, N., Bach, E., Thomsen, H. H., Pedersen, S. B., Nielsen, Thomas Svava, Jørgensen, J. O., Jessen, N. & Møller, N., 2016, In: P L o S One. 11, 9, p. 1-13 13 p., e0162167.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2015
  37. Published

    Intact Pituitary Function is Decisive for the Catabolic Response to TNF-α: Studies of Protein, Glucose and Fatty Acid Metabolism in Hypopituitary and Healthy Subjects

    Bach, E., Møller, A. B., Jørgensen, J. O. L., Vendelbo, M. H., Jessen, N., Olesen, J. F., Pedersen, S. B., Nielsen, Thomas Svava & Møller, N., Feb 2015, In: The Journal of clinical endocrinology and metabolism. 100, 2, p. 578-86 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2014
  39. Published

    Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

    Nielsen, Thomas Svava, Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., Jun 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    Adipose triglyceride lipase and g0/g1 switch gene 2: approaching proof of concept

    Nielsen, Thomas Svava & Møller, N., Mar 2014, In: Diabetes. 63, 3, p. 847-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, Nielsen, R., Albrechtsen, Anders & Hansen, Torben, 2014, In: Nature. 512, 7513, p. 190-193 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  42. Published

    Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

    Nellemann, B., Vendelbo, M. H., Nielsen, Thomas Svava, Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, Henriette, Møller, N., Jessen, N. & Jørgensen, J. O. L., 2014, In: Acta Physiologica. 210, 2, p. 392-402 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2012

  44. Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes

    Nielsen, Thomas Svava, Kampmann, U., Nielsen, R. R., Jessen, N., Orskov, L., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Jul 2012, In: The Journal of clinical endocrinology and metabolism. 97, 7, p. E1348-52

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

    Christensen, B., Lundby, C., Jessen, N., Nielsen, Thomas Svava, Vestergaard, P. F., Møller, N., Pilegaard, Henriette, Pedersen, S. B., Kopchick, J. J. & Jørgensen, J. O. L., 2012, In: P L o S One. 7, 2, 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

    Vendelbo, M., Clasen, B. F. F., Treebak, Jonas Thue, Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, Thomas Svava, Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, Jørgen F P, Møller, N. & Jessen, N., 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2011

  48. Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue

    Nielsen, Thomas Svava, Vendelbo, M., Jessen, N., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Aug 2011, In: The Journal of clinical endocrinology and metabolism. 96, 8, p. E1293-7

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

    Kampmann, U., Christensen, B., Nielsen, Thomas Svava, Pedersen, S. B., Ørskov, L., Lund, S., Møller, N. & Jessen, N., 2011, In: PLOS ONE. 6, 11, p. e27854

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2010

  51. Effects of GH in human muscle and fat

    Jørgensen, J. O. L., Rubeck, K. Z., Nielsen, Thomas Svava, Clasen, B. F. F., Vendelboe, M., Hafstrøm, T. K., Madsen, M. & Lund, S., Apr 2010, In: Pediatric nephrology (Berlin, Germany). 25, 4, p. 705-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese

    Bennetzen, M. F., Nielsen, Thomas Svava, Paulsen, S. K., Bendix, J., Fisker, S., Jessen, N., Lund, S., Richelsen, B. & Pedersen, S. B., Feb 2010, In: European Journal of Clinical Investigation. 40, 2, p. 121-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 37916430