Thomas Michael Frimurer

Thomas Michael Frimurer

Associate Professor

Member of:

    ORCID: 0000-0002-9682-8245

    Introductory remarks on publicationslist

    Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.

     


    Publication year:
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    21 - 30 out of 73Page size: 10
    1. 2019
    2. Published

      Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

      Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    3. 2018
    4. Published

      Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

      Petersen, N., Frimurer, Thomas Michael, Pedersen, M. T., Egerod, Kristoffer Lihme, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Grapin-Botton, A., Jensen, Kim Bak & Schwartz, Thue W., 2018, In: Gastroenterology. 155, 4, p. 1164-1176 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Ligand-selective small molecule modulators of the constitutively active vGPCR US28

      Amarandi, R., Lückmann, Michael, Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, Katja, Hjortø, Gertrud Malene, Pui, A., Frimurer, Thomas Michael & Rosenkilde, Mette, 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation

      Milanos, S., Kuenzel, K., Gilbert, D. F., Janzen, D., Sasi, M., Buettner, A., Frimurer, Thomas Michael & Villmann, C., 2018, In: Biological Chemistry. 399, 6, p. 549-563 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

      Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The HETE Is on FFAR1 and Pancreatic Islet Cells

      Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Translating biased signaling in the ghrelin receptor system into differential in vivo functions

      Mende, F., Johnsen, Cecilie Hundahl, Plouffe, B., Skov, Louise Julie, Sivertsen, B., Madsen, A. N., Lückmann, Michael, Diep, T. A., Offermanns, S., Frimurer, Thomas Michael, Bouvier, M. & Holst, Birgitte, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10255-E10264 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2017
    11. Published

      Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

      Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2

      Daugvilaite, V., Madsen, C. M., Lückmann, Michael, Castello Echeverria, C., Sailer, A. W., Frimurer, Thomas Michael, Rosenkilde, Mette & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

      Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 34520257