Stine Helene Falsig Pedersen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
- 2024
- Published
Acid–base transporters in the context of tumor heterogeneity
Pedersen, Stine Helene Falsig, 2024, In: Pflugers Archiv European Journal of Physiology. 476, p. 689–701 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2023
- Published
Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells
Edamana, S., Pedersen, Stine Helene Falsig & Nejsum, L. N., 2023, In: Biochemical and Biophysical Research Communications. 639, p. 126-133 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic acidosis rewires cancer cell metabolism through PPARα signaling
Rolver, M. G., Holland, L. K. K., Ponniah, M., Prasad, N. S., Yao, Jiayi, Schnipper, J., Kramer, S., Elingaard-Larsen, L., Pedraz-Cuesta, E., Liu, B., Pardo, L. A., Maeda, K., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 8, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness
Czaplinska, D., Ialchina, Renata, Andersen, Henriette Berg, Yao, Jiayi, Stigliani, Arnaud, Dannesboe, Johs, Flinck, M., Chen, X., Mitrega, J., Gnosa, S. P., Dmytriyeva, O., Alves, F., Napp, J., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 6, p. 1210-1225 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia
Severin, M., Pedersen, E. L., Borre, M. T., Axholm, I., Christiansen, F. B., Ponniah, M., Czaplinska, D., Larsen, T., Pardo, L. A. & Pedersen, Stine Helene Falsig, 2023, In: Journal of Cell Science. 136, 7, 20 p., jcs260687.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How protons pave the way to aggressive cancers
Swietach, P., Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2023, In: Nature Reviews Cancer. 23, p. 825-841 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM
Schnipper, J., Kouba, S., Hague, F., Girault, A., Telliez, M., Guenin, S., Ahidouch, A., Pedersen, Stine Helene Falsig & Ouadid-Ahidouch, H., 2022, In: Cancers. 14, 19, 27 p., 4946.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
Elingaard-Larsen, L. O., Rolver, M. G., Sørensen, E. E. & Pedersen, Stine Helene Falsig, 2022, From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Stock, C. & Pardo, L. A. (eds.). Springer, p. 1-38 38 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 182).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Sialylation of N-glycans affects the lipid secretion governed by specialized secretory lysosomal organelles through an effect on the V-ATPase
Khoder-Agha, F., Song, Ming, Borre, M. T., Marinova, I. N., Ye, Z., Pedersen, Stine Helene Falsig, Dabelsteen, Sally & Wandall, Hans H., 2022, In: Glycobiology. 32, 11, p. 1012-1013 2 p., P103.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner
Schnipper, J., Kouba, S., Hague, F., Girault, A., Rybarczyk, P., Telliez, M., Guenin, S., Tebbakha, R., Sevestre, H., Ahidouch, A., Pedersen, Stine Helene Falsig & Ouadid-Ahidouch, H., 2022, In: International Journal of Molecular Sciences . 23, 14, 20 p., 7923.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation
Sjøgaard-Frich, Lise Margrethe, Prestel, Andreas, Pedersen, E. S., Severin, M., Kristensen, Kristian Kølby, Olsen, Johan Gotthardt, Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2021, In: eLife. 10, 29 p., e60889.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Andersen, Henriette Berg, Ialchina, Renata, Pedersen, Stine Helene Falsig & Czaplinska, D., 2021, In: Cancer and Metastasis Reviews. 40, 4, p. 1093-1114 22 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer
Rolver, M. G. & Pedersen, Stine Helene Falsig, 2021, In: British Journal of Cancer. 124, p. 1-2 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
Pedersen, Stine Helene Falsig, Flinck, M. & Pardo, L. A., 2021, In: International Journal of Molecular Sciences. 22, 10, 27 p., 5209.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells
Doray, A., Lemoine, R., Severin, M., Chadet, S., Lopez-Charcas, O., Héraud, A., Baron, C., Besson, P., Monteil, A., Pedersen, Stine Helene Falsig & Roger, S., 2021, In: Cells. 10, 7, 15 p., 1624.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, Andreas, Cardenas, M., Pedraz-Cuesta, E., Arleth, Lise, Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4
Thiesen, L., Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Helene Falsig, Crocoll, C., Nour-Eldin, Hussam Hassan & Wellendorph, Petrine, 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer Cell Acid Adaptation Gene Expression Response is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival
Yao, Jiayi, Czaplinska, D., Ialchina, Renata, Schnipper, J., Liu, B., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2020, In: Cancers. 12, 8, 27 p., 2183.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
O-glycan initiation directs distinct biological pathways and controls epithelial differentiation
Bagdonaite, Ieva , Pallesen, E. M. H., Ye, Z., Vakhrushev, Sergey, Marinova, I. N., Nielsen, Mathias Alexander Ingemann, Kramer, S. H., Pedersen, Stine Helene Falsig, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2020, In: EMBO Reports. 21, 6, 17 p., e48885.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1
Rolver, M. G., Elingaard-Larsen, L. O., Andersen, Anne Poder, Counillon, L. & Pedersen, Stine Helene Falsig, 2020, In: Scientific Reports. 10, 17 p., 5800.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2020, In: Frontiers in Oncology. 10, 15 p., 687.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Acidic Tumor Microenvironment as a Driver of Cancer
Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2020, In: Annual Review of Physiology. 82, p. 103-126Research output: Contribution to journal › Review › Research › peer-review
- Published
The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells
Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz-Cuesta, E., Novak, Ivana, Stock, C. & Pedersen, Stine Helene Falsig, 2020, In: Cells. 9, 2, 22 p., 465.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies
Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer
Czaplinska, D., Elingaard-Larsen, L. O., Rolver, M. G., Severin, M. & Pedersen, Stine Helene Falsig, 20 Dec 2019, In: Biochemical Society Transactions. 47, 6, p. 1689-1700 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
Avnet, S., Baldini, N., Brisson, L., Pedersen, Stine Helene Falsig, Porporato, P. E., Sonveaux, P., Szabadkai, G. & Pastorekova, S., 2019, In: Frontiers in Oncology. 9, 5 p., 1332.Research output: Contribution to journal › Review › Research › peer-review
- Published
Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, Stine Helene Falsig, 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, Thomas, Rovira, C. & Pedersen, Stine Helene Falsig, 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Profibrotic epithelial phenotype: a central role for MRTF and TAZ
Bialik, J. F., Ding, M., Speight, P., Dan, Q., Miranda, M. Z., Di Ciano-Oliveira, C., Kofler, M. M., Rotstein, O. D., Pedersen, Stine Helene Falsig, Szászi, K. & Kapus, A., 2019, In: Scientific Reports. 9, p. 1-14 4323.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
Jensen, H. H., Pedersen, G. A., Morgen, J. J., Parsons, M., Pedersen, Stine Helene Falsig & Nejsum, L. N., 2019, In: Journal of Physiology. 597, 3, p. 849-867Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology
Pedersen, Stine Helene Falsig & Counillon, L., 2019, In: Physiological Reviews. 99, 4, p. 2015-2113 99 p.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice
Lee, S., Axelsen, T. V., Jesse, N., Pedersen, Stine Helene Falsig, Vahl, P. & Boedtkjer, E., 2018, In: Oncogene. 37, 41, p. 5569-5584Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Roles of pH in control of cell proliferation
Flinck, M., Kramer, S. H. & Pedersen, Stine Helene Falsig, 2018, In: Acta Physiologica. 223, 3, p. 1-17 e13068.Research output: Contribution to journal › Review › Research › peer-review
- Published
The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells
Flinck, M., Kramer, S. H., Schnipper, J., Andersen, Anne Poder & Pedersen, Stine Helene Falsig, 2018, In: Cell Cycle. 17, 9, p. 1056-1067Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms
Andersen, Anne Poder, Samsøe-Petersen, Jacob, Ørnbo, E. K., Bødtkjer, E., Moreira, José, Kveiborg, Marie & Pedersen, Stine Helene Falsig, 2018, In: International Journal of Cancer. 142, 12, p. 2529-2542 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trafficking, localization and degradation of the Na+,HCO3- Co-transporter NBCn1 in kidney and breast epithelial cells
Olesen, C. W., Vogensen, J., Axholm, I., Severin, M., Schnipper, J., Pedersen, I. S., von Stemann, J. H., Schrøder, J. M., Christensen, D. P. & Pedersen, Stine Helene Falsig, 2018, In: Scientific Reports. 8, p. 1-16 7435.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism
Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
Baldini, N., de Milito, A., Feron, O., Gillies, R. J., Michiels, C., Otto, A. M., Pastoreková, S., Pedersen, Stine Helene Falsig, Porporato, P. E., Sonveaux, P., Supuran, C. T. & Avnet, S., 4 Jul 2017, In: Frontiers in Pharmacology. 8, 5 p., 411.Research output: Contribution to journal › Comment/debate › Research
- Published
Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer
Pedersen, Stine Helene Falsig, Novak, Ivana, Alves, F., Schwab, A. & Pardo, L. A., Jun 2017, In: BioEssays. 39, 6, 10 p., 1600253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Roles of pH and the Na+/H+ exchanger NHE1 in cancer: from cell biology and animal models to an emerging translational perspective?
Stock, C. & Pedersen, Stine Helene Falsig, Apr 2017, In: Seminars in Cancer Biology. 43, p. 5-16 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism
Miranda, M. Z., Bialik, J. F., Speight, P., Dan, Q., Yeung, T., Szaszi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2017, In: Journal of Biological Chemistry. 292, 36, p. 14902-14920 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8742
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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer
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Cell volume regulation in epithelial physiology and cancer
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Research output: Contribution to journal › Journal article › Research › peer-review
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