Sine Larsen

Sine Larsen

Professor Emerita, Professor emeritus.

Member of:


    1. 2021
    2. Published

      The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

      Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

      Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 2021, In: IUCrJ. 8, 3, 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. 2020
    5. Published

      Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses

      Christiansen, T., Cotte, M., de Nolf, W., Mouro, E., Reyes-Herrera, J., de Meyer, S., Vanmeert, F., Lindelof, Poul Erik, Salvadó, N., Mortensen, Kell, Ryholt, Kim, Janssens, K. & Larsen, Sine, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 27825–27835 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      The structural basis of fungal glucuronoyl esterase activity on natural substrates

      Ernst, H. A., Mosbech, C., Langkilde, Annette Eva, Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, Sine, 2020, In: Nature Communications. 11, 1026, p. 1-12

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. 2018
    8. Published

      A comparative structural analysis of the surface properties of asco-laccases

      Ernst, H. A., Jørgensen, L. J., Bukh, C., Piontek, K., Plattner, D. A., Østergaard, L. H., Larsen, Sine & Bjerrum, Morten Jannik, 2018, In: PLoS ONE. 13, 11, p. 1-27 e0206589.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

      Skubak, P., Arac, D., Bowler, M. W., Correia, A. R., Hoelz, A., Larsen, Sine, Leonard, G. A., McCarthy, A. A., McSweeney, S., Mueller-Dieckmann, C., Otten, H., Salzman, G. & Pannu, N. S., 2018, In: I U Cr J. 5, Part 2, p. 166-171 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. 2017
    11. Published

      The nature of ancient Egyptian copper-containing carbon inks is revealed by synchrotron radiation based X-ray microscopy

      Christiansen, T., Cotte, M., Loredo-Portales, R., Lindelof, Poul Erik, Mortensen, Kell, Ryholt, Kim & Larsen, Sine, 10 Nov 2017, In: Scientific Reports. 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. 2015
    13. Published

      The function of the milk-clotting enzymes bovine and camel chymosin studied by a fluorescence resonance energy transfer assay

      Jensen, J. L., Jacobsen, J., Moss, M. L., Rasmussen, F., Qvist, K. B., Larsen, Sine & van den Brink, J. M., 2015, In: Journal of Dairy Science. 98, 5, p. 2853-2860 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Crystallography is more than crystal structures

      Larsen, Sine, 2015, In: IUCrJ. 2, p. 475-476 2 p.

      Research output: Contribution to journalEditorialResearchpeer-review

    15. 2014
    16. Published

      A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational study

      Czene, A., Tóth, E., Németh, E., Otten, H., Poulsen, Jens-Christian Navarro, Christensen, H. E. M., Rulíšek, L., Nagata, K., Larsen, Sine & Gyurcsik, B., 2014, In: Metallomics. 6, 11, p. 2090-2099 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Crystallography and large research infrastructures, a perfect marriage

      Larsen, Sine, 2014, In: IUCrJ. 1, Part 5, p. 261-262 2 p.

      Research output: Contribution to journalEditorialResearchpeer-review

    18. Published

      Polysaccharide lyase family 4

      Lo Leggio, Leila & Larsen, Sine, 2014, Cazypedia.

      Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

    19. Published

      Design of thermostable rhamnogalacturonan lyase mutants from Bacillus licheniformis by combination of targeted single point mutations

      da Silva, I. I. C. R., Jers, C., Otten, H., Nyffenegger, C., Larsen, D. M., Derkx, P. M. F., Meyer, A. S., Mikkelsen, J. D. & Larsen, Sine, 2014, In: Applied Microbiology and Biotechnology. 98, 10, p. 4521-4531 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. 2013
    21. Published

      Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1

      Brown, A., Turner, Louise, Christoffersen, S., Andrews, K. A., Szestak, T., Zhao, Y., Larsen, Sine, Craig, A. G. & Higgins, M. K., 22 Feb 2013, In: Journal of Biological Chemistry. 288, 8, p. 5992-6003 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7

      Czene, A., Toth, E., Gyurcsik, B., Otten, H., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Larsen, Sine, Christensen, H. E. M. & Nagata, K., 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, p. 551-554 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Camel and bovine chymosin: the relationship between their structures and cheese-making properties

      Jensen, J. L., Mølgaard, A., Poulsen, Jens-Christian Navarro, Harboe, M. K., Simonsen, J. B., Lorentzen, A. M., Hjernø, K., van den Brink, J. M., Qvist, K. B. & Larsen, Sine, 2013, In: Acta Crystallographica. Section D: Biological Crystallography. D69, p. 901-913 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      The binding of zinc ions to Emericella nidulans endo-β-1,4-galactanase is essential for crystal formation

      Otten, H., Michalak, M., Mikkelsen, J. D. & Larsen, Sine, 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. F69, 8, p. 850-854 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. 2012
    26. Published

      Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

      Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. 2011
    28. Published

      Understanding Thermodynamic Properties at the Molecular Level: Multiple Temperature Charge Density Study of Ribitol and Xylitol

      Madsen, Anders Østergaard, Mattson, R. & Larsen, Sine, 2011, In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. 115, p. 7794–7804

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. 2010
    30. Published

      Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family

      Harris, P. V., Welner, D. H., McFarland, K., Re, E., Poulsen, Jens-Christian Navarro, Brown, K., Salbo, R., Ding, H., Vlasenko, E., Marino, S., Xu, F., Cherry, J., Larsen, Sine & Lo Leggio, Leila, 2010, In: Biochemistry. 49, p. 3305-3316

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus

      Jensen, M. H., Otten, H., Christensen, U., Borchert, T. V., Christensen, L. L. H., Larsen, Sine & Lo Leggio, Leila, 2010, In: Journal of Molecular Biology. 404, p. 100-111

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Citations in supplementary material

      Weiss, M. S., Einspahr, H., Baker, E. N., Dauter, Z., Kaysser-Pyzalla, A. R., Kostorz, G. & Larsen, Sine, 2010, In: Journal of Applied Crystallography. 43, p. 1285-1286

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. 2009
    34. Published

      Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling

      Le Nours, J., De Maria, L., Welner, D. H., Jørgensen, C. T., Borchert, T. V., Christensen, L. L., Larsen, Sine & Lo Leggio, Leila, 2009, In: Proteins - Structure Function and Bioinformatics. 75, p. 977-989

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis

      Siggaard, J. H. B., Johansson, E., Vognsen, T. R., Helt, S. S., Harris, P., Larsen, Sine & Willemoës, Martin, 2009, In: Archives of Biochemistry and Biophysics. 490, 1, p. 42-9 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. 2008
    37. Published

      Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis

      Helt, S. S., Thymark, M., Harris, P., Aagaard, C., Dietrich, J., Larsen, Sine & Willemoës, Martin, 2008, In: Journal of Molecular Biology. 376, 2, p. 554-69 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

      Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Estimated H-atom anisotropic displacement parameters: a comparison between different methods and with neutron diffraction results

      Munshi, P., Madsen, Anders Østergaard, Spackman, M. A., Larsen, Sine & Destro, R., 2008, In: Acta Crystallographica. Section A: Foundations of Crystallography. A64, p. 465-75 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Identification of Quaternary Structure and functional domains of the CI repressor from Bacteriophage TP901-1

      Pedersen, M., Lo Leggio, Leila, Grossmann, J. G., Larsen, Sine & Hammer, K., 2008, In: Journal of Molecular Biology. 373, p. 983-996

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Structure and function of enzymes in biomass degradation

      Welner, D. H., Jensen, M. H., McFarland, K. C., Poulsen, Jens-Christian Navarro, Otten, H., Salbo, R., Christensen, U., Harris, P., Larsen, Sine, Borchert, T., Christensen, L. L. H., Friis, E. P. & Lo Leggio, Leila, 2008, Biotechnology of lignocellulose degradation and Biomass Utilization - Mie Bioforum 2008. p. 349-355

      Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

    42. 2007
    43. Published

      Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme

      Johansson, E., Thymark, M., Bynck, J. H., Fanø, M., Larsen, Sine & Willemoës, Martin, 2007, In: FEBS Journal. 274, 16, p. 4188-4198 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Insight into Solid-State Entropy from Diffraction Data

      Madsen, Anders Østergaard & Larsen, Sine, 2007, In: Angewandte Chemie - International Edition. 46, 45, p. 8609-8613

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2

      Mølgaard, A., Arnau, J., Lauritzen, C., Larsen, Sine, Petersen, G. & Pedersen, J., 2007, In: Biochemical Journal. 401, 3, p. 645-50 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase

      Thymark, M., Johansson, E., Larsen, Sine & Willemoës, Martin, 2007, In: Archives of Biochemistry and Biophysics. 470, 1, p. 20-6 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

      Wolfe, A. E., Thymark, M., Gattis, S. G., Fagan, R. L., Hu, Y., Johansson, E., Arent, S., Larsen, Sine & Palfey, B. A., 2007, In: Biochemistry. 46, 19, p. 5741-53 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. 2006
    49. Published

      The extraordinary specificity of xanthine phosphoribosyltransferase from Bacillus subtilis elucidated by reaction kinetics, ligand binding, and crystallography

      Arent, S., Kadziola, Anders, Larsen, Sine, Neuhard, J. & Jensen, K. F., 2006, In: Biochemistry. 45, 21, p. 6615-6627

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. High-throughput sample handling and data collection at synchrotrons: embedding the ESRF in the high-throughput gene-to-structure pipeline

      Beteva, A., Cipriani, F., Cusack, S., Delageniere, S., Gabadinho, J., Gordon, E. J., Guijarro, M., Hall, D. R., Larsen, S., Launer, L., Lavault, C. B., Leonard, G. A., Mairs, T., McCarthy, A., McCarthy, J., Meyer, J., Mitchell, E., Monaco, S., Nurizzo, D., Pernot, P. & 12 others, Pieritz, R., Ravelli, G. .. B., Rey, V., Shepard, W., Spruce, D., Stuart, D. I., Svensson, O., Theveneau, P., Thibault, X., Turkenburg, J., Walsh, M. & McSweeney, S. M., 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, 10, p. 1162-1169 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Automation of sample mounting for macromolecular crystallography

      Cipriani, F., Felisaz, F., Launer, L., Aksoy, J., Caserotto, H., Cusack, S., Dallery, M., di-Chiaro, F., Guijarr, M., Huet, J., Larsen, Sine, Lentini, M., McCarthy, J., McSweeeney, S., Ravelli, R., Renier, M., Taffut, C., Thompson, A., Leonard, G. A. & Walsh, M. A., 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, 10, p. 1251-1259 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31

      Ernst, H. A., Lo Leggio, Leila, Willemoës, Martin, Leonard, G. A., Blum, P. & Larsen, Sine, 2006, In: Journal of Molecular Biology. 358, 4, p. 1106-24

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. 2005
    54. Published

      Allosteric regulation and communication between subunits in uracil phosphoribosyltransferase from Sulfolobus solfataricus

      Arent, S., Harris, P., Jensen, K. F. & Larsen, Sine, 2005, In: Biochemistry. 44, 3, p. 883-892

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

      Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    56. Published

      Characterization of different crystal forms of the a-glucosidase MalA from Sulfolobus solfataricus

      Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica Section F. 61, p. 1039-1042

      Research output: Contribution to journalJournal articleResearchpeer-review

    57. Published

      Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

      Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 12, p. 1039-42 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    58. Published

      Probing the structure of glucan lyases by sequence analysis, circular dichroism and proteolysis

      Ernst, H. A., Lo Leggio, Leila, Yu, S., Finnie, C., Svensson, B. & Larsen, Sine, 2005, In: Biologia. 60, Suppl. 16, p. 149-159

      Research output: Contribution to journalJournal articleResearchpeer-review

    59. Published

      Allosteric properties of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermoacidophilic archeon Sulfolobus solfataricus

      Jensen, K. F., Arent, S., Larsen, Sine & Schack, L., 2005, In: FEBS Journal. 272, p. 1440-1453

      Research output: Contribution to journalJournal articleResearchpeer-review

    60. Published

      Allosteric regulation of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermophilic archaeon Sulfolobus solfataricus

      Jensen, K. F., Arent, S., Larsen, Sine & Schack, L., 2005, In: FEBS Journal. 272, 6, p. 1440-1453

      Research output: Contribution to journalJournal articleResearchpeer-review

    61. Published

      Structures of dCTP deaminase from Escherichia coli with bound substrate and product

      Johansson, E. H., Fanø, M., Bynck, J. H., Neuhard, J., Larsen, Sine, Sigurdskjold, B., Christensen, U. & Willemoës, M., 2005, In: The Journal of Biological Chemistry. 280, p. 3051-3059

      Research output: Contribution to journalJournal articleResearchpeer-review

    62. Published

      Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii.

      Kadziola, Anders, Jepsen, C. H., Johansson, E., McGuire, J., Larsen, Sine & Hove-Jensen, B., 2005, In: Journal of Molecular Biology. 354, 4, p. 815-28 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    63. Published

      Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A

      Møller, L. B., Bukrinsky, J. T., Mølgaard, A., Paulsen, M., Lund, C., Tümer, Z., Larsen, Sine & Horn, N., 2005, In: Human Mutation. 26, p. 84-93

      Research output: Contribution to journalJournal articleResearchpeer-review

    64. Published

      2-(1-Naphthyl)propionic acid

      Riis, E. P. & Larsen, Sine, 2005, In: Acta Crystallographica. Section E: Structure Reports Online. E61, p. o1396-o1397

      Research output: Contribution to journalJournal articleResearchpeer-review

    65. Published

      Tetra-tert-butyl-di-μ-hydroxo digallium(III) and 1,12-diaza-3,4:9,10- dibenzo-5,8-dioxo-cyclo-pentadecane. Structure and isomers of the coordination compound

      Sun, H., Thulstrup, Peter Waaben, Larsen, Sine & Larsen, Erik, 1 Nov 2005, In: International Journal of Molecular Sciences. 6, 11, p. 276-290 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

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    ID: 8853