Sine Larsen

Sine Larsen

Professor Emerita


  1. 2021
  2. Published

    Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

    Ramos, João Carlos Moreno, Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, Sine & Langkilde, Annette Eva, 2021, In: IUCrJ. 8, 3, 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2020
  4. Published

    Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses

    Christiansen, T., Cotte, M., de Nolf, W., Mouro, E., Reyes-Herrera, J., de Meyer, S., Vanmeert, F., Lindelof, Poul Erik, Salvadó, N., Mortensen, Kell, Ryholt, Kim, Janssens, K. & Larsen, Sine, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 27825–27835 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The structural basis of fungal glucuronoyl esterase activity on natural substrates

    Ernst, H. A., Mosbech, C., Langkilde, Annette Eva, Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, Sine, 2020, In: Nature Communications. 11, 1026, p. 1-12

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    A comparative structural analysis of the surface properties of asco-laccases

    Ernst, H. A., Jørgensen, L. J., Bukh, C., Piontek, K., Plattner, D. A., Østergaard, L. H., Larsen, Sine & Bjerrum, Morten Jannik, 2018, In: PLoS ONE. 13, 11, p. 1-27 e0206589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

    Skubak, P., Arac, D., Bowler, M. W., Correia, A. R., Hoelz, A., Larsen, Sine, Leonard, G. A., McCarthy, A. A., McSweeney, S., Mueller-Dieckmann, C., Otten, H., Salzman, G. & Pannu, N. S., 2018, In: I U Cr J. 5, Part 2, p. 166-171 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2017
  10. Published

    The nature of ancient Egyptian copper-containing carbon inks is revealed by synchrotron radiation based X-ray microscopy

    Christiansen, T., Cotte, M., Loredo-Portales, R., Lindelof, Poul Erik, Mortensen, Kell, Ryholt, Kim & Larsen, Sine, 10 Nov 2017, In: Scientific Reports. 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2015
  12. Published

    Crystallography is more than crystal structures

    Larsen, Sine, 2015, In: IUCrJ. 2, p. 475-476 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  13. Published

    The function of the milk-clotting enzymes bovine and camel chymosin studied by a fluorescence resonance energy transfer assay

    Jensen, J. L., Jacobsen, J., Moss, M. L., Rasmussen, F., Qvist, K. B., Larsen, Sine & van den Brink, J. M., 2015, In: Journal of Dairy Science. 98, 5, p. 2853-2860 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2014
  15. Published

    A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational study

    Czene, A., Tóth, E., Németh, E., Otten, H., Poulsen, Jens-Christian Navarro, Christensen, H. E. M., Rulíšek, L., Nagata, K., Larsen, Sine & Gyurcsik, B., 2014, In: Metallomics. 6, 11, p. 2090-2099 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Crystallography and large research infrastructures, a perfect marriage

    Larsen, Sine, 2014, In: IUCrJ. 1, Part 5, p. 261-262 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  17. Published

    Design of thermostable rhamnogalacturonan lyase mutants from Bacillus licheniformis by combination of targeted single point mutations

    da Silva, I. I. C. R., Jers, C., Otten, H., Nyffenegger, C., Larsen, D. M., Derkx, P. M. F., Meyer, A. S., Mikkelsen, J. D. & Larsen, Sine, 2014, In: Applied Microbiology and Biotechnology. 98, 10, p. 4521-4531 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Polysaccharide lyase family 4

    Lo Leggio, Leila & Larsen, Sine, 2014, Cazypedia.

    Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

  19. 2013
  20. Published

    Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1

    Brown, A., Turner, Louise, Christoffersen, S., Andrews, K. A., Szestak, T., Zhao, Y., Larsen, Sine, Craig, A. G. & Higgins, M. K., 22 Feb 2013, In: Journal of Biological Chemistry. 288, 8, p. 5992-6003 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Camel and bovine chymosin: the relationship between their structures and cheese-making properties

    Jensen, J. L., Mølgaard, A., Poulsen, Jens-Christian Navarro, Harboe, M. K., Simonsen, J. B., Lorentzen, A. M., Hjernø, K., van den Brink, J. M., Qvist, K. B. & Larsen, Sine, 2013, In: Acta Crystallographica. Section D: Biological Crystallography. D69, p. 901-913 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7

    Czene, A., Toth, E., Gyurcsik, B., Otten, H., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Larsen, Sine, Christensen, H. E. M. & Nagata, K., 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, p. 551-554 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The binding of zinc ions to Emericella nidulans endo-β-1,4-galactanase is essential for crystal formation

    Otten, H., Michalak, M., Mikkelsen, J. D. & Larsen, Sine, 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. F69, 8, p. 850-854 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2012
  25. Published

    Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

    Clausen, Thomas Mandel, Christoffersen, S., Dahlbäck, M., Langkilde, Annette Eva, Jensen, K. E., Resende, M., Agerbæk, Mette Ørskov, Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Larsen, Sine & Salanti, Ali, 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2011
  27. Published

    Understanding Thermodynamic Properties at the Molecular Level: Multiple Temperature Charge Density Study of Ribitol and Xylitol

    Madsen, Anders Østergaard, Mattson, R. & Larsen, Sine, 2011, In: Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. 115, p. 7794–7804

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2010
  29. Published

    Citations in supplementary material

    Weiss, M. S., Einspahr, H., Baker, E. N., Dauter, Z., Kaysser-Pyzalla, A. R., Kostorz, G. & Larsen, Sine, 2010, In: Journal of Applied Crystallography. 43, p. 1285-1286

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family

    Harris, P. V., Welner, D. H., McFarland, K., Re, E., Poulsen, Jens-Christian Navarro, Brown, K., Salbo, R., Ding, H., Vlasenko, E., Marino, S., Xu, F., Cherry, J., Larsen, Sine & Lo Leggio, Leila, 2010, In: Biochemistry. 49, p. 3305-3316

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus

    Jensen, M. H., Otten, H., Christensen, U., Borchert, T. V., Christensen, L. L. H., Larsen, Sine & Lo Leggio, Leila, 2010, In: Journal of Molecular Biology. 404, p. 100-111

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2009
  33. Published

    Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis

    Siggaard, J. H. B., Johansson, E., Vognsen, T. R., Helt, S. S., Harris, P., Larsen, Sine & Willemoës, Martin, 2009, In: Archives of Biochemistry and Biophysics. 490, 1, p. 42-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling

    Le Nours, J., De Maria, L., Welner, D. H., Jørgensen, C. T., Borchert, T. V., Christensen, L. L., Larsen, Sine & Lo Leggio, Leila, 2009, In: Proteins - Structure Function and Bioinformatics. 75, p. 977-989

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2008
  36. Published

    Estimated H-atom anisotropic displacement parameters: a comparison between different methods and with neutron diffraction results

    Munshi, P., Madsen, Anders Østergaard, Spackman, M. A., Larsen, Sine & Destro, R., 2008, In: Acta Crystallographica. Section A: Foundations of Crystallography. A64, p. 465-75 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Identification of Quaternary Structure and functional domains of the CI repressor from Bacteriophage TP901-1

    Pedersen, M., Lo Leggio, Leila, Grossmann, J. G., Larsen, Sine & Hammer, K., 2008, In: Journal of Molecular Biology. 373, p. 983-996

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis

    Helt, S. S., Thymark, M., Harris, P., Aagaard, C., Dietrich, J., Larsen, Sine & Willemoës, Martin, 2008, In: Journal of Molecular Biology. 376, 2, p. 554-69 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

    Langkilde, Annette Eva, Kristensen, S. M., Lo Leggio, Leila, Mølgaard, A., Jensen, Jan Halborg, Houk, A. R., Poulsen, Jens-Christian Navarro, Larsen, Sine & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Structure and function of enzymes in biomass degradation

    Welner, D. H., Jensen, M. H., McFarland, K. C., Poulsen, Jens-Christian Navarro, Otten, H., Salbo, R., Christensen, U., Harris, P., Larsen, Sine, Borchert, T., Christensen, L. L. H., Friis, E. P. & Lo Leggio, Leila, 2008, Biotechnology of lignocellulose degradation and Biomass Utilization - Mie Bioforum 2008. p. 349-355

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  41. 2007
  42. Published

    Insight into Solid-State Entropy from Diffraction Data

    Madsen, Anders Østergaard & Larsen, Sine, 2007, In: Angewandte Chemie - International Edition. 46, 45, p. 8609-8613

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

    Wolfe, A. E., Thymark, M., Gattis, S. G., Fagan, R. L., Hu, Y., Johansson, E., Arent, S., Larsen, Sine & Palfey, B. A., 2007, In: Biochemistry. 46, 19, p. 5741-53 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase

    Thymark, M., Johansson, E., Larsen, Sine & Willemoës, Martin, 2007, In: Archives of Biochemistry and Biophysics. 470, 1, p. 20-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme

    Johansson, E., Thymark, M., Bynck, J. H., Fanø, M., Larsen, Sine & Willemoës, Martin, 2007, In: FEBS Journal. 274, 16, p. 4188-4198 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2

    Mølgaard, A., Arnau, J., Lauritzen, C., Larsen, Sine, Petersen, G. & Pedersen, J., 2007, In: Biochemical Journal. 401, 3, p. 645-50 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2006
  48. Automation of sample mounting for macromolecular crystallography

    Cipriani, F., Felisaz, F., Launer, L., Aksoy, J., Caserotto, H., Cusack, S., Dallery, M., di-Chiaro, F., Guijarr, M., Huet, J., Larsen, Sine, Lentini, M., McCarthy, J., McSweeeney, S., Ravelli, R., Renier, M., Taffut, C., Thompson, A., Leonard, G. A. & Walsh, M. A., 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, 10, p. 1251-1259 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. High-throughput sample handling and data collection at synchrotrons: embedding the ESRF in the high-throughput gene-to-structure pipeline

    Beteva, A., Cipriani, F., Cusack, S., Delageniere, S., Gabadinho, J., Gordon, E. J., Guijarro, M., Hall, D. R., Larsen, Sine, Launer, L., Lavault, C. B., Leonard, G. A., Mairs, T., McCarthy, A., McCarthy, J., Meyer, J., Mitchell, E., Monaco, S., Nurizzo, D., Pernot, P., Pieritz, R., Ravelli, G. .. B., Rey, V., Shepard, W., Spruce, D., Stuart, D. I., Svensson, O., Theveneau, P., Thibault, X., Turkenburg, J., Walsh, M. & McSweeney, S. M., 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, 10, p. 1162-1169 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Structure of the Sulfolobus solfataricus alpha-glucosidase: Implications for domain conservation and substrate recognition in GH31

    Ernst, H. A., Lo Leggio, Leila, Willemoës, Martin, Leonard, G. A., Blum, P. & Larsen, Sine, 2006, In: Journal of Molecular Biology. 358, 4, p. 1106-24

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    The extraordinary specificity of xanthine phosphoribosyltransferase from Bacillus subtilis elucidated by reaction kinetics, ligand binding, and crystallography

    Arent, S., Kadziola, Anders, Larsen, Sine, Neuhard, J. & Jensen, K. F., 2006, In: Biochemistry. 45, 21, p. 6615-6627

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2005
  53. Published

    Tetra-tert-butyl-di-μ-hydroxo digallium(III) and 1,12-diaza-3,4:9,10- dibenzo-5,8-dioxo-cyclo-pentadecane. Structure and isomers of the coordination compound

    Sun, H., Thulstrup, Peter Waaben, Larsen, Sine & Larsen, Erik, 1 Nov 2005, In: International Journal of Molecular Sciences. 6, 11, p. 276-290 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    2-(1-Naphthyl)propionic acid

    Riis, E. P. & Larsen, Sine, 2005, In: Acta Crystallographica. Section E: Structure Reports Online. E61, p. o1396-o1397

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Allosteric properties of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermoacidophilic archeon Sulfolobus solfataricus

    Jensen, K. F., Arent, S., Larsen, Sine & Schack, L., 2005, In: FEBS Journal. 272, p. 1440-1453

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Allosteric regulation and communication between subunits in uracil phosphoribosyltransferase from Sulfolobus solfataricus

    Arent, S., Harris, P., Jensen, K. F. & Larsen, Sine, 2005, In: Biochemistry. 44, 3, p. 883-892

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Allosteric regulation of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermophilic archaeon Sulfolobus solfataricus

    Jensen, K. F., Arent, S., Larsen, Sine & Schack, L., 2005, In: FEBS Journal. 272, 6, p. 1440-1453

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Characterization of different crystal forms of the a-glucosidase MalA from Sulfolobus solfataricus

    Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica Section F. 61, p. 1039-1042

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

    Ernst, H. A., Willemoës, Martin, Lo Leggio, Leila, Leonard, G., Blum, P. & Larsen, Sine, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 12, p. 1039-42 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

    Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, Anders, Jacobsen, T. A., Langkilde, Annette Eva, Larsen, Sine, Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A

    Møller, L. B., Bukrinsky, J. T., Mølgaard, A., Paulsen, M., Lund, C., Tümer, Z., Larsen, Sine & Horn, N., 2005, In: Human Mutation. 26, p. 84-93

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii.

    Kadziola, Anders, Jepsen, C. H., Johansson, E., McGuire, J., Larsen, Sine & Hove-Jensen, B., 2005, In: Journal of Molecular Biology. 354, 4, p. 815-28 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Probing the structure of glucan lyases by sequence analysis, circular dichroism and proteolysis

    Ernst, H. A., Lo Leggio, Leila, Yu, S., Finnie, C., Svensson, B. & Larsen, Sine, 2005, In: Biologia. 60, Suppl. 16, p. 149-159

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Structures of dCTP deaminase from Escherichia coli with bound substrate and product

    Johansson, E. H., Fanø, M., Bynck, J. H., Neuhard, J., Larsen, Sine, Sigurdskjold, B., Christensen, U. & Willemoës, M., 2005, In: The Journal of Biological Chemistry. 280, p. 3051-3059

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. 2004
  66. Published

    Bis(quininium) (R,R)-tartrate monohydrate

    Ryttersgaard, C. & Larsen, Sine, 2004, In: Acta Crystallographica. Section E: Structure Reports Online. 60, p. 04-05

    Research output: Contribution to journalJournal articleResearchpeer-review

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