Signe Regner Michaelsen

Signe Regner Michaelsen

Postdoc


  1. 2023
  2. Published

    Differential expression of checkpoint markers in the normoxic and hypoxic microenvironment of glioblastomas

    Petterson, S. A., Sørensen, M. D., Burton, M., Thomassen, M., Kruse, T. A., Michaelsen, Signe Regner & Kristensen, Bjarne Winther, 2023, In: Brain Pathology. 33, 1, 14 p., e13111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

    Puig Blasco, Laia, Piotrowski, Kris, Michaelsen, Signe Regner, Bager, Nicolai Stilling Schou, Areškevičiūtiė, A., Thorseth, M., Sun, X., Keller, U. A. D., Kristensen, Bjarne Winther, Madsen, D. H., Gnosa, S. P. & Kveiborg, Marie, 2023, In: International Journal of Cancer. 153, 12, p. 2068–2081 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2022
  5. Published

    Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors

    Knudsen, A. M., Halle, B., Cédile, O., Burton, M., Baun, C., Thisgaard, H., Anand, Atul, Hubert, C., Thomassen, M., Michaelsen, Signe Regner, Olsen, B. B., Dahlrot, R. H., Bjerkvig, R., Lathia, J. D. & Kristensen, Bjarne Winther, 2022, In: Neuro-Oncology. 24, 7, p. 1074-1087 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2021
  7. Published

    A Prognostic Model for Glioblastoma Patients Treated With Standard Therapy Based on a Prospective Cohort of Consecutive Non-Selected Patients From a Single Institution

    Abedi, A. A., Grunnet, K., Christensen, I. J., Michaelsen, Signe Regner, Muhic, A., Møller, Søren, Hasselbalch, B., Poulsen, H. S. & Urup, T., 2021, In: Frontiers in Oncology. 11, 597587.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Drug Repurposing Screen Reveals Glioblastoma Cell Line Susceptibility to Statins

    Harwood, Dylan Scott Lykke, Michaelsen, Signe Regner, Mundt, F. & Kristensen, Bjarne Winther, 2021, In: Neuro-Oncology. 23, S6, p. 77-78 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  9. 2020
  10. Published

    Angiotensinogen promoter methylation predicts bevacizumab treatment response of patients with recurrent glioblastoma

    Urup, T., Gillberg, Linn, Kaastrup, K., Lü, M. J. S., Michaelsen, Signe Regner, Andrée Larsen, V., Christensen, I. J., Broholm, H., Lassen, Ulrik Niels, Grønbæk, Kirsten & Poulsen, H. S., 2020, In: Molecular Oncology. 14, 5, p. 964-973

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility – a prospective, translational study

    Nørøxe, D. S., Yde, C. W., Østrup, O., Michaelsen, Signe Regner, Schmidt, A. Y., Kinalis, S., Torp, M. H., Skjøth‐Rasmussen, J., Brennum, J., Hamerlik, P., Poulsen, H. S., Nielsen, Finn Cilius & Lassen, Ulrik Niels, 2020, In: Molecular Oncology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2019
  13. Published

    VEGF-C as a putative therapeutic target in cancer

    Michaelsen, Signe Regner, Poulsen, H. S. & Hamerlik, P., 18 Jun 2019, In: OncoTarget. 10, 40, p. 3988-3990 3 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  14. Published

    Angiotensinogen promoter methylation to predict bevacizumab response in recurrent glioblastoma patients

    Urup, T., Gillberg, Linn, Kaastrup, K., Lu, M. S., Michaelsen, Signe Regner, Larsen, V. A., Christensen, I. J., Broholm, H., Lassen, Ulrik Niels, Grønbæk, Kirsten & Poulsen, H. S., 2019, In: Neuro-Oncology. 21, Supplement 6, p. vi149

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study

    Nørøxe, D. S., Østrup, O., Yde, C. W., Ahlborn, L. B., Nielsen, Finn Cilius, Michaelsen, Signe Regner, Larsen, V. A., Skjøth-Rasmussen, J., Brennum, J., Hamerlik, P., Poulsen, H. S. & Lassen, Ulrik Niels, 2019, In: OncoTarget. 10, 43, p. 4397-4406 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Clinical Characteristics of Gliosarcoma and Outcomes From Standardized Treatment Relative to Conventional Glioblastoma

    Frandsen, S., Broholm, H., Larsen, V. A., Grunnet, K., Moller, S., Poulsen, H. S. & Michaelsen, Signe Regner, 2019, In: Frontiers in Oncology. 9, p. 1-11 01425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Extracranial metastases in glioblastoma—Two case stories

    Schou Nørøxe, D., Michaelsen, Signe Regner, Broholm, H., Møller, Søren, Skovgaard Poulsen, H. & Lassen, Ulrik Niels, 2019, In: Clinical Case Reports. 7, 2, p. 289-294 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2018
  19. Published

    Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan

    Toft, A., Urup, T., Christensen, I. J., Michaelsen, Signe Regner, Lukram, B., Grunnet, K., Kosteljanetz, M., Larsen, V. A., Lassen, Ulrik Niels, Broholm, H. & Poulsen, H. S., 2018, In: Cancer Investigation. 36, 2, p. 165-174 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    DNA methylation levels of the ELMO gene promoter CpG islands in human glioblastomas

    Michaelsen, Signe Regner, Aslan, D., Urup, T., Poulsen, H. S., Grønbæk, Kirsten, Broholm, H. & Kristensen, L. S., 2018, In: International Journal of Molecular Sciences . 19, 3, 13 p., 679.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular profiling of short-term and long-term surviving patients identifies CD34 mRNA level as prognostic for glioblastoma survival

    Michaelsen, Signe Regner, Urup, T., Olsen, L. R., Broholm, H., Lassen, Ulrik Niels & Poulsen, H. S., 2018, In: Journal of Neuro-Oncology. 137, 3, p. 533-542 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

    Staberg, M., Rasmussen, R. D., Michaelsen, Signe Regner, Pedersen, H., Jensen, K. E., Villingshøj, M., Skjoth-Rasmussen, J., Brennum, J., Vitting-Seerup, K., Poulsen, H. S. & Hamerlik, P., 2018, In: Molecular Oncology. 12, 3, p. 406-420 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance

    Michaelsen, Signe Regner, Staberg, M., Pedersen, H., Jensen, K. E., Majewski, W., Broholm, H., Nedergaard, M. K., Meulengracht, C., Urup, T., Villingshøj, M., Lukacova, S., Skjøth-Rasmussen, J., Brennum, J., Kjær, Andreas, Lassen, Ulrik Niels, Stockhausen, M., Poulsen, H. S. & Hamerlik, P., 2018, In: Neuro-Oncology. 20, 11, p. 1462-1474

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2017
  25. Published

    Transcriptional changes induced by bevacizumab combination therapy in responding and non-responding recurrent glioblastoma patients

    Urup, T., Staunstrup, L. M., Michaelsen, Signe Regner, Vitting-Seerup, K., Bennedbæk, M., Toft, A., Olsen, L. R., Jønson, L., Issazadeh-Navikas, Shohreh, Broholm, H., Hamerlik, P., Poulsen, H. S. & Lassen, Ulrik Niels, 18 Apr 2017, In: BMC Cancer. 17, 10 p., 278.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2016
  27. Published

    Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients

    Urup, T., Michaelsen, Signe Regner, Olsen, L. R., Toft, A., Christensen, I. J., Grunnet, K., Winther, Ole, Broholm, H., Kosteljanetz, M., Issazadeh-Navikas, Shohreh, Poulsen, H. S. & Lassen, Ulrik Niels, Oct 2016, In: Molecular Oncology. 10, 8, p. 1160-1168

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma

    Kristensen, L. S., Michaelsen, Signe Regner, Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, Kirsten & Broholm, H., Mar 2016, In: Journal of Neuropathology and Experimental Neurology. 75, 3, p. 246-55 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Comparison of (18)F-FET and (18)F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma

    Nedergaard, M. K., Michaelsen, Signe Regner, Perryman, L., Erler, Janine, Poulsen, H. S., Stockhausen, M., Lassen, Ulrik Niels & Kjær, Andreas, Mar 2016, In: Nuclear Medicine and Biology. 43, 3, p. 198-205 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma

    Persson, M., Nedergaard, M. K., Brandt-Larsen, M., Skovgaard, D., Jørgensen, Jesper Tranekjær, Michaelsen, Signe Regner, Madsen, J., Lassen, Ulrik Niels, Poulsen, H. S. & Kjær, Andreas, Feb 2016, In: Journal of Nuclear Medicine. 57, 2, p. 272-278 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro

    Staberg, M., Michaelsen, Signe Regner, Olsen, L. S., Nedergaard, M. K., Villingshøj, M., Stockhausen, M., Hamerlik, P. & Poulsen, H. S., 2016, In: Cancer Cell International. 16, 34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Development and validation of a prognostic model for recurrent glioblastoma patients treated with bevacizumab and irinotecan

    Urup, T., Dahlrot, R. H., Grunnet, K., Christensen, I. J., Michaelsen, Signe Regner, Toft, A., Larsen, V. A., Broholm, H., Kosteljanetz, M., Hansen, S., Poulsen, H. S. & Lassen, Ulrik Niels, 2016, In: Acta Oncologica. 55, 4, p. 418-22 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2015
  34. Published

    18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma

    Nedergaard, M. K., Michaelsen, Signe Regner, Urup, T., Broholm, H., El Ali, Henrik H., Poulsen, H. S., Stockhausen, M., Kjær, Andreas & Lassen, Ulrik Niels, 2015, In: P L o S One. 10, 2, p. 1-16 16 p., e0115315.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2014
  36. Published

    Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

    Christensen, C. L., Kwiatkowski, N., Abraham, B. J., Carretero, J., Al-Shahrour, F., Zhang, T., Chipumuro, E., Herter-Sprie, G. S., Akbay, E. A., Altabef, A., Zhang, J., Shimamura, T., Capelletti, M., Reibel, J. B., Cavanaugh, J. D., Gao, P., Liu, Y., Michaelsen, S. R., Poulsen, H. S., Aref, A. R. & 6 others, Barbie, D. A., Bradner, J. E., George, R. E., Gray, N. S., Young, R. A. & Wong, K., Dec 2014, In: Cancer Cell. 26, 6, p. 909-922 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The Use of Longitudinal 18F-FET MicroPET Imaging to Evaluate Response to Irinotecan in Orthotopic Human Glioblastoma Multiforme Xenografts

    Nedergaard, M. K., Kristoffersen, K., Michaelsen, Signe Regner, Madsen, J., Poulsen, H. S., Stockhausen, M., Lassen, Ulrik Niels & Kjær, Andreas, 2014, In: PloS one. 9, 6, p. 1-10 10 p., e100009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The impact of bevacizumab treatment on survival and quality of life in newly diagnosed glioblastoma patients

    Poulsen, H. S., Urup, T., Michaelsen, Signe Regner, Staberg, M., Villingshøj, M. & Lassen, Ulrik Niels, 2014, In: Cancer Management and Research. 6, p. 373-387 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. 2013
  40. Published

    Clinical variables serve as prognostic factors in a model for survival from glioblastoma multiforme: an observational study of a cohort of consecutive non-selected patients from a single institution

    Michaelsen, Signe Regner, Christensen, I. J., Grunnet, K., Stockhausen, M., Broholm, H., Kosteljanetz, M. & Poulsen, H. S., 2013, In: B M C Cancer. 13, p. 1-11 11 p., 402.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2012
  42. Published

    Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells

    Michaelsen, Signe Regner, Christensen, C. L., Sehested, M., Cramer, F., Poulsen, T. T., Patterson, A. V. & Poulsen, H. S., 2012, In: Journal of Gene Medicine (Online). 14, 7, p. 445-58 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 108812376