Ruth Loos
Professor
Loos Group
Blegdamsvej 3B, Mærsk Tårnet, 7. sal
2200 København N.
- 2024
- Published
A genomic mutational constraint map using variation in 76,156 human genomes
Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y., Banks, E., Donnelly, S. & 18 others, , 2024, In: Nature. 625, 7993, p. 92-100 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Carrasquilla, Germán D., Ängquist, Lars, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Loos, Ruth, 2024, In: Diabetologia. 67, p. 864–873 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children
Renier, T. J., Yeum, D., Emond, J. A., Lansigan, R. K., Ballarino, G. A., Carlson, D. D., Loos, Ruth & Gilbert-Diamond, D., 2024, In: International Journal of Obesity. 48, p. 71-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., Schroeder, P., Vanderwerff, B. & 31 others, , 2024, In: Nature. 627, 8003, p. 347-357 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Hughes, O., Bentley, A. R., Breeze, C. E., Aguet, F., Xu, X., Nadkarni, G., Sun, Q., Lin, B. M., Gilliland, T., Meyer, M. C., Du, J., Raffield, L. M., Kramer, H., Morton, R. W., Gouveia, M. H., Atkinson, E. G., Valladares-Salgado, A., Wacher-Rodarte, N., Dueker, N. D., Guo, X. & 54 others, , 2024, In: Cell Genomics. 4, 1, 13 p., 100468.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
ADA/EASD PMDI, A. P., Merino, Jordi, Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen, Clemmensen, Christoffer, Hansen, Torben, Nakabuye, Mariam, Loos, Ruth, Guasch Ferre, Marta & Vilsbøll, Tina, 2024, In: Communications Medicine. 4, 1, 8 p., 66.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., McQuillin, A., Bass, N. & 58 others, , 2024, In: Nature Genetics. 56, 2, p. 222–233Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Persistent thinness and anorexia nervosa differ on a genomic level
Hübel, C., Abdulkadir, M., Herle, M., Palmos, A. B., Loos, Ruth, Breen, G., Micali, Nadia & Bulik, C. M., 2024, In: European Journal of Human Genetics. 32, 1, p. 117-124Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
Bjørnsbo, K. S., Brøns, C., Aadahl, M., Kampmann, F. B., Friis Bryde Nielsen, C., Lundbergh, B., Christensen, R. W., Kårhus, L. L., Madsen, A. L., Hansen, C. S., Nørgaard, K., Jørgensen, N. R., Suetta, C., Kjaer, M., Grarup, N., Kanters, J., Larsen, M., Køber, L., Kofoed, K. F., Loos, R. & 3 others, , 2024, In: BMJ Open. 14, 1, 10 p., e078501.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Lennon, N. J., Kottyan, L. C., Kachulis, C., Abul-Husn, N. S., Arias, J., Belbin, G., Below, J. E., Berndt, S. I., Chung, W. K., Cimino, J. J., Clayton, E. W., Connolly, J. J., Crosslin, D. R., Dikilitas, O., Velez Edwards, D. R., Feng, Q. P., Fisher, M., Freimuth, R. R., Ge, T., Glessner, J. T. & 59 others, , 2024, In: Nature Medicine. 30, 2, p. 480-487 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop
Aagaard, K. M., Barkin, S. L., Burant, C. F., Carnell, S., Demerath, E., Donovan, S. M., Eneli, I., Francis, L. A., Gilbert-Diamond, D., Hivert, M. F., LeBourgeois, M. K., Loos, R. J. F., Lumeng, J. C., Miller, A. L., Okely, A. D., Osganian, S. K., Ramirez, A. G., Trasande, L., Van Horn, L. V., Wake, M. & 2 others, , 2024, In: Obesity Reviews. 25, 4, 21 p., e13690.Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Published
A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y-D. I. & 31 others, , 2023, bioRxiv, 71 p.Research output: Working paper › Preprint › Research
- Published
Ancestral diversity in lipoprotein(a) studies helps address evidence gaps
Lee, M. P., Dimos, S. F., Raffield, L. M., Wang, Z., Ballou, A. F., Downie, C. G., Arehart, C. H., Correa, A., De Vries, P. S., Du, Z., Gignoux, C. R., Gordon-Larsen, P., Guo, X., Haessler, J., Howard, A. G., Hu, Y., Kassahun, H., Kent, S. T., Lopez, J. A. G., Monda, K. L. & 14 others, , 2023, In: Open Heart. 10, 2, 11 p., e002382.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Approaches to addressing the rise in obesity levels
Apovian, C. M., Guo, X. R., Hawley, J. A., Karmali, S., Loos, Ruth & Waterlander, W. E., 2023, In: Nature Reviews Endocrinology. 19, p. 76-81Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation
Kittrell, H. D., DiMenna, F. J., Arad, A. D., Oh, W., Hofer, I., Walker, R. W., Loos, Ruth, Albu, J. B. & Nadkarni, G. N., 2023, In: Nutrition, Metabolism and Cardiovascular Diseases. 33, 11, p. 2189-2198Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distilling causality between physical activity traits and obesity via Mendelian randomization
Wang, Z., Davey Smith, G., Loos, Ruth & den Hoed, M., 2023, In: Communications Medicine. 3, 6 p., 173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins
Figaroa, M. N. S., Gielen, M., Casas, L., Loos, Ruth, Derom, C., Weyers, S., Nawrot, T. S., Zeegers, M. P. & Bijnens, E. M., 2023, In: Environmental Health. 22, 13 p., 18.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations
Gerhart-Hines, Zach & Loos, Ruth, 2023, In: Current Opinion in Genetics and Development. 83, 102117.Research output: Contribution to journal › Editorial › Research
- Published
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R. M., Ahlqvist, E., Thorleifsson, G., Gao, Η., Εvangelou, Ε., Benyamin, B. & 78 others, , 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic insights into resting heart rate and its role in cardiovascular disease
van de Vegte, Y. J., Eppinga, R. N., van der Ende, M. Y., Hagemeijer, Y. P., Mahendran, Y., Salfati, E., Smith, A. V., Tan, V. Y., Arking, D. E., Ntalla, I., Appel, E. V., Schurmann, C., Brody, J. A., Rueedi, R., Polasek, O., Sveinbjornsson, G., Lecoeur, C., Ladenvall, C., Zhao, J. H., Isaacs, A. & 31 others, , 2023, In: Nature Communications. 14, 4646.Research output: Contribution to journal › Journal article › Research › peer-review
Genome-Wide Polygenic Risk Score for CKD in Individuals with APOL1 High-Risk Genotypes
Vy, H. M. T., Coca, S. G., Sawant, A., Sakhuja, A., Gutierrez, O. M., Cooper, R., Loos, Ruth, Horowitz, C. R., Do, R. & Nadkarni, G. N., 2023, In: Clinical Journal of American Society of Nephrology. .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X. J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., Pei, Y. & 168 others, , 2023, In: Nature Genetics. 55, 7, p. 1091-1105 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Disorders in CKD across the Lifespan
Verbitsky, M., Krishnamurthy, S., Krithivasan, P., Hughes, D., Khan, A., Marasà, M., Vena, N., Khosla, P., Zhang, J., Lim, T. Y., Glessner, J. T., Weng, C., Shang, N., Shen, Y., Hripcsak, G., Hakonarson, H., Ionita-Laza, I., Levy, B., Kenny, E. E., Loos, R. J. F. & 11 others, , 2023, In: Journal of the American Society of Nephrology : JASN. 34, 4, p. 607-618 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Wang, Y., Namba, S., Lopera-Maya, E. A., Kerminen, S., Tsuo, K., Läll, K., Kanai, M., Zhou, W., Wu, K. H. H., Favé, M. J., Bhatta, L., Awadalla, P., Brumpton, B. M., Deelen, P., Hveem, K., Lo Faro, V., Mägi, R., Murakami, Y., Sanna, S., Smoller, J. W. & 49 others, , 2023, In: Cell Genomics. 3, 1, 18 p., 100241.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD PMDI, A. P., 2023, In: Communications Medicine. 3, 17 p., 133.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores
Hrytsenko, Y., Shea, B., Elgart, M., Kurniansyah, N., Lyons, G., Morrison, A. C., Carson, A. P., Haring, B., Mitchel, B. D., Psaty, B. M., Jaeger, B. C., Gu, C. C., Kooperberg, C., Levy, D., Lloyd-Jones, D., Choi, E., Brody, J. A., Smith, J. A., Rotter, J. I., Moll, M. & 18 others, , 2023, medRxiv, 41 p.Research output: Working paper › Preprint › Research
- Published
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Jakubek, Y. A., Zhou, Y., Stilp, A., Bacon, J., Wong, J. W., Ozcan, Z., Arnett, D., Barnes, K., Bis, J. C., Boerwinkle, E., Brody, J. A., Carson, A. P., Chasman, D. I., Chen, J., Cho, M., Conomos, M. P., Cox, N., Doyle, M. F., Fornage, M., Guo, X. & 31 others, , 2023, In: Nature Genetics. 55, 11, p. 1912-1919 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
VA Million Veteran Program, V. M. V. P., 2023, medRxiv, 39 p.Research output: Working paper › Preprint › Research
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Barry, A., McNulty, M. T., Jia, X., Gupta, Y., Debiec, H., Luo, Y., Nagano, C., Horinouchi, T., Jung, S., Colucci, M., Ahram, D. F., Mitrotti, A., Sinha, A., Teeninga, N., Jin, G., Shril, S., Caridi, G., Bodria, M., Lim, T. Y., Westland, R. & 50 others, , 2023, In: Nature Communications. 14, 1, 2481.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program
Small, A. M., Peloso, G. M., Linefsky, J., Aragam, J., Galloway, A., Tanukonda, V., Wang, L. C., Yu, Z., Sunitha Selvaraj, M., Farber-Eger, E. H., Baker, M. T., Setia-Verma, S., Lee, S. S. K., Preuss, M., Ritchie, M. D., Damrauer, S. M., Rader, D. J., Wells, Q. S., Loos, R., Lubitz, S. A. & 5 others, , 2023, In: Circulation. 147, 12, p. 942-955 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium
Flanagan, E. W., Spann, R., Berry, S. E., Berthoud, H. R., Broyles, S., Foster, G. D., Krakoff, J., Loos, Ruth, Lowe, M. R., Ostendorf, D. M., Powell-Wiley, T. M., Redman, L. M., Rosenbaum, M., Schauer, P. R., Seeley, R. J., Swinburn, B. A., Hall, K. & Ravussin, E., 2023, In: Obesity. 31, 12, p. 2895-2908Research output: Contribution to journal › Journal article › Research › peer-review
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes
Yu, M., Aguirre, M., Jia, M., Gjoni, K., Cordova-Palomera, A., Munger, C., Amgalan, D., Rosa Ma, X., Pereira, A., Tcheandjieu, C., Seidman, C., Seidman, J., Tristani-Firouzi, M., Chung, W., Goldmuntz, E., Srivastava, D., Loos, R. J. F., Chami, N., Cordell, H., Dreßen, M. & 8 others, , 2023, In: Circulation: Genomic and Precision Medicine. 16, 3, p. 258-266 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
India-Aldana, S., Yao, M., Midya, V., Colicino, E., Chatzi, L., Chu, J., Gennings, C., Jones, D. P., Loos, Ruth, Setiawan, V. W., Smith, M. R., Walker, R. W., Barupal, D., Walker, D. I. & Valvi, D., 2023, In: Current Pollution Reports. 9, p. 510-568Research output: Contribution to journal › Review › Research › peer-review
- Published
Polygenic Scores Help Reduce Racial Disparities in Predictive Accuracy of Automated Type 1 Diabetes Classification Algorithms
Deutsch, A. J., Stalbow, L., Majarian, T. D., Mercader, J. M., Manning, A. K., Florez, J. C., Loos, Ruth & Udler, M. S., 2023, In: Diabetes Care. 46, 4, p. 794-800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Precision medicine in complex diseases - Molecular subgrouping for improved prediction and treatment stratification
Johansson, Å., Andreassen, O. A., Brunak, Søren, Franks, P. W., Hedman, H., Loos, Ruth, Meder, B., Melén, E., Wheelock, C. E. & Jacobsson, B., 2023, In: Journal of Internal Medicine. 294, 4, p. 378-396 19 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study
Wang, Y., Selvaraj, M. S., Li, X., Li, Z., Holdcraft, J. A., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Cade, B. E., Carlson, J. C., Carson, A. P., Chen, Y. D. I., Curran, J. E., de Vries, P. S., Dutcher, S. K., Ellinor, P. T., Floyd, J. S., Fornage, M. & 31 others, , 2023, In: American Journal of Human Genetics. 110, 10, p. 1704-1717 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD Precision Medicine in Diabetes Initiative, A. P. M. I. D. I., 2023, medRxiv.Research output: Working paper › Preprint › Research
- Published
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Tobias, D. K., Merino, J., Ahmad, A., Aiken, C., Benham, J. L., Bodhini, D., Clark, A. L., Colclough, K., Corcoy, R., Cromer, S. J., Duan, D., Felton, J. L., Francis, E. C., Gillard, P., Gingras, V., Gaillard, R., Haider, E., Hughes, A., Ikle, J. M., Jacobsen, L. M. & 180 others, , 2023, In: Nature Medicine. 29, 10, p. 2438-2457 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
Gupta, Y., Friedman, D. J., McNulty, M. T., Khan, A., Lane, B., Wang, C., Ke, J., Jin, G., Wooden, B., Knob, A. L., Lim, T. Y., Appel, G. B., Huggins, K., Liu, L., Mitrotti, A., Stangl, M. C., Bomback, A., Westland, R., Bodria, M., Marasa, M. & 60 others, , 2023, In: Nature Communications. 14, 8 p., 7836.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
Stalbow, L. A., Preuss, M. H., Smit, Roelof Adriaan Johan, Chami, N., Bjørkhaug, L., Aukrust, I., Gloyn, A. L. & Loos, Ruth, 2023, In: Diabetologia. 66, p. 116-126 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
Weinstock, J. S., Laurie, C. A., Broome, J. G., Taylor, K. D., Guo, X., Shuldiner, A. R., O'Connell, J. R., Lewis, J. P., Boerwinkle, E., Barnes, K. C., Chami, N., Kenny, E. E., Loos, R. J. F., Fornage, M., Redline, S., Cade, B. E., Gilliland, F. D., Chen, Z., Gauderman, W. J., Kumar, R. & 31 others, , 2023, In: Science Advances. 9, 17, p. eabm4945Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes
Huerta-Chagoya, A., Schroeder, P., Mandla, R., Deutsch, A. J., Zhu, W., Petty, L., Yi, X., Cole, J. B., Udler, M. S., Dornbos, P., Porneala, B., DiCorpo, D., Liu, C. T., Li, J. H., Szczerbiński, L., Kaur, V., Kim, J., Lu, Y., Martin, A., Eizirik, D. L. & 31 others, , 2023, In: Diabetologia. 66, p. 1273-1288 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program
Armstrong, N. D., Srinivasasainagendra, V., Ammous, F., Assimes, T. L., Beitelshees, A. L., Brody, J., Cade, B. E., Ida Chen, Y-D., Chen, H., de Vries, P. S., Floyd, J. S., Franceschini, N., Guo, X., Hellwege, J. N., House, J. S., Hwu, C-M., Kardia, S. L. R., Lange, E. M., Lange, L. A., McDonough, C. W. & 24 others, , 2023, In: Frontiers in Genetics. 14, 1278215.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D. & 32 others, , 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A saturated map of common genetic variants associated with human height
Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, , 2022, In: Nature. 610, p. 704–712Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium
Fernández-Rhodes, L., Graff, M., Buchanan, V. L., Justice, A. E., Highland, H. M., Guo, X., Zhu, W., Chen, H. H., Young, K. L., Adhikari, K., Palmer, N. D., Below, J. E., Bradfield, J., Pereira, A. C., Glover, L. S., Kim, D., Lilly, A. G., Shrestha, P., Thomas, A. G., Zhang, X. & 96 others, , 2022, In: Human Genetics and Genomics Advances. 3, 2, 21 p., 100099.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical Characterization of Copy Number Variants Associated with Neurodevelopmental Disorders in a Large-scale Multiancestry Biobank
Birnbaum, R., Mahjani, B., Loos, Ruth & Sharp, A. J., 2022, In: JAMA Psychiatry. 79, 3, p. 250-259Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., Wuttke, M. & 31 others, , 2022, In: Communications Biology . 5, p. 580 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance
Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J. M., Bidault, G., Vázquez-Borrego, M. C., Dias, A. R., Pucker, B., Dale, M., Campbell, M., Carobbio, S., Lin, Y. H., Vacca, M., Aron-Wisnewsky, J., Mora, S., Masiero, M. M., Emmanouilidou, A. & 8 others, , 2022, In: Nature Metabolism. 4, 4, p. 476-494 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S. & 31 others, , 2022, In: Nature Communications. 13, 1, 18 p., 5144.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, , 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomics and phenomics of body mass index reveals a complex disease network
Huang, J., Huffman, J. E., Huang, Y., Do Valle, Í., Assimes, T. L., Raghavan, S., Voight, B. F., Liu, C., Barabási, A. L., Huang, R. D. L., Hui, Q., Nguyen, X. M. T., Ho, Y. L., Djousse, L., Lynch, J. A., Vujkovic, M., Tcheandjieu, C., Tang, H., Damrauer, S. M., Reaven, P. D. & 19 others, , 2022, In: Nature Communications. 13, 1, 10 p., 7973.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Zhou, W., Kanai, M., Wu, K. H. H., Rasheed, H., Tsuo, K., Hirbo, J. B., Wang, Y., Bhattacharya, A., Zhao, H., Namba, S., Surakka, I., Wolford, B. N., Lo Faro, V., Lopera-Maya, E. A., Läll, K., Favé, M. J., Partanen, J. J., Chapman, S. B., Karjalainen, J., Kurki, M. & 54 others, , 2022, In: Cell Genomics. 2, 10, 20 p., 100192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, , 2022, In: Genome Biology. 23, 1, 42 p., 268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., Pampana, A., Gibson, C. J., Griffin, G. K., Clarke, S. L., Bhattacharya, R., Assimes, T. L., Emery, L. S., Stilp, A. M., Wong, Q., Broome, J. & 32 others, , 2022, In: Science Advances. 8, 14, eabl6579.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, , 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Population-Based Penetrance of Deleterious Clinical Variants
Forrest, I. S., Chaudhary, K., Vy, H. M. T., Petrazzini, B. O., Bafna, S., Jordan, D. M., Rocheleau, G., Loos, Ruth, Nadkarni, G. N., Cho, J. H. & Do, R., 2022, In: JAMA. 327, 4, p. 350-359 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts
Silventoinen, K., Piirtola, M., Jelenkovic, A., Sund, R., Tarnoki, A. D., Tarnoki, D. L., Medda, E., Nisticò, L., Toccaceli, V., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Gatz, M., Butler, D. A., Lee, J., Lee, S. J., Sung, J., Franz, C. E. & 31 others, , 2022, In: Scientific Reports. 12, 1, 9 p., 13148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data
Huang, L., Rosen, J. D., Sun, Q., Chen, J., Wheeler, M. M., Zhou, Y., Min, Y. I., Kooperberg, C., Conomos, M. P., Stilp, A. M., Rich, S. S., Rotter, J. I., Manichaikul, A., Loos, R. J. F., Kenny, E. E., Blackwell, T. W., Smith, A. V., Jun, G., Sedlazeck, F. J., Metcalf, G. & 6 others, , 2022, In: American Journal of Human Genetics. 109, 6, p. 1175-1181 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations
Wang, Z., Choi, S. W., Chami, N., Boerwinkle, E., Fornage, M., Redline, S., Bis, J. C., Brody, J. A., Psaty, B. M., Kim, W., McDonald, M. L. N., Regan, E. A., Silverman, E. K., Liu, C. T., Vasan, R. S., Kalyani, R. R., Mathias, R. A., Yanek, L. R., Arnett, D. K., Justice, A. E. & 21 others, , 2022, In: Frontiers in Endocrinology. 13, 12 p., 863893.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The energy balance model of obesity: beyond calories in, calories out
Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, Ruth, Mangelsdorf, D. J., O'Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., Speakman, J. R. & Tobias, D. K., 2022, In: American Journal of Clinical Nutrition. 115, 5, p. 1243-1254 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study
Abdulkadir, M., Hübel, C., Herle, M., Loos, Ruth, Breen, G., Bulik, C. M. & Micali, N., 2022, In: American Journal of Human Genetics. 109, 7, p. 1242-1254 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole genome sequence analysis of blood lipid levels in >66,000 individuals
Selvaraj, M. S., Li, X., Li, Z., Pampana, A., Zhang, D. Y., Park, J., Aslibekyan, S., Bis, J. C., Brody, J. A., Cade, B. E., Chuang, L. M., Chung, R. H., Curran, J. E., de las Fuentes, L., de Vries, P. S., Duggirala, R., Freedman, B. I., Graff, M., Guo, X., Heard-Costa, N. & 27 others, , 2022, In: Nature Communications. 13, 18 p., 5995.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
Wheeler, M. M., Stilp, A. M., Rao, S., Halldórsson, B. V., Beyter, D., Wen, J., Mihkaylova, A. V., McHugh, C. P., Lane, J., Jiang, M. Z., Raffield, L. M., Jun, G., Sedlazeck, F. J., Metcalf, G., Yao, Y., Bis, J. B., Chami, N., de Vries, P. S., Desai, P., Floyd, J. S. & 39 others, , 2022, In: Nature Communications. 13, 18 p., 7592.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts
Silventoinen, K., Bogl, L. H., Jelenkovic, A., Vuoksimaa, E., Latvala, A., Li, W., Tan, Q., Zhang, D., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Rebato, E., Corley, R. P., Huibregtse, B. M., Hopper, J. L., Tyler, J. & 34 others, , 2021, In: Hormones and Behavior. 136, 105054.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study identifies 48 common genetic variants associated with handedness
Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., de Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M. & 98 others, , 2021, In: Nature Human Behaviour. 5, p. 59-70Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Liao, R. G., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Andrews, S. J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E. C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M. A., Wendt, F. R., Savage, J., Sloofman, L. & 41 others, , 2021, In: Nature. 600, p. 472-477Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., Thio, C. H. L., Kleber, M. E., Winkler, T. W., Wanner, V., Chai, J-F., Chu, A. Y., Cocca, M., Feitosa, M. F., Ghasemi, S., Hoppmann, A., Horn, K., Li, M., Nutile, T., Scholz, M. & 31 others, , 2021, In: Kidney International. 99, 4, p. 926-939Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetics of obesity: from discovery to biology
Loos, Ruth & Yeo, G. S. H., 2021, In: Nature Reviews Genetics. 23, p. 120-133Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla, I., Weng, L. C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O. & 167 others, , 1 Dec 2020, In: Nature Communications. 11, 1, 2542.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M. & 34 others, , 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic loci that increase obesity risk but protect against cardiometabolic comorbidities are embedded in regulatory regions of adipocyte function: P19.049.B
Huang, L. O., Rauch, A., Mazzaferro, E., Bayrak, C. S., Carribio, S., Preuss, M., Chami, N., Wang, Z., Schnick, U., Yang, N., Itan, Y., Vidal-Puig, A., den Hoed, M., Mandrup, S., Kilpelainen, T. O. & Loos, Ruth, 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 716-717 2 p.Research output: Contribution to journal › Conference abstract in journal › Research
- 2019
- Published
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J. & 263 others, , 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2615-2633Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F. & 32 others, , Apr 2019, In: Nature Genetics. 51, 4, p. 636-648 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, , 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disentangling the genetics of lean mass
Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, , 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. & 32 others, , 2019, In: Nature Communications. 10, 11 p., 376.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts
Silventoinen, K., Jelenkovic, A., Latvala, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Aaltonen, S., Piirtola, M., Freitas, D. L., Maia, J. A., Oncel, S. Y., Aliev, F., Ji, F., Ning, F., Pang, Z., Rebato, E., Saudino, K. J., Cutler, T. L. & 53 others, , 2019, In: Obesity. 27, 5, p. 855-865 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma
Kachroo, P., Hecker, J., Chawes, B. L., Ahluwalia, T. S., Cho, M. H., Qiao, D., Kelly, R. S., Chu, S. H., Virkud, Y. V., Huang, M., Barnes, K. C., Burchard, E. G., Eng, C., Hu, D., Celedón, J. C., Daya, M., Levin, A. M., Gui, H., Williams, L. K., Forno, E. & 31 others, , 2019, In: Chest. 156, 6, p. 1068-1079 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts
Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y-M., Ullemar, V., Almqvist, C., Magnusson, P. K. E., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Bogl, L. H., Pietilainen, K. H., Vuoksimaa, E., Ji, F., Ning, F., Pang, Z., Nelson, T. L., Whitfield, K. E., Rebato, E., Llewellyn, C. H. & 38 others, , 1 Dec 2018, In: Scientific Reports. 8, 1, p. 1-8 8 p., 6300.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Mace, A., Sidore, C., Trompet, S., Mangino, M. & 266 others, , 1 Nov 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ethnic genome-wide association study for atrial fibrillation
Roselli, C., Chaffin, M. D., Weng, L-C., Aeschbacher, S., Ahlberg, G., Albert, C. M., Almgren, P., Alonso, A., Anderson, C. D., Aragam, K. G., Arking, D. E., Barnard, J., Bartz, T. M., Benjamin, E. J., Bihlmeyer, N. A., Bis, J. C., Bloom, H. L., Boerwinkle, E., Bottinger, E. B., Brody, J. A. & 34 others, , Sep 2018, In: Nature Genetics. 50, 9, p. 1225-1233Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts
Piirtola, M., Jelenkovic, A., Latvala, A., Sund, R., Honda, C., Inui, F., Watanabe, M., Tomizawa, R., Iwatani, Y., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Tarnoki, A. D., Tarnoki, D. L., Martin, N. G., Montgomery, G. W., Medland, S. E., Rasmussen, F., Tynelius, P., Tan, Q. & 38 others, , 12 Jul 2018, In: PLoS ONE. 13, 7, e0200140.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, Y. J., Winkler, T. W., de Las Fuentes, L., Bentley, A. R., Brown, M. R., Kraja, A. T., Schwander, K., Ntalla, I., Guo, X., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Feitosa, M. F., Kilpeläinen, T. O., Richard, M. A. & 30 others, , 2018, In: American Journal of Human Genetics. 102, 3, p. 375-400 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight
Huang, L. O., Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Physiological Genomics. 50, 3, p. 169-178 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Magill, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., Preuss, M. H. & 95 others, , 2018, In: Nature Genetics. 50, 11, p. 1505-1513Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genes that make you fat, but keep you healthy
Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Journal of Internal Medicine. 284, 5, p. 450-463 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts
Yokoyama, Y., Jelenkovic, A., Hur, Y-M., Sund, R., Fagnani, C., Stazi, M. A., Brescianini, S., Ji, F., Ning, F., Pang, Z., Knafo-Noam, A., Mankuta, D., Abramson, L., Rebato, E., Hopper, J. L., Cutler, T. L., Saudino, K. J., Nelson, T. L., Whitfield, K. E., Corley, R. P. & 40 others, , 2018, In: International Journal of Epidemiology. 47, 4, p. 1195-1206 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, , 19 Dec 2017, In: Scientific Data. 4, p. 1-20 20 p., 170179.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts
Silventoinen, K., Jelenkovic, A., Latvala, A., Sund, R., Yokoyama, Y., Ullemar, V., Almqvist, C., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Kandler, C., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Rebato, E., Stazi, M. A., Fagnani, C., Brescianini, S., Hur, Y-M. & 81 others, , Oct 2017, In: Twin Research and Human Genetics. 20, 5, p. 395-405 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 122 others, , Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 34 others, , 1 Apr 2017, In: PLOS Genetics. 13, 4, e1006528.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M-H., Chen, T. C., Chen, Y-D. I., Chung, J., Del Greco Miglianico, F., Eriksson, J., Ferrucci, L., Friedrich, N. & 31 others, , 29 Jun 2016, In: Aging Cell. 15, 5, p. 811-824 14 p., e1006166.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
Jelenkovic, A., Sund, R., Hur, Y-M., Yokoyama, Y., Hjelmborg, J. V. B., Möller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., Aaltonen, S., Stazi, M. A., Fagnani, C., D'Ippolito, C., Freitas, D. L., Maia, J. A., Ji, F., Ning, F., Pang, Z., Rebato, E. & 83 others, , 23 Jun 2016, In: Scientific Reports. 6, p. 1-13 13 p., 28496.Research output: Contribution to journal › Journal article › Research › peer-review
Testing the role of predicted gene knockouts in human anthropometric trait variation
NHLBI GO Exome Sequence Project, N. G. E. S. P., GOT2D, G., T2D-GENES, T. & GIANT Consortium, G. C., 15 May 2016, In: Human Molecular Genetics. 25, 10, p. 2082-2092 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., Kanoni, S. & 239 others, , 1 Feb 2016, In: Nature Communications. 7, p. 1-15 15 p., 10495.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, Å. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikäinen, L-P., Eriksson, J. & 157 others, , 2016, In: Nature Communications. 7, 14 p., 10494.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
Hägg, S., Ganna, A., Van Der Laan, S. W., Esko, T., Pers, Tune H, Locke, A. E., Berndt, S. I., Justice, A. E., Kahali, B., Siemelink, M. A., Pasterkamp, G., Strachan, D. P., Speliotes, E. K., North, K. E., Loos, Ruth, Hirschhorn, J. N., Pawitan, Y., Ingelsson, E. & GIANT Consortium, G. C., 1 Dec 2015, In: Human Molecular Genetics. 24, 23, p. 6849-60 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Quality control and conduct of genome-wide association meta-analyses
Winkler, T. W., Day, F. R., Croteau-Chonka, D. C., Wood, A. R., Locke, A. E., Mägi, R., Ferreira, T., Fall, T., Graff, M., Justice, A. E., Luan, J., Gustafsson, S., Randall, J. C., Vedantam, S., Workalemahu, T., Kilpeläinen, T., Scherag, A., Esko, T., Kutalik, Z., Heid, I. M. & 2 others, , May 2014, In: Nature Protocols (Online). 9, 5, p. 1192-1212 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study
Brahe, L. K., Ängquist, Lars, Larsen, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, Ruth, Handjieva-Darlenska, T., Jebb, S. A., Hlavaty, P., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, Thorkild I.A., Holst, C., Langin, D., Astrup, A. & Saris, W. H. M., 2013, In: British Journal of Nutrition. 110, 5, p. 790-796 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, D. G. R. A. M. (. C., Sep 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study
Larsen, L. H., Ängquist, Lars, Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, Ruth, Handjieva-Darlenska, T., Jebb, S. A., Kunesova, M., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, Thorkild I.A., Holst, C., Langin, D., Astrup, A. & Saris, W. H. M., 2012, In: American Journal of Clinical Nutrition. 95, 5, p. 1254-1260 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
FTO: the first gene contributing to common forms of human obesity
Loos, Ruth & Bouchard, C., May 2008, In: Obesity reviews : an official journal of the International Association for the Study of Obesity. 9, 3, p. 246-50 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Genome-wide association analysis identifies 20 loci that influence adult height
Diabetes Genetics Initiative, D. G. I., May 2008, In: Nature Genetics. 40, 5, p. 575-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study
Ruchat, S., Loos, Ruth, Rankinen, T., Vohl, M., Weisnagel, S. J., Després, J., Bouchard, C. & Pérusse, L., Apr 2008, In: Diabetic Medicine Online. 25, 4, p. 400-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Progress in the genetics of common obesity: size matters
Li, S. & Loos, Ruth, Apr 2008, In: Current Opinion in Lipidology. 19, 2, p. 113-21 9 p.Research output: Contribution to journal › Review › Research › peer-review
Twin-specific intrauterine 'growth' charts based on cross-sectional birthweight data
Gielen, M., Lindsey, P. J., Derom, C., Loos, Ruth, Souren, N. Y., Paulussen, A. D. C., Zeegers, M. P., Derom, R., Vlietinck, R. & Nijhuis, J. G., Apr 2008, In: Twin Research and Human Genetics. 11, 2, p. 224-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure
Vimaleswaran, K. S., Franks, P. W., Barroso, I., Brage, S., Ekelund, U., Wareham, N. J. & Loos, Ruth, Mar 2008, In: American Journal of Hypertension. 21, 3, p. 297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LDL-cholesterol concentrations: a genome-wide association study
Wellcome Trust Case-Control Consortium, W. T. C. C., 9 Feb 2008, In: Lancet Oncology. 371, 9611, p. 483-91 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mendelian randomisation studies of type 2 diabetes: future prospects
Sandhu, M. S., Debenham, S. L., Barroso, I. & Loos, Ruth, Feb 2008, In: Diabetologia. 51, 2, p. 211-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
Li, H., Wu, Y., Loos, Ruth, Hu, F. B., Liu, Y., Wang, J., Yu, Z. & Lin, X., Jan 2008, In: Diabetes. 57, 1, p. 264-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
Loos, Ruth, Rankinen, T., Pérusse, L., Tremblay, A., Després, J. & Bouchard, C., Nov 2007, In: Obesity. 15, 11, p. 2723-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities
Souren, N. Y., Paulussen, A. D. C., Loos, Ruth, Gielen, M., Beunen, G., Fagard, R., Derom, C., Vlietinck, R. & Zeegers, M. P., Oct 2007, In: Diabetologia. 50, 10, p. 2107-16 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Genetic and environmental determination of tracking in subcutaneous fat distribution during adolescence
Peeters, M. W., Beunen, G. P., Maes, H. H., Loos, Ruth, Claessens, A. L., Vlietinck, R. & Thomis, M. A., Sep 2007, In: The American Journal of Clinical Nutrition. 86, 3, p. 652-60 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
Loos, Ruth, Franks, P. W., Francis, R. W., Barroso, I., Gribble, F. M., Savage, D. B., Ong, K. K., O'Rahilly, S. & Wareham, N. J., Jul 2007, In: Diabetes. 56, 7, p. 1943-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A-M., Ness, A. R., Ebrahim, S., Lawlor, D. A. & 21 others, , 11 May 2007, In: Science (New York, N.Y.). 316, 5826, p. 889-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
Franks, P. W., Loos, Ruth, Brage, S., O'Rahilly, S., Wareham, N. J. & Ekelund, U., May 2007, In: Journal of applied physiology (Bethesda, Md. : 1985). 102, 5, p. 1921-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies
Mesa, J. L., Loos, Ruth, Franks, P. W., Ong, K. K., Luan, J., O'Rahilly, S., Wareham, N. J. & Barroso, I., Mar 2007, In: Diabetes. 56, 3, p. 884-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
Loos, Ruth, Ruchat, S., Rankinen, T., Tremblay, A., Pérusse, L. & Bouchard, C., Jan 2007, In: The American Journal of Clinical Nutrition. 85, 1, p. 26-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Twin birth weight standards
Gielen, M., Lindsey, P. J., Derom, C., Loos, Ruth, Derom, R., Nijhuis, J. G. & Vlietinck, R., 2007, In: Neonatology. 92, 3, p. 164-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Melanocortin-4 receptor gene and physical activity in the Québec Family Study
Loos, Ruth, Rankinen, T., Tremblay, A., Pérusse, L., Chagnon, Y. & Bouchard, C., Apr 2005, In: International journal of obesity (2005). 29, 4, p. 420-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Determinants of birthweight and intrauterine growth in liveborn twins
Loos, Ruth, Derom, C., Derom, R. & Vlietinck, R., Jan 2005, In: Paediatric and Perinatal Epidemiology. 19 Suppl 1, p. 15-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gender mix: does it modify birthweight--outcome association?
Derom, R., Derom, C., Loos, Ruth, Thiery, E., Vlietinck, R. & Fryns, J., Jan 2005, In: Paediatric and Perinatal Epidemiology. 19 Suppl 1, p. 37-40 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Growth in peak aerobic power during adolescence
Geithner, C. A., Thomis, M. A., Vanden Eynde, B., Maes, H. H. M., Loos, Ruth, Peeters, M., Claessens, A. L. M., Vlietinck, R., Malina, R. M. & Beunen, G. P., Sep 2004, In: Medicine and Science in Sports and Exercise. 36, 9, p. 1616-24 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
Loos, Ruth, Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C. & Bouchard, C., Jul 2004, In: The Journal of Nutrition. 134, 7, p. 1772-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
HERITAGE Family Study, H. F. S., Dec 2003, In: The Journal of clinical endocrinology and metabolism. 88, 12, p. 5935-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Obesity--is it a genetic disorder?
Loos, Ruth & Bouchard, C., Nov 2003, In: Journal of Internal Medicine. 254, 5, p. 401-25 25 p.Research output: Contribution to journal › Review › Research › peer-review
Heritability of somatotype components from early adolescence into young adulthood: a multivariate analysis on a longitudinal twin study
Peeters, M. W., Thomis, M. A., Claessens, A. L., Loos, Ruth, Maes, H. H. M., Lysens, R., Vanden Eynde, B., Vlietinck, R. & Beunen, G., 26 Jul 2003, In: Annals of Human Biology. 30, 4, p. 402-18 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Influence of chorionicity on the heritability estimates of blood pressure: a study in twins
Fagard, R. H., Loos, Ruth, Beunen, G., Derom, C. & Vlietinck, R., Jul 2003, In: Journal of Hypertension. 21, 7, p. 1313-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Markers for cardiovascular disease in monozygotic twins discordant for the use of third-generation oral contraceptives
Loos, Ruth, Verhaeghe, J., De Zegher, F., Beunen, G., Derom, C., Fagard, R., Mathieu, C. & Vlietinck, R., Jul 2003, In: Journal of Human Hypertension. 17, 7, p. 481-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Age at menarche in relation to anthropometric characteristics, competition level and boat category in elite junior rowers
Claessens, A. L., Bourgois, J., Beunen, G., Philippaerts, R., Thomis, M., Lefevre, J., Loos, Ruth & Vrijens, J., 15 Mar 2003, In: Annals of Human Biology. 30, 2, p. 148-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Retrospective determination of chorion type in twins using a simple questionnaire
Derom, C., Derom, R., Loos, Ruth, Jacobs, N. & Vlietinck, R., Feb 2003, In: Twin research : the official journal of the International Society for Twin Studies. 6, 1, p. 19-21 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring
Loos, Ruth, Phillips, D. I. W., Fagard, R., Beunen, G., Derom, C., Mathieu, C., Verhaeghe, J. & Vlietinck, R., Dec 2002, In: Diabetes Care. Supplement. 25, 12, p. 2191-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birth weight and body composition in young women: a prospective twin study
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Apr 2002, In: The American Journal of Clinical Nutrition. 75, 4, p. 676-82 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Body composition estimations by BIA versus anthropometric equations in body builders and other power athletes
Huygens, W., Claessens, A. L., Thomis, M., Loos, Ruth, Van Langendonck, L., Peeters, M., Philippaerts, R., Meynaerts, E., Vlietinck, R. & Beunen, G., Mar 2002, In: The Journal of Sports Medicine and Physical Fitness. 42, 1, p. 45-55 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice
Spittaels, K., Van den Haute, C., Van Dorpe, J., Terwel, D., Vandezande, K., Lasrado, R., Bruynseels, K., Irizarry, M., Verhoye, M., Van Lint, J., Vandenheede, J. R., Ashton, D., Mercken, M., Loos, Ruth, Hyman, B., Van der Linden, A., Geerts, H. & Van Leuven, F., 2002, In: Neuroscience. 113, 4, p. 797-808 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
Birth weight and blood pressure in young adults: a prospective twin study
Loos, Ruth, Fagard, R., Beunen, G., Derom, C. & Vlietinck, R., 2 Oct 2001, In: Circulation. 104, 14, p. 1633-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birth weight and body composition in young adult men--a prospective twin study
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Oct 2001, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 25, 10, p. 1537-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The influence of zygosity and chorion type on fat distribution in young adult twins consequences for twin studies
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Oct 2001, In: Twin research : the official journal of the International Society for Twin Studies. 4, 5, p. 356-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birthweight in liveborn twins: the influence of the umbilical cord insertion and fusion of placentas
Loos, Ruth, Derom, C., Derom, R. & Vlietinck, R., Sep 2001, In: BJOG : an international journal of obstetrics and gynaecology. 108, 9, p. 943-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Length of gestation and birthweight in dizygotic twins
Loos, Ruth, Derom, C., Eeckels, R., Derom, R. & Vlietinck, R., 18 Aug 2001, In: Lancet. 358, 9281, p. 560-1 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
A quantitative genetic study of cephalometric variables in twins
Carels, C., Van Cauwenberghe, N., Savoye, I., Willems, G., Loos, Ruth, Derom, C. & Vlietinck, R., Aug 2001, In: Clinical orthodontics and research. 4, 3, p. 130-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modelling bivariate ordinal responses smoothly with examples from ophthalmology and genetics
Bustami, R., Lesaffre, E., Molenberghs, G., Loos, Ruth, Danckaerts, M. & Vlietinck, R., 30 Jun 2001, In: Statistics in Medicine. 20, 12, p. 1825-42 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
The impact of genetic and environmental influences on blood pressure variance across age-groups
Vinck, W. J., Fagard, R. H., Loos, Ruth & Vlietinck, R., Jun 2001, In: Journal of Hypertension. 19, 6, p. 1007-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Twin studies and estimates of heritability
Loos, Ruth, Beunen, G., Fagard, R., Derom, C., Vlietinck, R. & Phillips, D. I., 5 May 2001, In: Lancet. 357, 9266, p. 1445Research output: Contribution to journal › Journal article › Research › peer-review
Anthropometric characteristics of elite female junior rowers
Bourgois, J., Claessens, A. L., Janssens, M., Van Renterghem, B., Loos, Ruth, Thomis, M., Philippaerts, R., Lefevre, J. & Vrijens, J., Mar 2001, In: Journal of Sports Sciences. 19, 3, p. 195-202 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice
Spittaels, K., Van den Haute, C., Van Dorpe, J., Geerts, H., Mercken, M., Bruynseels, K., Lasrado, R., Vandezande, K., Laenen, I., Boon, T., Van Lint, J., Vandenheede, J., Moechars, D., Loos, Ruth & Van Leuven, F., 29 Dec 2000, In: The Journal of Biological Chemistry. 275, 52, p. 41340-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons
Van Dorpe, J., Smeijers, L., Dewachter, I., Nuyens, D., Spittaels, K., Van Den Haute, C., Mercken, M., Moechars, D., Laenen, I., Kuiperi, C., Bruynseels, K., Tesseur, I., Loos, Ruth, Vanderstichele, H., Checler, F., Sciot, R. & Van Leuven, F., Oct 2000, In: The American Journal of Pathology. 157, 4, p. 1283-98 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
A quantitative study of unpaid caregiving in multiple sclerosis
Carton, H., Loos, Ruth, Pacolet, J., Versieck, K. & Vlietinck, R., Aug 2000, In: Multiple Sclerosis Journal. 6, 4, p. 274-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Anthropometric characteristics of elite male junior rowers
Bourgois, J., Claessens, A. L., Vrijens, J., Philippaerts, R., Van Renterghem, B., Thomis, M., Janssens, M., Loos, Ruth & Lefevre, J., Jun 2000, In: British Journal of Sports Medicine. 34, 3, p. 213-6; discussion 216-7Research output: Contribution to journal › Journal article › Research › peer-review
Genetic variance of adolescent growth in stature
Beunen, G., Thomis, M., Maes, H. H., Loos, Ruth, Malina, R. M., Claessens, A. L. & Vlietinck, R., 18 Apr 2000, In: Annals of Human Biology. 27, 2, p. 173-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
Spittaels, K., Van den Haute, C., Van Dorpe, J., Bruynseels, K., Vandezande, K., Laenen, I., Geerts, H., Mercken, M., Sciot, R., Van Lommel, A., Loos, Ruth & Van Leuven, F., Dec 1999, In: The American Journal of Pathology. 155, 6, p. 2153-65 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
The East Flanders Prospective Twin Survey (Belgium): a population-based register
Loos, Ruth, Derom, C., Vlietinck, R. & Derom, R., Dec 1998, In: Twin research : the official journal of the International Society for Twin Studies. 1, 4, p. 167-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
A genetic study of anteroposterior and vertical facial proportions using model-fitting
Savoye, I., Loos, Ruth, Carels, C., Derom, C. & Vlietinck, R., Oct 1998, In: The Angle Orthodontist. 68, 5, p. 467-70 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Univariate and multivariate genetic analysis of subcutaneous fatness and fat distribution in early adolescence
Beunen, G., Maes, H. H., Vlietinck, R., Malina, R. M., Thomis, M., Feys, E., Loos, Ruth & Derom, C., Jul 1998, In: Behavior Genetics. 28, 4, p. 279-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Utilisation and cost of professional care and assistance according to disability of patients with multiple sclerosis in Flanders (Belgium)
Carton, H., Loos, Ruth, Pacolet, J., Versieck, K. & Vlietinck, R., Apr 1998, In: Journal of neurology, neurosurgery, and psychiatry. 64, 4, p. 444-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
The genetic contribution to dental maturation
Pelsmaekers, B., Loos, Ruth, Carels, C., Derom, C. & Vlietinck, R., Jul 1997, In: Journal of Dental Research. 76, 7, p. 1337-40 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gender-specific regional changes in genetic structure of muscularity in early adolescence
Loos, Ruth, Thomis, M., Maes, H. H., Beunen, G., Claessens, A. L., Derom, C., Legius, E., Derom, R. & Vlietinck, R., Jun 1997, In: Journal of applied physiology (Bethesda, Md. : 1985). 82, 6, p. 1802-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Risks of multiple sclerosis in relatives of patients in Flanders, Belgium
Carton, H., Vlietinck, R., Debruyne, J., De Keyser, J., D'Hooghe, M. B., Loos, Ruth, Medaer, R., Truyen, L., Yee, I. M. & Sadovnick, A. D., Apr 1997, In: Journal of neurology, neurosurgery, and psychiatry. 62, 4, p. 329-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in cord serum of twins: genetic versus environmental regulation
Verhaeghe, J., Loos, Ruth, Vlietinck, R., Herck, E. V., van Bree, R. & Schutter, A. M., Nov 1996, In: American Journal of Obstetrics and Gynecology. 175, 5, p. 1180-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Handedness in twins according to zygosity and chorion type: a preliminary report
Derom, C., Thiery, E., Vlietinck, R., Loos, Ruth & Derom, R., Jul 1996, In: Behavior Genetics. 26, 4, p. 407-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 183694311
Most downloads
-
817
downloads
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
265
downloads
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
136
downloads
Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Research output: Contribution to journal › Journal article › Research › peer-review
Published