Rasmus Prætorius Clausen

Rasmus Prætorius Clausen

Professor

ORCID: 0000-0001-9466-9431

Publication year:
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1 - 136 out of 136Page size: 500
  1. 2023
  2. Published

    In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

    Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, Lennart, Clausen, Rasmus Prætorius & Wünsch, B., 2023, In: Biological Chemistry. 404, 4, p. 255-265

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

    Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, Lennart, Hansen, K. B. & Clausen, Rasmus Prætorius, 2022, In: Journal of Medicinal Chemistry. 65, 1, p. 734-746

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

    Zhao, F., Mazis, G., Yi, F., Lotti, J. S., Layeux, M. S., Schultz, E. P., Bunch, Lennart, Hansen, K. B. & Clausen, Rasmus Prætorius, 2022, In: Frontiers in Chemistry. 10, 13 p., 1008233.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2021
  7. Published

    Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research

    Qiu, H., Clausen, Rasmus Prætorius, He, Y. & Zhu, H., 2021, In: Current Topics in Medicinal Chemistry. 21, 28, p. 2593-2608

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

    Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model

    Liu, J., Shelkar, G. P., Sarode, L. P., Gawande, D. Y., Zhao, F., Clausen, Rasmus Prætorius, Ugale, R. R. & Dravid, S. M., 2021, In: Neurobiology of Disease. 150, 10 p., 105254.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes

    El-Chami, C., Foster, A. R., Johnson, C., Clausen, Rasmus Prætorius, Cornwell, P., Haslam, I. S., Steward, M. C., Watson, R. E. B., Young, H. S. & O'Neill, C. A., 2021, In: British Journal of Dermatology. 184, 3, p. 482-494

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists

    Maolanon, A., Papangelis, A., Kawiecki, D., Mou, T. C., Syrenne, J. T., Yi, F., Hansen, K. B. & Clausen, Rasmus Prætorius, 2021, In: European Journal of Medicinal Chemistry. 212, 17 p., 113099.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. 2020
  14. Published

    Improved synthetic route for the GluN2-specific NMDA receptor glycine site agonist AICP

    Zhao, F., Rouzbeh, N., Hansen, K. B. & Clausen, Rasmus Prætorius, 31 Mar 2020, In: Tetrahedron Letters. 61, 12, 4 p., 151653.

    Research output: Contribution to journal › Letter › Research › peer-review

  15. Published

    Compounds for the treatment of acute brain injury

    Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041

    Research output: Patent

  16. Published

    Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

    Lie, M. E. K., Kickinger, S., Skovgaard-Petersen, J., Ecker, G. F., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Wellendorph, Petrine, 2020, In: Neurochemical Research. 45, p. 1551–1565

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2019
  18. Published

    Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors

    Liu, J., Shelkar, G. P., Zhao, F., Clausen, Rasmus Prætorius & Dravid, S. M., 2019, In: Molecular Pharmacology. 96, p. 193-203

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

    Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2018
  21. Published

    Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius, Jørgensen, E. B., Christoffersen, C. T. & Juhl, K., 2018, In: MedChemComm. 9, 5, p. 893-896 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia

    Lie, M. E., Gowing, E. K., Clausen, Rasmus Prætorius, Wellendorph, Petrine & Clarkson, A. N., 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2017
  24. Published

    Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1)

    Jørgensen, L., Al-Khawaja, A., Kickinger, S., Vogensen, S. B., Skovgaard-Petersen, J., Rosenthal, E., Borkar, N., Löffler, R., Madsen, K. K., Bräuner, Hans, Schousboe, Arne, Ecker, G. F., Wellendorph, Petrine & Clausen, Rasmus Prætorius, 9 Oct 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8834-8846

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites

    Maolanon, A. R., Risgaard, R., Wang, S. Y., Snoep, Y., Papangelis, A., Yi, F., Holley, D., Barslund, A. F., Svenstrup, N., Hansen, K. B. & Clausen, Rasmus Prætorius, 16 Aug 2017, In: ACS Chemical Neuroscience. 8, 8, p. 1681-1687 7 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  26. Published

    Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

    Jessen, M., Frederiksen, K., Yi, F., Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Kilburn, J. P. & Damholt, A., Aug 2017, In: Molecular Pharmacology. 92, 2, p. 151-161 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

    Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  28. Published

    Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

    Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  29. Published

    Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements

    Damgaard, M., Haugaard, A. S., Kickinger, S., Al-Khawaja, A., Lie, M. E. K., Ecker, G. F., Clausen, Rasmus Prætorius & Frølund, Bente, 2017, Advances in Neurobiology. Springer, Vol. 16. p. 315-332 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  30. Published

    Enantioselective Fluorination of Spirocyclic β-Prolinals Using Enamine Catalysis

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius & Juhl, K., 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 4, p. 425-428 4 p., st-2016-b0535-l.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius & Juhl, K., 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 2, p. 231-234 4 p., st-2016-b0534-l.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    gamma-Aminobutyric Acid and Glycine Neurotransmitter Transporters

    Wellendorph, Petrine, Jacobsen, Julie, Skovgaard-Petersen, J., Jurik, A., Vogensen, S. B., Ecker, G., Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2017, Transporters As Drug Targets.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  34. 2016
  35. Published

    Novel Approach toward 3,3-Difluoropiperidines from Easily Available Starting Materials and Synthesis of a New Phosphodiesterase Inhibitor

    Giacoboni, J., Clausen, Rasmus Prætorius & Marigo, M., Dec 2016, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 27, 20, p. 2803-2806 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA

    Klein, A. B., Bay, T., Villumsen, I. S., Falk-Petersen, C. B., Marek, A., Frølund, Bente, Clausen, Rasmus Prætorius, Hansen, H. D., Knudsen, Gitte Moos & Wellendorph, Petrine, Nov 2016, In: Neurochemistry International. 100, p. 138-145 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The labeling of unsaturated γ-hydroxybutyric acid by heavy isotopes of hydrogen: iridium complex-mediated H/D exchange by C─H bond activation vs reduction by boro-deuterides/tritides

    Marek, A., Pedersen, M. H. F., Vogensen, S. B., Clausen, Rasmus Prætorius, Frølund, Bente & Elbert, T., Oct 2016, In: Journal of Labelled Compounds and Radiopharmaceuticals. 59, 12, p. 476-483 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

    Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Positive allosteric modulation of AMPA receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action

    Fitzpatrick, C. M., Larsen, M., Madsen, L., Pickering, Darryl S, Clausen, Rasmus Prætorius & Andreasen T., Jesper, 26 Jun 2016, In: Behavioural Pharmacology. 27, 6, p. 549-555 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

    Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Diastereodivergent Access to Syn and Anti 3,4-Substituted β-Fluoropyrrolidines: Enhancing or Reversing Substrate Preference

    Fjelbye, K., Marigo, M., Clausen, Rasmus Prætorius & Juhl, K., 2016, In: Organic Letters. 18, 5, p. 1170-1173 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Opioid and cannabinoid receptors

    Clausen, Rasmus Prætorius & Hansen, Harald S., 2016, Textbook of drug design and discovery. 5. ed. CRC Press, p. 329-346

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  44. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

    Wang, S., Larsen, Y., Navarrete, C. V., Jensen, Anders A., Nielsen, Birgitte, Al-Musaed, A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Clausen, Rasmus Prætorius, 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. 2015
  46. Published

    Structure activity relationship of selective GABA uptake inhibitors

    Vogensen, S. B., Jørgensen, L., Madsen, K. K., Jurik, A., Borkar, N., Rosatelli, E., Nielsen, Birgitte, Ecker, G. F., Schousboe, Arne & Clausen, Rasmus Prætorius, 15 May 2015, In: Bioorganic & Medicinal Chemistry. 23, 10, p. 2480-2488 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action

    Andreasen T., Jesper, Fitzpatrick, C. M., Larsen, M., Skovgaard, L., Nielsen, S. D., Clausen, Rasmus Prætorius, Troelsen, K. & Pickering, Darryl S, 19 Mar 2015, In: Brain Research. 1601, p. 117-26 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    A fluorescence resonance energy transfer-based method for histone methyltransferases

    Devkota, K., Lohse, B., Nyby Jakobsen, C., Berthelsen, J. & Clausen, Rasmus Prætorius, 19 Feb 2015, In: Analytical Biochemistry. 476, p. 78-80 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    P2X7 receptor-mediated analgesia in cancer-induced bone pain

    Falk, S., D. Schwab, S., Frøsig-Jørgensen, M., Clausen, Rasmus Prætorius, Dickenson, A. & Heegaard, Anne-Marie, 13 Feb 2015, In: Neuroscience. 291, p. 93–105 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Identification of the first highly selective inhibitor of human GABA transporter GAT3

    Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1

    Thiesen, L., Kehler, J., Clausen, Rasmus Prætorius, Frølund, Bente, Bundgaard, C. & Wellendorph, Petrine, 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2014
  53. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

    Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)

    Al-Khawaja, A. M. A., Petersen, J. G., Damgaard, M., Jensen, M. H., Vogensen, S. B., Lie, M. E. K., Kragholm, B., Bräuner, Hans, Clausen, Rasmus Prætorius, Frølund, Bente & Wellendorph, Petrine, 23 May 2014, In: Neurochemical Research. 39, 10, p. 1988-1996 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

    Jørgensen, L., Nielsen, Birgitte, Pickering, Darryl S, Kristensen, Anders Skov, Frydenvang, Karla Andrea, Madsen, Ulf & Clausen, Rasmus Prætorius, 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Analogues of the natural product Sinefungin as inhibitors of EHMT1 and EHMT2

    Devkota, K., Lohse, B., Liu, Q., Wang, M., Stærk, Dan, Berthelsen, J. & Clausen, Rasmus Prætorius, 2014, In: A C S Medicinal Chemistry Letters. 5, 4, p. 293-297

    Research output: Contribution to journal › Letter › Research › peer-review

  58. 2013
  59. Published

    Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs

    Thomsen, M., Vogensen, S. B., Buchardt, J., Burkart, M. D. & Clausen, Rasmus Prætorius, 21 Nov 2013, In: Organic & Biomolecular Chemistry. 11, 43, p. 7606-7610

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

    Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In: P L o S One. 8, 7, p. e67653

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors

    Hansen, K. B., Tajima, N., Risgaard, R., Perszyk, R. E., Jørgensen, L., Vance, K. M., Ogden, K. K., Clausen, Rasmus Prætorius, Furukawa, H. & Traynelis, S. F., Jul 2013, In: Molecular Pharmacology. 84, 1, p. 114-127

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    A tandem chemoenzymatic methylation by S-adenosyl-L-methionine

    Lipson, J. M., Thomsen, M., Moore, B. S., Clausen, Rasmus Prætorius, La Clair, J. J. & Burkart, M. D., 27 May 2013, In: ChemBioChem. 14, 8, p. 950-953

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Development of 2 '-substituted (2S,1 ' R,2 ' S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-D-aspartic acid receptor agonists

    Risgaard, R., Nielsen, S. D., Hansen, K. B., Jensen, C. M., Nielsen, Birgitte, Traynelis, S. F. & Clausen, Rasmus Prætorius, 23 May 2013, In: Journal of Medicinal Chemistry. 56, 10, p. 4071-4081

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Selective mGAT2 (BGT-1) GABA Uptake Inhibitor: Design, synthesis and pharmacological characterization

    Vogensen, S. B., Jørgensen, L., Madsen, K. K., Borkar, N. N., Wellendorph, Petrine, Skovgaard-Petersen, J., Schousboe, Arne, White, H. S., Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 11 Feb 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 2160-2164 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile

    Kragholm, B., Kvist, T., Madsen, K. K., Jørgensen, L., Vogensen, S. B., Schousboe, Arne, Clausen, Rasmus Prætorius, Jensen, Anders A. & Bräuner, Hans, 2013, In: Biochemical Pharmacology. 86, p. 521-528

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

    Andreasen T., Jesper, Gynther, M. O. O., Rygaard, A., Bøgelund, T., Nielsen, S. D., Clausen, Rasmus Prætorius, Mogensen, J. & Pickering, Darryl S, 2013, In: Neuroscience Letters. 546, p. 6-10 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites

    Vogensen, S. B., Marek, A., Bay, T., Wellendorph, Petrine, Kehler, J., Bundgaard, C., Frølund, Bente, Pedersen, M. H. F. & Clausen, Rasmus Prætorius, 2013, In: Journal of Medicinal Chemistry. 56, 20, p. 8201–8205

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2012
  69. Published

    Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)

    Leurs, U., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Lohse, B., 15 Sep 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

    Absalom, N., Karim, N., Eghorn, L. F., Villumsen, I. S., Bay, T., Bräuner, Hans, Frølund, Bente, Clausen, Rasmus Prætorius, Olsen, Jesper Velgaard, Knudsen, Gitte Moos, Chebib, M. & Wellendorph, Petrine, 14 Aug 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 33, p. 13404-13409 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators

    Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. 2011
  74. Published

    Målrettet fisketur i hjernen giver ny viden om Fantasys virkningssted

    Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, Dec 2011, In: Lægemiddelforskning. 2011, p. 26-28

    Research output: Contribution to journal › Journal article › Communication

  75. Published

    Nanobodies fra kameler - En ny klasse antistoffer til diagnostik og behandling

    Skottrup, P. D., Clausen, Rasmus Prætorius & Riise, E., Dec 2011, In: Lægemiddelforskning. 2011, p. 4-6

    Research output: Contribution to journal › Journal article › Communication

  76. Published

    A highly selective agonist for the metabotropic glutamate receptor mGluR2

    Nielsen, S. D., Fulco, M., Serpi, M., Nielsen, Birgitte, Hansen, M. B., Hansen, K. L., Thomsen, C., Brodbeck, R., Bräuner, Hans, Pellicciari, R., Norrby, P., Greenwood, J. R. & Clausen, Rasmus Prætorius, 23 Sep 2011, In: MedChemComm. 2, 11, p. 1120-1124

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

    Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43

    Research output: Contribution to journal › Conference abstract in journal › Research

  79. Published

    Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol

    Madsen, K. K., Ebert, B., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 1 Jul 2011, In: Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 214-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments

    Mohr, A. Ø., Riise, E. S., Pickering, Darryl S, Jensen, A. A., Madden, D., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Skottrup, P. D., 16 Jun 2011.

    Research output: Contribution to conference › Poster › Research › peer-review

  82. Published

    Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice

    Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In: Epilepsy Research. 95, 1-2, p. 70-81

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Glutamate receptor agonists: stereochemical aspects

    Vogensen, S. B., Greenwood, J. R., Bunch, Lennart & Clausen, Rasmus Prætorius, Apr 2011, In: Current Topics in Medicinal Chemistry. 11, 7, p. 887-906

    Research output: Contribution to journal › Review › Research › peer-review

  84. Published

    Inhibitors of histone demethylases

    Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  85. Published

    Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis

    Skottrup, P. D., Leonard, P., Kaczmarek, J., Veillard, F., Johannes Enghild, J., O'Kennedy, R., Sroka, A., Clausen, Rasmus Prætorius, Potempa, J. & Riise, E. S., 2011, In: Analytical Biochemistry. 415, 2, p. 158-167

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Målrettet fisketur i hjernen giver ny viden om Fantasy’s virkningssted

    Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, 2011, In: Lægemiddelforskning. 2011, p. 26-28

    Research output: Contribution to journal › Journal article › Communication

  87. Published

    The cysteine protease RgpB as a biomarker for the periodonto-pathogen Porphyromonas gingivalis: Nanobody selection and assay development

    Skottrup, P. D., Leonard, P., Kaczmarek, J., Veillard, F., Johannes Enghild, J., O'Kennedy, R., Sroka, A., Clausen, Rasmus Prætorius, Potempa, J. & Riise, E. S., 2011.

    Research output: Contribution to conference › Poster › Research

  88. 2010
  89. Published

    Partial agonists and subunit selectivity at NMDA receptors

    Risgaard, R., Hansen, K. B. & Clausen, Rasmus Prætorius, 17 Dec 2010, In: Chemistry: A European Journal. 16, 47, p. 13910-13918

    Research output: Contribution to journal › Review › Research › peer-review

  90. Published

    Histonhaler: et nyt mål inden for kræftbehandling

    Kristensen, Jesper Langgaard, Lohse, B. & Clausen, Rasmus Prætorius, Dec 2010, In: Lægemiddelforskning. 2010, p. 7-9

    Research output: Contribution to journal › Journal article › Communication

  91. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  93. Published

    Subunit-Specific Activation of NMDA Receptors

    Hansen, K. B., Burger, P., Vance, K. M., Snyder, J. P., Clausen, Rasmus Prætorius & Traynelis, S. F., Jan 2010, In: Biophysical Journal. 98, 3, suppl. 1, p. 525A-526A

    Research output: Contribution to journal › Conference abstract in journal › Research

  94. Published

    Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites

    Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites

    Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Nye NMDA-receptor-ligander til udforskning af hjernen

    Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In: Dansk Kemi. 91, 6/7, p. 21-23

    Research output: Contribution to journal › Journal article › Communication

  97. Published

    Opioid and cannabinoid receptors

    Clausen, Rasmus Prætorius & Hansen, Harald S., 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 313-328

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  98. Published

    Ring opening of pymisyl-protected aziridines with organocuprates

    Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. 2009
  100. Published

    Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display

    Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Riise, E. S., 28 May 2009.

    Research output: Contribution to conference › Poster › Research

  101. Published

    Histone demethylases

    Clausen, Rasmus Prætorius, Pedersen, M. T. & Helin, K., 2009, Epigenetic targets in drug discovery. Sippl, W. & Jung, M. (eds.). Weinheim: Wiley-VCH, Vol. 42. p. 269-290 (Methods and Principles in Medicinal Chemistry, Vol. 42).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  102. Published

    Ind i hjernen med nye stoffer

    Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In: Lægemiddelforskning. p. 34-36

    Research output: Contribution to journal › Journal article › Communication

  103. Published

    Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors

    Sivaprakasam, M., Hansen, K. B., David, O., Nielsen, Birgitte, Traynelis, S. F., Clausen, Rasmus Prætorius, Couty, F. & Bunch, Lennart, 2009, In: ChemMedChem. 4, 1, p. 110-117

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs

    Madsen, K. K., Clausen, Rasmus Prætorius, Larsson, O. M., Krogsgaard-Larsen, Povl, Schousboe, Arne & White, H. S., 2009, In: Journal of Neurochemistry. 109, Suppl. 1, p. 139-44

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

    Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. 2008
  107. Published

    GABA-transportører: håb om bedre epilepsibehandling

    Madsen, K. K., Clausen, Rasmus Prætorius, Larsson, O. M. & Schousboe, Arne, 2008, In: Lægemiddelforskning. p. 22-24

    Research output: Contribution to journal › Journal article › Communication

  108. Published

    Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)

    Smith, M. D., Saunders, G. W., Clausen, Rasmus Prætorius, Frølund, Bente, Krogsgaard-Larsen, Povl, Larsson, O. M., Schousboe, Arne, Wilcox, K. S. & White, H. S., 2008, In: Epilepsy Research. 79, 1, p. 6-13

    Research output: Contribution to journal › Journal article › Research › peer-review

  109. Published

    Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

    Bach, Anders, Chi, C. N., Olsen, T. B., Pedersen, S. W., Røder, M. U., Pang, G. F., Clausen, Rasmus Prætorius, Jemth, P. & Strømgaard, Kristian, 2008, In: Journal of Medicinal Chemistry. 51, 20, p. 6450-6459

    Research output: Contribution to journal › Journal article › Research › peer-review

  110. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

    Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87

    Research output: Contribution to journal › Journal article › Research › peer-review

  111. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies

    Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095

    Research output: Contribution to journal › Journal article › Research › peer-review

  112. Published

    Pharmacological manipulation of extrasynaptic GABA transporters: implications for epilepsy management

    Madsen, K. K., Ebert, B., Larsson, O. M., Clausen, Rasmus Prætorius, Schousboe, Arne & White, H. S., 2008, In: Epilepsia. Suppl. 7, p. 347

    Research output: Contribution to journal › Conference abstract in journal › Research

  113. 2007
  114. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journal › Conference abstract in journal › Research

  115. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist

    Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

    Research output: Contribution to journal › Journal article › Research › peer-review

  116. Published

    Erratum: Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid (Organic and Biomolecular Chemistry (2007) 5 DOI:10.1039/b615162k)

    Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic and Biomolecular Chemistry. 5, 5, p. 848 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  117. Published

    Functional and pharmacological aspects of GABA transporters

    Madsen, K., White, H. S., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O. M., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2007, Handbook of nerochemistry and molecular neurobiology: Neural membranes and transport. Lajtha, A. & Reith, M. E. A. (eds.). 3rd. ed. Berlin: Springer, Vol. 3. p. 285-304

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  118. Published

    Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA

    Jensen, Anders A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, Tommy Nørskov, Egebjerg, J., Bräuner, Hans & Clausen, Rasmus Prætorius, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  119. Published

    Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors

    Jørgensen, Charlotte Grube, Bräuner, Hans, Nielsen, Birgitte, Kehler, J., Clausen, Rasmus Prætorius, Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Bioorganic & Medicinal Chemistry. 15, 10, p. 3524-3538

    Research output: Contribution to journal › Journal article › Research › peer-review

  120. Published

    Pharmacological characterisation of biarylisopropylalsulphonamide AMPA-R potentiators

    Pickering, Darryl S, Sanz, C., Harpsøe, Kasper, Clausen, Rasmus Prætorius, Sauerberg, P., Liljefors, T., Madsen, Ulf & Kaae, B. H., 2007, In: Journal of Neurochemistry. 102 (suppl. 1), 41

    Research output: Contribution to journal › Conference abstract in journal › Research

  121. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  122. Published

    Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

    Erreger, K., Geballe, M. T., Kristensen, Anders Skov, Chen, P. E., Hansen, K. B., Lee, C. J., Yuan, H., Le, P., Lyuboslavsky, P. N., Micale, N., Jørgensen, L., Clausen, Rasmus Prætorius, Wyllie, D. J. A., Snyder, J. P. & Traynelis, S. F., 2007, In: Molecular Pharmacology. 72, 4, p. 907-920

    Research output: Contribution to journal › Journal article › Research › peer-review

  123. Published

    Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

    Jørgensen, Charlotte Grube, Clausen, Rasmus Prætorius, Hansen, K. B., Bräuner, Hans, Nielsen, Birgitte, Metzler, B., Kehler, J., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2007, In: Organic & Biomolecular Chemistry. 5, 3, p. 463-471

    Research output: Contribution to journal › Journal article › Research › peer-review

  124. 2006
  125. Published

    Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  126. Published

    MEDI 480-Novel lipophilic gamma-hydroxybutyrate (GHB) analogs with high affinity to GHB sites in rat brain

    Hog, S., Wellendorph, Petrine, Nielsen, Birgitte, Frølund, Bente & Clausen, Rasmus Prætorius, 10 Sep 2006, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 232

    Research output: Contribution to journal › Conference abstract in journal › Research

  127. Published

    Organic chemistry at the interface to biology

    Clausen, Rasmus Prætorius, May 2006, In: ChemBioChem. 7, 5, p. 845-849

    Research output: Contribution to journal › Literature review › Research

  128. Published

    A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS

    Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642

    Research output: Contribution to journal › Journal article › Research › peer-review

  129. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In: Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  130. Published

    Functional and Pharmacological Aspects of GABA Transporters

    Madsen, K., White, S. H., Clausen, Rasmus Prætorius, Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, Handbook of Neurochemistry and Molecular neurobiology. p. 1-17

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  131. Published

    Structure-Activity Relationships of Selective GABA Uptake Inhibitors

    Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882

    Research output: Contribution to journal › Journal article › Research › peer-review

  132. Published

    Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor

    Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  133. 2005
  134. Published

    Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis

    Hansen, K. B., Clausen, Rasmus Prætorius, Bjerrum, E. J., Bechmann, C., Greenwood, J. R., Christensen, C., Kristensen, Jesper Langgaard, Egebjerg, J. & Bräuner, Hans, Dec 2005, In: Molecular Pharmacology. 68, 6, p. 1510-23

    Research output: Contribution to journal › Journal article › Research › peer-review

  135. Published

    Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain

    Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  136. Published

    Design, synthesis, and characterisation of selective GABA transport inhibitors

    Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150

    Research output: Contribution to journal › Conference abstract in journal › Research

  137. Published

    Effect of tiagabine and EF1502 on phenytoin-resistant spontaneous bursts in the entorhinal cortex of slices from kainic acid-treated rats

    Smith-Yockman, M., Saunders, G., Wilcox, K., Larsson, O., Clausen, Rasmus Prætorius, Frølund, Bente, Schousboe, Arne & White, H., Aug 2005, In: Journal of Neurochemistry. 94, p. 256-256

    Research output: Contribution to journal › Conference abstract in journal › Research

  138. Published

    Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues

    Vogensen, S., Clausen, Rasmus Prætorius, Greenwood, J., Johansen, Tommy Nørskov, Pickering, Darryl S, Nielsen, Birgitte, Ebert, B. & Krogsgaard-Larsen, Povl, 5 May 2005, In: Journal of Medicinal Chemistry. 48, 9, p. 3438-3442

    Research output: Contribution to journal › Journal article › Research › peer-review

  139. Published

    Differential effects of two GABA transport inhibitors, tiagabine and EF-1502, on phenytoin-resistant spontaneous bursting in the entorhinal cortex of slices from kainic acid treated rats

    Smith-Yockman, M., Saunders, G., Wilcox, K., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O., Schousboe, Arne & White, H., 2005, In: Epilepsia. 46, p. 188-188

    Research output: Contribution to journal › Conference abstract in journal › Research

  140. Published

    First Demonstration of a Functional Role for CNS Betaine/GABA Transporter (mGAT2) Based on Synergistic Anticonvulsant Action Among Inhibitors of mGAT1 and mGAT2

    White, S., Watson, W. P., Hansen, S. L., Slough, S., Perregård, J., Sarup, A., Bolvig, T., Petersen, G., Larsson, O. M., Clausen, Rasmus Prætorius, Frølund, Bente, Falch, E., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2005, In: The Journal of Pharmacology and Experimental Therapeutics. 312, p. 866–874

    Research output: Contribution to journal › Journal article › Research › peer-review

  141. Published

    Hvordan virker Fantasy i hjernen?

    Høg, S., Wellendorph, Petrine, Greenwood, J. & Clausen, Rasmus Prætorius, 2005, In: Lægemiddelforskning. 2005, p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  142. Published

    Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues

    Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908

    Research output: Contribution to journal › Journal article › Research › peer-review

  143. 2004
  144. Published

    Deprotection of 2-nitrobenzenesulfonamides using fluorous and solid phase reagents

    rtc312, rtc312, Clausen, Rasmus Prætorius, Begtrup, M. & Kristensen, Jesper Langgaard, 18 Oct 2004, In: Tetrahedron Letters. 45, 43, p. 7991-7993

    Research output: Contribution to journal › Journal article › Research › peer-review

  145. Published

    The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

    Clausen, Rasmus Prætorius, Hansen, K. B., Calí, P., Nielsen, Birgitte, Greenwood, J. R., Begtrup, M., Egebjerg, J. & Bräuner, Hans, 19 Sep 2004, In: European Journal of Pharmacology. 499, 1-2, p. 35-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  146. Published

    A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors

    Vogensen, S., Greenwood, J., Varming, A. R., Brehm, L., Pickering, Darryl S, Nielsen, Birgitte, Liljefors, T., Clausen, Rasmus Prætorius, Johansen, Tommy Nørskov & Krogsgaard-Larsen, Povl, 2004, In: Organic & Biomolecular Chemistry. 2, 2, p. 206-213

    Research output: Contribution to journal › Journal article › Research › peer-review

  147. Published

    Ny bioisoster kan skabe nye lægemidler

    Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2004, In: Lægemiddelforskning. 2004, p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  148. 2002
  149. Published

    Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid

    Clausen, Rasmus Prætorius, Bräuner, Hans, Greenwood, J. R., Hermit, M. B., Stensbøl, T. B., Nielsen, Birgitte & Krogsgaard-Larsen, Povl, 12 Sep 2002, In: Journal of Medicinal Chemistry. 45, 19, p. 4240-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  150. Published

    Enantiopharmacology of 1,2,5-thiadiazol-3-ol analogues of glutamic acid and 2-aminoadipic acid

    Johansen, T., Clausen, Rasmus Prætorius, Brauner-Osbome, H., Janin, Y., Greenwood, J. & Krogsgaard-Larsen, Povl, Aug 2002, In: Neuropharmacology. 43, 2, p. 290-290

    Research output: Contribution to journal › Conference abstract in journal › Research

  151. 2001
  152. Published

    Synthesis and pharmacology of 2-amino-4-(4-hydroxy-1,2,5-thiadiazol-3-yl)butyric acid.

    Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, Aug 2001, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 222, p. U660-U660

    Research output: Contribution to journal › Conference article › Research

  153. Published

    Et bud på fremtidens lægemidler mod epilepsi.

    Clausen, Rasmus Prætorius, Larsson, O. M., Greenwood, J. & Krogsgaard-Larsen, Povl, 2001, In: Lægemiddelforskning. p. 20-21

    Research output: Contribution to journal › Journal article › Communication

  154. 2000

  155. A method for syn-dihydroxylation of double bonds cis to a hydroxymethyl substituent

    Clausen, Rasmus Prætorius & Bols, M., 5 May 2000, In: Journal of Organic Chemistry. 65, 9, p. 2797-2801

    Research output: Contribution to journal › Journal article › Research › peer-review

  156. 1998
  157. Published

    Structure and Si-29 NMR spectroscopy of chiral tri- and tetra-alkoxysilanes. Observation of restricted rotation of 1,2 : 4,5-di-O-isopropylidene-beta-D-fructopyranose

    Madsen, J., Clausen, Rasmus Prætorius, Hazell, R., Jacobsen, H., Bols, Mikael & Perry, C., Sep 1998, In: Dalton Transactions (Print Edition). 52, 9, p. 1165-1170

    Research output: Contribution to journal › Journal article › Research › peer-review

  158. 1997

  159. The first tri- and tetraalkoxysilanes with four different substituents

    Clausen, Rasmus Prætorius & Bols, M., 27 Jun 1997, In: Journal of Organic Chemistry. 62, 13, p. 4457-4464

    Research output: Contribution to journal › Journal article › Research › peer-review

  160. 1996
  161. Published

    The 1,2-thiadiazole route to new vinylogue tetrathiafulvalenes

    Clausen, Rasmus Prætorius & Becher, J., 26 Feb 1996, In: Tetrahedron. 52, 9, p. 3171-3188

    Research output: Contribution to journal › Journal article › Research › peer-review

  162. 1994
  163. Published

    The synthesis of 4,4'(5')diformylterathiafulvalene

    ANDREU, R., GARIN, J., ORDUNA, J., SAVIRON, M., COUSSEAU, J., GORGUES, A., MORISSON, V., NOZDRYN, T., BECHER, J., CLAUSEN, R., BRYCE, M., SKABARA, P., DEHAEN, W. & Clausen, Rasmus Prætorius, 5 Dec 1994, In: Tetrahedron Letters. 35, 49, p. 9243-9246

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 1302218