Per Mårten Hägglund
Associate Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- 2024
- Published
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Mozzicato, Anthony Michael, Bastrup, Joakim Armstrong, Sanchez-Alonso, J. L., van der Horst, Jennifer, Gorelik, J., Hägglund, Per Mårten & Jepps, Thomas Andrew Qvistgaard, 2024, In: The Biochemical journal. 481, 5, p. 387-403Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Exposure to peroxynitrite impacts the ability of anastellin to modulate the structure of extracellular matrix
He, Jianfei, Chuang, Christine, Hawkins, Clare Louise, Davies, Michael J. & Hägglund, Per Mårten, 2023, In: Free Radical Biology and Medicine. 206, p. 83-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FK506-Binding Protein 2 Participates in Proinsulin Folding
Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, , 2023, In: Biomolecules. 13, 1, 20 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite
Xu, Shuqi, Chuang, Christine, Hawkins, Clare Louise, Hägglund, Per Mårten & Davies, Michael J., 2023, In: Redox Biology. 64, 13 p., 102799.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation
Campolo, N., Mastrogiovanni, M., Mariotti, M., Issoglio, F. M., Estrin, D., Hägglund, Per Mårten, Grune, T., Davies, Michael J., Bartesaghi, S. & Radi, R., 2023, In: Journal of Biological Chemistry. 299, 3, 22 p., 102941.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers
Jensen, M., Thorsen, N. W., Hallberg, L. A. E., Hägglund, Per Mårten & Hawkins, Clare Louise, 2023, In: Free Radical Biology and Medicine. 202, p. 97-109 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers
Doblas, L., Hägglund, Per Mårten, Fuentes Lemus, Eduardo & Davies, Michael J., 2023, In: Archives of Biochemistry and Biophysics. 733, 7 p., 109482.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification
Fuentes Lemus, Eduardo, Hägglund, Per Mårten, López-Alarcón, C. & Davies, Michael J., 1 Jan 2022, In: Molecules. 27, 1, p. 1-31 15.Research output: Contribution to journal › Review › Research › peer-review
- Published
Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
He, Jianfei, Steffen, Jonas Hyld, Thulstrup, Peter Waaben, Pedersen, J. N., Sauerland, Max Benjamin, Otzen, D. E., Hawkins, Clare Louise, Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2022, In: Scientific Reports. 12, 1, 15 p., 22051.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway
Reyes, J. S., Fuentes Lemus, Eduardo, Figueroa, J. D., Rojas, J., Fierro, A., Arenas, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Scientific Reports. 12, 1, 19 p., 21191.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)
Hallberg, L. A. E., Thorsen, N. W., Hartsema, E. A., Hägglund, Per Mårten & Hawkins, Clare Louise, 2022, In: Free Radical Biology and Medicine. 192, p. 152-164 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic Profiling of Interspecies Interactions During Sessile Bacterial Cultivation Reveals Growth and Sporulation Induction in Paenibacillus amylolyticus in Response to Xanthomonas retroflexus
Herschend, J., Ernst, M., Koren, K., Melnik, A. V., da Silva, R. R., Røder, Henriette Lyng, Damholt, Z. B. V., Hägglund, Per Mårten, Svensson, B., Sørensen, Søren Johannes, Kühl, Michael, Dorrestein, P. C. & Burmølle, Mette, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 17 p., 805473.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of amino acid oxidation and protein unfolding in peroxyl radical and peroxynitrite-induced inactivation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides
Figueroa, J. D., Fuentes Lemus, Eduardo, Reyes, J. S., Loaiza, M., Aliaga, M. E., Fierro, A., Leinisch, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Free Radical Biology and Medicine. 190, p. 292-306Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Characterization of gluten-degrading prolyl endoprotease from Thermococcus kodakarensis
Shetty, R., Bang-Berthelsen, C. H., Ciurkot, K. W., Vestergaard, M., Hägglund, Per Mårten, Prakash, H. S. & Hobley, T. J., 1 Dec 2021, In: FEMS Microbiology Letters. 368, 21-24, 7 p., 368.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cross-linking and modification of fibronectin by peroxynitrous acid: Mapping and quantification of damage provides a new model for domain interactions
Mariotti, M., Rogowska-Wrzesinska, A., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Journal of Biological Chemistry. 296, 100360.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crosslinking of human plasma C-reactive protein to human serum albumin via disulfide bond oxidation
Jiang, S., Hägglund, Per Mårten, Carroll, L., Rasmussen, L. M. & Davies, Michael J., 2021, In: Redox Biology. 41, 17 p., 101925.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynein regulates Kv7.4 channel trafficking from the cell membrane
van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exceptionally rich keratinolytic enzyme profile found in the rare actinomycetes Amycolatopsis keratiniphila D2T
Espersen, R., Huang, Y., Falco, F. C., Hägglund, Per Mårten, Gernaey, K. V., Lange, L. & Svensson, B., 2021, In: Applied Microbiology and Biotechnology. 105, 21-22, p. 8129-8138 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Formation of protein cross-links by singlet oxygen-mediated disulfide oxidation
Jiang, S., Carroll, L., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Redox Biology. 41, 16 p., 101874.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High concentrations of casein proteins exacerbate radical chain reactions and increase the extent of oxidative damage
Fuentes Lemus, Eduardo, Jiang, S., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Food Hydrocolloids. 121, 16 p., 107060.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidation of lysozyme induced by peroxyl radicals involves amino acid modifications, loss of activity, and formation of specific crosslinks
Fuentes Lemus, Eduardo, Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2021, In: Free Radical Biology and Medicine. 167, p. 258-270Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ROLE OF EXTRACELLULAR TRAP RELEASE BY MACROPHAGES DURING THE DEVELOPMENT OF CHRONIC INFLAMMATION.
Jensen, M., Hägglund, Per Mårten, Zhang, Y., Rayner, B. & Hawkins, Clare Louise, 2021, In: Atherosclerosis. 331, p. E72-E72 PO51.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Tryptophan and Cysteine residues mediate chain reactions and propagation of oxidative damage in concentrated casein solutions
Fuentes Lemus, Eduardo, Jiang, S., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 562 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- 2020
- Published
Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization
Gamon, Luke Francis, Guo, C., He, Jianfei, Hägglund, Per Mårten, Hawkins, Clare Louise & Davies, Michael J., Sep 2020, In: Redox Biology. 36, 9 p., 101586.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In silico approach to predict pancreatic β-cells classically secreted proteins
Pinheiro-Machado, E., Sandberg, T. O. M., Pihl, Celina, Hägglund, Per Mårten & Marzec, Michal Tomasz, 1 Jan 2020, In: Bioscience Reports. 40, 2, 13 p., BSR20193708.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway
Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael J., Jan 2020, In: Redox Biology. 29, UNSP 101400.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Azo dying of α-keratin material improves microbial keratinase screening and standardization
Gonzalo, M., Espersen, R., Al-Soud, W. A., Cristiano Falco, F., Hägglund, Per Mårten, Sørensen, Søren Johannes, Svensson, B. & Jacquiod, S., 2020, In: Microbial Biotechnology. 13, 4, p. 984-996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin
He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Photo -oxidation of lysozyme triggered by riboflavin is O 2-dependent, occurs via mixed type 1 and type 2 pathways, and results in inactivation, site-specific damage and intra- and inter -molecular crosslinks
Fuentes-Lemus, E., Mariotti, M., Reyes, J., Leinisch, F., Hägglund, Per Mårten, Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2020, In: Free Radical Biology and Medicine. 152, p. 61-73Research output: Contribution to journal › Journal article › Research › peer-review
Two novel S1 peptidases from Amycolatopsis keratinophila subsp. keratinophila D2T degrading keratinous slaughterhouse by-products
Espersen, R., Falco, F. C., Hägglund, Per Mårten, Gernaey, K. V., Lantz, A. E. & Svensson, B., 2020, In: Applied Microbiology and Biotechnology. 104, 6, p. 2513-2522 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites
Leinisch, F., Mariotti, M., Andersen, S. H., Lindemose, Søren, Hägglund, Per Mårten, Møllegaard, Niels Erik & Davies, Michael J., 2020, In: Scientific Reports. 10, 1, 11 p., 3106.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]
Shu, N., Hägglund, Per Mårten & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Binding of rose bengal to lysozyme modulates photooxidation and cross-linking reactions involving tyrosine and tryptophan
Fuentes-Lemus, E., Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Lopez-Alarcon, C. & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 143, p. 375-386Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copper ion / H2O2 oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action
Tiwari, M. K., Hägglund, Per Mårten, Møller, I. M., Davies, Michael J. & Bjerrum, Morten Jannik, 2019, In: Redox Biology. 26, 15 p., 101262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients
Sharma, M., Danigaard, D., Senolt, L., Svensson, B., Bay-Jensen, A., Nielsen, Claus Henrik & Hägglund, Per Mårten, 2019, In: Journal of Proteomics. 208, 103484.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo
Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Karsdal, M. A., Mobasheri, A., Hägglund, Per Mårten, Bay-Jensen, A. & Thudium, C. S., 2019, In: Biochemical Pharmacology. 165, p. 91-98Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
New Insights into the Potential of Endogenous Redox Systems in Wheat Bread Dough
Navrot, N., Holstborg, R. B., Hägglund, Per Mårten, Povlsen, I. L. & Svensson, B., Dec 2018, In: Antioxidants. 7, 12, 190 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals
Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function
Degendorfer, G., Chuang, Christine, Mariotti, M., Hammer, A., Hoefler, G., Hägglund, Per Mårten, Malle, E., Wise, S. G. & Davies, Michael J., 1 Feb 2018, In: Free Radical Biology & Medicine. 115, S1, p. 202-214 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of alginate size, mannuronic/guluronic acid content and pH on particle size, thermodynamics and composition of complexes with β-lactoglobulin
Stender, E. G. P., Khan, S., Ipsen, Richard, Madsen, F., Hägglund, Per Mårten, Abou Hachem, M., Almdal, K., Westh, P. & Svensson, B., 2018, In: Food Hydrocolloids. 75, p. 157-163 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of protein cross-links induced by oxidative reactions
Hägglund, Per Mårten, Mariotti, M. & Davies, Michael J., 2018, In: Expert Review of Proteomics. 15, 8, p. 665-681Research output: Contribution to journal › Review › Research › peer-review
- Published
Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation
Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A meta-proteomics approach to study the interspecies interactions affecting microbial biofilm development in a model community
Herschend, J., Damholt, Z. B. V., Marquard, A. M., Svensson, B., Sørensen, Søren Johannes, Hägglund, Per Mårten & Burmølle, Mette, 28 Nov 2017, In: Scientific Reports. 7, 13 p., 16483.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications
Rykær, M., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 3 Nov 2017, In: Journal of Proteome Research. 16, 11, p. 3978-3988 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues
Leinisch, F., Mariotti, M., Rykaer, M., López-Alarcón, C., Hägglund, Per Mårten & Davies, Michael J., Nov 2017, In: Free Radical Biology & Medicine. 112, p. 240-252 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ulcerative colitis, Crohn’s disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn’s disease
Mortensen, J. H., Manon-Jensen, T., Jensen, M. D., Hägglund, Per Mårten, Klinge, L. G., Kjeldsen, J., Krag, A., Karsdal, M. A. & Bay-Jensen, A. C., Oct 2017, In: PLoS ONE. 12, 10, e0185855.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage
Skjoldager, N., Blanner Bang, M., Rykaer, M., Björnberg, O., Davies, Michael J., Svensson, B., Harris, P. & Hägglund, Per Mårten, Apr 2017, In: Scientific Reports. 7, 10 p., 46282.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery, cloning and characterisation of proline specific prolyl endopeptidase, a gluten degrading thermo-stable enzyme from Sphaerobacter thermophiles
Shetty, R., Vestergaard, M., Jessen, F., Hägglund, Per Mårten, Knorr, V., Koehler, P., Prakash, H. S. & Hobley, T. J., 2017, In: Enzyme and Microbial Technology. 107, p. 57-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functional and structural characterization of plastidic starch phosphorylase during barley endosperm development
Cuesta-Seijo, J. A., Ruzanski, C., Krucewicz, K., Meier, S., Hägglund, Per Mårten, Svensson, B. & Palcic, M. M., 2017, In: PLoS ONE. 12, 4, e0175488.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Reducing Capacity of Thioredoxin on Oxidized Thiols in Boiled Wort
Murmann, A. N., Hägglund, Per Mårten, Svensson, B. & Lund, Marianne N., 2017, In: Journal of Agricultural and Food Chemistry. 65, 46, p. 10101-10106 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 182565837
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A meta-proteomics approach to study the interspecies interactions affecting microbial biofilm development in a model community
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
210
downloads
The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
121
downloads
Copper ion / H2O2 oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action
Research output: Contribution to journal › Journal article › Research › peer-review
Published