Per Mårten Hägglund

Per Mårten Hägglund

Associate Professor


  1. 2024
  2. Published

    Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation

    Mozzicato, Anthony Michael, Bastrup, Joakim Armstrong, Sanchez-Alonso, J. L., van der Horst, Jennifer, Gorelik, J., Hägglund, Per Mårten & Jepps, Thomas Andrew Qvistgaard, 2024, In: The Biochemical journal. 481, 5, p. 387-403

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2023
  4. Published

    Exposure to peroxynitrite impacts the ability of anastellin to modulate the structure of extracellular matrix

    He, Jianfei, Chuang, Christine, Hawkins, Clare Louise, Davies, Michael J. & Hägglund, Per Mårten, 2023, In: Free Radical Biology and Medicine. 206, p. 83-93 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    FK506-Binding Protein 2 Participates in Proinsulin Folding

    Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2023, In: Biomolecules. 13, 1, 20 p., 152.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation

    Campolo, N., Mastrogiovanni, M., Mariotti, M., Issoglio, F. M., Estrin, D., Hägglund, Per Mårten, Grune, T., Davies, Michael J., Bartesaghi, S. & Radi, R., 2023, In: Journal of Biological Chemistry. 299, 3, 22 p., 102941.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers

    Jensen, M., Thorsen, N. W., Hallberg, L. A. E., Hägglund, Per Mårten & Hawkins, Clare Louise, 2023, In: Free Radical Biology and Medicine. 202, p. 97-109 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers

    Doblas, L., Hägglund, Per Mårten, Fuentes Lemus, Eduardo & Davies, Michael J., 2023, In: Archives of Biochemistry and Biophysics. 733, 7 p., 109482.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2022
  11. Published

    Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification

    Fuentes Lemus, Eduardo, Hägglund, Per Mårten, López-Alarcón, C. & Davies, Michael J., 1 Jan 2022, In: Molecules. 27, 1, p. 1-31 15.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published
  13. Published

    Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway

    Reyes, J. S., Fuentes Lemus, Eduardo, Figueroa, J. D., Rojas, J., Fierro, A., Arenas, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Scientific Reports. 12, 1, 19 p., 21191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)

    Hallberg, L. A. E., Thorsen, N. W., Hartsema, E. A., Hägglund, Per Mårten & Hawkins, Clare Louise, 2022, In: Free Radical Biology and Medicine. 192, p. 152-164 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Metabolic Profiling of Interspecies Interactions During Sessile Bacterial Cultivation Reveals Growth and Sporulation Induction in Paenibacillus amylolyticus in Response to Xanthomonas retroflexus

    Herschend, J., Ernst, M., Koren, K., Melnik, A. V., da Silva, R. R., Røder, Henriette Lyng, Damholt, Z. B. V., Hägglund, Per Mårten, Svensson, B., Sørensen, Søren Johannes, Kühl, Michael, Dorrestein, P. C. & Burmølle, Mette, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 17 p., 805473.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Role of amino acid oxidation and protein unfolding in peroxyl radical and peroxynitrite-induced inactivation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides

    Figueroa, J. D., Fuentes Lemus, Eduardo, Reyes, J. S., Loaiza, M., Aliaga, M. E., Fierro, A., Leinisch, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Free Radical Biology and Medicine. 190, p. 292-306

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2021
  18. Published

    Characterization of gluten-degrading prolyl endoprotease from Thermococcus kodakarensis

    Shetty, R., Bang-Berthelsen, C. H., Ciurkot, K. W., Vestergaard, M., Hägglund, Per Mårten, Prakash, H. S. & Hobley, T. J., 1 Dec 2021, In: FEMS Microbiology Letters. 368, 21-24, 7 p., 368.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Cross-linking and modification of fibronectin by peroxynitrous acid: Mapping and quantification of damage provides a new model for domain interactions

    Mariotti, M., Rogowska-Wrzesinska, A., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Journal of Biological Chemistry. 296, 100360.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Crosslinking of human plasma C-reactive protein to human serum albumin via disulfide bond oxidation

    Jiang, S., Hägglund, Per Mårten, Carroll, L., Rasmussen, L. M. & Davies, Michael J., 2021, In: Redox Biology. 41, 17 p., 101925.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Dynein regulates Kv7.4 channel trafficking from the cell membrane

    van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Exceptionally rich keratinolytic enzyme profile found in the rare actinomycetes Amycolatopsis keratiniphila D2T

    Espersen, R., Huang, Y., Falco, F. C., Hägglund, Per Mårten, Gernaey, K. V., Lange, L. & Svensson, B., 2021, In: Applied Microbiology and Biotechnology. 105, 21-22, p. 8129-8138 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Formation of protein cross-links by singlet oxygen-mediated disulfide oxidation

    Jiang, S., Carroll, L., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Redox Biology. 41, 16 p., 101874.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    High concentrations of casein proteins exacerbate radical chain reactions and increase the extent of oxidative damage

    Fuentes Lemus, Eduardo, Jiang, S., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Food Hydrocolloids. 121, 16 p., 107060.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Oxidation of lysozyme induced by peroxyl radicals involves amino acid modifications, loss of activity, and formation of specific crosslinks

    Fuentes Lemus, Eduardo, Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2021, In: Free Radical Biology and Medicine. 167, p. 258-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    ROLE OF EXTRACELLULAR TRAP RELEASE BY MACROPHAGES DURING THE DEVELOPMENT OF CHRONIC INFLAMMATION.

    Jensen, M., Hägglund, Per Mårten, Zhang, Y., Rayner, B. & Hawkins, Clare Louise, 2021, In: Atherosclerosis. 331, p. E72-E72 PO51.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  27. Published

    Tryptophan and Cysteine residues mediate chain reactions and propagation of oxidative damage in concentrated casein solutions

    Fuentes Lemus, Eduardo, Jiang, S., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 562 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  28. 2020
  29. Published

    Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

    Gamon, Luke Francis, Guo, C., He, Jianfei, Hägglund, Per Mårten, Hawkins, Clare Louise & Davies, Michael J., Sep 2020, In: Redox Biology. 36, 9 p., 101586.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    In silico approach to predict pancreatic β-cells classically secreted proteins

    Pinheiro-Machado, E., Sandberg, T. O. M., Pihl, Celina, Hägglund, Per Mårten & Marzec, Michal Tomasz, 1 Jan 2020, In: Bioscience Reports. 40, 2, 13 p., BSR20193708.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

    Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael J., Jan 2020, In: Redox Biology. 29, UNSP 101400.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Azo dying of α-keratin material improves microbial keratinase screening and standardization

    Gonzalo, M., Espersen, R., Al-Soud, W. A., Cristiano Falco, F., Hägglund, Per Mårten, Sørensen, Søren Johannes, Svensson, B. & Jacquiod, S., 2020, In: Microbial Biotechnology. 13, 4, p. 984-996

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin

    He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Photo -oxidation of lysozyme triggered by riboflavin is O 2-dependent, occurs via mixed type 1 and type 2 pathways, and results in inactivation, site-specific damage and intra- and inter -molecular crosslinks

    Fuentes-Lemus, E., Mariotti, M., Reyes, J., Leinisch, F., Hägglund, Per Mårten, Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2020, In: Free Radical Biology and Medicine. 152, p. 61-73

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Two novel S1 peptidases from Amycolatopsis keratinophila subsp. keratinophila D2T degrading keratinous slaughterhouse by-products

    Espersen, R., Falco, F. C., Hägglund, Per Mårten, Gernaey, K. V., Lantz, A. E. & Svensson, B., 2020, In: Applied Microbiology and Biotechnology. 104, 6, p. 2513-2522 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites

    Leinisch, F., Mariotti, M., Andersen, S. H., Lindemose, Søren, Hägglund, Per Mårten, Møllegaard, Niels Erik & Davies, Michael J., 2020, In: Scientific Reports. 10, 1, 11 p., 3106.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2019
  38. Published

    Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]

    Shu, N., Hägglund, Per Mårten & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.

    Research output: Contribution to journalConference abstract in journalResearch

  39. Published

    Binding of rose bengal to lysozyme modulates photooxidation and cross-linking reactions involving tyrosine and tryptophan

    Fuentes-Lemus, E., Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Lopez-Alarcon, C. & Davies, Michael J., 2019, In: Free Radical Biology and Medicine. 143, p. 375-386

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Copper ion / H2O2 oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action

    Tiwari, M. K., Hägglund, Per Mårten, Møller, I. M., Davies, Michael J. & Bjerrum, Morten Jannik, 2019, In: Redox Biology. 26, 15 p., 101262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

    Sharma, M., Danigaard, D., Senolt, L., Svensson, B., Bay-Jensen, A., Nielsen, Claus Henrik & Hägglund, Per Mårten, 2019, In: Journal of Proteomics. 208, 103484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo

    Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Karsdal, M. A., Mobasheri, A., Hägglund, Per Mårten, Bay-Jensen, A. & Thudium, C. S., 2019, In: Biochemical Pharmacology. 165, p. 91-98

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2018
  44. Published

    New Insights into the Potential of Endogenous Redox Systems in Wheat Bread Dough

    Navrot, N., Holstborg, R. B., Hägglund, Per Mårten, Povlsen, I. L. & Svensson, B., Dec 2018, In: Antioxidants. 7, 12, 190 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals

    Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function

    Degendorfer, G., Chuang, Christine, Mariotti, M., Hammer, A., Hoefler, G., Hägglund, Per Mårten, Malle, E., Wise, S. G. & Davies, Michael J., 1 Feb 2018, In: Free Radical Biology & Medicine. 115, S1, p. 202-214 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Effect of alginate size, mannuronic/guluronic acid content and pH on particle size, thermodynamics and composition of complexes with β-lactoglobulin

    Stender, E. G. P., Khan, S., Ipsen, Richard, Madsen, F., Hägglund, Per Mårten, Abou Hachem, M., Almdal, K., Westh, P. & Svensson, B., 2018, In: Food Hydrocolloids. 75, p. 157-163 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Identification and characterization of protein cross-links induced by oxidative reactions

    Hägglund, Per Mårten, Mariotti, M. & Davies, Michael J., 2018, In: Expert Review of Proteomics. 15, 8, p. 665-681

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation

    Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. 2017
  51. Published

    A meta-proteomics approach to study the interspecies interactions affecting microbial biofilm development in a model community

    Herschend, J., Damholt, Z. B. V., Marquard, A. M., Svensson, B., Sørensen, Søren Johannes, Hägglund, Per Mårten & Burmølle, Mette, 28 Nov 2017, In: Scientific Reports. 7, 13 p., 16483.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications

    Rykær, M., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 3 Nov 2017, In: Journal of Proteome Research. 16, 11, p. 3978-3988 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues

    Leinisch, F., Mariotti, M., Rykaer, M., López-Alarcón, C., Hägglund, Per Mårten & Davies, Michael J., Nov 2017, In: Free Radical Biology & Medicine. 112, p. 240-252 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Ulcerative colitis, Crohn’s disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn’s disease

    Mortensen, J. H., Manon-Jensen, T., Jensen, M. D., Hägglund, Per Mårten, Klinge, L. G., Kjeldsen, J., Krag, A., Karsdal, M. A. & Bay-Jensen, A. C., Oct 2017, In: PLoS ONE. 12, 10, e0185855.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage

    Skjoldager, N., Blanner Bang, M., Rykaer, M., Björnberg, O., Davies, Michael J., Svensson, B., Harris, P. & Hägglund, Per Mårten, Apr 2017, In: Scientific Reports. 7, 10 p., 46282.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Discovery, cloning and characterisation of proline specific prolyl endopeptidase, a gluten degrading thermo-stable enzyme from Sphaerobacter thermophiles

    Shetty, R., Vestergaard, M., Jessen, F., Hägglund, Per Mårten, Knorr, V., Koehler, P., Prakash, H. S. & Hobley, T. J., 2017, In: Enzyme and Microbial Technology. 107, p. 57-63 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Functional and structural characterization of plastidic starch phosphorylase during barley endosperm development

    Cuesta-Seijo, J. A., Ruzanski, C., Krucewicz, K., Meier, S., Hägglund, Per Mårten, Svensson, B. & Palcic, M. M., 2017, In: PLoS ONE. 12, 4, e0175488.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    The Reducing Capacity of Thioredoxin on Oxidized Thiols in Boiled Wort

    Murmann, A. N., Hägglund, Per Mårten, Svensson, B. & Lund, Marianne N., 2017, In: Journal of Agricultural and Food Chemistry. 65, 46, p. 10101-10106 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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