Paul Cloos
Paul Cloos

Associate Professor

 

Education

2000   Ph.D., Erhversforsker, Molecular Medicine, Univ. of Copenhagen
1995   Master of Science, Copenhagen


Career

2010-                      
Associate Professor, Biotech Research Innovation Centre.

2007-                      
Assistant Professor, Biotech Research Innovation Centre.

2004-                      
Post Doc. Fellow, Biotech Research Innovation Centre (BRIC).

2003                       
Senior Research Scientist, Sanos Bioscience.

1999-2003             
Project Manager, Nordic Bioscience A/S.

1994-1999             
Research scientist, Project Leader, Osteometer Biotech A/S.


My Research Focus

Although each human cell has some 30000 genes, only small subsets of these are expressed in a specific cell type. In the last decade it has become clear that the establishment and specification of the unique gene expression patterns in each individual cell type involves the interplay between specific transcription factors on one-hand and regulatory protein complexes that modify the chromatin structure on the other hand.

My research aims to unravel the mechanistic basis through which protein complexes and covalent histone modifications regulate gene expression patterns during human development and differentiation. In particular, I focus on characterizing enzymatic activities responsible for "erasing" the methyl mark on histones, so-called histone demethylases and how they interact with other protein factors to modify the chromatin template and regulate transcription.


 

PATENTS, PATENT FAMILIES (Paul Andreas Cloos)

  

9. Title: Testing the ability of a test compound to modulate the activity of Jumonji proteins.

Patent Numbers: WO2007104314-A2; WO2007104314-A3.

Inventors: CLOOS PA; CHRISTENSEN J; AGGER K, et al.

 

8. Title: New annulene derivatives are glyceraldehyde-3-phosphate dehydrogenase regulators used for treating e.g. diabetes and autoimmune response and/or disease

Patent Numbers: WO2004039773-A2; AU2003285296-A1

Inventors: CLOOS PA; JENSEN FR; BOISSY P, et al.

 

7. Title: New and known dibenz[b,f]oxepine compounds have adrenolytic and systemic activity.

Patent Numbers: WO2003057204-A; WO2003057204-A2; AU2003235799-A1...

Inventor: CLOOS PA.

 

6. Title: Immunoassay of human osteocalcin in diagnostic specimens.

Patent Numbers: WO200277639-A; WO200277639-A2; AU2002257678-A1...

Inventor: CLOOS PA.

 

5. Title: An assay for the diagnosis or assessment of the severity of osteoarthritis or rheumatoid arthritis comprising detecting an isomerized or optically inverted protein in a sample.

Patent Numbers: WO200295415-A2; EP1415163-A2; AU2002321030-A1...

Inventors: CHRISTGAU S; HENRIKSEN D B; CLOOS PA.

 

4. Title: Measuring rate of protein degradation by determining peptide(s) containing D-amino acids.

Patent Numbers: WO200213844-A; WO200213844-A2; AU200187669-A...

Inventors: CLOOS PA; CHRISTGAU S.

 

3. Title: New antiphospholipid analogues and conjugates containing them.

Patent Numbers: WO200113110-A; EP1208379-A; WO200113110-A2...

Inventors: CLOOS PA; CHRISTGAU S.

 

2. Title: Determination of collagen fragmentation patterns.

Patent Numbers: WO200138872-A; EP1232396-A; WO200138872-A2...

Inventors: CHRISTGAU S; HENRIKSEN DB; CLOOS PA.

 

1. Title: Assaying collagen fragments in body fluid by immunoassay, particularly for assessing collagen degradation in osteoporosis etc., also new specific antibodies and synthetic peptide analogues containing D-amino acids.

Patent Numbers: WO9808098-A; WO9808098-A2; AU9739435

Inventors: FLEDELIUS C; CLOOS PA, QUIST P.

ID: 8513