Ole Haagen Nielsen

Ole Haagen Nielsen

Clinical Professor


  1. 2020
  2. Published

    SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases

    Jensen, Simone Lindhardt Wittorff, Seidelin, Jakob Benedict, LaCasse, E. C. & Nielsen, Ole Haagen, 18 Feb 2020, In : Science signaling. 13, 619

    Research output: Contribution to journalReviewResearchpeer-review

  3. Accepted/In press

    Efficacy and safety of methotrexate in the management of inflammatory bowel disease: A systematic review and meta-analysis of randomized, controlled trials

    Nielsen, Ole Haagen, Steenholdt, C., Juhl, C. B. & Rogler, G., 1 Jan 2020, (Accepted/In press) In : EClinicalMedicine. 100271.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

    Fenton, T. M., Jørgensen, P. B., Niss, Kristoffer, Rubin, S. J. S., Mörbe, U. M., Riis, Lene Buhl, Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., Brunak, Søren, Habtezion, A., Nielsen, Ole Haagen, Johansson-Lindbom, B. & Agace, W. W., 2020, In : Immunity. 52, 3, p. 557-570, e1-e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2019
  6. Published

    Metabonomics in gastroenterology and hepatology

    Bjerrum, Jakob Tveiten & Nielsen, Ole Haagen, 1 Aug 2019, In : International Journal of Molecular Sciences. 20, 15, 3638.

    Research output: Contribution to journalEditorialResearchpeer-review

  7. Published

    Biosimilars for management of Crohn disease

    Nielsen, Ole Haagen & Ainsworth, M. A., 2019, In : Annals of Internal Medicine. 170, 2, p. 129-130 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  8. Published

    Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy

    Bergenheim, F., Seidelin, Jakob Benedict, Pedersen, Marianne Terndrup, Mead, B. E., Jensen, Kim Bak, Karp, J. M. & Nielsen, Ole Haagen, 2019, In : Stem Cell Research & Therapy. 10, 1, p. 1-12 12 p., 148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Managing vitamin D deficiency in inflammatory bowel disease

    Nielsen, Ole Haagen, Hansen, T. I., Gubatan, J. M., Jensen, Kim Bak & Rejnmark, L., 2019, In : Frontline Gastroenterology. 10, 4, p. 394-400 7 p., 31656565.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    Methotrexate for inflammatory bowel disease: time for reconsideration

    Nielsen, Ole Haagen, Ainsworth, M. A. & Steenholdt, C., 2019, In : Expert Review of Gastroenterology and Hepatology. 13, 5, p. 407-409 3 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  11. Published

    Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

    Gubatan, J., Chou, N. D., Nielsen, Ole Haagen & Moss, A. C., 2019, In : Alimentary Pharmacology and Therapeutics. 50, 11-12, p. 1146-1158 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. 2018
  13. Published

    Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier

    Holmberg, F. E. O., Pedersen, J., Jørgensen, P., Soendergaard, C., Jensen, Kim Bak & Nielsen, Ole Haagen, Apr 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 4

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

    Yui, S., Azzolin, L., Maimets, Martti, Pedersen, Marianne Terndrup, Fordham, R. P., Hansen, Stine Lind, Larsen, Hjalte List, Guiu, Jordi, Alves, M. R. P., Friis, Carsten, Johansen, Jens Vilstrup, Li, Y., Madsen, C. D., Nakamura, T., Watanabe, M., Nielsen, Ole Haagen, Schweiger, Pawel, Piccolo, S. & Jensen, Kim Bak, 1 Jan 2018, In : Cell Stem Cell. 22, 1, p. 35-49. e7 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

    Li, Y., Soendergaard, C., Bergenheim, F. H., Aronoff, D. M., Milne, G., Riis, Lene Buhl, Seidelin, Jakob Benedict, Jensen, Kim Bak & Nielsen, Ole Haagen, 2018, In : EBioMedicine. 36, p. 497-507

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

    Boyd, M., Thodberg, M., Vitezic, M., Lange, J. B., Vitting-Seerup, Kristoffer, Chen, Y., Coskun, M., Li, Y., Lo, B. Z. S., Klausen, P., Schweiger, Pawel, Pedersen, A. G., Rapin, N. P. J., Skovgaard, K., Dahlgaard, K., Andersson, Robin, Terkelsen, T. B., Lilje, B., Troelsen, J. T., Petersen, Andreas Munk, Jensen, Kim Bak, Gögenur, Ismail, Thielsen, P., Seidelin, Jakob Benedict, Nielsen, Ole Haagen, Bjerrum, Jakob Tveiten & Sandelin, Albin Gustav, 2018, In : Nature Communications. 9, 19 p., 1661.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

    Christensen, R., Heitmann, Berit, Andersen, K. W., Nielsen, Ole Haagen, Sørensen, S. B., Jawhara, M., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F., Bojesen, A. B., Sørensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Bennike, T. B., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Boye, M., Werner, L., Nielsen, C. L., Munk, H. L., Nexoe, A. B., Ellingsen, T., Holmskov, U., Kjeldsen, J. & Andersen, V., 2018, In : BMJ Open. 8, 2, 15 p., :e018166.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Inflammatory bowel disease with primary sclerosing cholangitis: A Danish population-based cohort study 1977-2011

    Sørensen, J. Ø., Nielsen, Ole Haagen, Andersson, M., Ainsworth, M. A., Ytting, H., Bélard, E. & Jess, T., 2018, In : Liver International. 38, 3, p. 532-541

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD

    Soendergaard, C., Seidelin, Jakob Benedict, Steenholdt, C. & Nielsen, Ole Haagen, 2018, In : B M J Open Gastroenterology. 5, 1, e000208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Rational Management of Iron-Deficiency Anaemia in Inflammatory Bowel Disease

    Nielsen, Ole Haagen, Soendergaard, C., Vikner, M. E. & Weiss, G., 2018, In : Nutrients. 10, 1, 25 p., 82.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Role of Vitamin D in the Natural History of Inflammatory Bowel Disease

    Nielsen, Ole Haagen, Rejnmark, L. & Moss, A. C., 2018, In : Journal of Crohn's and Colitis. 12, 6, p. 742-752 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Targeting JAK-STAT signal transduction in IBD

    Soendergaard, C., Bergenheim, F. H., Bjerrum, Jakob Tveiten & Nielsen, Ole Haagen, 2018, In : Pharmacology & Therapeutics. 192, p. 100-111

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2017
  24. Published

    Inflammatory Bowel Disease and Small Bowel Cancer Risk, Clinical Characteristics, and Histopathology: A Population-Based Study

    Bojesen, R. D., Riis, Lene Buhl, Høgdall, Estrid Vilma Solyom, Nielsen, Ole Haagen & Jess, T., Dec 2017, In : Clinical Gastroenterology and Hepatology. 15, 12, p. 1900-1907.e2

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis

    Soendergaard, C., Kvist, P. H., Thygesen, P., Reslow, M., Nielsen, Ole Haagen, Kopchick, J. J. & Holm, T. L., 23 Sep 2017, In : International Journal of Molecular Sciences (Online). 18, 10, 20 p., 2046.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    A proposal for a study on treatment selection and lifestyle recommendations in chronic inflammatory diseases: A danish multidisciplinary collaboration on prognostic factors and personalised medicine

    Andersen, V., Holmskov, U., Bek Sørensen, S., Jawhara, M., Andersen, K. W., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F., Nielsen, Ole Haagen, Christensen, R., Bo Bojesen, A., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Heitmann, Berit, Boye, M., Nielsen, C. L., Werner, L., Kjeldsen, J. & Ellingsen, T., May 2017, In : Nutrients. 9, 5, 16 p., 499.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    An open prospective study evaluating efficacy and safety of a new medical device for rectal application of activated carbon in the treatment of chronic, uncomplicated perianal fistulas

    Zawadzki, A., Johnson, L. B., Bohe, M., Johansson, C., Ekelund, M. & Nielsen, Ole Haagen, Apr 2017, In : International Journal of Colorectal Disease. 32, 4, p. 509-512 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Sphingosine-1-phosphate signaling in inflammatory bowel disease

    Nielsen, Ole Haagen, Li, Y., Lindbom, B. J. & Coskun, M., Apr 2017, In : Trends in Molecular Medicine. 23, 4, p. 362-374 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Novel targeted therapies for inflammatory bowel disease

    Coskun, M., Vermeire, S. & Nielsen, Ole Haagen, Feb 2017, In : Trends in Pharmacological Sciences. 38, 2, p. 127-142 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease

    Holmberg, F. E., Seidelin, Jakob Benedict, Yin, X., Mead, B. E., Tong, Z., Li, Y., Karp, J. M. & Nielsen, Ole Haagen, 2017, In : EMBO Molecular Medicine. 9, 5, p. 558-570 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    How genetic testing can lead to targeted management of XIAP deficiency-related inflammatory bowel disease

    Nielsen, Ole Haagen & LaCasse, E. C., 2017, In : Genetics In Medicine. 19, p. 133-143

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Impact of feedback and monitoring on colonoscopy withdrawal times and polyp detection rates

    Nielsen, Amalie Bach, Nielsen, Ole Haagen & Hendel, J., 2017, In : BMJ Open Gastroenterology. 4, 6 p., e000142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

    Bjerrum, J. T., Steenholdt, C., Ainsworth, M., Nielsen, Ole Haagen, Reed, M. A. C., Atkins, K., Günther, U. L., Hao, F. & Wang, Y., 2017, In : BMC Medicine. 15, 1, 13 p., 184.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Modulation of Gut Microbiota in Pathological States

    Wang, Y., Wang, B., Wu, J., Jiang, X., Tang, H. & Nielsen, Ole Haagen, 2017, In : Engineering. 3, 1, p. 83-89 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Regulation of laminin γ2 expression by CDX2 in colonic epithelial cells is impaired during active inflammation

    Coskun, M., Soendergaard, C., Joergensen, S., Dahlgaard, K., Riis, Lene Buhl, Nielsen, Ole Haagen, Sandelin, Albin Gustav & Troelsen, J. T., 2017, In : Journal of Cellular Biochemistry. 118, 2, p. 298-307 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels

    Chen, Y., Salem, M., Boyd, M., Bornholdt, J., Li, Y., Coskun, M., Seidelin, Jakob Benedict, Sandelin, Albin Gustav & Nielsen, Ole Haagen, 2017, In : npj Genomic Medicine. 2, 11 p., 3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2016
  38. Published

    Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994-2010: a population-based study

    Bojesen, R. D., Andersson, M., Riis, Lene Buhl, Nielsen, Ole Haagen & Jess, T., Sep 2016, In : Journal of Gastroenterology. 51, 9, p. 891-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes

    Søndergaard, C., Kvist, P. H., Seidelin, Jakob Benedict, Pelzer, H. & Nielsen, Ole Haagen, Aug 2016, In : Journal of Gastroenterology. 51, 8, p. 796-807 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases

    Olesen, C. M., Coskun, M., Peyrin-Biroulet, L. & Nielsen, Ole Haagen, Mar 2016, In : Pharmacology & Therapeutics. 159, p. 110-119 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Circulating cytokines and cytokine receptors in infliximab treatment failure due to TNF-α independent Crohn disease

    Steenholdt, C., Coskun, M., Buhl, S., Bendtzen, K., Ainsworth, M. A., Brynskov, J. & Nielsen, Ole Haagen, 2016, In : Medicine (Baltimore). 95, 16, 8 p., e3417.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Iron replacement therapy: do we need new guidelines?

    Nielsen, Ole Haagen, Coskun, M. & Weiss, G., 2016, In : Current Opinion in Gastroenterology. 32, 2, p. 128-135 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Pharmacology and optimization of thiopurines and methotrexate in inflammatory bowel disease

    Coskun, M., Steenholdt, C., de Boer, N. K. & Nielsen, Ole Haagen, 2016, In : Clinical Pharmacokinetics. 55, 3, p. 257-274 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Will novel oral formulations change the management of inflammatory bowel disease?

    Nielsen, Ole Haagen, Seidelin, Jakob Benedict, Ainsworth, M. A. & Coskun, M., 2016, In : Expert Opinion on Investigational Drugs. 25, 6, p. 709-718 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  45. 2015
  46. Published

    Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease

    Salem, M., Nielsen, Ole Haagen, Nys, K., Yazdanyar, S. & Seidelin, Jakob Benedict, Nov 2015, In : Clinical and Translational Gastroenterology. 6, 9 p., e122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Preface

    Rogler, G., Herfarth, H., Hibi, T. & Nielsen, Ole Haagen, 9 Jul 2015, Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. Karger, p. viii

    Research output: Chapter in Book/Report/Conference proceedingPreface/postscriptResearchpeer-review

  48. Published

    Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD

    Casén, C., Vebø, H. C., Sekelja, M., Hegge, F. T., Karlsson, M. K., Ciemniejewska, E., Dzankovic, S., Frøyland, C., Nestestog, R., Engstrand, L., Munkholm, Pia, Nielsen, Ole Haagen, Rogler, G., Simrén, M., Öhman, L., Vatn, M. H. & Rudi, K., Jul 2015, In : Alimentary Pharmacology and Therapeutics. 42, 1, p. 71-83 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review

    Nielsen, Ole Haagen, Ainsworth, M., Coskun, M. & Weiss, G., Jun 2015, In : Medicine (Baltimore). 94, 23, p. 1-14 14 p., e963.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Alpha-1 antitrypsin and granulocyte colony-stimulating factor as serum biomarkers of disease severity in ulcerative colitis

    Soendergaard, C., Nielsen, Ole Haagen, Seidelin, Jakob Benedict, Kvist, P. H. & Bjerrum, J. T., May 2015, In : Inflammatory Bowel Diseases. 21, 5, p. 1077-88 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    ATG16L1: A multifunctional susceptibility factor in Crohn disease

    Salem, M., Ammitzboell, M., Nys, K., Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 3 Apr 2015, In : Autophagy. 11, 4, p. 585-94 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants

    Salem, M., Seidelin, Jakob Benedict, Eickhardt-Dalbøge, S. R., Alhede, M., Rogler, G. & Nielsen, Ole Haagen, Mar 2015, In : Clinical and Experimental Immunology. 179, 3, p. 426-34 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis

    Seidelin, Jakob Benedict, Coskun, M., Kvist, P. H., Holm, T. L., Holgersen, Kristine & Nielsen, Ole Haagen, Feb 2015, In : Journal of Gastroenterology. 50, 2, p. 180-190 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Integrative Transcriptomic and Metabonomic Molecular Profiling of Colonic Mucosal Biopsies Indicates a Unique Molecular Phenotype for Ulcerative Colitis

    Rantalainen, M., Bjerrum, Jakob Tveiten , Olsen, Jørgen, Nielsen, Ole Haagen & Wang, Y., 2 Jan 2015, In : Journal of Proteome Research. 14, 1, p. 479-90 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation

    Seidelin, Jakob Benedict, Larsen, S., Linnemann, D., Vainer, B., Coskun, M., Troelsen, J. T. & Nielsen, Ole Haagen, Jan 2015, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 308, 2, p. G92-G99 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Anti-TNF-α Therapy for Extraintestinal Manifestations of Inflammatory Bowel Disease

    Nielsen, Ole Haagen, Bendtzen, K. & Pedersen, J., 2015, In : Frontiers of Gastrointestinal Research. 34, p. 206-213

    Research output: Contribution to journalJournal articleResearchpeer-review

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