Özcan Met
Visiting associate professor, Gæstelektor
Immunology
Blegdamsvej 3B
2200 København N.
Member of:
- 2023
- Published
of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes
Hulen, T. M., Friese, C., Kristensen, N. P., Granhøj, J. S., Borch, T. H., Peeters, M. J. W., Donia, M., Andersen, Mads Hald, Hadrup, S. R., Svane, Inge Marie & Met, Özcan, 2023, In: Frontiers in Immunology. 14, 15 p., 1180997.Research output: Contribution to journal › Journal article › peer-review
- Published
Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy
Mortensen, R. E. J., Holmström, M. O., Lisle, T. L., Hasselby, Jane Preuss, Willemoe, G. L., Met, Özcan, Svane, Inge Marie, Johansen, Julia Sidenius, Nielsen, Dorte Lisbet, Chen, I. M. & Andersen, Mads Hald, 2023, In: Journal for ImmunoTherapy of Cancer. 11, 3Research output: Contribution to journal › Journal article › peer-review
- Published
Restoring tumor immunogenicity with dendritic cell reprogramming
Zimmermannova, O., Ferreira, A. G., Ascic, E., Santiago, M. V., Kurochkin, I., Hansen, M., Met, Ö., Caiado, I., Shapiro, I. E., Michaux, J., Humbert, M., Soto-Cabrera, D., Benonisson, H., Silvério-Alves, R., Gomez-Jimenez, D., Bernardo, C., Bauden, M., Andersson, R., Höglund, M., Miharada, K. & 9 others, , 2023, In: Science immunology. 8, 85, 20 p., eadd4817.Research output: Contribution to journal › Journal article › peer-review
- Published
TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy
Tvingsholm, S. A., Frej, M. S., Rafa, V. M., Hansen, U. K., Ormhøj, M., Tyron, A., Jensen, A. W. P., Kadivar, M., Bentzen, A. K., Munk, K. K., Aasbjerg, G. N., Ternander, J. S. H., Heeke, C., Tamhane, T., Schmess, C., Funt, S. A., Kjeldsen, J. W., Kverneland, A. H., Met, Ö., Draghi, A. & 4 others, , 2023, In: Journal for ImmunoTherapy of Cancer. 11, 8, 16 p., e006847.Research output: Contribution to journal › Journal article › peer-review
- 2022
- Published
Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV
Klausen, U., Grauslund, J. H., Jørgensen, N. G. D., Ahmad, S. M., Jonassen, M., Weis-Banke, S. E., Martinenaite, E., Pedersen, L. B., Lisle, T. L., Gang, Anne Ortved, Enggaard, L., Hansen, M., Holmström, M. O., Met, Özcan, Svane, Inge Marie, Niemann, Carsten, Pedersen, Lars Møller & Andersen, Mads Hald, 2022, In: Frontiers in Oncology. 12, 1023015.Research output: Contribution to journal › Journal article › peer-review
- Published
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Weis-Banke, S. E., Lisle, T. L., Perez Penco, Maria, Schina, A., Hübbe, M. L., Siersbæk, M., Holmström, M. O., Jørgensen, M. A., Svane, Inge Marie, Met, Özcan, Ødum, Niels, Madsen, Daniel Hargbøl, dqp123, dqp123, Grøntved, L. & Andersen, Mads Hald, 2022, In: Journal for ImmunoTherapy of Cancer. 10, 10, e005326.Research output: Contribution to journal › Journal article › peer-review
- Published
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine
Gigoux, M., Holmström, M. O., Zappasodi, R., Park, J. J., Pourpe, S., Bozkus, C. C., Mangarin, L. M. B., Redmond, D., Verma, S., Schad, S., George, M. M., Venkatesh, D., Ghosh, A., Hoyos, D., Molvi, Z., Kamaz, B., Marneth, A. E., Duke, W., Leventhal, M. J., Jan, M. & 23 others, , 2022, In: Science Translational Medicine. 14, 649, eaba4380.Research output: Contribution to journal › Journal article › peer-review
- Published
Clinical advances and ongoing trials on mRNA vaccines for cancer treatment
Lorentzen, C. L., Haanen, J. B., Met, Özcan & Svane, Inge Marie, 2022, In: The Lancet Oncology. 23, 10, p. e450-e458Research output: Contribution to journal › Review › peer-review
- Published
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy
Chamberlain, C. A., Bennett, Eric Paul, Kverneland, Anders Handrup, Svane, Inge Marie, dqp123, dqp123 & Met, Özcan, 2022, In: Molecular Therapy - Oncolytics. 24, p. 417-428 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment
Bendtsen, S. K., Perez Penco, Maria, Hübbe, M. L., Martinenaite, E., Orebo Holmström, M., Weis-Banke, S. E., Grønne Dahlager Jørgensen, N., Jørgensen, M. A., Munir Ahmad, S., Jensen, K. M., Friese, C., Lundsager, M. T., Johansen, A. Z., Carretta, M., Ødum, Niels, Met, Özcan, Svane, Inge Marie, Madsen, Daniel Hargbøl & Andersen, Mads Hald, 2022, In: OncoImmunology. 11, 1, 2026020.Research output: Contribution to journal › Journal article › peer-review
- Published
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.
Rohaan, M. W., Borch, T. H., Van Den Berg, J. H., Met, Ö., Kessels, R., Geukes Foppen, M. H., Stoltenborg Granhøj, J., Nuijen, B., Nijenhuis, C., Jedema, I., Van Zon, M., Scheij, S., Beijnen, J. H., Hansen, M., Voermans, C., Noringriis, I. M., Monberg, T. J., Holmstroem, R. B., Wever, L. D. V., Van Dijk, M. & 37 others, , 2022, In: New England Journal of Medicine. 387, 23, p. 2113-2125 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Tumor-infiltrating lymphocytes for adoptive cell therapy: recent advances, challenges, and future directions
Granhøj, J. S., Jensen, Agnete Witness Præst, Presti, M., Met, Özcan, Svane, Inge Marie & dqp123, dqp123, 2022, In: Expert Opinion on Biological Therapy. 22, 5, p. 627-641 15 p.Research output: Contribution to journal › Review › peer-review
- 2021
- Published
Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms
Handlos Grauslund, J., Holmström, M. O., Jørgensen, N. G., Klausen, U., Weis-Banke, S. E., El Fassi, D., Schöllkopf, C., Clausen, M. B., Gjerdrum, L. M. R., Breinholt, M. F., Kjeldsen, J. W., Hansen, M., Koschmieder, S., Chatain, N., Novotny, G. W., Petersen, J., Kjær, L., Skov, V., Met, Ö., Svane, I. M. & 2 others, , 26 Feb 2021, In: Frontiers in Oncology. 11, 17 p., 637420.Research output: Contribution to journal › Journal article › peer-review
- Published
Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner
Holmström, M. O., Mortensen, R. E. J., Pavlidis, A. M., Martinenaite, E., Weis-Banke, S. E., Aaboe-Jørgensen, M., Bendtsen, S. K., Met, Özcan, Pedersen, A. W., Donia, M., Svane, Inge Marie & Andersen, Mads Hald, Feb 2021, In: Cellular and Molecular Immunology. 18, 2, p. 415-426 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
ACT Up TIL Now: The Evolution of Tumor-Infiltrating Lymphocytes in Adoptive Cell Therapy for the Treatment of Solid Tumors
Morgan Hulen , T., Chamberlain, C. A., Svane, Inge Marie & Met, Özcan, 2021, In: Immuno. 1, 3, p. 194-211Research output: Contribution to journal › Journal article › peer-review
- Published
An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma
Klausen, U., Grønne Dahlager Jørgensen, N., Grauslund, J. H., Munir Ahmad, S., Gang, Anne Ortved, Martinenaite, E., Weis-Banke, S. E., Breinholt, M. F., Novotny, G. W., Kjeldsen, J. W., Orebo Holmström, M., Pedersen, L. B., Poulsen, C. B., Hansen, P. B., Met, Özcan, Svane, Inge Marie, Niemann, Carsten, Pedersen, Lars Møller & Andersen, Mads Hald, 2021, In: OncoImmunology. 10, 1, 1975889.Research output: Contribution to journal › Journal article › peer-review
- Published
Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma
Borch, T. H., Harbst, K., Rana, A. H., Andersen, R., Martinenaite, E., Kongsted, P., Pedersen, M., Nielsen, M., Kjeldsen, J. W., Kverneland, Anders Handrup, Lauss, M., Hølmich, Lisbet Rosenkrantz, Hendel, Helle Westergren, Met, Özcan, Jönsson, G., dqp123, dqp123 & Svane, Inge Marie, 2021, In: Journal for ImmunoTherapy of Cancer. 9, 7, 15 p., e00270.Research output: Contribution to journal › Journal article › peer-review
- Published
Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules
Peeters, M. J. W., Aehnlich, P., Pizzella, A., Mølgaard, K., Seremet, T., Met, Özcan, Rasmussen, Lene Juel, thor Straten, Per & Desler, Claus, 2021, In: Frontiers in Immunology. 12, 718863.Research output: Contribution to journal › Journal article › peer-review
- Published
Real-time monitoring of mitochondrial respiration in cytokine-differentiated human primary T cells
Mølgaard, K., Rahbech, A., Met, Özcan, Svane, Inge Marie, thor Straten, Per, Desler, Claus & Peeters, M. J. W., 2021, In: Journal of Visualized Experiments. 176, e62984.Research output: Contribution to journal › Journal article › peer-review
- Published
The Thioredoxin-Interacting Protein TXNIP Is a Putative Tumour Suppressor in Cutaneous T-Cell Lymphoma
Stolearenco, V., Levring, T. B., Nielsen, H. M., Lindahl, L., Fredholm, S., Kongsbak-Wismann, Martin, Willerslev-Olsen, A., Buus, Terkild Brink, Nastasi, C., Hu, T., Gluud, Maria, Côme, Christophe Roger Michel, Krejsgaard, T., Iversen, L., Bonefeld, Charlotte Menne, Grønbæk, Kirsten, Met, Özcan, Woetmann, Anders , Ødum, Niels & Geisler, Carsten, 2021, In: Dermatology. 237, 2, p. 283-290 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Vaccination against pd-l1 with io103 a novel immune modulatory vaccine in basal cell carcinoma: A phase iia study
Jørgensen, N. G., Kaae, Jeanette, Grauslund, J. H., Met, Özcan, Nielsen, S. L., Pedersen, A. W., Svane, Inge Marie, Ehrnrooth, E., Andersen, Mads Hald, Zachariae, Claus & Skov, Lone, 2021, In: Cancers. 13, 4, p. 1-15 15 p., 911.Research output: Contribution to journal › Journal article › peer-review
- Published
Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens
Holmen Olofsson, G., Idorn, M., Carnaz Simões, A. M., Aehnlich, P., Skadborg, S. K., Noessner, E., Debets, R., Moser, B., Met, Özcan & thor Straten, Per, 2021, In: Frontiers in Immunology. 12, 645131.Research output: Contribution to journal › Journal article › peer-review
- 2020
- Published
Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer
Kverneland, Anders Handrup, Pedersen, M., Wulff Westergaard, M. C., Nielsen, M., Borch, T. H., Olsen, L. R., Aasbjerg, G., Santegoets, S. J., van der Burg, S. H., Milne, K., Nelson, B. H., Met, Özcan, dqp123, dqp123 & Svane, Inge Marie, 2020, In: OncoTarget. 11, 22, p. 2092-2105 14 p.Research output: Contribution to journal › Journal article › peer-review
- Published
CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer
Friese, C., Harbst, K., Borch, T. H., Westergaard, M. C. W., Pedersen, M., Kverneland, A., Jönsson, G., dqp123, dqp123, Svane, Inge Marie & Met, Özcan, 2020, In: Scientific Reports. 10, 1, 12 p., 3914.Research output: Contribution to journal › Journal article › peer-review
- Published
Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma
Borch, T. H., Andersen, R., Ellebaek, E., Met, Özcan, dqp123, dqp123 & Svane, Inge Marie, 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, e000668.Research output: Contribution to journal › Journal article › peer-review
- Published
INDEL detection, the 'Achilles heel' of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels
Bennett, Eric Paul, Petersen, B. L., Johansen, I. E., Niu, Yiyuan, Yang, Zhang, Chamberlain, C. A., Met, Özcan, Wandall, Hans H. & Frödin, Morten, 2020, In: Nucleic Acids Research. 48, 21, p. 11958-11981 24 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Peptide Vaccination Against PD-L1 With IO103 a Novel Immune Modulatory Vaccine in Multiple Myeloma: A Phase I First-in-Human Trial
Jørgensen, N. G., Klausen, U., Grauslund, J. H., Helleberg, C., Aagaard, T. G., Do, T. H., Ahmad, S. M., Olsen, L. R., Klausen, T. W., Breinholt, M. F., Hansen, M., Martinenaite, E., Met, Özcan, Svane, Inge Marie, Knudsen, L. M. & Andersen, Mads Hald, 2020, In: Frontiers in Immunology. 11, 11 p., 595035.Research output: Contribution to journal › Journal article › peer-review
- Published
Qualitative analysis of tumor-infiltrating lymphocytes across human tumor types reveals a higher proportion of bystander CD8+ T cells in non-melanoma cancers compared to melanoma
Gokuldass, A., Draghi, A., Papp, K., Borch, T. H., Nielsen, M., Westergaard, M. C. W., Andersen, R., Schina, A., Bol, K. F., Chamberlain, C. A., Presti, M., Met, Özcan, Harbst, K., Lauss, M., Soraggi, S., Csabai, I., Szállási, Z., Jönsson, G., Svane, Inge Marie & dqp123, dqp123, 2020, In: Cancers. 12, 11, p. 1-15 15 p., 3344.Research output: Contribution to journal › Journal article › peer-review
- Published
T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road
Crowther, M. D., Svane, Inge Marie & Met, Özcan, 2020, In: Cells. 9, 7, 18 p., 1588.Research output: Contribution to journal › Review › peer-review
- Published
The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Weis-Banke, S. E., Hübbe, M. L., Holmström, M. O., Jørgensen, M. A., Bendtsen, S. K., Martinenaite, E., Carretta, M., Svane, Inge Marie, Ødum, Niels, Pedersen, A. W., Met, Özcan, Madsen, D. H. & Andersen, Mads Hald, 2020, In: OncoImmunology. 9, 1, 16 p., 1771142.Research output: Contribution to journal › Journal article › peer-review
- 2019
- Published
Principles of adoptive T cell therapy in cancer
Met, Özcan, Jensen, K. M., Chamberlain, C. A., dqp123, dqp123 & Svane, Inge Marie, 11 Jan 2019, In: Seminars in Immunopathology. 41, 1, p. 49–58Research output: Contribution to journal › Journal article › peer-review
- Published
Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome
Hu, T., Buus, T. B., Krejsgaard, T., Nansen, A., Lundholt, B. K., Spee, P., Fredholm, S., Petersen, D. L., Blümel, E., Gluud, M., Monteiro, M. N., Willerslev-Olsen, A., Andersen, M. H., Straten, P. T., Met, Ö., Stolearenco, V., Fogh, H., Gniadecki, R., Nastasi, C., Litman, T. & 3 others, , 2019, In: OncoTarget. 10, 47, p. 4894-4906 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Inflammation induced PD-L1-specific T cells
Munir, S., Lundsager, M. T., Jørgensen, M. A., Hansen, M., Petersen, T. H., Bonefeld, Charlotte Menne, Friese, C., Met, Özcan, thor Straten, Per & Andersen, Mads Hald, 2019, In: Cell Stress & Chaperones. 3, 10, p. 319-327Research output: Contribution to journal › Journal article › peer-review
- Published
MERTK Acts as a costimulatory receptor on human cd8 t cells
Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Desler, Claus & thor Straten, Per, 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
Viborg, N., Ramskov, S., Andersen, R. S., Sturm, T., Fugmann, T., Bentzen, A. K., Rafa, V. M., thor Straten, Per, Svane, Inge Marie, Met, Özcan & Hadrup, S. R., 2019, In: OncoImmunology. 8, 12, 11 p., 1663107.Research output: Contribution to journal › Journal article › peer-review
- Published
Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells
Levring, T. B., Kongsbak-Wismann, Martin, Rode, A. K. O., Al-Jaberi, F. A. H., Lopez, D. V., Met, Özcan, Woetmann, Anders , Bonefeld, Charlotte Menne, Ødum, Niels & Geisler, Carsten, 2019, In: Scientific Reports. 9, 13 p., 16725.Research output: Contribution to journal › Journal article › peer-review
- 2018
- Published
The calreticulin (CALR) exon 9 mutations are promising targets for cancer immune therapy
Holmstrom, M. O., Martinenaite, E., Ahmad, S. M., Met, Özcan, Friese, C., Kjaer, L., Riley, C. H., thor Straten, Per, Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 1 Feb 2018, In: Leukemia. 32, 2, p. 429-437Research output: Contribution to journal › Journal article › peer-review
- Published
Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model
Idorn, M., Skadborg, S. K., Kellermann, L., Halldórsdóttir, H. R., Holmen Olofsson, G., Met, Özcan & thor Straten, Per, 2018, In: OncoImmunology. 7, 8, 10 p., e1450715.Research output: Contribution to journal › Journal article › peer-review
- Published
Frequent adaptive immune responses against arginase-1
Martinenaite, E., Mortensen, R. E. J., Hansen, M., Orebo Holmström, M., Munir Ahmad, S., Grønne Dahlager Jørgensen, N., Met, Özcan, dqp123, dqp123, Svane, Inge Marie & Andersen, Mads Hald, 2018, In: OncoImmunology. 7, 3, 9 p., e1404215.Research output: Contribution to journal › Journal article › peer-review
- Published
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction
Idorn, M., Olsen, M., Halldórsdóttir, H. R., Skadborg, S. K., Pedersen, M., Høgdall, Claus Kim, Høgdall, Estrid Vilma Solyom, Met, Özcan & thor Straten, Per, 2018, In: OncoImmunology. 7, 4, 12 p., e1412029.Research output: Contribution to journal › Journal article › peer-review
- Published
SATB1 in malignant T cells
Fredholm, S. M., Willerslev-Olsen, A., Met, Ö., Kubat, L., Gluud, M., Mathiasen, S. L., Friese, C., Blümel, E., Petersen, D. L., Hu, T., Nastasi, C., Lindahl, L. M., Buus, T. B., Krejsgaard, T. F., Wasik, M. A., Kopp, K. L. M., Koralov, S. B., Persson, J. L., Bonefeld, C. M., Geisler, C. & 4 others, , 2018, In: The Journal of Investigative Dermatology. 138, 8, p. 1805-1815 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
T cells isolated from patients with checkpoint inhibitor-resistant melanoma are functional and can mediate tumor regression
Andersen, R., Borch, T. H., Draghi, A., Gokuldass, A., Rana, M. A. H., Pedersen, M., Nielsen, M., Kongsted, P., Kjeldsen, J. W., Westergaard, M. C. W., Radic, H. D., Chamberlain, C. A., Hølmich, Lisbet Rosenkrantz, Hendel, Helle Westergren, Larsen, M. S., Met, Özcan, Svane, Inge Marie & dqp123, dqp123, 2018, In: Annals of Oncology. 29, 7, p. 1575-1581 7 p.Research output: Contribution to journal › Journal article › peer-review
- Published
T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma-Implications for Adoptive Cell Therapy
Andersen, R., Westergaard, M. C. W., Kjeldsen, J. W., Müller, A., Pedersen, N. W., Hadrup, S. R., Met, Özcan, Seliger, B., Kromann-Andersen, B., Hasselager, T., dqp123, dqp123 & Svane, Inge Marie, 2018, In: Cancer Immunology Research. 6, 2, p. 222-235 14 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy
Ahmad, S. M., Martinenaite, E., Holmström, M., Jørgensen, M. A., Met, Özcan, Nastasi, C., Klausen, U., dqp123, dqp123, Pedersen, Lars Møller, Munksgaard, Lars, Ødum, Niels, Woetmann, Anders , Svane, Inge Marie & Andersen, Mads Hald, 2018, In: OncoImmunology. 7, 2, 10 p., e1390641.Research output: Contribution to journal › Journal article › peer-review
- 2017
- Published
Dendritic cell vaccination in combination with docetaxel for patients with metastatic castration-resistant prostate cancer: A randomized phase II study
Kongsted, P., Borch, T. H., Ellebaek, E., Iversen, T. Z., Andersen, R., Met, Özcan, Hansen, M., Lindberg, H., Sengeløv, L. & Svane, Inge Marie, 1 Apr 2017, In: Cytotherapy. 19, 4, p. 500-513 14 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
Holmström, M. O., Hjortso, M. D., Ahmad, S. M., Met, Özcan, Martinenaite, E., Riley, C., Straten, P., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: Leukemia. 31, p. 495-498Research output: Contribution to journal › Letter › peer-review
- 2016
- Published
Therapeutic Vaccination against A Modified Minimal Survivin Epitope Induces Functional CD4 T Cells That Recognize Survivin-Expressing Cells
Nitschke, N. J., Bjoern, J., Met, Özcan, Svane, Inge Marie & Andersen, M. H., 1 Sep 2016, In: Scandinavian Journal of Immunology. 84, 3, p. 191-193 3 p.Research output: Contribution to journal › Comment/debate › peer-review
- Published
mRNA-transfected dendritic cell vaccine in combination with metronomic cyclophosphamide as treatment for patients with advanced malignant melanoma
Borch, T. H., Engell-Noerregaard, L., Iversen, T. Z., Ellebaek, E., Met, Özcan, Hansen, M., Andersen, Mads Hald, thor Straten, Per & Svane, Inge Marie, 1 Sep 2016, In: OncoImmunology. 5, 9, 12 p., e1207842.Research output: Contribution to journal › Journal article › peer-review
- Published
Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21
Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196Research output: Contribution to journal › Journal article › peer-review
- Published
PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine
Munir Ahmad, S., Martinenaite, E., Hansen, M., Junker, N., Borch, T. H., Met, Özcan, Donia, M., Svane, Inge Marie & Andersen, Mads Hald, 2 Aug 2016, In: OncoImmunology. 5, 8, e1202391.Research output: Contribution to journal › Journal article › peer-review
- Published
Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen
Andersen, R., Donia, M., Ellebæk, E., Borch, T. H., Kongsted, P., Iversen, T. Z., Hølmich, Lisbet Rosenkrantz, Hendel, Helle Westergren, Met, Özcan, Andersen, Mads Hald, thor Straten, Per & Svane, Inge Marie, Aug 2016, In: Clinical Cancer Research. 22, 15, p. 3734-3745 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment
Martinenaite, E., Munir Ahmad, S., Hansen, M., Met, Özcan, Westergaard, M. W., Larsen, S. K., Klausen, T. W., Donia, M., Svane, Inge Marie & Andersen, Mads Hald, 2016, In: OncoImmunology. 5, 11, 10 p., e1238541.Research output: Contribution to journal › Journal article › peer-review
- Published
Immune monitoring using mRNA-transfected dendritic cells
Borch, T. H., Svane, Inge Marie & Met, Özcan, 2016, Synthetic mRNA: Production, Introduction Into Cells, and Physiological Consequences. Humana Press, Vol. 1428. p. 245-259 15 p. (Methods in Molecular Biology, Vol. 1428).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Large-scale mRNA transfection of dendritic cells by electroporation in continuous flow systems
Selmeczi, D., Hansen, T. S., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 2016, Methods in Molecular Biology. Humana Press, Vol. 1428. p. 151-161 11 p. (Methods in Molecular Biology, Vol. 1428).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Transfection of tumor-infiltrating T cells with mRNA encoding CXCR2
Idorn, M., thor Straten, Per, Svane, Inge Marie & Met, Özcan, 2016, Synthetic mRNA: Production, Introduction Into Cells, and Physiological Consequences. Rhoads, R. E. (ed.). Springer, Vol. 1428. p. 261-276 16 p. (Methods in Molecular Biology, Vol. 1428).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2015
- Published
Broadening the repertoire of melanoma-associated T-cell epitopes
Frøsig, T. M., Lyngaa, R., Met, Özcan, Larsen, S. K., Donia, M., Svane, Inge Marie, Thor Straten, P. & Hadrup, S. R., May 2015, In: Cancer immunology, immunotherapy : CII. 64, 5, p. 609-20 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer
Hjortsø, M. D., Larsen, S. K., Kongsted, P., Met, Özcan, Frøsig, T. M., Andersen, G. H., Ahmad, S. M., Svane, Inge Marie, Becker, J. C., Straten, P. T. & Andersen, Mads Hald, Jan 2015, In: OncoImmunology. 4, 1, e968480.Research output: Contribution to journal › Journal article › peer-review
- 2014
- Published
Simplified protocol for clinical-grade tumor-infiltrating lymphocyte manufacturing with use of the Wave bioreactor
Donia, M., Larsen, S. M., Met, Özcan & Svane, Inge Marie, Aug 2014, In: Cytotherapy. 16, 8, p. 1117–1120 4 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Spontaneous presence of FOXO3-specific T cells in cancer patients
Larsen, S. K., Ahmad, S. M., Idorn, M., Met, Özcan, Martinenaite, E., Svane, Inge Marie, Straten, P. T. & Andersen, Mads Hald, 1 Jan 2014, In: OncoImmunology. 3, 8, e953411.Research output: Contribution to journal › Journal article › peer-review
T-cell responses to oncogenic Merkel cell polyomavirus proteins distinguish patients with Merkel cell carcinoma from healthy donors
Lyngaa, R., Pedersen, N. W., Schrama, D., Thrue, C. A., Ibrani, D., Met, Özcan, Straten, P., Nghiem, P., Becker, J. C. & Hadrup, S. R., 2014, In: Clinical Cancer Research. 20, 7, p. 1768-1778 11 p.Research output: Contribution to journal › Journal article › peer-review
- 2013
- Published
In-chip fabrication of free-form 3D constructs for directed cell migration analysis
Olsen, M. H., Hjortø, Gertrud Malene, Hansen, M., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 21 Dec 2013, In: Lab On a Chip. 13, 24, p. 4800-4809 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Munir, S., Andersen, G. H., Met, Özcan, Donia, M., Frøsig, T. M., Larsen, S. K., Klausen, T. W., Svane, Inge Marie & Andersen, Mads Hald, 15 Mar 2013, In: Cancer Research. 73, 6, p. 1764-76 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Analysis of Survivin-Specific T Cells in Breast Cancer Patients Using Human DCs Engineered with Survivin mRNA
Met, Özcan & Svane, Inge Marie, 2013, Synthetic Messenger RNA and Cell Metabolism Modulation. Vol. 969. p. 275-292 18 p. (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy
Hansen, M., Hjortø, Gertrud Malene, Donia, M., Met, Özcan, Larsen, N. B., Andersen, M. H., Thor Straten, P. & Svane, Inge Marie, 2013, In: Vaccine. 31, 4, p. 639-46 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
High frequency of T cells specific for cryptic epitopes in melanoma patients
Andersen, R. S., Andersen, S. R., Hjortsø, M. D., Lyngaa, R., Idorn, M., Køllgård, T. M., Met, Özcan, Straten, P. & Hadrup, S. R., 2013, In: OncoImmunology. 2, 7, e25374.Research output: Contribution to journal › Journal article › peer-review
- Published
Silencing of the glucocorticoid-induced leucine zipper improves the immunogenicity of clinical-grade dendritic cells
Cathelin, D., Met, Özcan & Svane, Inge Marie, 2013, In: Cytotherapy. 15, 6, p. 740-749 10 p.Research output: Contribution to journal › Journal article › peer-review
- 2012
- Published
Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients
Ellebaek, E., Iversen, T. Z., Junker, N., Donia, M., Engell-Noerregaard, L., Met, Özcan, Hølmich, Lisbet Rosenkrantz, Andersen, R. S., Hadrup, S. R., Andersen, M. H., Thor Straten, P. & Svane, Inge Marie, 2012, In: Journal of Translational Medicine. 10, p. 169Research output: Contribution to journal › Journal article › peer-review
- Published
Cellular based cancer vaccines: type 1 polarization of dendritic cells
Hansen, M., Met, Özcan, Svane, Inge Marie & Andersen, M. H., 2012, In: Current Medicinal Chemistry. 19, 25, p. 4239-46 8 p.Research output: Contribution to journal › Review › peer-review
- 2011
- Published
Efficient large volume electroporation of dendritic cells through micrometer scale manipulation of flow in a disposable polymer chip
Selmeczi, D., Hansen, T. S., Met, Özcan, Svane, Inge Marie & Larsen, N. B., Apr 2011, In: Biomedical Microdevices. 13, 2, p. 383-92 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Cell culture plastics with immobilized interleukin-4 for monocyte differentiation
Hansen, M., Hjortø, Gertrud Malene, Met, Özcan, Jakobsen, M. H., Svane, Inge Marie & Larsen, N. B., Feb 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
High immunogenic potential of p53 mRNA-transfected dendritic cells in patients with primary breast cancer
Met, Özcan, Balslev, E., Flyger, H. & Svane, Inge Marie, 1 Jan 2011, In: Breast Cancer Research and Treatment. 125, 2, p. 395-406 12 p.Research output: Contribution to journal › Journal article › peer-review
- 2009
- Published
Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function
Trepiakas, R., Pedersen, Anders Elm, Met, Özcan & Svane, Inge Marie, 2009, In: Vaccine. 27, 16, p. 2213-9 6 p.Research output: Contribution to journal › Journal article › peer-review
- 2008
- Published
Studies on mRNA electroporation of immature and mature dendritic cells: effects on their immunogenic potential
Met, Özcan, Eriksen, J. & Svane, Inge Marie, Oct 2008, In: Molecular Biotechnology. 40, 2, p. 151-60 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Comparison of alpha-Type-1 polarizing and standard dendritic cell cytokine cocktail for maturation of therapeutic monocyte-derived dendritic cell preparations from cancer patients.
Trepiakas, R., Pedersen, Anders Elm, Met, Özcan, Hansen, M. H., Berntsen, A. & Svane, I. M., 2008, In: Vaccine. 26, 23, p. 2824-32 8 p.Research output: Contribution to journal › Journal article › peer-review
- 2006
- Published
The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling.
Met, Özcan, Wang, M., Pedersen, Anders Elm, Nissen, Mogens Holst, Buus, Søren & Claesson, Mogens Helweg, 2006, In: Cancer Letters. 231, 2, p. 247-56 9 p.Research output: Contribution to journal › Journal article › peer-review
- 2003
- Published
Immunobiological Effects of Glucosamine In Vitro
Forchhammer, L., Thorn, M., Met, Özcan, Gad, M., Weidner, M. S. & Claesson, Mogens Helweg, 1 Oct 2003, In: Scandinavian Journal of Immunology. 58, 4, p. 404-11 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Peptide-loaded dendritic cells prime and activate MHC-class I-restricted T cells more efficiently than protein-loaded cross-presenting DC
Met, Özcan, Buus, Søren & Claesson, Mogens Helweg, 2003, In: Cellular Immunology. 222, 2, p. 126-33 7 p.Research output: Contribution to journal › Journal article › peer-review
ID: 33971757
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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
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Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction
Research output: Contribution to journal › Journal article › peer-review
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The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Research output: Contribution to journal › Journal article › peer-review
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