Nikos Hatzakis

Nikos Hatzakis

Professor

ORCID: 0000-0003-4202-0328

Publication year:
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  1. 2024
  2. Published

    Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

    Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Probing Activation and Conformational Dynamics of the Vesicle-Reconstituted β2 Adrenergic Receptor at the Single-Molecule Level

    Tutkus, M., Lundgaard, C. V., Veshaguri, S., Tønnesen, A., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2024, In: Journal of Physical Chemistry B. 128, 9, p. 2124–2133 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Protein Tracking: Everything, everywhere, almost at once

    Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: eLife. 13, 3 p., e95362.

    Research output: Contribution to journal › Editorial › Research › peer-review

  5. Published

    SEMORE: SEgmentation and MORphological fingErprinting by machine learning automates super-resolution data analysis

    Bender, S. W. B., Dreisler, M. W., Zhang, Min, Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: Nature Communications. 15, 1, 13 p., 1763.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2023
  7. Published

    Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

    Benning, N. A., Kæstel-Hansen, Jacob, Rashid, F., Park, S., Urteaga, R. M., Liao, T., Hao, J., Berger, J. M., Hatzakis, Nikos & Ha, T., 2023, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 127, 9, p. 1922–1931 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Direct observation and classification of heterogeneous protein aggregation in real-time through super-resolution and aggregational fingerprinting

    Bender, S., Kæstel-Hansen, Jacob, Zhang, Min & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 16a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  9. Published

    Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

    Bohr, Freja Schmidt-Rasmussen, Bohr, S. S. R., Mishra, N. K., González-Foutel, N. S., Pinholt, H. D., Wu, S., Nielsen, E. M., Zhang, Min, Kjaergaard, M., Jensen, Knud Jørgen & Hatzakis, Nikos, 2023, In: Communications Biology . 6, 1, 14 p., 178.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

    Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

    Thorlaksen, C., Schultz, H. S., Gammelgaard, S. K., Jiskoot, W., Hatzakis, Nikos, Nielsen, F. S., Solberg, H., Foderà, Vito, Bartholdy, C. & Groenning, M., 2023, In: International Journal of Pharmaceutics. 631, 122490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Making the undetectable detectable: Pushing limits of biomolecular recognition by ultra-sensitive multiplexed single-particle liposome readouts

    Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 231a-232a 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Rapid extraction of time-dependent behaviors of endo-lysosomal structures and their cargo aided by deep learning

    Kæstel-Hansen, Jacob, Kreutzberger, A., Kirchhausen, T. & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 517a 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

    Iversen, J. F., Bohr, S. S. R., Pinholt, H. D., Moses, M. E., Iversen, L., Christensen, S. M., Hatzakis, Nikos & Zhang, Min, 2023, In: Biomolecules. 13, 4, 11 p., 631.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2022
  17. Published

    Biased metabolism via small-molecule ligands binding to P450 oxidoreductase

    Hatzakis, Nikos, Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Knudsen, C., Giudice, R. D., Lund, P. M., Castano, P., Bustamante, Y. G., Jorgennsen, F. S., Pandey, A. V., Laursen, Tomas & Møller, Birger Lindberg, 1 Feb 2022, In: Biophysical Journal. 121, 3, p. 52a 1 p., 250-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  18. Published

    A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

    Goetz, M., Barth, A., Bohr, S. S-R., Boerner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J. & 9 others, Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P. & Schmid, S., 2022, In: Nature Communications. 13, 1, 12 p., 5402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Direct observation of heterogeneous formation of amyloid spherulites in real-time by super-resolution microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2022, In: Communications Biology . 5, 1, 10 p., 850.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Direct observations of drug nanocarrier interactions and mobility within biological interfaces

    Bohr, S. S. R., Streck, S., Pinholt, H., Wan, F., Mcdowell, A., Nielsen, Hanne Mørck & Hatzakis, Nikos, 2022, In: Biophysical Journal. 121, 3, p. 72a-73a 2 p., 355-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  21. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

    Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Robust Dual Optical Sensor for pH and Dissolved Oxygen

    Wang, L., Jensen, K., Hatzakis, Nikos, Zhang, Min & Sørensen, Thomas Just, 2022, In: ACS Sensors. 7, 5, p. 1506–1513

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Single Vesicle Fluorescence-Bleaching Assay for Multi-Parameter Analysis of Proteoliposomes by Total Internal Reflection Fluorescence Microscopy

    Veit, S., Paweletz, L. C., Bohr, S. S., Menon, A. K., Hatzakis, Nikos & Pomorski, Thomas Guenther, 2022, In: ACS applied materials & interfaces. 14, 26, p. 29659−29667 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Single-particle combinatorial multiplexed liposome fusion mediated by DNA

    Malle, M., Loffler, P., Bohr, S. S., Sletfjerding, M., Risgaard, N., Jensen, S., Zhang, Min, Hedegård, Per, Vogel, S. & Hatzakis, Nikos, 2022, In: Nature Chemistry. 14, 5, p. 558–565 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2021
  28. Published

    Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

    Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, Cecilie Ida Cetti, Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., Castaño, P. R., Bustamante, Y. G., Velazquez, M. N. R., Jørgensen, Flemming Steen, Pandey, A. V., Laursen, Tomas, Møller, Birger Lindberg & Hatzakis, Nikos, 2021, In: Nature Communications. 12, 1, 14 p., 2260.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery

    Holmstrøm, T., Galsgaard Malle, M., Wu, S., Jensen, Knud Jørgen, Hatzakis, Nikos & Pedersen, Christian Marcus, 2021, In: Chemistry - A European Journal. 27, 23, p. 6917-6922 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Direct Observation of Anisotropy-Driven Formation of Amyloid Spherulites in Real-time by Super-resolution Microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2021, 19 p.

    Research output: Working paper › Preprint › Research

  31. Published

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Lerner, E., Barth, A., Hendrix, J., Ambrose, B., Birkedal, V., Blanchard, S. C., Börner, R., Chung, H. S., Cordes, T., Craggs, T. D., Deniz, A. A., Diao, J., Fei, J., Gonzalez, R. L., Gopich, I. V., Ha, T., Hanke, C. A., Haran, G., Hatzakis, N. S., Hohng, S. & 27 others, Hong, S. C., Hugel, T., Ingargiola, A., Joo, C., Kapanidis, A. N., Kim, H. D., Laurence, T., Lee, N. K., Lee, T. H., Lemke, E. A., Margeat, E., Michaelis, J., Michalet, X., Myong, S., Nettels, D., Peulen, T. O., Ploetz, E., Razvag, Y., Robb, N. C., Schuler, B., Soleimaninejad, H., Tang, C., Vafabakhsh, R., Lamb, D. C., Seidel, C. A. M., Weiss, S. & Boudker, O., 2021, In: eLife. 10, 69 p., e60416.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking

    Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Single-Molecule Study of Thermomyces lanuginosus Lipase in a Detergency Application System Reveals Diffusion Pattern Remodeling by Surfactants and Calcium

    Moses, M. E., Lund, P. M., Bohr, S. S., Iversen, J. F., Kæstel-Hansen, J., Kallenbach, A. S., Iversen, L., Christensen, S. M. & Hatzakis, Nikos, 2021, In: A C S Applied Materials and Interfaces. 13, 28, 9 p., 33704.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion

    Pinholt, H. D., Bohr, S. S. R., Iversen, J. F., Boomsma, Wouter & Hatzakis, Nikos, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 7 p., e2104624118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. 2020
  36. Published

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Label-Free Fluorescence Quantification of Hydrolytic Enzyme Activity on Native Substrates Reveals How Lipase Function Depends on Membrane Curvature

    Bohr, S. S., Thorlaksen, C., Kühnel, R. M., Pomorski, Thomas Guenther & Hatzakis, Nikos, 16 Jun 2020, In: Langmuir. 36, 23, p. 6473-6481 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  39. Published

    Direct Observation of Sophorolipid Micelle Docking in Model Membranes and Cells by Single Particle Studies Reveals Optimal Fusion Conditions

    Singh, P. K., Bohr, S. S. & Hatzakis, Nikos, 2020, In: Biomolecules. 10, 9, 16 p., 1291.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    How Membrane Geometry Regulates Protein Sorting Independently of Mean Curvature

    Larsen, J. B., Rosholm, K. R., Kennard, C., Pedersen, S. L., Munch, H. K., Tkach, Vadym, Sakon, J. J., Bjornholm, T., Weninger, K. R., Bendix, Poul Martin, Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2020, In: ACS Central Science. 6, 7, p. 1159-1168 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2019
  43. Published

    A large size-selective DNA nanopore with sensing applications

    Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, Nikos & Kjems, J., 2019, In: Nature Communications. 10, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition

    Bohr, S. S., Lund, P. M., Kallenbach, A. S., Pinholt, H., Thomsen, J., Iversen, L., Svendsen, A., Christensen, S. M. & Hatzakis, Nikos, 2019, In: Scientific Reports. 9, 11 p., 16169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

    Bech, E. M., Kaiser, A., Bellmann-Sickert, K., Nielsen, S. S., Sørensen, K. K., Elster, L., Hatzakis, Nikos, Pedersen, S. L., Beck-Sickinger, A. G. & Jensen, Knud Jørgen, 2019, In: Molecular Pharmaceutics. 16, 8, p. 3665-3677

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

    Mazurenko, I., Hatzakis, Nikos & Jeuken, L. J. C., 2019, In: Journal of Visualized Experiments. 144

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2018
  48. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

    Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, Troels Christian, Møller, Birger Lindberg, Hatzakis, Nikos & Laursen, Tomas, 2018, In: Scientific Reports. 8, 9 p., 6817.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Functionalized Gold Nanoclusters Identify Highly Reactive Oxygen Species in Living Organisms

    Xie, Y., Xianyu, Y., Wang, N., Yan, Z., Liu, Y., Zhu, K., Hatzakis, Nikos & Jiang, X., 2018, In: Advanced Functional Materials. 28, 14, 7 p., 1702026.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2017
  52. Published

    Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

    Rosholm, K. R., Leijnse, Natascha, Mantsiou, A., Tkach, Vadym, Pedersen, S. L., Wirth, V. F., Oddershede, L. B., Jensen, Knud Jørgen, Martinez, Karen Laurence, Hatzakis, Nikos, Bendix, Poul Martin, Callan-Jones, A. & Stamou, Dimitrios, 8 May 2017, In: Nature Chemical Biology. 13, 7, p. 724-729

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Effects of membrane curvature and pH on proton pumping activity of single cytochrome bo3 enzymes

    Li, M., Khan, S., Rong, H., Tuma, R., Hatzakis, Nikos & Jeuken, L. J. C., 2017, In: Biochimica et Biophysica Acta - Bioenergetics. 1858, 9, p. 763-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2017, In: Biophysical Journal. 113, 6, p. 1269-1279 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2016
  56. Published

    Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

    Laursen, Tomas, Borch-Jensen, J., Baden, C. K., Bavishi, K., Torta, F., Martens, Helle Jakobe, Silvestro, D., Hatzakis, Nikos, Wenk, M. R., Dafforn, T. R., Olsen, C. E., Motawie, Mohammed Saddik, Hamberger, B. R., Møller, Birger Lindberg & Bassard, J. A., 2016, In: Science (New York, N.Y.). 354, 6314, p. 890-893 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Direct observation of proton pumping by a eukaryotic P-type ATPase

    Veshaguri, S., Christensen, S. F., Kemmer, G. C., Ghale, G., Møller, M. P., Lohr, C., Christensen, A. L., Justesen, B. H., Jørgensen, I. L., Schiller, J., Hatzakis, Nikos, Grabe, M., Pomorski, Thomas Guenther & Stamou, Dimitrios, 2016, In: Science. 351, 6280, p. 1469-1473 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Links of conformational sampling to functional plasticity and clinical phenotypes by single molecule studies

    Moses, M. E., Thodberg, S., Bavishi, K., Eiersholt, S., Li, D., Stamou, Dimitrios, Møller, Birger Lindberg, Laursen, Tomas & Hatzakis, Nikos, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 397A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  59. Published

    N-RAS lipid anchor adsorption to membranes as a function of lipid composition and curvature

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 579A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

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