Morten Scheibye-Knudsen
Associate Professor
Molecular Aging Program
Blegdamsvej 3
2200 København N.
Member of:
Web: Center for Healthy Aging
Web Track 1: Modifiable pathways of damage and repair in aging
- 2024
- Published
Defining the progeria phenome
Worm, C., Schambye, M. E. R., Mkrtchyan, Garik, Veviorskiy, A., Shneyderman, A., Ozerov, I. V., Zhavoronkov, A., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2024, In: Aging. 16, 3, p. 2026-2046 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, , 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological interventions in human aging
Petr, Michael Angelo, Matiyevskaya, Frida, Osborne, Brenna, Berglind, M., Reves, Simon William Nayberg, Zhang, B., Ben Ezra, Michael, Carmona Marin, Lina Maria, Syadzha, Muhammad Farraz, Mediavilla, M. C., Keijzers, G., Bakula, Daniela Janina, Mkrtchyan, Garik & Scheibye-Knudsen, Morten, 2024, In: Ageing Research Reviews. 95, 14 p., 102213.Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Published
CD38 regulates ovarian function and fecundity via NAD+ metabolism
Perrone, R., Ashok Kumaar, P. V., Haky, L., Hahn, C., Riley, R., Balough, J., Zaza, G., Soygur, B., Hung, K., Prado, L., Kasler, H. G., Tiwari, R., Matsui, H., Hormazabal, G. V., Heckenbach, Indra John, Scheibye-Knudsen, Morten, Duncan, F. E. & Verdin, E., 2023, In: iScience. 26, 10, 27 p., 107949.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone malonylation is regulated by SIRT5 and KAT2A
Zhang, R., Bons, J., Scheidemantle, G., Liu, X., Bielska, O., Carrico, C., Rose, J., Heckenbach, Indra John, Scheibye-Knudsen, Morten, Schilling, B. & Verdin, E., 2023, In: iScience. 26, 3, 106193.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging
Sola-García, A., Cáliz-Molina, M. Á., Espadas, I., Petr, M., Panadero-Morón, C., González-Morán, D., Martín-Vázquez, M. E., Narbona-Pérez, Á. J., López-Noriega, L., Martínez-Corrales, G., López-Fernández-Sobrino, R., Carmona-Marin, L. M., Martínez-Force, E., Yanes, O., Vinaixa, M., López-López, D., Reyes, J. C., Dopazo, J., Martín, F., Gauthier, B. R. & 3 others, , 2023, In: Communications Biology . 6, 250.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tracking the dynamics of cellular senescence
Heckenbach, Indra John & Scheibye-Knudsen, Morten, 2023, In: Aging. 15, 9, p. 3219-3220 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2022
- Published
A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function
Boutoual, R., Jo, H., Heckenbach, Indra John, Tiwari, R., Kasler, H., Lerner, C. A., Shah, S., Schilling, B., Calvanese, V., Rardin, M. J., Scheibye-Knudsen, Morten & Verdin, E., 2022, In: Scientific Reports. 12, 14804.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CNOT6: A Novel Regulator of DNA Mismatch Repair
Song, P., Liu, S., Liu, D., Keijzers, G., Bakula, Daniela Janina, Duan, S., de Wind, N., Ye, Z., Vakhrushev, Sergey, Scheibye-Knudsen, Morten & Rasmussen, Lene Juel, 2022, In: Cells. 11, 3, 521.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical Trials Targeting Aging
Nielsen, J. L., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2022, In: Frontiers in Aging. 3, 10 p., 820215.Research output: Contribution to journal › Review › Research › peer-review
- Published
Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
Wnorowski, A., Dudzik, D., Bernier, M., Wójcik, J., Keijzers, G., Diaz-Ruiz, A., Mazur, K., Zhang, Y., Han, H., Scheibye-Knudsen, Morten, Jozwiak, K., Barbas, C. & Wainer, I. W., 2022, In: Scientific Reports. 12, 1, 3618.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
Mkrtchyan, Garik, Veviorskiy, A., Izumchenko, E., Shneyderman, A., Pun, F. W., Ozerov, I. V., Aliper, A., Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2022, In: Cell Death and Disease. 13, 11, 999.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meeting Report: Aging Research and Drug Discovery
Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., Fortney, K. & 58 others, , 2022, In: Aging. 14, 2, p. 530-543 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., Ding, L., Duncan, F. E., Eickelberg, O., Fan, R., Finkel, T., Furman, D., Garovic, V., Gehlenborg, N., Glass, C., Heckenbach, I., Joseph, Z. B., Katiyar, P. & 48 others, , 2022, In: Nature Aging. 2, 12, p. 1090-1100 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nuclear morphology is a deep learning biomarker of cellular senescence
Heckenbach, Indra John, Mkrtchyan, Garik, Ben Ezra, Michael, Bakula, Daniela Janina, Madsen, Jakob Sture, Nielsen, M. H., Oró, D., Osborne, Brenna, Covarrubias, A. J., Idda, M. L., Gorospe, M., Mortensen, Laust Hvas, Verdin, E., Westendorp, Rudi GJ & Scheibye-Knudsen, Morten, 2022, In: Nature Aging. 2, 8, p. 742-755 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Petr, Michael Angelo, Alfaras, I., Krawcyzk, M., Bair, W. N., Mitchell, S. J., Morrell, C. H., Studenski, S. A., Price, N. L., Fishbein, K. W., Spencer, R. G., Scheibye-Knudsen, Morten, Lakatta, E. G., Ferrucci, L., Aon, M. A., Bernier, M. & de Cabo, R., 2021, In: eLife. 10, 25 p., e62952.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration
Durhuus, J. A., Rozing, Maarten Pieter, Nielsen, M. K., Molbech, C. R., Keijzers, G., Scheibye-Knudsen, Morten, Rasmussen, Lene Juel, Westendorp, Rudi GJ & Sørensen, Torben Lykke, 2021, In: Scientific Reports. 11, 1, 8226.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity
McIntyre, R. L., Denis, S. W., Kamble, R., Molenaars, M., Petr, Michael Angelo, Schomakers, B. V., Rahman, M., Gupta, S., Toth, M. L., Vanapalli, S. A., Jongejan, A., Scheibye-Knudsen, Morten, Houtkooper, R. H. & Janssens, G. E., 2021, In: Aging Cell. 20, 8, p. e13381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Longevity medicine: upskilling the physicians of tomorrow
Bischof, E., Scheibye-Knudsen, Morten, Siow, R. & Moskalev, A., 2021, In: The Lancet Healthy Longevity. 2, 4, p. e187-e188Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis
Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, Indra John, Scheibye-Knudsen, Morten, De, S., Sen, P., Abdelmohsen, K. & Gorospe, M., 2021, In: Nucleic Acids Research. 49, 13, p. 7389-7405 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MitophAging: Mitophagy in Aging and Disease
Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2020, In: Frontiers in Cell and Developmental Biology. 8, 16 p., 239.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mitophagy and Neuroprotection
Lou, G., Palikaras, K., Lautrup, S., Scheibye-Knudsen, Morten, Tavernarakis, N. & Fang, E. F., 2020, In: Trends in Molecular Medicine. 26, 1, p. 8-20Research output: Contribution to journal › Review › Research › peer-review
- Published
New methodologies in ageing research
Osborne, Brenna, Bakula, Daniela Janina, Ben Ezra, Michael, Dresen, C., Hartmann, E., Kristensen, S. M., Mkrtchyan, Garik, Nielsen, M. H., Petr, Michael Angelo & Scheibye-Knudsen, Morten, 2020, In: Ageing Research Reviews. 62, 11 p., 101094.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protecting the Aging Genome
Petr, Michael Angelo, Tulika, T., Carmona Marin, Lina Maria & Scheibye-Knudsen, Morten, 2020, In: Trends in Cell Biology. 30, 2, p. 117-132 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., Wong, H. S., Gibbs, E., Iyer, S. S., Basisty, N., Wu, Q., Kim, I. J., Silva, E., Vitangcol, K., Shin, K. O., Lee, Y. M. & 11 others, , 2020, In: Nature Metabolism. 2, 11, p. 1265-1283 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
A defined human aging phenome
Andreassen, Søren Norge, Ben Ezra, Michael & Scheibye-Knudsen, Morten, 2019, In: Aging. 11, 15, p. 5786-5806 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Artificial intelligence for aging and longevity research: Recent advances and perspectives
Zhavoronkov, A., Mamoshina, P., Vanhaelen, Q., Scheibye-Knudsen, Morten, Moskalev, A. & Aliper, A., 2019, In: Ageing Research Reviews. 49, p. 49-66 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers
Mamoshina, P., Kochetov, K., Cortese, F., Kovalchuk, A., Aliper, A., Putin, E., Scheibye-Knudsen, Morten, Cantor, C. R., Skjodt, N. M., Kovalchuk, O. & Zhavoronkov, A., 2019, In: Scientific Reports. 9, 10 p., 142.Research output: Contribution to journal › Journal article › Research › peer-review
Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)
Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In: Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lamin A/C promotes DNA base excision repair
Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Latest advances in aging research and drug discovery
Bakula, D., Ablasser, A., Aguzzi, A., Antebi, A., Barzilai, N., Bittner, M. I., Jensen, M. B., Calkhoven, C. F., Chen, D., de Grey, A. D. N. J., Feige, J. N., Georgievskaya, A., Gladyshev, V. N., Golato, T., Gudkov, A. V., Hoppe, T., Kaeberlein, M., Katajisto, P., Kennedy, B. K., Lal, U. & 10 others, , 2019, In: Aging. 11, 22, p. 9971-9981 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Monogenic Diseases of DNA Repair
Keijzers, G., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 1 Feb 2018, In: The New England Journal of Medicine. 378, 5, p. 491-492 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The authors reply
Keijzers, G., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 1 Feb 2018, In: New England Journal of Medicine. 378, 5, p. 491-492 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Aging and drug discovery
Bakula, D., Aliper, A. M., Mamoshina, P., Petr, M. A., Teklu, A., Baur, J. A., Campisi, J., Ewald, C. Y., Georgievskaya, A., Gladyshev, V. N., Kovalchuk, O., Lamming, D. W., Luijsterburg, M. S., Martín-Montalvo, A., Maudsley, S., Mkrtchyan, G. V., Moskalev, A., Jay Olshansky, S., Ozerov, I. V., Pickett, A. & 3 others, , 2018, In: Aging. 10, 11, p. 3079-3088 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population specific biomarkers of human aging: A big data study using South Korean, Canadian, and Eastern European patient populations
Mamoshina, P., Kochetov, K., Putin, E., Cortese, F., Aliper, A., Lee, W. S., Ahn, S. M., Uhn, L., Skjodt, N., Kovalchuk, O., Scheibye-Knudsen, Morten & Zhavoronkov, A., 2018, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 11, p. 1482-1490 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vive la radiorésistance! Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization
Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., Izumchenko, E. & 10 others, , 2018, In: OncoTarget. 9, 18, p. 14692-14722 31 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Monogenic diseases of DNA repair
Keijzers, G., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, Nov 2017, In: New England Journal of Medicine. 377, 19, p. 1868-1876 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cockayne syndrome: Clinical features, model systems and pathways
Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, 2017, In: Ageing Research Reviews. 33, p. 3-17Research output: Contribution to journal › Review › Research › peer-review
- Published
Mitophagy in neurodegeneration and aging
Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In: Neurochemistry International. 109, p. 202-209Research output: Contribution to journal › Review › Research › peer-review
- Published
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In: Scientific Reports. 7, 46208.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons
Marosi, K., Kim, S. W., Moehl, K., Scheibye-Knudsen, Morten, Cheng, A., Cutler, R., Camandola, S. & Mattson, M. P., Dec 2016, In: Journal of Neurochemistry. 139, 5, p. 769-781 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, L. H., Dec 2016, In: Neurobiology of Aging. 48, p. 34-47Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J. & 2 others, , 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurodegeneration in Accelerated Aging
Scheibye-Knudsen, Morten, Nov 2016, In: Danish Medical Journal. 63, 11, 21 p., B5308.Research output: Contribution to journal › Review › Research › peer-review
- Published
NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P. & 2 others, , 11 Oct 2016, In: Cell Metabolism. 24, 4, p. 566-581 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., Gonzalez-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Buron, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C. & 27 others, , 14 Jun 2016, In: Cell Metabolism. 23, 6, p. 1093-1112Research output: Contribution to journal › Journal article › Research › peer-review
Nuclear DNA damage signalling to mitochondria in ageing
Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In: Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurodegeneration in accelerated aging
Scheibye-Knudsen, Morten, 2016, 190 p.Research output: Book/Report › Doctoral thesis › Research
ID: 144763346
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Artificial intelligence for aging and longevity research: Recent advances and perspectives
Research output: Contribution to journal › Review › Research › peer-review
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A defined human aging phenome
Research output: Contribution to journal › Journal article › Research › peer-review
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Research output: Contribution to journal › Journal article › Research › peer-review
Published