Morten Scheibye-Knudsen
Associate Professor
Molecular Aging Program
Blegdamsvej 3
2200 København N.
Member of:
Web: Center for Healthy Aging
Web Track 1: Modifiable pathways of damage and repair in aging
- 2024
- Published
Defining the progeria phenome
Worm, C., Schambye, M. E. R., Mkrtchyan, Garik, Veviorskiy, A., Shneyderman, A., Ozerov, I. V., Zhavoronkov, A., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2024, In: Aging. 16, 3, p. 2026-2046 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, , 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological interventions in human aging
Petr, Michael Angelo, Matiyevskaya, Frida, Osborne, Brenna, Berglind, M., Reves, Simon William Nayberg, Zhang, B., Ben Ezra, Michael, Carmona Marin, Lina Maria, Syadzha, Muhammad Farraz, Mediavilla, M. C., Keijzers, G., Bakula, Daniela Janina, Mkrtchyan, Garik & Scheibye-Knudsen, Morten, 2024, In: Ageing Research Reviews. 95, 14 p., 102213.Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Published
CD38 regulates ovarian function and fecundity via NAD+ metabolism
Perrone, R., Ashok Kumaar, P. V., Haky, L., Hahn, C., Riley, R., Balough, J., Zaza, G., Soygur, B., Hung, K., Prado, L., Kasler, H. G., Tiwari, R., Matsui, H., Hormazabal, G. V., Heckenbach, Indra John, Scheibye-Knudsen, Morten, Duncan, F. E. & Verdin, E., 2023, In: iScience. 26, 10, 27 p., 107949.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone malonylation is regulated by SIRT5 and KAT2A
Zhang, R., Bons, J., Scheidemantle, G., Liu, X., Bielska, O., Carrico, C., Rose, J., Heckenbach, Indra John, Scheibye-Knudsen, Morten, Schilling, B. & Verdin, E., 2023, In: iScience. 26, 3, 106193.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging
Sola-García, A., Cáliz-Molina, M. Á., Espadas, I., Petr, M., Panadero-Morón, C., González-Morán, D., Martín-Vázquez, M. E., Narbona-Pérez, Á. J., López-Noriega, L., Martínez-Corrales, G., López-Fernández-Sobrino, R., Carmona-Marin, L. M., Martínez-Force, E., Yanes, O., Vinaixa, M., López-López, D., Reyes, J. C., Dopazo, J., Martín, F., Gauthier, B. R. & 3 others, , 2023, In: Communications Biology . 6, 250.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tracking the dynamics of cellular senescence
Heckenbach, Indra John & Scheibye-Knudsen, Morten, 2023, In: Aging. 15, 9, p. 3219-3220 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2022
- Published
A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function
Boutoual, R., Jo, H., Heckenbach, Indra John, Tiwari, R., Kasler, H., Lerner, C. A., Shah, S., Schilling, B., Calvanese, V., Rardin, M. J., Scheibye-Knudsen, Morten & Verdin, E., 2022, In: Scientific Reports. 12, 14804.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CNOT6: A Novel Regulator of DNA Mismatch Repair
Song, P., Liu, S., Liu, D., Keijzers, G., Bakula, Daniela Janina, Duan, S., de Wind, N., Ye, Z., Vakhrushev, Sergey, Scheibye-Knudsen, Morten & Rasmussen, Lene Juel, 2022, In: Cells. 11, 3, 521.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical Trials Targeting Aging
Nielsen, J. L., Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2022, In: Frontiers in Aging. 3, 10 p., 820215.Research output: Contribution to journal › Review › Research › peer-review
- Published
Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
Wnorowski, A., Dudzik, D., Bernier, M., Wójcik, J., Keijzers, G., Diaz-Ruiz, A., Mazur, K., Zhang, Y., Han, H., Scheibye-Knudsen, Morten, Jozwiak, K., Barbas, C. & Wainer, I. W., 2022, In: Scientific Reports. 12, 1, 3618.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
Mkrtchyan, Garik, Veviorskiy, A., Izumchenko, E., Shneyderman, A., Pun, F. W., Ozerov, I. V., Aliper, A., Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2022, In: Cell Death and Disease. 13, 11, 999.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meeting Report: Aging Research and Drug Discovery
Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., Fortney, K. & 58 others, , 2022, In: Aging. 14, 2, p. 530-543 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., Ding, L., Duncan, F. E., Eickelberg, O., Fan, R., Finkel, T., Furman, D., Garovic, V., Gehlenborg, N., Glass, C., Heckenbach, I., Joseph, Z. B., Katiyar, P. & 48 others, , 2022, In: Nature Aging. 2, 12, p. 1090-1100 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nuclear morphology is a deep learning biomarker of cellular senescence
Heckenbach, Indra John, Mkrtchyan, Garik, Ben Ezra, Michael, Bakula, Daniela Janina, Madsen, Jakob Sture, Nielsen, M. H., Oró, D., Osborne, Brenna, Covarrubias, A. J., Idda, M. L., Gorospe, M., Mortensen, Laust Hvas, Verdin, E., Westendorp, Rudi GJ & Scheibye-Knudsen, Morten, 2022, In: Nature Aging. 2, 8, p. 742-755 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Petr, Michael Angelo, Alfaras, I., Krawcyzk, M., Bair, W. N., Mitchell, S. J., Morrell, C. H., Studenski, S. A., Price, N. L., Fishbein, K. W., Spencer, R. G., Scheibye-Knudsen, Morten, Lakatta, E. G., Ferrucci, L., Aon, M. A., Bernier, M. & de Cabo, R., 2021, In: eLife. 10, 25 p., e62952.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration
Durhuus, J. A., Rozing, Maarten Pieter, Nielsen, M. K., Molbech, C. R., Keijzers, G., Scheibye-Knudsen, Morten, Rasmussen, Lene Juel, Westendorp, Rudi GJ & Sørensen, Torben Lykke, 2021, In: Scientific Reports. 11, 1, 8226.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity
McIntyre, R. L., Denis, S. W., Kamble, R., Molenaars, M., Petr, Michael Angelo, Schomakers, B. V., Rahman, M., Gupta, S., Toth, M. L., Vanapalli, S. A., Jongejan, A., Scheibye-Knudsen, Morten, Houtkooper, R. H. & Janssens, G. E., 2021, In: Aging Cell. 20, 8, p. e13381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Longevity medicine: upskilling the physicians of tomorrow
Bischof, E., Scheibye-Knudsen, Morten, Siow, R. & Moskalev, A., 2021, In: The Lancet Healthy Longevity. 2, 4, p. e187-e188Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis
Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, Indra John, Scheibye-Knudsen, Morten, De, S., Sen, P., Abdelmohsen, K. & Gorospe, M., 2021, In: Nucleic Acids Research. 49, 13, p. 7389-7405 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MitophAging: Mitophagy in Aging and Disease
Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2020, In: Frontiers in Cell and Developmental Biology. 8, 16 p., 239.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mitophagy and Neuroprotection
Lou, G., Palikaras, K., Lautrup, S., Scheibye-Knudsen, Morten, Tavernarakis, N. & Fang, E. F., 2020, In: Trends in Molecular Medicine. 26, 1, p. 8-20Research output: Contribution to journal › Review › Research › peer-review
- Published
New methodologies in ageing research
Osborne, Brenna, Bakula, Daniela Janina, Ben Ezra, Michael, Dresen, C., Hartmann, E., Kristensen, S. M., Mkrtchyan, Garik, Nielsen, M. H., Petr, Michael Angelo & Scheibye-Knudsen, Morten, 2020, In: Ageing Research Reviews. 62, 11 p., 101094.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protecting the Aging Genome
Petr, Michael Angelo, Tulika, T., Carmona Marin, Lina Maria & Scheibye-Knudsen, Morten, 2020, In: Trends in Cell Biology. 30, 2, p. 117-132 16 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 144763346
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Artificial intelligence for aging and longevity research: Recent advances and perspectives
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A defined human aging phenome
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
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