Morten Grunnet

Morten Grunnet

Affiliate Professor


Publication year:
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1 - 100 out of 109Page size: 100
  1. 2024
  2. E-pub ahead of print

    A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation

    Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, Morten Steen Salling, Bentzen, Bo Hjorth, Grunnet, Morten, Eveleens Maarse, B. C., Diness, Jonas Goldin, Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, (E-pub ahead of print) In: British Journal of Clinical Pharmacology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2020
  4. Published

    Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing

    Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Gentilini, F., Forni, M., Zannoni, A., Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction

    Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Pharmacology. 11, 11 p., 556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

    Diness, J. G., Kirchhoff, J. E., Speerschneider, T., Abildgaard, L., Edvardsson, N., Sorensen, U. S., Grunnet, Morten & Bentzen, Bo Hjorth, 2020, In: Frontiers in Pharmacology. 11, 9 p., 159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2019
  8. Published

    Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model

    Lubberding, Anniek Frederike, Sattler, Stefan M, Grunnet, Morten, Sørensen, U. S., Tfelt-Hansen, Jacob & Jespersen, Thomas, Oct 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 10, p. 1584–1593

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Impact of arrhythmogenic calmodulin variants on small conductance Ca2+-activated K+ (SK3) channels

    Saljic, Arnela, Muthukumarasamy, K. M., la Cour, J. M., Boddum, K., Grunnet, Morten, Berchtold, Martin Werner & Jespersen, Thomas, 2019, In: Physiological Reports. 7, 19, 13 p., e14210.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

    Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, Sofia Hammami, Abildgaard, L., Jespersen, Thomas, Sørensen, U. S., Grunnet, Morten, Bentzen, Bo Hjorth & Diness, Jonas Goldin, 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2018
  12. Published

    Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death

    Richards, K. L., Milligan, C. J., Richardson, R. J., Jancovski, N., Grunnet, Morten, Jacobson, L. H., Undheim, E. A. B., Mobli, M., Chow, C. Y., Herzig, V., Csoti, A., Panyi, G., Reid, C. A., King, G. F. & Petrou, S., 21 Aug 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 34, p. E8077-E8085

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Pharmacological rescue of mutated K(v)3.1 ion-channel linked to progressive myoclonus epilepsies

    Munch, A. S., Saljic, Arnela, Boddum, K., Grunnet, Morten, Hougaard, C. & Jespersen, Thomas, 2018, In: European Journal of Pharmacology. 833, p. 255-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2017
  15. Published

    A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels

    Simo Vicens, R., Kirchhoff, J. E., Dolce , B., Abildgaard, L., Speerschneider, T., Sørensen, U. S., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 5 Dec 2017, In: British Journal of Pharmacology. 174, 23, p. 4396-4408 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Phosphodiesterase 1a inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries

    Khammy, M. M., Dalsgaard, T., Larsen, P. H., Christoffersen, C. T., Clausen, D., Rasmussen, L. K., Folkersen, L., Grunnet, Morten, Kehler, J., Aalkjær, Christian & Nielsen, J., Nov 2017, In: British Journal of Pharmacology. 174, 22, p. 4186-4198 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs

    Diness, Jonas Goldin, Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, Pia Rengtved, Citerni, C., Sauter, D. R. P., Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, U. S., Jespersen, Thomas, Grunnet, Morten & Bentzen, Bo Hjorth, 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats

    Laursen, M., Beck, L., Kehler, J., Christoffersen, C. T., Bundgaard, C., Mogensen, S., Mow, T. J., Pinilla, E., Knudsen, J. S., Hedegaard, E. R., Grunnet, Morten & Simonsen, U., Aug 2017, In: British Journal of Pharmacology. 174, 15, p. 2563-2575 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels

    Simo Vicens, R., Sauter, D. R. P., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 15 May 2017, In: European Journal of Pharmacology. 803, p. 118-123 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Novel negative allosteric modulator inhibits small conductance calcium-activated potassium channels and selectively prolongs atrial refractoriness in conscious pigs

    Simó-Vicens, R., Citerni, C., Edvardsson, N. G., Sørensen, U. S., Grunnet, Morten, Diness, Jonas Goldin & Bentzen, Bo Hjorth, 11 May 2017, In: Heart Rhythm. 14, 5 suppl., p. S149-S150 P-PO02-15.

    Research output: Contribution to journal › Conference abstract in journal › Research

  21. 2016
  22. Published

    Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

    Kirchhoff, J. E., Diness, Jonas Goldin, Abildgaard, L., Sheykhzade, Majid, Grunnet, Morten & Jespersen, Thomas, 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2015
  24. Published

    Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

    Diness, Jonas Goldin, Bentzen, Bo Hjorth, S. Sørensen, U. & Grunnet, Morten, Nov 2015, In: Journal of Cardiovascular Pharmacology. 66, 5, p. 441-448 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium

    Skibsbye, L., Wang, X., Axelsen, L. N., Bomholtz, Sofia Hammami, Nielsen, Morten Schak, Grunnet, Morten, Bentzen, Bo Hjorth & Jespersen, Thomas, Aug 2015, In: Journal of Cardiovascular Pharmacology. 66, 2, p. 165-176 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation

    Poulet, C., Wettwer, E., Grunnet, Morten, Jespersen, Thomas, Fabritz, L., Matschke, K., Knaut, M. & Ravens, U., 29 Jun 2015, In: PLOS ONE. 10, 6, p. 1-19 19 p., e0131432.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family

    Kanters, Jørgen K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

    Jabbari, J., Olesen, Morten Steen Salling, Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, Ahmad, Ellinor, P. T., Grunnet, Morten, Haunsø, Stig, Holst, A. G., Svendsen, Jesper Hastrup & Jespersen, Thomas, 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2014
  30. Published

    Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

    Schmitt, Nicole, Grunnet, Morten & Olesen, Søren-Peter, Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.

    Kanters, Jørgen K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

    Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, Hanne Borger, Wickman, K., Grunnet, Morten, Olesen, Søren-Peter & Jespersen, Thomas, 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 175-84 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    BK channel activators and their therapeutic perspectives

    Bentzen, Bo Hjorth, Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2013
  35. Published

    GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology

    Wang, X., Liang, B., Skibsbye, L., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, Aug 2013, In: Journal of Cardiovascular Pharmacology. 62, 2, p. 192-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Benzimidazolyl-acetamide derivatives useful as potassium channel modulators

    SØRENSEN, U. S., Grunnet, Morten, Bentzen, Bo Hjorth, Christophersen, P., Diness, Jonas Goldin, SKIBSBYE, L. & Strøbæk, D., 7 Jan 2013

    Research output: Other contribution › Research

  37. 2012
  38. Published

    Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury

    Hostrup, A., Christensen, G. L., Bentzen, Bo Hjorth, Liang, B., Aplin, M., Grunnet, Morten, Hansen, J. L. & Jespersen, Thomas, 30 Jul 2012, In: Cellular Physiology and Biochemistry. 30, 3, p. 642-652 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats

    Bentzen, Bo Hjorth, Grunnet, Morten, Hyveled-Nielsen, L., Sundgreen, C., lassen, J. B. & Hansen, H. H., 2012, In: Obesity.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure

    Nissen, J. D., Thomsen, Morten Bækgaard, Bentzen, Bo Hjorth, Diness, Jonas Goldin, Diness, T. G., Jespersen, Thomas & Grunnet, Morten, 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

    Krzystanek, K., Rasmussen, Hanne Borger, Grunnet, Morten, Staub, O., Olesen, Søren-Peter, Abriel, H. & Jespersen, Thomas, 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts

    Laursen, M., Grunnet, Morten, Olesen, Søren-Peter, Jespersen, Thomas & Mow, T., 2012, In: Journal of Pharmacological and Toxicological Methods. 64, 2, p. 134-44 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2011
  44. Published

    Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits

    Bentzen, Bo Hjorth, Bahrke, S., Wu, K., Larsen, A. P., Odening, K. E., Franke, G., Storm vans Gravesande, K., Biermann, J., Peng, X., Koren, G., Zehender, M., Bode, C., Grunnet, Morten & Brunner, M., Feb 2011, In: Journal of Cardiovascular Pharmacology. 57, 2, p. 223-30 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Cardiac channelopathies and sudden infant death syndrome

    Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Cardiac ion channels and mechanisms for protection against atrial fibrillation.

    Grunnet, Morten, Bentzen, Bo Hjorth, Sørensen, U. S. & Diness, Jonas Goldin, 2011, In: Reviews of Physiology, Biochemistry and Pharmacology. 162, p. 1-58 59 p.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal

    Bentzen, Bo Hjorth & Grunnet, Morten, 2011, In: Advances in Pharmacological Sciences. 2011, 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Characterization of cardiac repolarization in the Göttingen minipig

    Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

    Diness, Jonas Goldin, Skibsbye, L., Jespersen, Thomas, Bartels, Emil Daniel, Sørensen, U. S., Hansen, R. S. & Grunnet, Morten, 2011, In: Hypertension. 57, 6, p. 1129-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state

    Larsen, A. P., Steffensen, Annette Buur, Grunnet, Morten & Olesen, Søren-Peter, 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1

    Andersen, A., Bentzen, Bo Hjorth, Salling, H., Klingberg, H., Kanneworff, M., Grunnet, Morten & Pedersen, Stine Helene Falsig, 2011, In: Cellular Physiology and Biochemistry. 28, 1, p. 13-24 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca2+-activated K+ channels.

    Skibsbye, L., Diness, Jonas Goldin, Sørensen, U. S., Hansen, R. S. & Grunnet, Morten, 2011, In: Journal of Cardiovascular Pharmacology. 57, 6, p. 672-681

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2010
  54. Published

    Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels

    Larsen, A. P., Bentzen, Bo Hjorth & Grunnet, Morten, Oct 2010, In: British Journal of Pharmacology. 161, 3, p. 614-28 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

    Diness, Jonas Goldin, Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, Morten, Hansen, R. S. & Jespersen, Thomas, Aug 2010, In: Circulation. Arrhythmia and electrophysiology. 3, 4, p. 380-90 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

    Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S-P., Rasmussen, H. B., Ellinor, P. T., Gao, L., Lin, X., Li, L., Wang, L., Xiao, J., Liu, Y., Liu, Y., Zhang, S., Liang, D., Peng, L., Jespersen, T. & 1 others, Chen, Y., 2010, In: American Journal of Human Genetics. 86, 6, p. 872-80 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. 2009
  58. Published

    Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.

    Tfelt-Hansen, Jacob, Winkel, B., Grunnet, Morten & Jespersen, Thomas, Oct 2009, In: Journal of Cardiovascular Electrophysiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

    Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours

    Poulsen, H. S., Grunnet, Morten, Sorensen, M., Olsen, P., Hasselbalch, B., Nelausen, K., Kosteljanetz, M. & Lassen, U., 2009, In: Acta Oncologica. 48, 1, p. 52-58 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria

    Aon, M. A., Cortassa, S., Wei, A., Grunnet, Morten & O'Rourke, B., 2009, In: BBA General Subjects. 1797, 1, p. 71-80 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Functional properties of human neuronal Kv11 channels

    Einarsen, K., Callø, Kirstine, Grunnet, Morten, Olesen, Søren-Peter & Schmitt, Nicole, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel

    Tfelt-Hansen, J., Winkel, B. G., Grunnet, Morten & Jespersen, Thomas, 2009, In: Cardiovascular Electrophysiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Negative Modulation of SK Channels Terminates and Protects Against Atrial Fibrillation in Rat and Guinea Pig Ex Vivo and in vivo Models

    Diness, Jonas Goldin, Schultz Hansen, R., Sørensen, U. S. & Grunnet, Morten, 2009, In: Circulation. Supplement. 2009;120 (18): S712-S712 Suppl. 2.

    Research output: Contribution to journal › Conference article › Research › peer-review

  65. Published

    Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes

    Nissen, J. D., Diness, Jonas Goldin, Diness, T. G., Hansen, R. S., Grunnet, Morten & Jespersen, Thomas, 2009, In: Journal of Cardiovascular Pharmacology. 54, 2, p. 169-77 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo

    Bentzen, Bo Hjorth, Andersen, R. W., Olesen, Søren-Peter, Grunnet, Morten & Nardi, A., 2009, In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts

    Soltysinska, E., Olesen, Søren-Peter, Christ, T., Wettwer, E., Varró, A., Grunnet, Morten & Jespersen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2008
  69. Published

    A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome

    Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Antiarrhythmic effect of IKr activation in a cellular model of LQT3

    Diness, Jonas Goldin, Hansen, R. S., Nissen, J. D., Jespersen, Thomas & Grunnet, Morten, 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.

    Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function

    Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

    Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.

    Peitersen, T., Grunnet, Morten, Benson, A. P., Holden, A. V., von Holstein-Rathlou, Niels-Henrik & Olesen, Søren-Peter, 2008, In: Heart Rhythm. 5, 5, p. 734-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Fetal arrhythmia caused by dysregulation of HERG channels.

    Grunnet, Morten, 2008, In: Heart Rhythm. 5, 4, p. 562-4 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.

    Hansen, R. S., Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2008, In: Journal of Cardiovascular Pharmacology. 52, 1, p. 35-41 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro

    Fanoe, S., Jensen, G. B., Sjøgren, P., Korsgaard, M. P. G., Grunnet, Morten, Fanoe, S., Jensen, G. B., Sjøgren, P., Korsgaard, M. P. G. & Grunnet, M., 2008, In: British Journal of Clinical Pharmacology. 67, 2, p. 172-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Single-copy insertion of transgenes in Caenorhabditis elegans.

    Frøkjær-Jensen, Christian, Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, Søren-Peter, Grunnet, Morten & Jorgensen, E. M., 2008, In: Nature Genetics. 40, 11, p. 1375-83 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. 2007
  80. Published

    Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

    Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Inactivation as a new regulatory mechanism for neuronal Kv7 channels.

    Jensen, H. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Biophysical Journal. 92, 8, p. 2747-56 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

    Callø, Kirstine, Nielsen, Morten Schak, Grunnet, Morten, Schmitt, Nicole & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Modulation of ERG channels by XE991.

    Elmedyb, P., Callø, Kirstine, Schmitt, Nicole, Hansen, R. S., Grunnet, Morten & Olesen, Søren-Peter, 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.

    Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, Morten, Christiansen, M., Olesen, Søren-Peter & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.

    Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 996-1002 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

    Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. 2006
  89. Published

    Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]

    Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.

    Bøttger, P., Hede, S. E., Grunnet, Morten, Høyer, B., Klærke, Dan Arne & Pedersen, L., 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C1377-87

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.

    Diness, T. G., Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 4, p. 1224-33 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Subtype-specific, bi-component inhibition of SK channels by low internal pH.

    Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

    Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?

    Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. 2005
  96. Published

    Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

    Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.

    Grunnet, Morten, Behr, E. R., Callø, Kirstine, Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, Søren-Peter & Schmitt, Nicole, 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.

    Callø, Kirstine, Elmedyb, P., Olesen, Søren-Peter, Jorgensen, N. K. & Grunnet, Morten, 2005, In: Biophysical Journal. 89, 3, p. 2159-69 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Quantification and distribution of big conductance Ca2+-activated K+ channels in kidney epithelia.

    Grunnet, Morten, Hay-Schmidt, Anders & Klærke, Dan Arne, 2005, In: BBA General Subjects. 1714, 2, p. 114-24 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    The KCNQ1 potassium channel: from gene to physiological function.

    Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  101. Published

    hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.

    Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. 2004
  103. Published

    5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.

    Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.

    Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brain.

    Grunnet, Morten & Kaufmann, W. A., 2004, In: Journal of Biological Chemistry. 279, 35, p. 36445-53 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  106. Published

    Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype.

    Dunø, M., Colding-Jørgensen, E., Grunnet, Morten, Jespersen, Thomas, Vissing, John & Schwartz, M., 2004, In: European Journal of Human Genetics. 12, 9, p. 738-43 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  107. Published

    Does KCNE5 play a role in long QT syndrome?

    Hofman-Bang, J., Jespersen, Thomas, Grunnet, Morten, Larsen, Lars Allan, Andersen, P. S., Kanters, Jørgen K., Kjeldsen, K. & Christiansen, M., 2004, In: Clinica Chimica Acta. 345, 1-2, p. 49-53 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  108. Published

    Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog

    Grunnet, Morten, Jespersen, Thomas & Perrier, Jean-Francois Marie, 2004, In: Journal of Neuroscience Research. 78, p. 845-854

    Research output: Contribution to journal › Journal article › Research › peer-review

  109. 2003
  110. Published

    A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.

    Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  111. Published

    Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.

    Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  112. Published

    Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis.

    Nørremølle, Anne, Grunnet, Morten, Hasholt, Lis Frydenreich & Sørensen, S. A., 2003, In: Journal of Neuroscience Research. 71, 1, p. 132-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  113. Published

    Characterization of two new dominant ClC-1 channel mutations associated with myotonia.

    Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  114. Published

    Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.

    Ljungstrom, T., Grunnet, Morten, Jensen, B. S. & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 6, p. 684-94 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  115. Published

    KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.

    Grunnet, Morten, Rasmussen, H. B., Hay-Schmidt, Anders, Rosenstierne, M., Klærke, Dan Arne, Olesen, Søren-Peter & Jespersen, Thomas, 2003, In: Biophysical Journal. 85, 3, p. 1525-37 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  116. Published

    KCNQ1 channels sense small changes in cell volume.

    Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  117. Published

    Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.

    Hay-Schmidt, Anders, Grunnet, Morten, Abrahamse, S. L., Knaus, H. & Klærke, Dan Arne, 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 61-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  118. Published

    Pharmacological investigation of the role of ion channels in salivary secretion.

    Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Rasmussen, Hanne Borger, Olesen, Søren-Peter & Jorgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 78-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  119. Published

    Solid-phase synthesis and biological activity of a thioether analogue of conotoxin G1.

    Bondebjerg, J., Grunnet, Morten, Jespersen, Thomas & Meldal, Morten Peter, 2003, In: ChemBioChem. 4, 2-3, p. 186-94 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 182570346